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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
Clotrimazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Clotrimazole results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
affects binding multiple interactions increases expression |
ISO |
Clotrimazole binds to ABCB1 protein Clotrimazole inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] Clotrimazole results in increased expression of ABCB1 protein Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon] |
CTD |
PMID:8632764 PMID:8917702 PMID:12235267 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO |
Clotrimazole results in increased expression of ABCC2 mRNA; Clotrimazole results in increased expression of ABCC2 protein |
CTD |
PMID:11836020 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions increases expression |
ISO |
MAPK14 promotes the reaction [Clotrimazole results in increased expression of ABCC3 mRNA]; SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ABCC3 mRNA] |
CTD |
PMID:27507784 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Adcy9 |
adenylate cyclase 9 |
decreases activity |
ISO |
Clotrimazole results in decreased activity of ADCY9 protein |
CTD |
PMID:30607468 |
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NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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G |
Ahr |
aryl hydrocarbon receptor |
increases activity |
ISO |
Clotrimazole results in increased activity of AHR protein |
CTD |
PMID:26187274 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aldob |
aldolase, fructose-bisphosphate B |
affects localization |
ISO |
Clotrimazole affects the localization of ALDOB protein |
CTD |
PMID:12126931 |
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NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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G |
Atf3 |
activating transcription factor 3 |
increases expression multiple interactions |
ISO |
Clotrimazole results in increased expression of ATF3 mRNA SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ATF3 mRNA] |
CTD |
PMID:27507784 PMID:27965148 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
Clotrimazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 mRNA] [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP3 protein] |
CTD |
PMID:22033380 PMID:24239969 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP8 protein] |
CTD |
PMID:22033380 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Cat |
catalase |
multiple interactions |
ISO |
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in decreased activity of CAT protein]; Clotrimazole inhibits the reaction [lead acetate results in decreased activity of CAT protein] |
CTD |
PMID:22033380 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
Clotrimazole results in decreased expression of CDK1 |
CTD |
PMID:20724915 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Clotrimazole results in decreased expression of CDK4 |
CTD |
PMID:20724915 |
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NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
Clotrimazole results in decreased expression of CDKN1A |
CTD |
PMID:20724915 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
Clotrimazole results in increased expression of CDKN1B |
CTD |
PMID:20724915 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Clotrimazole results in decreased activity of CYP17A1 protein |
CTD |
PMID:31330226 |
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Clotrimazole results in decreased activity of CYP19A1 protein |
CTD |
PMID:15554355 |
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NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression decreases activity |
EXP ISO |
Clotrimazole results in increased expression of CYP1A1 protein Clotrimazole results in decreased activity of CYP1A1 protein |
CTD |
PMID:7986207 PMID:33814510 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression multiple interactions |
EXP |
Clotrimazole results in increased expression of CYP1A2 protein Clotrimazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin] |
CTD |
PMID:7986207 PMID:19858067 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Clotrimazole results in decreased activity of CYP1B1 protein |
CTD |
PMID:33814510 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2a2 |
cytochrome P450, family 2, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
Clotrimazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline] |
CTD |
PMID:19858067 |
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NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions increases expression increases activity |
EXP ISO |
Clotrimazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin] Clotrimazole results in increased expression of CYP2B1 protein NR1I3 protein affects the reaction [Clotrimazole results in increased expression of CYP2B10 mRNA] Clotrimazole results in increased activity of CYP2B1 protein |
CTD |
PMID:1372805 PMID:7986207 PMID:12049174 PMID:19858067 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
increases expression |
EXP |
Clotrimazole results in increased expression of CYP2B2 mRNA; Clotrimazole results in increased expression of CYP2B2 protein |
CTD |
PMID:7986207 PMID:12971794 |
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NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions increases activity increases expression |
ISO |
Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]; NR1I2 protein affects the reaction [Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA] Clotrimazole results in increased activity of CYP2B6 protein Clotrimazole results in increased expression of CYP2B6 protein |
CTD |
PMID:12571232 PMID:12695351 PMID:14977870 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions decreases expression |
EXP |
Clotrimazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] Clotrimazole results in decreased expression of CYP2C11 protein |
CTD |
PMID:7986207 PMID:19858067 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
multiple interactions |
EXP |
Clotrimazole inhibits the reaction [CYP2C6V1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] |
CTD |
PMID:19858067 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
Clotrimazole results in decreased activity of CYP2C8 protein |
CTD |
PMID:15601807 PMID:33775687 |
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G |
Cyp2d2 |
cytochrome P450, family 2, subfamily d, polypeptide 2 |
multiple interactions |
EXP |
Clotrimazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] |
CTD |
PMID:19858067 |
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NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions increases activity increases expression decreases activity |
EXP ISO |
Clotrimazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] Clotrimazole results in increased activity of CYP3A4 protein Clotrimazole results in increased expression of CYP3A4 mRNA; Clotrimazole results in increased expression of CYP3A4 protein Clotrimazole results in decreased activity of CYP3A4 protein Clotrimazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Clotrimazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:8632764 PMID:12065438 PMID:12505310 PMID:12673034 PMID:14977870 PMID:15135088 PMID:15466163 PMID:16837568 PMID:17998298 PMID:19299527 PMID:19858067 PMID:27507784 More...
