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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:clotrimazole
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Accession:CHEBI:3764 term browser browse the term
Definition:A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
Synonyms:exact_synonym: 1-[(2-chlorophenyl)(diphenyl)methyl]-1H-imidazole
 related_synonym: 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole;   1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole;   1-(o-Chloro-alpha,alpha-diphenylbenzyl)imidazole;   1-(o-Chlorotrityl)imidazole;   Formula=C22H17ClN2;   InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H;   InChIKey=VNFPBHJOKIVQEB-UHFFFAOYSA-N;   Lotrimin (TN);   Mycelex (TN);   SMILES=Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
 xref: Beilstein:622318;   CAS:23593-75-1;   DrugBank:DB00257;   Drug_Central:719;   HMDB:HMDB0001922;   KEGG:C06922;   KEGG:D00282;   LINCS:LSM-5341
 xref_mesh: MESH:D003022
 xref: PDBeChem:CL6;   PMID:18728240;   PMID:24892421;   Reaxys:622318;   Wikipedia:Clotrimazole

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clotrimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Clotrimazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Clotrimazole results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
multiple interactions
increases expression		 ISO Clotrimazole binds to ABCB1 protein
Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
Clotrimazole results in increased expression of ABCB1 protein
Clotrimazole inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]		 CTD PMID:8632764 PMID:8917702 PMID:12235267 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Clotrimazole results in increased expression of ABCC2 mRNA; Clotrimazole results in increased expression of ABCC2 protein CTD PMID:11836020 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression		 ISO MAPK14 promotes the reaction [Clotrimazole results in increased expression of ABCC3 mRNA]; SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ABCC3 mRNA] CTD PMID:27507784 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Adcy9 adenylate cyclase 9 decreases activity ISO Clotrimazole results in decreased activity of ADCY9 protein CTD PMID:30607468 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Clotrimazole results in increased activity of AHR protein CTD PMID:26187274 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B affects localization ISO Clotrimazole affects the localization of ALDOB protein CTD PMID:12126931 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824 		JBrowse link
G Atf3 activating transcription factor 3 increases expression
multiple interactions		 ISO Clotrimazole results in increased expression of ATF3 mRNA
SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ATF3 mRNA]		 CTD PMID:27507784 PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Clotrimazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 mRNA]
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP3 protein]		 CTD PMID:22033380 PMID:24239969 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP8 protein] CTD PMID:22033380 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cat catalase multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in decreased activity of CAT protein]; Clotrimazole inhibits the reaction [lead acetate results in decreased activity of CAT protein] CTD PMID:22033380 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Clotrimazole results in decreased expression of CDK1 CTD PMID:20724915 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Clotrimazole results in decreased expression of CDK4 CTD PMID:20724915 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Clotrimazole results in decreased expression of CDKN1A CTD PMID:20724915 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Clotrimazole results in increased expression of CDKN1B CTD PMID:20724915 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Clotrimazole results in decreased activity of CYP17A1 protein CTD PMID:31330226 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Clotrimazole results in decreased activity of CYP19A1 protein CTD PMID:15554355 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Clotrimazole results in increased expression of CYP1A1 protein CTD PMID:7986207 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions		 EXP Clotrimazole results in increased expression of CYP1A2 protein
Clotrimazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin]		 CTD PMID:7986207 PMID:19858067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 multiple interactions EXP Clotrimazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 NCBI chr 1:83,744,229...83,766,490
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases activity
increases expression		 EXP
ISO		 Clotrimazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin]
Clotrimazole results in increased activity of CYP2B1 protein
NR1I3 protein affects the reaction [Clotrimazole results in increased expression of CYP2B10 mRNA]
Clotrimazole results in increased expression of CYP2B1 protein		 CTD PMID:1372805 PMID:7986207 PMID:12049174 PMID:19858067 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Clotrimazole results in increased expression of CYP2B2 mRNA; Clotrimazole results in increased expression of CYP2B2 protein CTD PMID:7986207 PMID:12971794 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
increases activity		 ISO Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]; NR1I2 protein affects the reaction [Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]
Clotrimazole results in increased expression of CYP2B6 protein
Clotrimazole results in increased activity of CYP2B6 protein		 CTD PMID:12571232 PMID:12695351 PMID:14977870 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions
