Nedd4 (neural precursor cell expressed, developmentally down-regulated 4) - Rat Genome Database

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Gene: Nedd4 (neural precursor cell expressed, developmentally down-regulated 4) Mus musculus
Analyze
Symbol: Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
RGD ID: 10967
MGI Page MGI
Description: Enables several functions, including ionotropic glutamate receptor binding activity; proline-rich region binding activity; and protein phosphorylated amino acid binding activity. Involved in negative regulation of vascular endothelial growth factor receptor signaling pathway and regulation of dendrite morphogenesis. Acts upstream of or within several processes, including circulatory system development; negative regulation of transcription by RNA polymerase II; and protein monoubiquitination. Located in cytosol and membrane. Part of ubiquitin ligase complex. Is active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; limb; and nervous system. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA959633; AL023035; AU019897; E3 ubiquitin-protein ligase NEDD4; E430025J12Rik; EG639396; Gm7265; HECT-type E3 ubiquitin transferase NEDD4; KIAA0093; mKIAA0093; Nedd; NEDD-4; Nedd4-; Nedd4-1; Nedd4a; neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated gene 4a; neural precursor cell expressed, developmentally down-regulted gene 4; predicted gene 7265
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39972,569,613 - 72,657,133 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl972,569,628 - 72,657,134 (+)EnsemblGRCm39 Ensembl
GRCm38972,662,331 - 72,749,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl972,662,346 - 72,749,852 (+)EnsemblGRCm38mm10GRCm38
MGSCv37972,510,154 - 72,597,655 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36972,460,914 - 72,548,414 (+)NCBIMGSCv36mm8
Celera969,852,010 - 69,939,539 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map940.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chloroprene  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clotrimazole  (ISO)
clozapine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
desmopressin  (ISO)
dextran sulfate  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
glycidyl methacrylate  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
indoles  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lead(0)  (EXP)
lead(II) chloride  (EXP)
lithium chloride  (ISO)
melatonin  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
nickel subsulfide  (ISO)
olanzapine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phlorizin  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
resveratrol  (EXP)
rimonabant  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
warfarin  (ISO)
wortmannin  (ISO)
zinc sulfate  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IMP)
biological_process  (ND)
blood vessel morphogenesis  (IGI,IMP)
cellular response to UV  (ISO)
DNA damage response  (ISO)
endocardial cushion development  (IGI,IMP)
establishment of localization in cell  (IDA)
formation of structure involved in a symbiotic process  (ISO)
immune response  (ISO)
innate immune response  (ISO)
lysosomal transport  (ISO)
negative regulation of sodium ion transmembrane transporter activity  (ISO)
negative regulation of sodium ion transport  (IDA,ISO)
negative regulation of transcription by RNA polymerase II  (IMP,ISO)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (IDA)
nervous system development  (IEA)
neuromuscular junction development  (IBA,IMP)
neuron projection development  (IBA)
nuclear receptor-mediated glucocorticoid signaling pathway  (ISO)
outflow tract morphogenesis  (IGI,IMP)
positive regulation of nucleocytoplasmic transport  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein catabolic process  (IDA,ISO)
progesterone receptor signaling pathway  (ISO)
protein K63-linked ubiquitination  (ISO,ISS)
protein monoubiquitination  (IDA)
protein targeting to lysosome  (ISO)
protein ubiquitination  (IDA,ISO)
receptor catabolic process  (IBA,ISO)
receptor internalization  (IBA,ISO)
regulation of dendrite morphogenesis  (IBA,IMP,ISO)
regulation of membrane potential  (ISO)
regulation of monoatomic ion transmembrane transport  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of potassium ion transmembrane transporter activity  (ISO)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (ISO)
regulation of synapse organization  (IBA,IMP)
regulation protein catabolic process at postsynapse  (ISO)
response to denervation involved in regulation of muscle adaptation  (ISO)
sodium ion transport  (IDA)
T cell activation  (IMP)
ubiquitin-dependent protein catabolic process  (IBA,IMP,ISO,ISS)
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  (ISO)
viral budding  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavior  (IEA)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal gait  (IEA)
