Kctd12 (potassium channel tetramerization domain containing 12) - Rat Genome Database

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Gene: Kctd12 (potassium channel tetramerization domain containing 12) Rattus norvegicus
Analyze
Symbol: Kctd12
Name: potassium channel tetramerization domain containing 12
RGD ID: 1309421
Description: Predicted to enable identical protein binding activity. Predicted to be involved in protein homooligomerization. Predicted to act upstream of or within regulation of G protein-coupled receptor signaling pathway. Predicted to be located in postsynaptic membrane and presynaptic membrane. Predicted to be part of receptor complex. Orthologous to human KCTD12 (potassium channel tetramerization domain containing 12); INTERACTS WITH 17alpha-ethynylestradiol; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BTB/POZ domain-containing protein KCTD12; LOC364458; potassium channel tetramerisation domain containing 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21579,800,078 - 79,806,017 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1579,801,191 - 79,806,282 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1583,784,596 - 83,790,535 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01584,907,607 - 84,913,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01581,835,232 - 81,841,173 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01587,384,632 - 87,390,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01590,884,584 - 90,890,565 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41586,986,827 - 86,987,810NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1578,950,071 - 78,956,067 (-)NCBICelera
Cytogenetic Map15q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20400944   PMID:21700703   PMID:22681889   PMID:23376485   PMID:27073217   PMID:27152988  


Genomics

Comparative Map Data
Kctd12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21579,800,078 - 79,806,017 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1579,801,191 - 79,806,282 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1583,784,596 - 83,790,535 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01584,907,607 - 84,913,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01581,835,232 - 81,841,173 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01587,384,632 - 87,390,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01590,884,584 - 90,890,565 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41586,986,827 - 86,987,810NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1578,950,071 - 78,956,067 (-)NCBICelera
Cytogenetic Map15q21NCBI
KCTD12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381376,880,175 - 76,886,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1376,880,175 - 76,886,405 (-)EnsemblGRCh38hg38GRCh38
GRCh371377,454,310 - 77,460,540 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361376,352,305 - 76,358,541 (-)NCBINCBI36Build 36hg18NCBI36
Build 341376,352,312 - 76,358,526NCBI
Celera1358,352,296 - 58,358,541 (-)NCBICelera
Cytogenetic Map13q22.3NCBI
HuRef1358,151,993 - 58,158,238 (-)NCBIHuRef
CHM1_11377,422,214 - 77,428,462 (-)NCBICHM1_1
T2T-CHM13v2.01376,103,834 - 76,110,076 (-)NCBIT2T-CHM13v2.0
Kctd12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914103,214,017 - 103,220,073 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14103,214,017 - 103,220,073 (-)EnsemblGRCm39 Ensembl
GRCm3814102,976,581 - 102,982,637 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14102,976,581 - 102,982,637 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714103,375,798 - 103,381,854 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614101,864,140 - 101,869,137 (-)NCBIMGSCv36mm8
Celera14101,609,268 - 101,615,325 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1451.55NCBI
Kctd12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540430,325,144 - 30,326,121 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540430,325,019 - 30,330,953 (+)NCBIChiLan1.0ChiLan1.0
KCTD12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11377,045,536 - 77,057,044 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01358,097,764 - 58,104,972 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11377,141,611 - 77,147,172 (-)NCBIpanpan1.1PanPan1.1panPan2
KCTD12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12230,506,906 - 30,508,782 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2230,503,932 - 30,508,632 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2230,363,633 - 30,369,895 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02230,814,574 - 30,820,852 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12230,482,086 - 30,488,335 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02230,520,448 - 30,526,697 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02230,589,920 - 30,596,172 (-)NCBIUU_Cfam_GSD_1.0
Kctd12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945128,972,357 - 128,978,403 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365114,389,755 - 4,390,738 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365114,389,558 - 4,395,630 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCTD12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1149,025,131 - 49,031,309 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11149,025,134 - 49,033,208 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21153,668,328 - 53,669,623 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCTD12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1355,970,438 - 55,973,640 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl355,972,438 - 55,973,415 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604612,175,983 - 12,182,244 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kctd12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475123,574,456 - 23,575,433 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475123,574,254 - 23,580,266 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kctd12
46 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
1581555Eae19Experimental allergic encephalomyelitis QTL 194.7nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)157630609990088744Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat

Markers in Region
RH141929  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21579,803,377 - 79,803,557 (+)MAPPERmRatBN7.2
Rnor_6.01587,387,935 - 87,388,114NCBIRnor6.0
Rnor_5.01590,887,888 - 90,888,067UniSTSRnor5.0
RGSC_v3.41586,985,369 - 86,985,548UniSTSRGSC3.4
Celera1578,953,375 - 78,953,554UniSTS
RH 3.4 Map15502.69UniSTS
Cytogenetic Map15q22UniSTS
AI408351  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21579,800,146 - 79,800,313 (+)MAPPERmRatBN7.2
Rnor_6.01587,384,704 - 87,384,870NCBIRnor6.0
Rnor_5.01590,884,657 - 90,884,823UniSTSRnor5.0
RGSC_v3.41586,982,138 - 86,982,304UniSTSRGSC3.4
Celera1578,950,143 - 78,950,309UniSTS
RH 3.4 Map15498.0UniSTS
Cytogenetic Map15q22UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000110749   ⟹   ENSRNOP00000077409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1579,801,191 - 79,806,282 (-)Ensembl
RefSeq Acc Id: NM_001399515   ⟹   NP_001386444
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21579,800,078 - 79,806,017 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386444 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02446 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077409.1
RefSeq Acc Id: ENSRNOP00000077409   ⟸   ENSRNOT00000110749
RefSeq Acc Id: NP_001386444   ⟸   NM_001399515
- UniProtKB: A6HU83 (UniProtKB/TrEMBL),   A0A8I5Y7I2 (UniProtKB/TrEMBL)
Protein Domains
BTB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309421 AgrOrtholog
BioCyc Gene G2FUF-12703 BioCyc
Ensembl Genes ENSRNOG00000066973 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000110749.1 UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
KEGG Report rno:364458 UniProtKB/TrEMBL
NCBI Gene 364458 ENTREZGENE
PANTHER BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD12 UniProtKB/TrEMBL
  POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/TrEMBL
PhenoGen Kctd12 PhenoGen
RatGTEx ENSRNOG00000066973 RatGTEx
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
UniProt A0A8I5Y7I2 ENTREZGENE, UniProtKB/TrEMBL
  A6HU83 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Kctd12  potassium channel tetramerization domain containing 12  Kctd12  potassium channel tetramerization domain containing 12  Data merged from RGD:149736453 737654 PROVISIONAL
2021-08-09 Kctd12  potassium channel tetramerization domain containing 12      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-07-09 Kctd12  potassium channel tetramerization domain containing 12  Kctd12  potassium channel tetramerisation domain containing 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Kctd12  potassium channel tetramerisation domain containing 12   Kctd12_predicted  potassium channel tetramerisation domain containing 12 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Kctd12_predicted  potassium channel tetramerisation domain containing 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED