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The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.

Authors: Plant, PJ  Correa, J  Goldenberg, N  Bain, J  Batt, J 
Citation: Plant PJ, etal., Biochem J. 2009 Apr 1;419(1):57-63. doi: 10.1042/BJ20081866.
Pubmed: (View Article at PubMed) PMID:19125695
DOI: Full-text: DOI:10.1042/BJ20081866

The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased in atrophying muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown.


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RGD Object Information
RGD ID: 7242174
Created: 2013-03-27
Species: All species
Last Modified: 2013-03-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.