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Gene: Nedd4 (NEDD4 E3 ubiquitin protein ligase) Rattus norvegicus
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Symbol: Nedd4
Name: NEDD4 E3 ubiquitin protein ligase
Description: Exhibits protein C-terminus binding activity and ubiquitin-protein transferase activity. Involved in several processes, including regulation of postsynaptic neurotransmitter receptor internalization; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to denervation involved in regulation of muscle adaptation. Localizes to the glutamatergic synapse; membrane raft; and microvillus. Biomarker of muscular atrophy. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase); PARTICIPATES IN vascular endothelial growth factor signaling pathway; endocytosis pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2-amino-2-deoxy-D-glucopyranose; 2-methoxyethanol; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase NEDD4; HECT-type E3 ubiquitin transferase NEDD4; Nedd4a; Neural precursor cell expressed developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated 4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; Neural precursor cell expressed, developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated gene 4A
Orthologs:
Homo sapiens (human) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)  HGNC  Alliance
Mus musculus (house mouse) : Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)
Sus scrofa (pig) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Chlorocebus sabaeus (African green monkey) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Heterocephalus glaber (naked mole-rat) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0879,323,408 - 79,408,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl879,323,408 - 79,408,833 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0873,679,012 - 73,764,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4877,252,500 - 77,337,402 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1877,271,630 - 77,353,830 (+)NCBI
Celera868,281,153 - 68,365,646 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nedd4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3157
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.