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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3440
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pth
Name: parathyroid hormone
Acc ID: CHEBI:28940
Term: calciol
Definition: A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.
Chemical ID: MESH:D002762
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pthdecreases expressionEXP 6480464CTDCholecalciferol results in decreased expression of PTH mRNAPMID:11332696
Pthdecreases secretionEXP 6480464CTDCholecalciferol results in decreased secretion of PTH proteinPMID:11332696
Pthdecreases expressionISOPTH (Homo sapiens)6480464CTDCholecalciferol results in decreased expression of PTH proteinPMID:21179201 PMID:8711172
Pthmultiple interactionsISOPTH (Homo sapiens)6480464CTD[Cholecalciferol co-treated with Calcium] results in decreased expression of PTH proteinPMID:80633
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