F2rl1 (F2R like trypsin receptor 1) - Rat Genome Database

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Gene: F2rl1 (F2R like trypsin receptor 1) Rattus norvegicus
Symbol: F2rl1
Name: F2R like trypsin receptor 1
RGD ID: 620866
Description: Predicted to enable several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and proteinase-activated receptor activity. Involved in positive regulation of glomerular filtration. Acts upstream of or within with a positive effect on vasodilation. Predicted to be located in early endosome; plasma membrane; and pseudopodium. Biomarker of lung disease. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1); PARTICIPATES IN protease mediated signaling via protease-activated receptor 2; sleeping sickness pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
Previously known as: coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; Par-2; Par2; proteinase-activated receptor 2; Proteinase-activated receptor-2 G protein-coupled receptor 11; Proteinase-activated receptor-2, G protein-coupled receptor 11; thrombin receptor-like 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2226,772,274 - 26,785,226 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,772,278 - 26,785,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,810,431 - 33,823,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,910,649 - 31,923,604 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,726,513 - 26,739,491 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0225,222,324 - 25,235,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,222,328 - 25,235,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0244,378,262 - 44,391,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,886,177 - 25,899,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,808,013 - 25,819,410 (-)NCBI
Celera222,836,384 - 22,849,335 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
barium(0)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
bumetanide  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clotrimazole  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dinophysistoxin 1  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edelfosine  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
graphite  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (EXP)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
pentanal  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood coagulation  (IEA)
cell-cell junction maintenance  (ISO)
defense response to virus  (ISO,ISS)
establishment of endothelial barrier  (ISO)
G protein-coupled receptor signaling pathway  (ISO,TAS)
inflammatory response  (IEA)
innate immune response  (IEA)
leukocyte migration  (ISO,ISS)
leukocyte proliferation  (ISO,ISS)
mature conventional dendritic cell differentiation  (ISO,ISS)
negative regulation of chemokine production  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of JNK cascade  (ISO)
negative regulation of toll-like receptor 3 signaling pathway  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
neutrophil activation  (ISO,ISS)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA)
positive regulation of actin filament depolymerization  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO,ISS)
positive regulation of cell migration  (ISO,ISS)
positive regulation of chemokine production  (ISO,ISS)
positive regulation of chemotaxis  (ISO,ISS)
positive regulation of cytokine production involved in immune response  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (ISO,ISS)
positive regulation of eosinophil degranulation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO,ISS)
positive regulation of glomerular filtration  (IDA)
positive regulation of interleukin-1 beta production  (ISO,ISS)
positive regulation of interleukin-10 production  (ISO,ISS)
positive regulation of interleukin-6 production  (ISO,ISS)
positive regulation of interleukin-8 production  (ISO,ISS)
positive regulation of JNK cascade  (ISO)
positive regulation of leukocyte chemotaxis  (ISO)
positive regulation of neutrophil mediated killing of gram-negative bacterium  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
positive regulation of positive chemotaxis  (ISO)
positive regulation of pseudopodium assembly  (ISO,ISS)
positive regulation of renin secretion into blood stream  (ISO,ISS)
positive regulation of Rho protein signal transduction  (IBA,ISO,ISS)
positive regulation of superoxide anion generation  (ISO,ISS)
positive regulation of toll-like receptor 2 signaling pathway  (ISO)
positive regulation of toll-like receptor 3 signaling pathway  (ISO)
positive regulation of toll-like receptor 4 signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of type II interferon production  (ISO,ISS)
positive regulation of vasoconstriction  (ISO)
potassium channel activating, G protein-coupled receptor signaling pathway  (ISO)
regulation of blood coagulation  (ISO)
regulation of canonical NF-kappaB signal transduction  (ISO,ISS)
regulation of chemokine (C-X-C motif) ligand 2 production  (ISO,ISS)
regulation of JNK cascade  (ISO,ISS)
T cell activation involved in immune response  (ISO,ISS)
thrombin-activated receptor signaling pathway  (IEA)
vasodilation  (IDA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. House dust mite extract activates apical Cl(-) channels through protease-activated receptor 2 in human airway epithelia. Cho HJ, etal., J Cell Biochem. 2010 Apr 15;109(6):1254-63.
2. Essential role for proteinase-activated receptor-2 in arthritis. Ferrell WR, etal., J Clin Invest 2003 Jan;111(1):35-41.
3. Cross Talk Pathways Between Coagulation and Inflammation. Foley JH and Conway EM, Circ Res. 2016 Apr 29;118(9):1392-408. doi: 10.1161/CIRCRESAHA.116.306853.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Bidirectional regulation of renal hemodynamics by activation of PAR1 and PAR2 in isolated perfused rat kidney. Gui Y, etal., Am J Physiol Renal Physiol. 2003 Jul;285(1):F95-104. Epub 2003 Mar 18.
7. Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury. Hidaka S, etal., J Surg Res. 2011 Jan;165(1):142-50. Epub 2009 Jun 25.
8. Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion. Kawabata A, etal., Life Sci 2002 Oct 4;71(20):2435-46.
9. Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats. Kawabata A, etal., Neurosci Lett 2002 Sep 6;329(3):349-53.
10. Up-regulation of protease-activated receptor 2 in allergic rhinitis. Lee HM, etal., Ann Otol Rhinol Laryngol. 2007 Jul;116(7):554-8.
11. TRPV4-Mediated Calcium-influx into Human Bronchial Epithelia upon Exposure to Diesel Exhaust Particles. Li J, etal., Environ Health Perspect. 2011 Jan 18.
12. p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. Luo W, etal., J Biol Chem. 2007 Oct 12;282(41):30246-55. Epub 2007 Aug 10.
13. Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils. Matsuwaki Y, etal., J Immunol. 2009 Nov 15;183(10):6708-16. Epub 2009 Oct 28.
14. Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers. McLean PG, etal., Circ Res. 2002 Mar 8;90(4):465-72.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Protease-activated receptor-2 activation improves efficiency of experimental ischemic preconditioning. Napoli C, etal., Am J Physiol Heart Circ Physiol 2002 Jun;282(6):H2004-10.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors. Riek-Burchardt M, etal., Neurosci Lett 2002 Aug 30;329(2):181-4.
23. Protease-activated receptor subtype expression in developing eye and adult retina of the rat after optic nerve crush. Rohatgi T, etal., J Neurosci Res 2003 Jul 15;73(2):246-54.
24. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Saifeddine M, etal., Br J Pharmacol 1996 Jun;118(3):521-30.
25. Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2. Stenton GR, etal., J Pharmacol Exp Ther 2002 Aug;302(2):466-74.
26. PAR-2 elicits afferent arteriolar vasodilation by NO-dependent and NO-independent actions. Trottier G, etal., Am J Physiol Renal Physiol 2002 May;282(5):F891-7.
Additional References at PubMed
PMID:9918574   PMID:10725339   PMID:11413129   PMID:11441110   PMID:11447194   PMID:11714832   PMID:11867180   PMID:11910355   PMID:12477932   PMID:12821670   PMID:15155775   PMID:15188179  
PMID:15265236   PMID:15328067   PMID:15369704   PMID:15561975   PMID:16150484   PMID:16410250   PMID:16478888   PMID:16709636   PMID:16942465   PMID:17064469   PMID:17102904   PMID:17136598  
PMID:17404307   PMID:17500066   PMID:17571167   PMID:17623652   PMID:17720772   PMID:17848177   PMID:17991872   PMID:18453611   PMID:18622013   PMID:18678869   PMID:18755806   PMID:19247167  
PMID:19333145   PMID:19362118   PMID:19410009   PMID:19494303   PMID:19540892   PMID:19558454   PMID:19683949   PMID:19772634   PMID:19781631   PMID:19815543   PMID:19845798   PMID:19865078  
PMID:19954757   PMID:20044436   PMID:20046028   PMID:20118742   PMID:20128384   PMID:20215560   PMID:20347884   PMID:20431298   PMID:20487037   PMID:20826780   PMID:21311307   PMID:21461568  
PMID:21501162   PMID:21576245   PMID:21859963   PMID:21914290   PMID:21999702   PMID:22018669   PMID:22028393   PMID:22132161   PMID:22168801   PMID:22200983   PMID:22227167   PMID:22244874  
PMID:22461388   PMID:22505524   PMID:22541444   PMID:22547407   PMID:22616675   PMID:22849826   PMID:22957757   PMID:23202369   PMID:23238933   PMID:23288842   PMID:23290058   PMID:23408423  
PMID:23430254   PMID:23463389   PMID:23627841   PMID:23982204   PMID:24057889   PMID:24506284   PMID:24641950   PMID:24886294   PMID:24897276   PMID:25109437   PMID:25410909   PMID:25519044  
PMID:26133236   PMID:26398586   PMID:26760532   PMID:27012211   PMID:28245472   PMID:28445455   PMID:28694438   PMID:29131007   PMID:29709920   PMID:30628825   PMID:31485622   PMID:32949662  
PMID:33176506   PMID:33744763   PMID:33866617   PMID:35092732   PMID:35637468   PMID:36657618   PMID:36791026  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2226,772,274 - 26,785,226 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,772,278 - 26,785,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,810,431 - 33,823,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,910,649 - 31,923,604 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,726,513 - 26,739,491 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0225,222,324 - 25,235,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,222,328 - 25,235,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0244,378,262 - 44,391,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,886,177 - 25,899,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,808,013 - 25,819,410 (-)NCBI
Celera222,836,384 - 22,849,335 (-)NCBICelera
