RGD Reference Report - Effects of dietary Pi on the renal Na+-dependent Pi transporter NaPi-2 in thyroparathyroidectomized rats. - Rat Genome Database

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Effects of dietary Pi on the renal Na+-dependent Pi transporter NaPi-2 in thyroparathyroidectomized rats.

Authors: Takahashi, F  Morita, K  Katai, K  Segawa, H  Fujioka, A  Kouda, T  Tatsumi, S  Nii, T  Taketani, Y  Haga, H  Hisano, S  Fukui, Y  Miyamoto, KI  Takeda, E 
Citation: Takahashi F, etal., Biochem J. 1998 Jul 1;333 ( Pt 1):175-81.
RGD ID: 7242931
Pubmed: PMID:9639577   (View Abstract at PubMed)
PMCID: PMC1219570   (View Article at PubMed Central)

Dietary Pi and parathyroid hormone (PTH) are two most important physiological and pathophysiological regulators of Pi re-absorption in the renal proximal tubule. Effects of dietary Pi on Na+/Pi co-transporter NaPi-2 were investigated in thyroparathyroidectomized (TPTX) rats. NaPi-2 protein and mRNA in the kidney cortex of TPTX rats were increased approximately 3.8- and 2.4-fold in amount respectively compared with those in the sham-operated animals. Administration of PTH to the TPTX rats resulted in a decrease in the amount of NaPi-2 protein, but not in the abundance of NaPi-2 mRNA. Deprivation of dietary Pi in the TPTX rats did not affect the amount of NaPi-2 mRNA and protein. In the Pi-deprived TPTX rats, feeding of a high-Pi diet resulted in marked decreases in Pi transport activity and the amount of NaPi-2 protein in the superficial nephrons. Immunohistochemical analysis demonstrated that administration of PTH to TPTX rats resulted in a decrease in NaPi-2 immunoreactivity from both superficial and juxtamedullary nephrons within 4 h. Switching TPTX animals from a low-Pi diet to the high-Pi diet decreased NaPi-2 immunoreactivity from superficial nephrons, but not from juxtamedullary nephrons, within 4 h. These results suggest that dietary Pi could regulate the amount of NaPi-2 protein in the superficial nephrons in a PTH-independent manner.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
PthRatresponse to parathyroid hormone  IEP  RGD 

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Slc34a1Ratapical plasma membrane  IDA  RGD 


Genes (Rattus norvegicus)
Pth  (parathyroid hormone) Slc34a1  (solute carrier family 34 member 1)