decreases expression		 EXP Clotrimazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Clotrimazole results in decreased expression of CYP2C11 protein		 CTD PMID:7986207 PMID:19858067 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions EXP Clotrimazole inhibits the reaction [CYP2C6V1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] CTD PMID:19858067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Clotrimazole results in decreased activity of CYP2C8 protein CTD PMID:15601807 PMID:33775687 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP Clotrimazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP Clotrimazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
multiple interactions		 EXP Clotrimazole results in increased expression of CYP3A23-3A1 mRNA
Clotrimazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]		 CTD PMID:12971794 PMID:16125621 PMID:19858067 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO Clotrimazole results in increased expression of CYP3A5 protein CTD PMID:8632764 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
decreases response to substance		 ISO Clotrimazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Clotrimazole		 CTD PMID:16989930 PMID:18694951 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Clotrimazole results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions
increases phosphorylation		 ISO [Clotrimazole results in increased phosphorylation of EIF2A protein] which results in increased expression of TMEFF2 protein CTD PMID:23405127 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity EXP Clotrimazole results in increased activity of EPHX1 protein CTD PMID:1372805 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO Clotrimazole inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] CTD PMID:11804840 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein] CTD PMID:22033380 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Clotrimazole results in decreased expression of FOS protein CTD PMID:10223459 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO Clotrimazole results in increased expression of GFAP protein CTD PMID:10223459 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GOT1 protein] CTD PMID:22033380 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GPT protein] CTD PMID:22033380 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Clotrimazole results in increased expression of GSTA2 mRNA CTD PMID:12971794 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Clotrimazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Hk2 hexokinase 2 affects localization
decreases expression		 ISO Clotrimazole affects the localization of HK2 protein
Clotrimazole results in decreased expression of HK2 mRNA		 CTD PMID:20724915 PMID:25863232 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression
increases secretion		 ISO Clotrimazole results in increased expression of IGFBP1 mRNA
Clotrimazole results in increased secretion of IGFBP1 protein		 CTD PMID:12659874 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Clotrimazole results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 multiple interactions
decreases activity		 ISO Clotrimazole inhibits the reaction [[Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein]
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]
Clotrimazole results in decreased activity of KCNN4 protein		 CTD PMID:14985237 PMID:15921678 PMID:17699636 PMID:20050851 PMID:22033380 NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 promotes the reaction [Clotrimazole results in increased expression of ABCC3 mRNA] CTD PMID:27507784 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mir96 microRNA 96 increases expression EXP Clotrimazole results in increased expression of MIR96 mRNA CTD PMID:27427493 NCBI chr 4:57,463,366...57,463,471
Ensembl chr 4:57,463,366...57,463,471 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Clotrimazole results in decreased expression of MYC protein CTD PMID:10223459 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Clotrimazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]		 CTD PMID:17998298 PMID:18973326 PMID:21924250 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOR1 protein] CTD PMID:18973326 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
increases expression		 ISO
EXP		 Clotrimazole binds to and results in increased activity of NR1I2 protein; Clotrimazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]; NR1I2 protein affects the reaction [Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP3A4 mRNA]
Clotrimazole results in increased activity of NR1I2 protein
Clotrimazole results in increased expression of NR1I2 mRNA		 CTD PMID:12049174 PMID:12065438 PMID:12695351 PMID:14977870 PMID:15548381 PMID:15849716 PMID:16919048 PMID:17998298 PMID:20869355 PMID:23899473 PMID:25680588 PMID:26187274 PMID:27507784 PMID:27732639 PMID:28259787 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases activity
increases activity
affects binding		 ISO
EXP		 1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Clotrimazole binds to NR1I3 protein]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Clotrimazole binds to NR1I3 protein]; androstan-3-ol inhibits the reaction [Clotrimazole binds to NR1I3 protein]; bisphenol A inhibits the reaction [Clotrimazole binds to NR1I3 protein]; bisphenol B inhibits the reaction [Clotrimazole binds to NR1I3 protein]; Clotrimazole binds to and affects the activity of NR1I3 protein; Clotrimazole binds to and results in decreased activity of NR1I3 protein; Clotrimazole binds to and results in increased activity of and results in increased localization of NR1I3 protein mutant form; Clotrimazole binds to and results in increased activity of NR1I3 protein alternative form; Clotrimazole inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; Clotrimazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime binds to and results in increased activity of NR1I3 protein mutant form]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Clotrimazole results in decreased activity of NR1I3 protein
