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Gene: PTH (parathyroid hormone) Chlorocebus sabaeus

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Symbol:

PTH

Name:

parathyroid hormone

RGD ID:

18449226

Description:

ENCODES a protein that exhibits parathyroid hormone receptor binding (ortholog); type 1 parathyroid hormone receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); bone mineralization (ortholog); cell-cell signaling (ortholog); PARTICIPATES IN parathyroid hormone signaling pathway; ASSOCIATED WITH Albuminuria (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PTH (parathyroid hormone)	NCBI	Ortholog
Mus musculus (house mouse):	Pth (parathyroid hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Pth (parathyroid hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pth (parathyroid hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PTH (parathyroid hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PTH (parathyroid hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pth (parathyroid hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PTH (parathyroid hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pth (parathyroid hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	51,327,555 - 51,330,810 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	148,907,988 - 148,910,728 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (ISO)

anemia (ISO)

Animal Disease Models (ISO)

atrial fibrillation (ISO)

atrophic gastritis (ISO)

autosomal dominant hypocalcemia (ISO)

Bone Fractures (ISO)

bone resorption disease (ISO)

Calcification of Aortic Valve (ISO)

calcium oxalate nephrolithiasis (ISO)

chronic kidney disease (ISO)

congestive heart failure (ISO)

coronary artery disease (ISO)

Diabetic Nephropathies (ISO)

end stage renal disease (ISO)

Endocrine Bone Diseases (ISO)

familial isolated hypoparathyroidism (ISO)

Familial Isolated Hypoparathyroidism 1 (ISO)

hereditary hypophosphatemic rickets with hypercalciuria (ISO)

hypercalcemia (ISO)

Hypercalciuria (ISO)

hyperostosis (ISO)

hyperphosphatemia (ISO)

hypertension (ISO)

hyperthyroidism (ISO)

Hypocalcemia (ISO)

Hypoparathyroidism, Autosomal Recessive (ISO)

intellectual disability (ISO)

Left Ventricular Hypertrophy (ISO)

nephrocalcinosis (ISO)

nevoid basal cell carcinoma syndrome (ISO)

osteoporosis (ISO)

osteosarcoma (ISO)

otitis media (ISO)

Parathyroid Neoplasms (ISO)

Phosphaturia (ISO)

Postmenopausal Osteoporosis (ISO)

primary hyperparathyroidism (ISO)

renal osteodystrophy (ISO)

rickets (ISO)

secondary hyperparathyroidism (ISO)

Stroke (ISO)

Tibial Fractures (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

uremia (ISO)

Vascular Calcification (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA,ISO)

bone mineralization (IEA,ISO)

calcium ion homeostasis (IEA)

cell-cell signaling (IEA,ISO)

homeostasis of number of cells within a tissue (IEA)

intracellular calcium ion homeostasis (IEA,ISO)

magnesium ion homeostasis (IEA)

negative regulation of apoptotic process in bone marrow cell (IEA)

negative regulation of bone mineralization involved in bone maturation (ISO)

negative regulation of chondrocyte differentiation (ISO)

negative regulation of gene expression (IEA)

phosphate ion homeostasis (IEA)

positive regulation of bone mineralization (IEA,ISO)

positive regulation of cell proliferation in bone marrow (IEA)

positive regulation of D-glucose import (IEA)

positive regulation of gene expression (ISO)

positive regulation of glycogen biosynthetic process (IEA)

positive regulation of inositol phosphate biosynthetic process (IEA)

positive regulation of ossification (ISO)

positive regulation of osteoclast proliferation (IEA)

positive regulation of signal transduction (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of gene expression (IEA)

response to cadmium ion (ISO)

response to ethanol (ISO)

response to fibroblast growth factor (ISO)

response to lead ion (ISO)

response to nutrient levels (ISO)

response to parathyroid hormone (ISO)

response to vitamin D (ISO)

response to xenobiotic stimulus (ISO)

