RGD Reference Report - The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. - Rat Genome Database
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The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.

Authors: Plant, PJ  Correa, J  Goldenberg, N  Bain, J  Batt, J 
Citation: Plant PJ, etal., Biochem J. 2009 Apr 1;419(1):57-63. doi: 10.1042/BJ20081866.
RGD ID: 7242174
Pubmed: (View Article at PubMed) PMID:19125695
DOI: Full-text: DOI:10.1042/BJ20081866

The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased in atrophying muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown.

Annotation

Disease Annotations    
muscular atrophy  (IEP,ISO)

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Mtmr4  (myotubularin related protein 4)
Nedd4  (NEDD4 E3 ubiquitin protein ligase)

Genes (Mus musculus)
Mtmr4  (myotubularin related protein 4)
Nedd4  (neural precursor cell expressed, developmentally down-regulated 4)

Genes (Homo sapiens)
MTMR4  (myotubularin related protein 4)
NEDD4  (NEDD4 E3 ubiquitin protein ligase)


Additional Information