Nedd4 (NEDD4 E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Nedd4 (NEDD4 E3 ubiquitin protein ligase) Rattus norvegicus
Analyze
Symbol: Nedd4
Name: NEDD4 E3 ubiquitin protein ligase
RGD ID: 3157
Description: Enables ubiquitin-protein transferase activity. Involved in several processes, including protein K63-linked ubiquitination; regulation of postsynaptic neurotransmitter receptor internalization; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Located in microvillus. Is active in glutamatergic synapse. Biomarker of muscular atrophy. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase); PARTICIPATES IN vascular endothelial growth factor signaling pathway; endocytosis pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase NEDD4; HECT-type E3 ubiquitin transferase NEDD4; Nedd4a; Neural precursor cell expressed developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated 4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; Neural precursor cell expressed, developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated gene 4A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2873,384,095 - 73,468,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl873,383,695 - 73,468,951 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx878,909,673 - 78,994,418 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0877,182,291 - 77,267,035 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0875,019,698 - 75,104,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0879,323,408 - 79,408,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl879,323,408 - 79,408,833 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0873,679,012 - 73,764,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4877,252,500 - 77,337,402 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1877,271,630 - 77,353,830 (+)NCBI
Celera868,281,153 - 68,365,646 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
chloroprene  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
desmopressin  (EXP)
dextran sulfate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
glycidyl methacrylate  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indoles  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
lithium chloride  (EXP)
melatonin  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel subsulfide  (EXP)
olanzapine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)
wortmannin  (EXP)
zinc sulfate  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO)
blood vessel morphogenesis  (ISO)
cellular response to UV  (IEA,ISO)
DNA damage response  (IEA,ISO)
endocardial cushion development  (ISO)
establishment of localization in cell  (ISO)
formation of structure involved in a symbiotic process  (IEA)
glucocorticoid receptor signaling pathway  (IEA,ISO)
immune response  (IEP)
innate immune response  (IEA,ISO)
lysosomal transport  (ISO)
negative regulation of sodium ion transport  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (ISO,ISS)
neuromuscular junction development  (IBA,IEA,ISO)
neuron projection development  (IBA,IEA,ISO)
outflow tract morphogenesis  (ISO)
positive regulation of nucleocytoplasmic transport  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein catabolic process  (IEA,ISO)
progesterone receptor signaling pathway  (IEA,ISO)
protein K63-linked ubiquitination  (IDA)
protein monoubiquitination  (ISO)
protein polyubiquitination  (IEA)
protein targeting to lysosome  (IEA,ISO)
protein ubiquitination  (IBA,ISO,ISS)
receptor catabolic process  (IBA,IEA,ISO)
receptor internalization  (IBA,IEA,ISO)
regulation of dendrite morphogenesis  (IBA,IDA,IEA,ISO)
regulation of membrane potential  (IEA,ISO)
regulation of monoatomic ion transmembrane transport  (IEA,ISO)
regulation of neurotransmitter secretion  (IEA)
regulation of postsynaptic neurotransmitter receptor internalization  (IDA,IEP,IMP)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (IDA,IEP,IMP)
regulation of synapse organization  (IBA,ISO)
regulation protein catabolic process at postsynapse  (IDA,IEP,IMP)
response to denervation involved in regulation of muscle adaptation  (IEP)
sodium ion transport  (ISO)
T cell activation  (ISO)
ubiquitin-dependent protein catabolic process  (IBA,IEA,ISO,ISS)
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  (IEA,ISO)
viral budding  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of interactions between Nedd4 and beta and gammaENaC using surface plasmon resonance. Asher C, etal., Biochem Biophys Res Commun. 2001 Sep 7;286(5):1228-31.
2. The Nedd4-like family of E3 ubiquitin ligases and cancer. Chen C and Matesic LE, Cancer Metastasis Rev. 2007 Dec;26(3-4):587-604.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel. Kanelis V, etal., Biochem Cell Biol. 1998;76(2-3):341-50.
5. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Kawabe H, etal., Neuron. 2010 Feb 11;65(3):358-72. doi: 10.1016/j.neuron.2010.01.007.
6. Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signaling. Lafont F and Simons K, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3180-4.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. Plant PJ, etal., Biochem J. 2009 Apr 1;419(1):57-63. doi: 10.1042/BJ20081866.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Activity-dependent ubiquitination of GluA1 mediates a distinct AMPA receptor endocytosis and sorting pathway. Schwarz LA, etal., J Neurosci. 2010 Dec 8;30(49):16718-29. doi: 10.1523/JNEUROSCI.3686-10.2010.
16. Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. Shi H, etal., J Biol Chem 2002 Apr 19;277(16):13539-47.
17. Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC). Staub O, etal., Am J Physiol. 1997 Jun;272(6 Pt 1):C1871-80.
18. WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. Staub O, etal., EMBO J 1996 May 15;15(10):2371-80.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8649367   PMID:8889548   PMID:9182527   PMID:9305852   PMID:9990509   PMID:10037602   PMID:10212229   PMID:10642508   PMID:11042109   PMID:11323714   PMID:11342538   PMID:11717310  
PMID:11748237   PMID:12654927   PMID:12796489   PMID:12907594   PMID:12947022   PMID:14645220   PMID:14973438   PMID:15060076   PMID:15126635   PMID:15677482   PMID:15908698   PMID:16118794  
PMID:16172119   PMID:16571785   PMID:16885233   PMID:16931598   PMID:17116753   PMID:17218260   PMID:17218261   PMID:17289006   PMID:17322297   PMID:17996703   PMID:18174164   PMID:18305167  
PMID:18544533   PMID:18931680   PMID:19051070   PMID:19345204   PMID:19794060   PMID:19835873   PMID:19864419   PMID:19953087   PMID:20026598   PMID:20086093   PMID:20100827   PMID:20237237  
PMID:21199218   PMID:21920314   PMID:21936631   PMID:22417925   PMID:22745772   PMID:23146885   PMID:23533145   PMID:23639431   PMID:24236122   PMID:24388974   PMID:25505317   PMID:25631046  
PMID:25748165   PMID:25879670   PMID:26006083   PMID:26263374   PMID:26280536   PMID:26508620   PMID:26841867   PMID:26888924   PMID:27226107   PMID:27592201   PMID:27837380   PMID:27917940  
PMID:30632068   PMID:30826466   PMID:32360748   PMID:33712741   PMID:35352799   PMID:35355403   PMID:36781297  


Genomics

Comparative Map Data
Nedd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2873,384,095 - 73,468,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl873,383,695 - 73,468,951 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx878,909,673 - 78,994,418 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0877,182,291 - 77,267,035 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0875,019,698 - 75,104,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0879,323,408 - 79,408,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl879,323,408 - 79,408,833 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0873,679,012 - 73,764,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4877,252,500 - 77,337,402 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1877,271,630 - 77,353,830 (+)NCBI
Celera868,281,153 - 68,365,646 (-)NCBICelera
Cytogenetic Map8q24NCBI
NEDD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381555,826,917 - 55,993,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1555,826,922 - 55,993,660 (-)EnsemblGRCh38hg38GRCh38
GRCh371556,119,115 - 56,285,810 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361553,906,412 - 54,073,127 (-)NCBINCBI36Build 36hg18NCBI36
Build 341553,906,420 - 53,996,621NCBI
Celera1533,007,634 - 33,174,352 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1532,943,160 - 33,109,724 (-)NCBIHuRef
CHM1_11556,237,532 - 56,404,177 (-)NCBICHM1_1
T2T-CHM13v2.01553,630,346 - 53,797,054 (-)NCBIT2T-CHM13v2.0
Nedd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39972,569,613 - 72,657,133 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl972,569,628 - 72,657,134 (+)EnsemblGRCm39 Ensembl
GRCm38972,662,331 - 72,749,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl972,662,346 - 72,749,852 (+)EnsemblGRCm38mm10GRCm38
MGSCv37972,510,154 - 72,597,655 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36972,460,914 - 72,548,414 (+)NCBIMGSCv36mm8
Celera969,852,010 - 69,939,539 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map940.08NCBI
Nedd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955409183,545 - 281,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955409183,645 - 281,252 (+)NCBIChiLan1.0ChiLan1.0
NEDD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11549,273,091 - 49,441,071 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01534,798,880 - 34,963,823 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11553,118,400 - 53,283,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1553,118,411 - 53,283,076 (-)Ensemblpanpan1.1panPan2
NEDD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13021,123,333 - 21,229,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3021,126,043 - 21,229,870 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3021,088,774 - 21,211,642 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03021,272,328 - 21,395,438 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3021,274,704 - 21,395,561 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13021,215,729 - 21,338,560 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03021,299,239 - 21,422,293 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03021,433,575 - 21,556,459 (-)NCBIUU_Cfam_GSD_1.0
Nedd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864099,406,714 - 99,526,684 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647117,252,234 - 17,374,804 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647117,254,777 - 17,374,725 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,941,940 - 116,070,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,941,945 - 116,069,884 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21128,545,541 - 128,557,317 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEDD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12627,487,652 - 27,655,742 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2627,487,796 - 27,655,992 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048113,632,934 - 113,801,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nedd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247315,862,626 - 5,951,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247315,855,678 - 5,954,119 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nedd4
175 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1188
Count of miRNA genes:332
Interacting mature miRNAs:448
Transcripts:ENSRNOT00000064818
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat

Markers in Region
RH128183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2873,468,421 - 73,468,624 (+)MAPPERmRatBN7.2
Rnor_6.0879,408,313 - 79,408,515NCBIRnor6.0
Rnor_5.0873,679,339 - 73,679,541UniSTSRnor5.0
RGSC_v3.4877,336,873 - 77,337,075UniSTSRGSC3.4
Celera868,281,480 - 68,281,682UniSTS
Cytogenetic Map8q24UniSTS
RH139229  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2873,466,889 - 73,467,055 (+)MAPPERmRatBN7.2
Rnor_6.0879,406,781 - 79,406,946NCBIRnor6.0
Rnor_5.0873,680,908 - 73,681,073UniSTSRnor5.0
RGSC_v3.4877,335,341 - 77,335,506UniSTSRGSC3.4
Celera868,283,049 - 68,283,214UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4 2 2 2 6 12 10
Medium 3 39 55 39 19 39 8 11 68 23 31 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BQ191927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB326200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB568921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB615796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF110862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK365888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY312717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY318090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV775947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000088391   ⟹   ENSRNOP00000074683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl873,384,037 - 73,468,951 (+)Ensembl
Rnor_6.0 Ensembl879,323,408 - 79,408,833 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090258   ⟹   ENSRNOP00000071377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl873,384,156 - 73,468,945 (+)Ensembl
Rnor_6.0 Ensembl879,323,485 - 79,406,219 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096175   ⟹   ENSRNOP00000087335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl873,411,874 - 73,468,914 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101505   ⟹   ENSRNOP00000092670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl873,383,695 - 73,439,930 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102529   ⟹   ENSRNOP00000095121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl873,384,079 - 73,468,951 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103492   ⟹   ENSRNOP00000078919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl873,384,069 - 73,468,951 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105176   ⟹   ENSRNOP00000097943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl873,390,777 - 73,441,736 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118222   ⟹   ENSRNOP00000093946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl873,416,302 - 73,468,951 (+)Ensembl
RefSeq Acc Id: NM_012986   ⟹   NP_037118
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2873,384,095 - 73,468,951 (+)NCBI
Rnor_6.0879,323,408 - 79,408,842 (+)NCBI
Rnor_5.0873,679,012 - 73,764,446 (-)NCBI
RGSC_v3.4877,252,500 - 77,337,402 (+)RGD
Celera868,281,153 - 68,365,646 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595479   ⟹   XP_017450968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2873,415,537 - 73,468,545 (+)NCBI