abnormal glossopharyngeal ganglion morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal meiosis  (IAGP)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal neural crest cell physiology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal premaxilla morphology  (IAGP)
abnormal Sertoli cell development  (IAGP)
abnormal sex determination  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal synaptic vesicle number  (IAGP)
abnormal T cell activation  (IAGP)
abnormal temporal bone tympanic part morphology  (IAGP)
abnormal testis development  (IAGP)
abnormal tongue position  (IAGP)
abnormal vagus ganglion morphology  (IAGP)
absent palate bones  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
cleft palate  (IAGP)
decreased B cell number  (IAGP)
decreased birth weight  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone ossification  (IAGP)
decreased circulating creatinine level  (IEA)
decreased cranial neural crest cell number  (IAGP)
decreased embryo size  (IAGP)
decreased excitatory postsynaptic current amplitude  (IAGP)
decreased fetal size  (IAGP)
decreased fetal weight  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased locomotor activity  (IEA)
decreased T cell proliferation  (IAGP)
decreased thigmotaxis  (IEA)
delayed muscle development  (IAGP)
fetal growth retardation  (IAGP)
hemorrhage  (IAGP)
impaired glucose tolerance  (IEA)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cranial neural crest cell apoptosis  (IAGP)
increased embryonic neuroepithelium apoptosis  (IAGP)
increased grip strength  (IEA)
increased IgM level  (IAGP)
increased leukocyte cell number  (IEA)
increased lymphocyte cell number  (IEA)
increased T cell number  (IAGP)
increased variability of skeletal muscle fiber size  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
neonatal lethality  (IEA)
palatal shelves fail to meet at midline  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
primary sex reversal  (IAGP)
prominent forehead  (IAGP)
sex reversal  (IAGP)
small basioccipital bone  (IAGP)
small exoccipital bone  (IAGP)
small gonad  (IAGP)
small mandible  (IAGP)
small maxilla  (IAGP)
small trigeminal ganglion  (IAGP)
small vertebrae  (IAGP)
thin cerebral cortex  (IAGP)
tremors  (IEA)
underdeveloped hair follicles  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The Nedd4-like family of E3 ubiquitin ligases and cancer. Chen C and Matesic LE, Cancer Metastasis Rev. 2007 Dec;26(3-4):587-604.
2. A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. Kamynina E, etal., FASEB J 2001 Jan;15(1):204-214.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48.
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. Plant PJ, etal., Biochem J. 2009 Apr 1;419(1):57-63. doi: 10.1042/BJ20081866.
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. Staub O, etal., EMBO J 1996 May 15;15(10):2371-80.
Additional References at PubMed
PMID:1378265   PMID:7671812   PMID:9073511   PMID:9182527   PMID:9305852   PMID:9407065   PMID:10037602   PMID:10212229   PMID:10322449   PMID:10349636   PMID:10446181   PMID:10512203  
PMID:10591541   PMID:10842081   PMID:10922068   PMID:11042109   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11435423   PMID:11717310   PMID:11748237   PMID:11779188   PMID:12124942  
PMID:12460120   PMID:12477932   PMID:12520002   PMID:12559917   PMID:12697834   PMID:12904583   PMID:14610273   PMID:14973438   PMID:15013426   PMID:15060076   PMID:15123669   PMID:15226823  
PMID:15548568   PMID:15581898   PMID:15782199   PMID:15840001   PMID:15908775   PMID:16099816   PMID:16141072   PMID:16141073   PMID:16337426   PMID:16452087   PMID:16537572   PMID:16602821  
PMID:17218260   PMID:17544362   PMID:18286479   PMID:18307411   PMID:18554416   PMID:18562292   PMID:18687683   PMID:18799693   PMID:18812566   PMID:18931680   PMID:18981174   PMID:19054764  
PMID:19164599   PMID:19345204   PMID:19423771   PMID:19463158   PMID:19521500   PMID:19682092   PMID:19794060   PMID:20026598   PMID:20100827   PMID:20159449   PMID:20855896   PMID:20980250  
PMID:21220429   PMID:21267068   PMID:21478478   PMID:21505443   PMID:21873192   PMID:21873635   PMID:21920314   PMID:22083510   PMID:22096579   PMID:22417925   PMID:22431752   PMID:22679284  
PMID:22745772   PMID:22763434   PMID:22768111   PMID:22875931   PMID:23110050   PMID:23253940   PMID:23460917   PMID:23604909   PMID:23639431   PMID:23707720   PMID:23964096   PMID:24036464  
PMID:24080509   PMID:24194600   PMID:24280120   PMID:24413081   PMID:24457600   PMID:24614057   PMID:24743017   PMID:25072696   PMID:25157163   PMID:25258171   PMID:25344756   PMID:25505317  
PMID:25879670   PMID:26147758   PMID:26280536   PMID:26304770   PMID:26556890   PMID:26681395   PMID:26821291   PMID:26854353   PMID:26904956   PMID:27086928   PMID:27325702   PMID:27917940  
PMID:27939692   PMID:28029182   PMID:28106071   PMID:28378742   PMID:28432080   PMID:28585553   PMID:28671696   PMID:28706196   PMID:28784777   PMID:28890072   PMID:29251248   PMID:29254152  
PMID:30125728   PMID:30550785   PMID:30642949   PMID:30816303   PMID:31055087   PMID:31802037   PMID:32325033   PMID:32450490   PMID:32792353   PMID:33484199   PMID:33993186   PMID:34756879  
