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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3440
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pth
Name: parathyroid hormone
Acc ID: CHEBI:16708
Term: adenine
Definition: The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.
Chemical ID: MESH:D000225
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pthincreases expressionEXP 6480464CTDAdenine results in increased expression of PTH proteinPMID:16272627
Pthincreases stabilityEXP 6480464CTDAdenine results in increased stability of PTH mRNAPMID:18583400
Pthmultiple interactionsEXP 6480464CTD[Adenine co-treated with Phosphorus] results in increased expression of PTH mRNA; [Adenine co-treated with Phosphorus] results in increased expression of PTH protein; Adenine inhibits the reaction [KHSRP protein binds to PTH 3' UTR]; Adenine promotes the reaction [HNRNPD protein binds to PTH 3' UTR]; N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine inhibits the reaction [[Adenine co-treated with Phosphorus] results in increased expression of PTH protein]PMID:16291838 PMID:18583400
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