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein alternative form
Clotrimazole results in decreased activity of NR1I3 protein; Clotrimazole results in decreased activity of NR1I3 protein alternative form
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein alternative form; Clotrimazole results in increased activity of NR1I3 protein mutant form
androstan-3-ol inhibits the reaction [Clotrimazole results in increased activity of NR1I3 protein mutant form]; Clotrimazole inhibits the reaction [androstan-3-ol results in decreased activity of NR1I3 protein alternative form]; Clotrimazole inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [Clotrimazole results in increased activity of NR1I3 protein mutant form]
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form
Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOR1 protein]; NR1I3 protein affects the reaction [Clotrimazole results in increased expression of CYP2B10 mRNA]		 CTD PMID:12049174 PMID:15905360 PMID:16919048 PMID:18973326 PMID:20686338 PMID:20869355 PMID:21315811 PMID:21778469 PMID:21924250 PMID:23015691 PMID:23899473 PMID:25625231 PMID:26187274 PMID:27732639 PMID:31195007 PMID:31312845 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]] CTD PMID:12695351 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Clotrimazole results in increased expression of ODC1 mRNA CTD PMID:12971794 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Pfkm phosphofructokinase, muscle decreases expression ISO Clotrimazole results in decreased expression of PFKM mRNA CTD PMID:25863232 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132 		JBrowse link
G Pfkp phosphofructokinase, platelet affects localization ISO Clotrimazole affects the localization of PFKP protein CTD PMID:12126931 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471 		JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]; Clotrimazole inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]] CTD PMID:22033380 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094 		JBrowse link
G Rgn regucalcin decreases expression EXP Clotrimazole results in decreased expression of RGN mRNA CTD PMID:12971794 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity		 EXP Clotrimazole inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]
Clotrimazole results in decreased activity of SLC19A1 protein		 CTD PMID:17482559 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of SMPD1 protein] CTD PMID:22033380 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP Clotrimazole results in decreased expression of SULT1A1 mRNA CTD PMID:9566755 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Clotrimazole results in decreased expression of SULT2A1 mRNA CTD PMID:9566755 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230 		JBrowse link
G Tmeff2 transmembrane protein with EGF-like and two follistatin-like domains 2 multiple interactions ISO [Clotrimazole results in increased phosphorylation of EIF2A protein] which results in increased expression of TMEFF2 protein CTD PMID:23405127 NCBI chr 9:55,379,130...55,673,704
Ensembl chr 9:55,384,100...55,673,829 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Clotrimazole results in increased expression of TP53 protein CTD PMID:10223459 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions EXP
ISO		 Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]
[Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]		 CTD PMID:21900507 PMID:22036725 NCBI chr20:11,434,062...11,482,880
Ensembl chr20:11,436,267...11,482,051 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression ISO Clotrimazole affects the expression of UGT1A1 mRNA CTD PMID:15849716 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases secretion		 ISO [Clotrimazole co-treated with Imatinib Mesylate] results in increased secretion of VEGFA protein
Clotrimazole results in increased secretion of VEGFA protein		 CTD PMID:25863232 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
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  CHEBI ontology 19775
    role 19722
      biological role 19722
        xenobiotic 18416
          clotrimazole 68
Path 2
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  CHEBI ontology 19775
    subatomic particle 19774
      composite particle 19774
        hadron 19774
          baryon 19774
            nucleon 19774
              atomic nucleus 19774
                atom 19774
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19584
                        carbon atom 19574
                          organic molecular entity 19574
                            organic molecule 19508
                              organic cyclic compound 19338
                                organic heterocyclic compound 18567
                                  heteroarene 16533
                                    monocyclic heteroarene 13399
                                      azole 12576
                                        diazole 8253
                                          imidazoles 7685
                                            imidazole antifungal agent 1293
                                              imidazole antifungal drug 822
                                                clotrimazole 68
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