RGD Reference Report - Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD. - Rat Genome Database

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Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD.

Authors: London, GM  Marchais, SJ  Guerin, AP  Boutouyrie, P  Metivier, F  De Vernejoul, MC 
Citation: London GM, etal., J Am Soc Nephrol. 2008 Sep;19(9):1827-35. doi: 10.1681/ASN.2007050622. Epub 2008 May 14.
RGD ID: 7242687
Pubmed: PMID:18480316   (View Abstract at PubMed)
PMCID: PMC2518431   (View Article at PubMed Central)
DOI: DOI:10.1681/ASN.2007050622   (Journal Full-text)

An inverse relationship between arterial calcifications and bone activity has been documented in patients with ESRD. Calcium overload is associated with arterial calcification, which is associated with arterial stiffening. Whether bone activity interacts with calcium load, aortic stiffness, or arterial calcification is unknown. This study assessed the impact of bone activity on the relationships between the dosage of calcium-containing phosphate binders and aortic stiffness (measured by pulse wave velocity) or abdominal aorta calcification score. Aortic stiffness and calcification were both positively associated with calcium load and negatively associated with bone activity. A significant interaction was found between dosage of calcium-containing phosphate binders and bone activity such that calcium load had a significantly greater influence on aortic calcifications and stiffening in the presence of adynamic bone disease. Independent of any other factor, including dosage of calcium-containing phosphate binders, adynamic bone was associated with greater aortic stiffening, suggesting cross-talk between the bone and arterial walls.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renal osteodystrophy  IEP 7242687associated with Kidney Failure more ...RGD 
renal osteodystrophy  ISOPTH (Homo sapiens)7242687; 7242687associated with Kidney Failure more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pth  (parathyroid hormone)

Genes (Mus musculus)
Pth  (parathyroid hormone)

Genes (Homo sapiens)
PTH  (parathyroid hormone)


Additional Information