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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3157
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nedd4
Name: NEDD4 E3 ubiquitin protein ligase
Acc ID: CHEBI:35176
Term: zinc sulfate
Definition: A metal sulfate compound having zinc(2+) as the counterion.
Chemical ID: MESH:D019287
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nedd4increases expressionEXP 6480464CTDZinc Sulfate results in increased expression of NEDD4 mRNA; Zinc Sulfate results in increased expression of NEDD4 proteinPMID:20100827
Nedd4multiple interactionsEXP 6480464CTDWortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]; Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]PMID:20100827
Nedd4increases expressionISONedd4 (Mus musculus)6480464CTDZinc Sulfate results in increased expression of NEDD4 proteinPMID:20100827
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