PMID:35075134   PMID:35452957   PMID:35670107   PMID:35773260   PMID:36002265   PMID:36278411   PMID:36631006   PMID:36732831   PMID:36908855   PMID:36923932   PMID:37139424   PMID:37423323  
PMID:37481723   PMID:37792248   PMID:37932175   PMID:38355793   PMID:38733337   PMID:38888282  


Genomics

Comparative Map Data
Nedd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39972,569,613 - 72,657,133 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl972,569,628 - 72,657,134 (+)EnsemblGRCm39 Ensembl
GRCm38972,662,331 - 72,749,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl972,662,346 - 72,749,852 (+)EnsemblGRCm38mm10GRCm38
MGSCv37972,510,154 - 72,597,655 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36972,460,914 - 72,548,414 (+)NCBIMGSCv36mm8
Celera969,852,010 - 69,939,539 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map940.08NCBI
NEDD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381555,826,917 - 55,993,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1555,826,922 - 55,993,660 (-)EnsemblGRCh38hg38GRCh38
GRCh371556,119,115 - 56,285,810 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361553,906,412 - 54,073,127 (-)NCBINCBI36Build 36hg18NCBI36
Build 341553,906,420 - 53,996,621NCBI
Celera1533,007,634 - 33,174,352 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1532,943,160 - 33,109,724 (-)NCBIHuRef
CHM1_11556,237,532 - 56,404,177 (-)NCBICHM1_1
T2T-CHM13v2.01553,630,346 - 53,797,054 (-)NCBIT2T-CHM13v2.0
Nedd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8882,264,751 - 82,349,642 (+)NCBIGRCr8
mRatBN7.2873,384,095 - 73,468,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl873,383,695 - 73,468,951 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx878,909,673 - 78,994,418 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0877,182,291 - 77,267,035 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0875,019,698 - 75,104,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0879,323,408 - 79,408,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl879,323,408 - 79,408,833 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0873,679,012 - 73,764,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4877,252,500 - 77,337,402 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1877,271,630 - 77,353,830 (+)NCBI
Celera868,281,153 - 68,365,646 (-)NCBICelera
Cytogenetic Map8q24NCBI
Nedd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955409183,545 - 281,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955409183,645 - 281,252 (+)NCBIChiLan1.0ChiLan1.0
NEDD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21645,093,131 - 45,258,171 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11549,273,091 - 49,441,071 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01534,798,880 - 34,963,823 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11553,118,400 - 53,283,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1553,118,411 - 53,283,076 (-)Ensemblpanpan1.1panPan2
NEDD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13021,123,333 - 21,229,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3021,126,043 - 21,229,870 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3021,088,774 - 21,211,642 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03021,272,328 - 21,395,438 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3021,274,704 - 21,395,561 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13021,215,729 - 21,338,560 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03021,299,239 - 21,422,293 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03021,433,575 - 21,556,459 (-)NCBIUU_Cfam_GSD_1.0
Nedd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864099,406,714 - 99,526,684 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647117,252,234 - 17,374,804 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647117,254,777 - 17,374,725 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,941,940 - 116,070,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,941,945 - 116,069,884 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21128,545,541 - 128,557,317 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEDD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12627,487,652 - 27,655,742 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2627,487,796 - 27,655,992 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048113,632,934 - 113,801,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nedd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247315,862,626 - 5,951,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247315,855,678 - 5,954,119 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nedd4
2510 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2351
Count of miRNA genes:759
Interacting mature miRNAs:1013
Transcripts:ENSMUST00000034740, ENSMUST00000183375, ENSMUST00000183451, ENSMUST00000184020, ENSMUST00000184180, ENSMUST00000184287, ENSMUST00000184333, ENSMUST00000184386, ENSMUST00000184450, ENSMUST00000184737
