Tpm2 (tropomyosin 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tpm2 (tropomyosin 2) Rattus norvegicus
Analyze
Symbol: Tpm2
Name: tropomyosin 2
RGD ID: 1559479
Description: Enables actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATP-dependent activity. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-tropomyosin; MGC109519; similar to tropomyosin 1, embryonic fibroblast - rat; tropomyosin; tropomyosin 2, beta; tropomyosin beta chain; tropomyosin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,566,712 - 62,576,066 (-)NCBIGRCr8
mRatBN7.2557,770,919 - 57,780,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,770,864 - 57,779,992 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,750,807 - 59,759,817 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,569,623 - 61,578,633 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,540,839 - 61,549,996 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,016,616 - 59,025,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,016,622 - 59,025,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,541,215 - 63,550,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,994,101 - 60,003,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera556,351,476 - 56,360,486 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clotrimazole  (EXP)
clozapine  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP,ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
entinostat  (ISO)
furan  (EXP)
graphene oxide  (ISO)
graphite  (ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP)
inulin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
nitrates  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
spermine  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly. Gimona M, etal., Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9776-80.
3. In vitro formation and characterization of the skeletal muscle a·ß tropomyosin heterodimers. Kalyva A, etal., Biochemistry. 2012 Aug 14;51(32):6388-99. Epub 2012 Aug 3.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2432392   PMID:3840484   PMID:8889548   PMID:12947022   PMID:17194691   PMID:19182904   PMID:25369766   PMID:29183317   PMID:35352799  


Genomics

Comparative Map Data
Tpm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,566,712 - 62,576,066 (-)NCBIGRCr8
mRatBN7.2557,770,919 - 57,780,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,770,864 - 57,779,992 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,750,807 - 59,759,817 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,569,623 - 61,578,633 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,540,839 - 61,549,996 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,016,616 - 59,025,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,016,622 - 59,025,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,541,215 - 63,550,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,994,101 - 60,003,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera556,351,476 - 56,360,486 (-)NCBICelera
Cytogenetic Map5q22NCBI
TPM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,681,993 - 35,690,056 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,681,992 - 35,690,056 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,681,990 - 35,690,053 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,671,990 - 35,680,053 (-)NCBINCBI36Build 36hg18NCBI36
Celera935,615,536 - 35,623,601 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,637,598 - 35,645,663 (-)NCBIHuRef
CHM1_1935,681,818 - 35,689,882 (-)NCBICHM1_1
T2T-CHM13v2.0935,702,645 - 35,710,710 (-)NCBIT2T-CHM13v2.0
Tpm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,513,726 - 43,523,583 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,514,711 - 43,523,765 (-)EnsemblGRCm39 Ensembl
GRCm38443,513,726 - 43,523,583 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,514,711 - 43,523,765 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,527,584 - 43,536,260 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,535,812 - 43,544,488 (-)NCBIMGSCv36mm8
Celera443,548,571 - 43,557,214 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Tpm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472611,028 - 617,821 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955472611,079 - 617,823 (+)NCBIChiLan1.0ChiLan1.0
TPM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,896,692 - 88,905,357 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,903,269 - 88,911,296 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,533,982 - 35,542,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,336,307 - 36,345,394 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,336,307 - 36,345,394 (-)Ensemblpanpan1.1panPan2
TPM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,212,372 - 52,219,947 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,212,401 - 52,219,923 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,779,956 - 50,787,531 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,277,326 - 53,284,901 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,277,355 - 53,284,866 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,821,901 - 51,829,478 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,805,386 - 51,812,960 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,507,526 - 52,515,101 (-)NCBIUU_Cfam_GSD_1.0
Tpm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,132,139 - 167,140,168 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,679,560 - 3,688,308 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,679,719 - 3,687,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,402,251 - 236,410,905 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,402,249 - 236,410,390 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,127,284 - 264,135,301 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q23-q27NCBI
TPM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,912,250 - 44,920,615 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,912,223 - 44,919,456 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603842,015,821 - 42,025,459 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248685,101,090 - 5,109,820 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248685,101,713 - 5,109,560 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tpm2
48 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:135
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000022801, ENSRNOT00000049000
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat

Markers in Region
RH127874  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8562,566,829 - 62,567,184 (+)Marker Load Pipeline
mRatBN7.2557,771,041 - 57,771,396 (+)MAPPERmRatBN7.2
Rnor_6.0559,016,739 - 59,017,093NCBIRnor6.0
Rnor_5.0563,541,333 - 63,541,687UniSTSRnor5.0
RGSC_v3.4559,994,219 - 59,994,573UniSTSRGSC3.4
Celera556,351,594 - 56,351,948UniSTS
RH 3.4 Map5394.8UniSTS
Cytogenetic Map5q22UniSTS
BI277374  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,771,921 - 57,772,126 (+)MAPPERmRatBN7.2
Rnor_6.0559,017,619 - 59,017,823NCBIRnor6.0
Rnor_5.0563,542,213 - 63,542,417UniSTSRnor5.0
RGSC_v3.4559,995,099 - 59,995,303UniSTSRGSC3.4
Celera556,352,474 - 56,352,678UniSTS
RH 3.4 Map5394.8UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001024345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF110059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV796622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ118075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022801   ⟹   ENSRNOP00000022801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,770,864 - 57,779,875 (-)Ensembl
Rnor_6.0 Ensembl559,017,575 - 59,025,631 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000049000   ⟹   ENSRNOP00000044473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,770,924 - 57,779,992 (-)Ensembl
Rnor_6.0 Ensembl559,016,622 - 59,025,631 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093971   ⟹   ENSRNOP00000083091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,771,156 - 57,779,861 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102327   ⟹   ENSRNOP00000080861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,770,864 - 57,779,875 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114391   ⟹   ENSRNOP00000091881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,771,877 - 57,779,992 (-)Ensembl
RefSeq Acc Id: NM_001024345   ⟹   NP_001019516
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,566,712 - 62,575,726 (-)NCBI
mRatBN7.2557,770,924 - 57,779,938 (-)NCBI
Rnor_6.0559,016,621 - 59,025,631 (-)NCBI
Rnor_5.0563,541,215 - 63,550,146 (-)NCBI
RGSC_v3.4559,994,101 - 60,003,261 (-)RGD
Celera556,351,476 - 56,360,486 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301235   ⟹   NP_001288164
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,567,665 - 62,575,726 (-)NCBI
mRatBN7.2557,771,877 - 57,779,938 (-)NCBI
Rnor_6.0559,017,574 - 59,025,631 (-)NCBI
Celera556,352,429 - 56,360,486 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763680   ⟹   XP_008761902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,566,712 - 62,576,066 (-)NCBI
mRatBN7.2557,770,919 - 57,780,278 (-)NCBI
Rnor_6.0559,016,616 - 59,025,971 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763681   ⟹   XP_008761903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,566,712 - 62,576,066 (-)NCBI
mRatBN7.2557,771,877 - 57,780,278 (-)NCBI
Rnor_6.0559,017,574 - 59,025,971 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001019516   ⟸   NM_001024345
- Peptide Label: isoform Tpm2.1sm/cy
- UniProtKB: Q5FVG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761902   ⟸   XM_008763680
- Peptide Label: isoform X1
- UniProtKB: A6IJ28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761903   ⟸   XM_008763681
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001288164   ⟸   NM_001301235
- Peptide Label: isoform Tpm2.2st
- UniProtKB: P06395 (UniProtKB/Swiss-Prot),   P58775 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022801   ⟸   ENSRNOT00000022801
Ensembl Acc Id: ENSRNOP00000044473   ⟸   ENSRNOT00000049000
Ensembl Acc Id: ENSRNOP00000080861   ⟸   ENSRNOT00000102327
Ensembl Acc Id: ENSRNOP00000091881   ⟸   ENSRNOT00000114391
Ensembl Acc Id: ENSRNOP00000083091   ⟸   ENSRNOT00000093971

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P58775-F1-model_v2 AlphaFold P58775 1-284 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693677
Promoter ID:EPDNEW_R4202
Type:initiation region
Name:Tpm2_1
Description:tropomyosin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0559,025,568 - 59,025,628EPDNEW
RGD ID:6849480
Promoter ID:EP25019
Type:single initiation site
Name:RN_TPM1
Description:Tropomyosin-beta (skeletal muscle beta)
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 140; Mammalian tropomyosin beta
Experiment Methods:Nuclease protection; Primer extension
Regulation:skel (repressed by or weakly expressed in) m., smooth muscle, fibroblasts
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.4560,003,279 - 60,003,339EPD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559479 AgrOrtholog
BioCyc Gene G2FUF-41506 BioCyc
Ensembl Genes ENSRNOG00000016731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022801 ENTREZGENE
  ENSRNOT00000022801.7 UniProtKB/Swiss-Prot
  ENSRNOT00000049000 ENTREZGENE
  ENSRNOT00000049000.7 UniProtKB/Swiss-Prot
  ENSRNOT00000093971.1 UniProtKB/TrEMBL
  ENSRNOT00000102327 ENTREZGENE
  ENSRNOT00000102327.1 UniProtKB/TrEMBL
  ENSRNOT00000114391.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.370 UniProtKB/TrEMBL
  1.20.5.400 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7324151 IMAGE-MGC_LOAD
InterPro Tropomyosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XRCC4-like_C UniProtKB/TrEMBL
KEGG Report rno:500450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109519 IMAGE-MGC_LOAD
NCBI Gene 500450 ENTREZGENE
PANTHER TROPOMYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tropomyosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tpm2 PhenoGen
PRINTS TROPOMYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TROPOMYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016731 RatGTEx
Superfamily-SCOP Tropomyosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZR83_RAT UniProtKB/TrEMBL
  A0A8I5ZZ90_RAT UniProtKB/TrEMBL
  A0A8I6AG31_RAT UniProtKB/TrEMBL
  A6IJ28 ENTREZGENE, UniProtKB/TrEMBL
  P06395 ENTREZGENE
  P58775 ENTREZGENE
  Q5FVG5 ENTREZGENE, UniProtKB/TrEMBL
  TPM2_RAT UniProtKB/Swiss-Prot
UniProt Secondary P02560 UniProtKB/Swiss-Prot
  P06395 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-12 Tpm2  tropomyosin 2  Tpm2  tropomyosin 2, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Tpm2  tropomyosin 2, beta  Tpm2  tropomyosin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Tpm2  tropomyosin 2  MGC109519  similar to tropomyosin 1, embryonic fibroblast - rat  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC109519  similar to tropomyosin 1, embryonic fibroblast - rat      Symbol and Name status set to provisional 70820 PROVISIONAL