Rho protein signal transduction (ISO)

signal transduction (IEA)

transcription by RNA polymerase II (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA,ISO)

Molecular Function

hormone activity (IEA)

parathyroid hormone receptor binding (IEA,ISO)

peptide hormone receptor binding (IEA)

protein binding (ISO)

receptor ligand activity (IEA)

type 1 parathyroid hormone receptor binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

parathyroid hormone signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PTH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	51,327,555 - 51,330,810 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	148,907,988 - 148,910,728 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PTH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	13,492,054 - 13,496,181 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	13,492,054 - 13,496,181 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	13,513,601 - 13,517,728 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	13,470,177 - 13,474,143 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	13,470,177 - 13,474,143	NCBI
Celera	11	13,639,772 - 13,643,738 (-)	NCBI		Celera
Cytogenetic Map	11	p15.3	NCBI
HuRef	11	13,193,715 - 13,197,681 (-)	NCBI		HuRef
CHM1_1	11	13,512,571 - 13,516,537 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	13,584,795 - 13,588,918 (-)	NCBI		T2T-CHM13v2.0

Pth
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	112,984,783 - 112,987,879 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	112,984,787 - 112,987,777 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	113,385,576 - 113,388,672 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	113,385,580 - 113,388,570 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	120,529,090 - 120,532,087 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	113,176,759 - 113,179,753 (-)	NCBI		MGSCv36	mm8
Celera	7	113,358,705 - 113,361,703 (-)	NCBI		Celera
Cytogenetic Map	7	F1	NCBI
cM Map	7	59.19	NCBI

Pth
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	176,942,901 - 176,946,034 (-)	NCBI		GRCr8
GRCr8 Ensembl	1	176,943,102 - 176,946,034 (-)	Ensembl		GRCr8 Ensembl
mRatBN7.2	1	167,508,121 - 167,511,530 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	167,508,598 - 167,511,530 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	175,843,980 - 175,846,912 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	183,030,070 - 183,033,002 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	175,725,437 - 175,728,369 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	178,215,829 - 178,218,761 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	178,215,829 - 178,218,761 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	185,183,456 - 185,186,388 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	171,240,596 - 171,243,528 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	165,378,267 - 165,381,199 (-)	NCBI		Celera
RGSC_v3.1	1	171,360,529 - 171,363,462 (-)	NCBI
Cytogenetic Map	1	q33	NCBI

Pth
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	28,825,651 - 28,831,117 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	28,828,389 - 28,831,417 (-)	NCBI	ChiLan1.0	ChiLan1.0

PTH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	15,932,137 - 15,936,264 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	15,894,484 - 15,898,611 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	13,653,777 - 13,657,901 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	13,347,829 - 13,351,951 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	13,347,838 - 13,351,802 (-)	Ensembl	panpan1.1		panPan2

PTH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	36,417,062 - 36,419,967 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	36,417,058 - 36,419,967 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	35,920,892 - 35,923,798 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	37,300,338 - 37,303,244 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	37,300,334 - 37,303,244 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	36,558,731 - 36,561,637 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	36,734,945 - 36,737,853 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	37,024,013 - 37,026,919 (-)	NCBI		UU_Cfam_GSD_1.0

Pth
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	49,049,606 - 49,050,285 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936528	5,083,596 - 5,084,030 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936528	5,081,569 - 5,084,030 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	45,757,398 - 45,760,415 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	45,757,398 - 45,760,433 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	49,290,017 - 49,290,981 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Pth
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	5,489,800 - 5,492,871 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	5,489,857 - 5,492,777 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PTH
54 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008006211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037997638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JBLKOC010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_008006211 ⟹ XP_008004402

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	1	51,327,555 - 51,330,810 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	148,907,988 - 148,910,728 (+)	NCBI