Rnor_6.0879,353,383 - 79,408,842 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080889   ⟹   XP_038936817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2873,384,145 - 73,468,951 (+)NCBI
RefSeq Acc Id: NP_037118   ⟸   NM_012986
- UniProtKB: Q62940 (UniProtKB/Swiss-Prot),   A0A0G2K8P3 (UniProtKB/TrEMBL),   A6KEM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450968   ⟸   XM_017595479
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GFW6 (UniProtKB/TrEMBL),   A0A8I6AJU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071377   ⟸   ENSRNOT00000090258
RefSeq Acc Id: ENSRNOP00000074683   ⟸   ENSRNOT00000088391
RefSeq Acc Id: XP_038936817   ⟸   XM_039080889
- Peptide Label: isoform X2
- UniProtKB: Q62940 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000078919   ⟸   ENSRNOT00000103492
RefSeq Acc Id: ENSRNOP00000097943   ⟸   ENSRNOT00000105176
RefSeq Acc Id: ENSRNOP00000093946   ⟸   ENSRNOT00000118222
RefSeq Acc Id: ENSRNOP00000095121   ⟸   ENSRNOT00000102529
RefSeq Acc Id: ENSRNOP00000087335   ⟸   ENSRNOT00000096175
RefSeq Acc Id: ENSRNOP00000092670   ⟸   ENSRNOT00000101505
Protein Domains
C2   HECT   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62940-F1-model_v2 AlphaFold Q62940 1-887 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696116
Promoter ID:EPDNEW_R6641
Type:initiation region
Name:Nedd4_1
Description:neural precursor cell expressed, developmentally down-regulated4, E3 ubiquitin protein ligase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0879,323,426 - 79,323,486EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3157 AgrOrtholog
BioCyc Gene G2FUF-29876 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000058898 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088391 ENTREZGENE
  ENSRNOT00000088391.2 UniProtKB/TrEMBL
  ENSRNOT00000090258.2 UniProtKB/TrEMBL
  ENSRNOT00000096175 ENTREZGENE
  ENSRNOT00000096175.1 UniProtKB/TrEMBL
  ENSRNOT00000101505.1 UniProtKB/TrEMBL
  ENSRNOT00000102529.1 UniProtKB/TrEMBL
  ENSRNOT00000103492.1 UniProtKB/TrEMBL
  ENSRNOT00000105176.1 UniProtKB/TrEMBL
  ENSRNOT00000118222.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HECT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25489 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25489 ENTREZGENE
PANTHER C2 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  DYSFERLIN-RELATED UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE NEDD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00397 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nedd4 PhenoGen
PIRSF E3_ub_ligase_SMURF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS C2DOMAIN UniProtKB/TrEMBL
PROSITE HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058898 RatGTEx
SMART HECTc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00456 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51045 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56204 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216867
UniProt A0A0G2K0B4_RAT UniProtKB/TrEMBL
  A0A0G2K8P3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLT5_RAT UniProtKB/TrEMBL
  A0A8I6AED0_RAT UniProtKB/TrEMBL
  A0A8I6AJU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANY7_RAT UniProtKB/TrEMBL
  A0A8I6ATW8_RAT UniProtKB/TrEMBL
  A0A8I6GFW6 ENTREZGENE, UniProtKB/TrEMBL
  A6KEM7 ENTREZGENE, UniProtKB/TrEMBL
  NEDD4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Nedd4  NEDD4 E3 ubiquitin protein ligase  Nedd4  neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 Nedd4  neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase  Nedd4  neural precursor cell expressed, developmentally down-regulated 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Nedd4  neural precursor cell expressed, developmentally down-regulated 4  Nedd4  neural precursor cell expressed, developmentally down-regulated gene 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27     Nedd4  neural precursor cell expressed, developmentally down-regulated gene 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-18 Nedd4  neural precursor cell expressed, developmentally down-regulated gene 4  Nedd4a  neural precursor cell expressed, developmentally down-regulated gene 4A  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-11-06 Nedd4a  neural precursor cell expressed, developmentally down-regulated gene 4A  Nedd4  Neural precursor cell expressed, developmentally down-regulated gene 4  Symbol and Name updated 625702 APPROVED
2002-06-10 Nedd4  Neural precursor cell expressed, developmentally down-regulated gene 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a Ca2+ lipid binding domain, three WW domains, and a ubiquitin ligase domain 633483
gene_physical_interaction binds the P2 regions of the beta and gamma subunits of amiloride-sensitive epithelial sodium channel ENaC 633483