Cytogenetic Map2q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38576,819,030 - 76,835,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,818,933 - 76,835,315 (+)EnsemblGRCh38hg38GRCh38
GRCh37576,114,855 - 76,131,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,150,610 - 76,166,896 (+)NCBINCBI36Build 36hg18NCBI36
Build 34576,150,609 - 76,166,895NCBI
Celera572,008,729 - 72,025,166 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,322,693 - 71,339,004 (+)NCBIHuRef
CHM1_1575,547,934 - 75,564,299 (+)NCBICHM1_1
T2T-CHM13v2.0577,300,842 - 77,317,122 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391395,648,226 - 95,661,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,648,240 - 95,661,735 (-)EnsemblGRCm39 Ensembl
GRCm381395,511,718 - 95,525,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,511,732 - 95,525,227 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,281,673 - 96,295,195 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,612,431 - 96,634,965 (-)NCBIMGSCv36mm8
Celera1399,130,515 - 99,143,639 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.53NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495542524,050,901 - 24,054,039 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1536,619,680 - 36,636,075 (-)NCBINHGRI_mPanPan1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1329,801,119 - 29,810,006 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,800,211 - 29,810,180 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,040,276 - 31,049,162 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,720,255 - 29,729,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,719,346 - 29,729,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,656,957 - 29,665,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,637,871 - 29,646,815 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,007,024 - 30,015,914 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213190,705,232 - 190,716,606 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549141,512 - 153,602 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936549142,281 - 153,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl285,732,189 - 85,750,858 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,732,082 - 85,747,552 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,348,813 - 87,364,248 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1471,095,446 - 71,109,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,095,500 - 71,110,005 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,926,695 - 19,941,181 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248691,326,605 - 1,337,195 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in F2rl1
79 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:327
Count of miRNA genes:204
Interacting mature miRNAs:229
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 12 1
Low 43 37 23 19 23 7 10 56 23 41 10 7
Below cutoff 16 14 14 1 1 16 1


RefSeq Acc Id: ENSRNOT00000061580   ⟹   ENSRNOP00000058298
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,772,278 - 26,785,226 (-)Ensembl
Rnor_6.0 Ensembl225,222,328 - 25,235,275 (-)Ensembl
RefSeq Acc Id: NM_053897   ⟹   NP_446349
Rat AssemblyChrPosition (strand)Source
mRatBN7.2226,772,274 - 26,785,226 (-)NCBI
Rnor_6.0225,222,324 - 25,235,275 (-)NCBI
Rnor_5.0244,378,262 - 44,391,213 (-)NCBI
RGSC_v3.4225,886,177 - 25,899,128 (-)RGD
Celera222,836,384 - 22,849,335 (-)RGD
Protein Sequences
Protein RefSeqs NP_446349 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52703 (Get FASTA)   NCBI Sequence Viewer  
  AAH99765 (Get FASTA)   NCBI Sequence Viewer  
  EDM10102 (Get FASTA)   NCBI Sequence Viewer  
  Q63645 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446349   ⟸   NM_053897
- Peptide Label: precursor
- UniProtKB: Q499T9 (UniProtKB/Swiss-Prot),   Q63645 (UniProtKB/Swiss-Prot),   A6I4Z4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058298   ⟸   ENSRNOT00000061580
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63645-F1-model_v2 AlphaFold Q63645 1-397 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620866 AgrOrtholog
BioCyc Gene G2FUF-54805 BioCyc
Ensembl Genes ENSRNOG00000018003 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000058298 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000061580 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_rcpt_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protea_act_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116677 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen F2rl1 PhenoGen
  PROTEASEAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASEAR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAR2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q499T9 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 F2rl1  F2R like trypsin receptor 1  F2rl1  coagulation factor II (thrombin) receptor-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 F2rl1  coagulation factor II (thrombin) receptor-like 1    Proteinase-activated receptor-2, G protein-coupled receptor 11  Name updated 1299863 APPROVED
2002-08-07 F2rl1        Symbol and Name status set to provisional 70820 PROVISIONAL