Sequence:

show sequence

TAAAGGACTGCTGTGAAGATCTAGTGGGATGATGTATGTAATTAGGCATGCAGTTAGTGCTTAT
CAAATGTTGTTATTACAGATTAAGATGCACAAGTAAAATATAAGTTAAATAAATTTTAAAATAA
TTTCACTTTTGAAGCTTTTAAAGTAATTATGTACCAAGAGCATTTTCTCAAATTATTTTTAACA
ATTCCTTTAAGAAAAGGGCTACATCTGTGTTTTTGAAAGATGACCAGAAGTGATATGGATTGGT
TGAAAATGACTTGTAAAATAAGCATAACATCTATGATTTATTATCATAAAATTGTACCAACAGT
ATGGTTATAACAAATATACTTATTTTTGGATTTTACTTTCGAGTAAGATAATGACTTTATCATA
AATCTTTGAAATCAGTCTTTTCACAGTTTAAATTCAGATTCATTAATCCAGGTAGAATTTTTCT
AGGTGGCATAATTCTGTATATGTTAAAAGTCTTTGCATAAGCCCCTTTTCAAGCCAAATGCTGT
TTTCCTTTTAGTATCCAACTAACCAAAACTTAAGAAGAGTGTGCACCGCCCTGTGGGTGTGTGT
ATGTGCTGCTTTGAACCTATAGTTGAGATCCAGAGAATTGGGAGTGACATCATCTGTAACAATA
AAAGAACCTCTCTTGTGAAGATGATACCTGCAAAAGACATGGCTAAAATAATGATTGTCATGTT
GGCAATTTGTTTTCTTGCAAAATCAGATGGGAAATCTGTTAAGAAGAGATCTGTGAGTGAAATA
CAGCTTATGCATAACCTGGGAAAACATCTGAACTCGATGGAGAGAGTAGAATGGCTGCGTAAGA
AGCTGCAGGATGTGCATAATTTTATTGCCCTTGGAGCTCCTCTAGCTCCCAGAGATGCTGGTTC
CCAGAGGCCCCGAAAAAAGGAAGACAATATCTTGGTTGAGAGCCATGAAAAAAGTCTTGGAGAG
GCAGACAAAGCTGATGTGGATGTATTAACTAAAGCTAAATCCCAATGAAAATGAAAATAGATAC
GGTCAGAGCTCTGCTCTAGACAGTGTAGGGCAACGATACATGCTGCTAATTTTTCAAAGGTCTA
TTAAGATTTCCAAGTACCAATATCTCTGATATAACAAACTACATATAATCCATCACTAGCCATG
ATAGCTGCAATTTTAATTGATTATTTTGATTCTACTTTTATGCATTTGAGTTATTTTAATTATT
CTTTTCTATAGTTTATTCTTTTTAAAGTATGTTATTGCATAATTTATGAAAGAATAAAATTGCA
TTTTTAACCTCTCTTCTACCTTAAAATGTAAAACAAAAATGTAATGATCATAAGTCTAAATAAA
TGAAGCATTTCTCACTCA

hide sequence

RefSeq Acc Id:

XM_037997638 ⟹ XP_037853566

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666038	148,908,063 - 148,910,728 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008004402	(Get FASTA)	NCBI Sequence Viewer
	XP_037853566	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000001014.1

RefSeq Acc Id:	XP_008004402 ⟸ XM_008006211
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037853566 ⟸ XM_037997638
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9QXC5 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000004688	UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000002718.1	UniProtKB/TrEMBL
InterPro	PTH	UniProtKB/TrEMBL
	PTH/PTH-rel	UniProtKB/TrEMBL
NCBI Gene	PTH	ENTREZGENE
PANTHER	PARATHYROID HORMONE	UniProtKB/TrEMBL
	PARATHYROID HORMONE	UniProtKB/TrEMBL
Pfam	Parathyroid	UniProtKB/TrEMBL
PIRSF	PTH	UniProtKB/TrEMBL
PROSITE	PARATHYROID	UniProtKB/TrEMBL
SMART	PTH	UniProtKB/TrEMBL
UniProt	A0A0D9QXC5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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