Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Nedd4 (neural precursor cell expressed, developmentally down-regulated 4) Mus musculus
Analyze
Symbol: Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Description: Exhibits several functions, including ionotropic glutamate receptor binding activity; protein phosphorylated amino acid binding activity; and sodium channel inhibitor activity. Involved in several processes, including cellular protein metabolic process; circulatory system development; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Localizes to several cellular components, including the dendritic spine; glutamatergic synapse; and postsynaptic cytosol. Is expressed in several structures, including alimentary system; eye; limb; nervous system; and respiratory system. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase); PARTICIPATES IN vascular endothelial growth factor signaling pathway; endocytosis pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA959633; AL023035; AU019897; E3 ubiquitin-protein ligase NEDD4; E430025J12Rik; EG639396; Gm7265; HECT-type E3 ubiquitin transferase NEDD4; KIAA0093; mKIAA0093; NEDD-4; Nedd4-1; Nedd4a; neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated gene 4a; neural precursor cell expressed, developmentally down-regulted gene 4; predicted gene 7265
Orthologs:
Homo sapiens (human) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nedd4 (NEDD4 E3 ubiquitin protein ligase)
Sus scrofa (pig) : NEDD4 (NEDD4 E3 ubiquitin protein ligase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38972,662,331 - 72,749,851 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37972,510,154 - 72,597,655 (+)NCBIGRCm37mm9NCBIm37
MGSCv36972,460,914 - 72,548,414 (+)NCBImm8
Celera969,852,010 - 69,939,539 (+)NCBICelera
Cytogenetic Map9 DNCBI
cM Map940.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Nedd4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10967
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.