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95936994693370128Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96926774798701707Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95780504786121973Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966089077100089175Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967006220101006220Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95936994693370128Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96504119195522808Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969121898103121973Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969428566103428698Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95902438793024534Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95936994693370128Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968779563102779705Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95902438793024534Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96214976796149881Mouse
1301290Smgd1_msubmucosal gland distribution 1 (mouse)Not determined96583105686577967Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95643910890439255Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968779563102779705Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse

Markers in Region
RH136317  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38972,749,396 - 72,749,582UniSTSGRCm38
MGSCv37972,597,203 - 72,597,389UniSTSGRCm37
Celera969,939,087 - 69,939,273UniSTS
Cytogenetic Map9DUniSTS
cM Map940.0UniSTS
D9Mit34.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map2C1.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map1E3UniSTS
Cytogenetic Map5E1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map19D3UniSTS
Cytogenetic Map1H5UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map13A1UniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map12A3UniSTS
Cytogenetic Map1H2.1UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map19CUniSTS
Cytogenetic Map17E1.3UniSTS
Cytogenetic Map5A1UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map13A5UniSTS
Cytogenetic MapXA1.1UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map3A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map8CUniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map1H1UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map5G1.3UniSTS
Cytogenetic Map7D1-E2UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map1H2.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map15F2UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map1H4-H6UniSTS
Cytogenetic Map12D2UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map1H3UniSTS
Cytogenetic Map19BUniSTS
cM Map950.0UniSTS
Whitehead Genetic943.7UniSTS
AA959633  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38972,749,513 - 72,749,622UniSTSGRCm38
MGSCv37972,597,320 - 72,597,429UniSTSGRCm37
Celera969,939,204 - 69,939,313UniSTS
Cytogenetic Map9DUniSTS
cM Map940.0UniSTS
Whitehead/MRC_RH9701.68UniSTS
RH125447  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38972,748,444 - 72,748,556UniSTSGRCm38
MGSCv37972,596,251 - 72,596,363UniSTSGRCm37
Celera969,938,135 - 69,938,247UniSTS
Cytogenetic Map9DUniSTS
cM Map940.0UniSTS
RH139229  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38972,747,790 - 72,747,960UniSTSGRCm38
MGSCv37972,595,597 - 72,595,767UniSTSGRCm37
Celera969,937,482 - 69,937,652UniSTS
Cytogenetic Map9DUniSTS
cM Map940.0UniSTS
Nedd4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37972,596,092 - 72,597,082UniSTSGRCm37
Celera969,937,976 - 69,938,966UniSTS
Cytogenetic Map9DUniSTS
cM Map940.0UniSTS
Nedd4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38972,748,285 - 72,749,275UniSTSGRCm38
MGSCv37972,596,092 - 72,597,082UniSTSGRCm37
Celera969,937,976 - 69,938,966UniSTS
Cytogenetic Map9DUniSTS
Nedd4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
Nedd4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW553531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB542352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC080710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ177728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ899954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY059586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY068934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD807110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF736340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO426280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT027588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX565415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX566785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U96635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000034740   ⟹   ENSMUSP00000034740
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,569,628 - 72,657,134 (+)Ensembl
GRCm38.p6 Ensembl972,662,346 - 72,749,852 (+)Ensembl
Ensembl Acc Id: ENSMUST00000183375   ⟹   ENSMUSP00000138852
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,569,769 - 72,619,511 (+)Ensembl
GRCm38.p6 Ensembl972,662,487 - 72,712,229 (+)Ensembl
Ensembl Acc Id: ENSMUST00000183451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,648,726 - 72,654,435 (+)Ensembl
GRCm38.p6 Ensembl972,741,444 - 72,747,153 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184020   ⟹   ENSMUSP00000139297
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,646,754 - 72,655,440 (+)Ensembl
GRCm38.p6 Ensembl972,739,472 - 72,748,158 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184180
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,575,951 - 72,579,411 (+)Ensembl
GRCm38.p6 Ensembl972,668,669 - 72,672,129 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184287
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,653,121 - 72,654,545 (+)Ensembl
GRCm38.p6 Ensembl972,745,839 - 72,747,263 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184333   ⟹   ENSMUSP00000139190
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,575,962 - 72,627,637 (+)Ensembl
GRCm38.p6 Ensembl972,668,680 - 72,720,355 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184386
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,569,772 - 72,570,581 (+)Ensembl
GRCm38.p6 Ensembl972,662,490 - 72,663,299 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184450   ⟹   ENSMUSP00000138983
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,569,764 - 72,628,072 (+)Ensembl
GRCm38.p6 Ensembl972,662,482 - 72,720,790 (+)Ensembl
Ensembl Acc Id: ENSMUST00000184737
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,569,720 - 72,579,430 (+)Ensembl
GRCm38.p6 Ensembl972,662,438 - 72,672,148 (+)Ensembl
Ensembl Acc Id: ENSMUST00000238315   ⟹   ENSMUSP00000158796
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,600,721 - 72,657,134 (+)Ensembl
GRCm38.p6 Ensembl972,693,439 - 72,749,852 (+)Ensembl
Ensembl Acc Id: ENSMUST00000238368   ⟹   ENSMUSP00000158642
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl972,569,628 - 72,657,134 (+)Ensembl
GRCm38.p6 Ensembl972,662,346 - 72,749,852 (+)Ensembl
RefSeq Acc Id: NM_001357998   ⟹   NP_001344927
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39972,600,580 - 72,657,133 (+)NCBI
GRCm38972,693,298 - 72,749,851 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010890   ⟹   NP_035020
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39972,569,613 - 72,657,133 (+)NCBI
GRCm38972,662,331 - 72,749,851 (+)NCBI
MGSCv37972,510,154 - 72,597,655 (+)RGD
Celera969,852,010 - 69,939,539 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242672   ⟹   XP_011240974
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39972,609,568 - 72,657,129 (+)NCBI
GRCm38972,702,286 - 72,749,180 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001344927 (Get FASTA)   NCBI Sequence Viewer  
  NP_035020 (Get FASTA)   NCBI Sequence Viewer  
  XP_011240974 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB63360 (Get FASTA)   NCBI Sequence Viewer  
  AAI27071 (Get FASTA)   NCBI Sequence Viewer  
  AAI38814 (Get FASTA)   NCBI Sequence Viewer  
  AAI47148 (Get FASTA)   NCBI Sequence Viewer  
  AAI47149 (Get FASTA)   NCBI Sequence Viewer  
  BAA12803 (Get FASTA)   NCBI Sequence Viewer  
  BAC37885 (Get FASTA)   NCBI Sequence Viewer  
  BAC39966 (Get FASTA)   NCBI Sequence Viewer  
  BAC40458 (Get FASTA)   NCBI Sequence Viewer  
  BAC40558 (Get FASTA)   NCBI Sequence Viewer  
  BAC65485 (Get FASTA)   NCBI Sequence Viewer  
  BAE20674 (Get FASTA)   NCBI Sequence Viewer  
  BAE21875 (Get FASTA)   NCBI Sequence Viewer  
  BAE35880 (Get FASTA)   NCBI Sequence Viewer  
  EDL26264 (Get FASTA)   NCBI Sequence Viewer  
  EDL26265 (Get FASTA)   NCBI Sequence Viewer  
  EDL26266 (Get FASTA)   NCBI Sequence Viewer  
  EDL26267 (Get FASTA)   NCBI Sequence Viewer  
  EDL26268 (Get FASTA)   NCBI Sequence Viewer  
  EDL26269 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000034740
  ENSMUSP00000034740.8
  ENSMUSP00000138852.2
  ENSMUSP00000138983.2
  ENSMUSP00000139190.2
  ENSMUSP00000139297.2
  ENSMUSP00000158642.2
  ENSMUSP00000158796
  ENSMUSP00000158796.2
GenBank Protein P46935 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035020   ⟸   NM_010890
- Peptide Label: isoform 1
- UniProtKB: Q3UZI2 (UniProtKB/Swiss-Prot),   O08758 (UniProtKB/Swiss-Prot),   Q8BGB3 (UniProtKB/Swiss-Prot),   P46935 (UniProtKB/Swiss-Prot),   B2RSC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240974   ⟸   XM_011242672
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001344927   ⟸   NM_001357998
- Peptide Label: isoform 2
- UniProtKB: A0A571BDN7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000139297   ⟸   ENSMUST00000184020
Ensembl Acc Id: ENSMUSP00000139190   ⟸   ENSMUST00000184333
Ensembl Acc Id: ENSMUSP00000138983   ⟸   ENSMUST00000184450
Ensembl Acc Id: ENSMUSP00000138852   ⟸   ENSMUST00000183375
Ensembl Acc Id: ENSMUSP00000034740   ⟸   ENSMUST00000034740
Ensembl Acc Id: ENSMUSP00000158796   ⟸   ENSMUST00000238315
