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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10967
Species: Mus musculus
RGD Object: Gene
Symbol: Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:7366126480464CTDNEDD4 protein affects the susceptibility to Fluorouracil

PMID:16217747
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.