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases expression multiple interactions |
EXP |
Clotrimazole results in increased expression of CYP3A23-3A1 mRNA Clotrimazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline] |
CTD |
PMID:12971794 PMID:16125621 PMID:19858067 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases expression |
ISO |
Clotrimazole results in increased expression of CYP3A5 protein |
CTD |
PMID:8632764 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Cyp51 |
cytochrome P450, family 51 |
decreases activity decreases response to substance |
ISO |
Clotrimazole results in decreased activity of CYP51A1 protein CYP51A1 gene results in decreased susceptibility to Clotrimazole |
CTD |
PMID:16989930 PMID:18694951 |
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NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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G |
Dnajb4 |
DnaJ heat shock protein family (Hsp40) member B4 |
increases expression |
ISO |
Clotrimazole results in increased expression of DNAJB4 mRNA |
CTD |
PMID:27965148 |
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NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
multiple interactions increases phosphorylation |
ISO |
[Clotrimazole results in increased phosphorylation of EIF2A protein] which results in increased expression of TMEFF2 protein |
CTD |
PMID:23405127 |
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NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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G |
Ephx1 |
epoxide hydrolase 1 |
increases activity |
EXP |
Clotrimazole results in increased activity of EPHX1 protein |
CTD |
PMID:1372805 |
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NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
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G |
F2rl1 |
F2R like trypsin receptor 1 |
multiple interactions |
ISO |
Clotrimazole inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] |
CTD |
PMID:11804840 |
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NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO |
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein] |
CTD |
PMID:22033380 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
Clotrimazole results in decreased expression of FOS protein |
CTD |
PMID:10223459 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gfap |
glial fibrillary acidic protein |
increases expression |
ISO |
Clotrimazole results in increased expression of GFAP protein |
CTD |
PMID:10223459 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
ISO |
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GOT1 protein] |
CTD |
PMID:22033380 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GPT protein] |
CTD |
PMID:22033380 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP |
Clotrimazole results in increased expression of GSTA2 mRNA |
CTD |
PMID:12971794 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Clotrimazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Hk2 |
hexokinase 2 |
affects localization decreases expression |
ISO |
Clotrimazole affects the localization of HK2 protein Clotrimazole results in decreased expression of HK2 mRNA |
CTD |
PMID:20724915 PMID:25863232 |
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NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
Clotrimazole results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression increases secretion |
ISO |
Clotrimazole results in increased expression of IGFBP1 mRNA Clotrimazole results in increased secretion of IGFBP1 protein |
CTD |
PMID:12659874 |
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NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Clotrimazole results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Kcnn4 |
potassium calcium-activated channel subfamily N member 4 |
multiple interactions decreases activity |
ISO |
Clotrimazole inhibits the reaction [[Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein] Clotrimazole results in decreased activity of KCNN4 protein [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of KCNN4 protein] |
CTD |
PMID:14985237 PMID:15921678 PMID:17699636 PMID:20050851 PMID:22033380 |
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NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
MAPK14 promotes the reaction [Clotrimazole results in increased expression of ABCC3 mRNA] |
CTD |
PMID:27507784 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mir96 |
microRNA 96 |
increases expression |
EXP |
Clotrimazole results in increased expression of MIR96 mRNA |
CTD |
PMID:27427493 |
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NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
Clotrimazole results in decreased expression of MYC protein |
CTD |
PMID:10223459 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Ncoa1 |
nuclear receptor coactivator 1 |
multiple interactions |
ISO |
Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein] Clotrimazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein] |
CTD |
PMID:17998298 PMID:18973326 PMID:21924250 |
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NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
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G |
Ncor1 |
nuclear receptor co-repressor 1 |
multiple interactions |
ISO |
Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOR1 protein] |
CTD |
PMID:18973326 |
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NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity increases expression |
ISO EXP |
Clotrimazole binds to and results in increased activity of NR1I2 protein; Clotrimazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]; NR1I2 protein affects the reaction [Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP3A4 mRNA] Clotrimazole results in increased activity of NR1I2 protein Clotrimazole results in increased expression of NR1I2 mRNA |
CTD |
PMID:12049174 PMID:12065438 PMID:12695351 PMID:14977870 PMID:15548381 PMID:15849716 PMID:16919048 PMID:17998298 PMID:20869355 PMID:23899473 PMID:25680588 PMID:26187274 PMID:27507784 PMID:27732639 PMID:28259787 More...