Ensembl Acc Id: ENSMUSP00000158642   ⟸   ENSMUST00000238368
Protein Domains
C2   HECT   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46935-F1-model_v2 AlphaFold P46935 1-887 view protein structure

Promoters
RGD ID:6844872
Promoter ID:MM_KWN:58033
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_010890
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36972,509,471 - 72,510,652 (+)MPROMDB
RGD ID:6844874
Promoter ID:MM_KWN:58034
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:UC009QQF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36972,516,861 - 72,518,077 (+)MPROMDB
RGD ID:6848436
Promoter ID:MM_ACW:51212
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3
Transcripts:NEDD4.MSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36972,569,191 - 72,569,691 (+)MPROMDB
RGD ID:6848439
Promoter ID:MM_ACW:51214
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NEDD4.PSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36972,582,661 - 72,583,161 (+)MPROMDB
RGD ID:6848434
Promoter ID:MM_ACW:51216
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6
Transcripts:NEDD4.KSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36972,586,996 - 72,587,496 (+)MPROMDB
RGD ID:6848435
Promoter ID:MM_ACW:51217
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   MEF_B6
Transcripts:NEDD4.OSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36972,589,211 - 72,589,711 (+)MPROMDB
RGD ID:6848438
Promoter ID:MM_ACW:51218
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NEDD4.QSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36972,590,491 - 72,591,562 (+)MPROMDB
RGD ID:6848432
Promoter ID:MM_ACW:51219
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NEDD4.HSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36972,593,721 - 72,594,221 (+)MPROMDB
RGD ID:8670144
Promoter ID:EPDNEW_M13102
Type:initiation region
Name:Nedd4_2
Description:Mus musculus neural precursor cell expressed, developmentallydown-regulated 4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13103  EPDNEW_M13104  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38972,662,297 - 72,662,357EPDNEW
RGD ID:8670146
Promoter ID:EPDNEW_M13103
Type:initiation region
Name:Nedd4_1
Description:Mus musculus neural precursor cell expressed, developmentallydown-regulated 4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13102  EPDNEW_M13104  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38972,662,482 - 72,662,542EPDNEW
RGD ID:8670148
Promoter ID:EPDNEW_M13104
Type:multiple initiation site
Name:Nedd4_3
Description:Mus musculus neural precursor cell expressed, developmentallydown-regulated 4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13102  EPDNEW_M13103  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38972,669,992 - 72,670,052EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97297 AgrOrtholog
Ensembl Genes ENSMUSG00000032216 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034740 ENTREZGENE
  ENSMUST00000034740.15 UniProtKB/Swiss-Prot
  ENSMUST00000183375.8 UniProtKB/TrEMBL
  ENSMUST00000184020.8 UniProtKB/TrEMBL
  ENSMUST00000184333.2 UniProtKB/TrEMBL
  ENSMUST00000184450.8 UniProtKB/TrEMBL
  ENSMUST00000238315 ENTREZGENE
  ENSMUST00000238315.2 UniProtKB/TrEMBL
  ENSMUST00000238368.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E3_ubiq-protein_ligase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HECT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17999 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97297 ENTREZGENE
NCBI Gene 17999 ENTREZGENE
PANTHER C2 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  DYSFERLIN-RELATED UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE NEDD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00397 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nedd4 PhenoGen
PIRSF E3_ub_ligase_SMURF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS C2DOMAIN UniProtKB/TrEMBL
PROSITE HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HECTc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00456 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51045 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56204 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A571BDN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A571BEP7_MOUSE UniProtKB/TrEMBL
  A0JNZ0_MOUSE UniProtKB/TrEMBL
  B2RSC8 ENTREZGENE, UniProtKB/TrEMBL
  NEDD4_MOUSE UniProtKB/Swiss-Prot
  O08758 ENTREZGENE
  P46935 ENTREZGENE
  Q3TUU1_MOUSE UniProtKB/TrEMBL
  Q3UZI2 ENTREZGENE
  Q3V335_MOUSE UniProtKB/TrEMBL
  Q8BGB3 ENTREZGENE
  Q8BNU7_MOUSE UniProtKB/TrEMBL
  Q8BU52_MOUSE UniProtKB/TrEMBL
  V9GWV8_MOUSE UniProtKB/TrEMBL
  V9GXK3_MOUSE UniProtKB/TrEMBL
  V9GXS6_MOUSE UniProtKB/TrEMBL
UniProt Secondary O08758 UniProtKB/Swiss-Prot
  Q3UZI2 UniProtKB/Swiss-Prot
  Q8BGB3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-11-21 Nedd4  neural precursor cell expressed, developmentally down-regulated 4  Gm7265  predicted gene 7265  Data merged from RGD:1615349 737654 PROVISIONAL