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Gene: NEDD4 (NEDD4 E3 ubiquitin protein ligase) Homo sapiens
Symbol: NEDD4
Name: NEDD4 E3 ubiquitin protein ligase
Description: Exhibits several functions, including beta-2 adrenergic receptor binding activity; sodium channel inhibitor activity; and ubiquitin protein ligase activity. Involved in several processes, including intracellular steroid hormone receptor signaling pathway; receptor metabolic process; and regulation of ion transmembrane transporter activity. Localizes to several cellular components, including the Golgi apparatus; chromatin; and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; HECT-type E3 ubiquitin transferase NEDD4; KIAA0093; MGC176705; NEDD-4; NEDD4-1; neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4a; receptor-potentiating factor 1; RPF1
Mus musculus (house mouse) : Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)
Sus scrofa (pig) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1555,826,922 - 55,993,746 (-)Ensembl
GRCh381555,826,917 - 55,993,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371556,119,120 - 56,285,835 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361553,906,412 - 54,073,127 (-)NCBINCBI36hg18NCBI36
Build 341553,906,420 - 53,996,621NCBI
Celera1533,007,634 - 33,174,352 (-)NCBI
Cytogenetic Map15q21.3NCBI
HuRef1532,943,160 - 33,109,724 (-)NCBIHuRef
CHM1_11556,237,527 - 56,404,286 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NEDD4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736612
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.