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions increases activity affects binding decreases activity |
ISO EXP |
1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Clotrimazole binds to NR1I3 protein]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Clotrimazole binds to NR1I3 protein]; androstan-3-ol inhibits the reaction [Clotrimazole binds to NR1I3 protein]; bisphenol A inhibits the reaction [Clotrimazole binds to NR1I3 protein]; bisphenol B inhibits the reaction [Clotrimazole binds to NR1I3 protein]; Clotrimazole binds to and affects the activity of NR1I3 protein; Clotrimazole binds to and results in decreased activity of NR1I3 protein; Clotrimazole binds to and results in increased activity of and results in increased localization of NR1I3 protein mutant form; Clotrimazole binds to and results in increased activity of NR1I3 protein alternative form; Clotrimazole inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; Clotrimazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime binds to and results in increased activity of NR1I3 protein mutant form]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein] Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOR1 protein]; NR1I3 protein affects the reaction [Clotrimazole results in increased expression of CYP2B10 mRNA] Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form androstan-3-ol inhibits the reaction [Clotrimazole results in increased activity of NR1I3 protein mutant form]; Clotrimazole inhibits the reaction [androstan-3-ol results in decreased activity of NR1I3 protein alternative form]; Clotrimazole inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [Clotrimazole results in increased activity of NR1I3 protein mutant form] Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein alternative form; Clotrimazole results in increased activity of NR1I3 protein mutant form Clotrimazole results in decreased activity of NR1I3 protein; Clotrimazole results in decreased activity of NR1I3 protein alternative form |
CTD |
PMID:12049174 PMID:15905360 PMID:16919048 PMID:18973326 PMID:20686338 PMID:20869355 PMID:21315811 PMID:21778469 PMID:21924250 PMID:23015691 PMID:23899473 PMID:25625231 PMID:26187274 PMID:27732639 PMID:31195007 PMID:31312845 More...
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]] |
CTD |
PMID:12695351 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Odc1 |
ornithine decarboxylase 1 |
increases expression |
EXP |
Clotrimazole results in increased expression of ODC1 mRNA |
CTD |
PMID:12971794 |
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NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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Pfkm |
phosphofructokinase, muscle |
decreases expression |
ISO |
Clotrimazole results in decreased expression of PFKM mRNA |
CTD |
PMID:25863232 |
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NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
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Pfkp |
phosphofructokinase, platelet |
affects localization |
ISO |
Clotrimazole affects the localization of PFKP protein |
CTD |
PMID:12126931 |
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NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018
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Prdx2 |
peroxiredoxin 2 |
multiple interactions |
ISO |
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]; Clotrimazole inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]] |
CTD |
PMID:22033380 |
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NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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Rgn |
regucalcin |
decreases expression |
EXP |
Clotrimazole results in decreased expression of RGN mRNA |
CTD |
PMID:12971794 |
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NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450
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Slc19a1 |
solute carrier family 19 member 1 |
multiple interactions decreases activity |
EXP |
Clotrimazole inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate] Clotrimazole results in decreased activity of SLC19A1 protein |
CTD |
PMID:17482559 |
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NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
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Smpd1 |
sphingomyelin phosphodiesterase 1 |
multiple interactions |
ISO |
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of SMPD1 protein] |
CTD |
PMID:22033380 |
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NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
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Sult1a1 |
sulfotransferase family 1A member 1 |
decreases expression |
EXP |
Clotrimazole results in decreased expression of SULT1A1 mRNA |
CTD |
PMID:9566755 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Sult2a1 |
sulfotransferase family 2A member 1 |
decreases expression |
EXP |
Clotrimazole results in decreased expression of SULT2A1 mRNA |
CTD |
PMID:9566755 |
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NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134
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Tmeff2 |
transmembrane protein with EGF-like and two follistatin-like domains 2 |
multiple interactions |
ISO |
[Clotrimazole results in increased phosphorylation of EIF2A protein] which results in increased expression of TMEFF2 protein |
CTD |
PMID:23405127 |
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NCBI chr 9:50,445,550...50,733,482
Ensembl chr 9:50,436,079...50,733,475
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Tp53 |
tumor protein p53 |
increases expression |
ISO |
Clotrimazole results in increased expression of TP53 protein |
CTD |
PMID:10223459 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trpm2 |
transient receptor potential cation channel, subfamily M, member 2 |
multiple interactions |
EXP ISO |
Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]] [Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium] |
CTD |
PMID:21900507 PMID:22036725 |
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NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
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Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
affects expression |
ISO |
Clotrimazole affects the expression of UGT1A1 mRNA |
CTD |
PMID:15849716 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Vegfa |
vascular endothelial growth factor A |
multiple interactions increases secretion |
ISO |
[Clotrimazole co-treated with Imatinib Mesylate] results in increased secretion of VEGFA protein Clotrimazole results in increased secretion of VEGFA protein |
CTD |
PMID:25863232 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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