Nedd4 (NEDD4 E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Nedd4 (NEDD4 E3 ubiquitin protein ligase) Heterocephalus glaber
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Symbol: Nedd4
Name: NEDD4 E3 ubiquitin protein ligase
RGD ID: 18913769
Description: ENCODES a protein that exhibits beta-2 adrenergic receptor binding (ortholog); enzyme binding (ortholog); ionotropic glutamate receptor binding (ortholog); INVOLVED IN adaptive immune response (ortholog); blood vessel morphogenesis (ortholog); cellular response to UV (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN cell cortex (ortholog); chromatin (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247315,862,626 - 5,951,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247315,855,678 - 5,954,119 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO)
blood vessel morphogenesis  (ISO)
cellular response to UV  (ISO)
DNA damage response  (ISO)
endocardial cushion development  (ISO)
establishment of localization in cell  (ISO)
immune response  (ISO)
innate immune response  (ISO)
lysosomal transport  (ISO)
negative regulation of sodium ion transmembrane transporter activity  (ISO)
negative regulation of sodium ion transport  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
neuromuscular junction development  (IEA,ISO)
neuron projection development  (IEA)
nuclear receptor-mediated glucocorticoid signaling pathway  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of nucleocytoplasmic transport  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein catabolic process  (ISO)
progesterone receptor signaling pathway  (ISO)
protein K63-linked ubiquitination  (ISO)
protein monoubiquitination  (ISO)
protein targeting to lysosome  (ISO)
protein ubiquitination  (IEA,ISO)
receptor catabolic process  (IEA)
receptor internalization  (IEA)
regulation of dendrite morphogenesis  (IEA)
regulation of membrane potential  (ISO)
regulation of monoatomic ion transmembrane transport  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of potassium ion transmembrane transporter activity  (ISO)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (ISO)
regulation of synapse organization  (IEA,ISO)
regulation protein catabolic process at postsynapse  (ISO)
response to denervation involved in regulation of muscle adaptation  (ISO)
sodium ion transport  (ISO)
T cell activation  (ISO)
ubiquitin-dependent protein catabolic process  (IEA,ISO)
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nedd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247315,862,626 - 5,951,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247315,855,678 - 5,954,119 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NEDD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381555,826,917 - 55,993,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1555,826,922 - 55,993,660 (-)EnsemblGRCh38hg38GRCh38
GRCh371556,119,115 - 56,285,810 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361553,906,412 - 54,073,127 (-)NCBINCBI36Build 36hg18NCBI36
Build 341553,906,420 - 53,996,621NCBI
Celera1533,007,634 - 33,174,352 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1532,943,160 - 33,109,724 (-)NCBIHuRef
CHM1_11556,237,532 - 56,404,177 (-)NCBICHM1_1
T2T-CHM13v2.01553,630,346 - 53,797,054 (-)NCBIT2T-CHM13v2.0
Nedd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39972,569,613 - 72,657,133 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl972,569,628 - 72,657,134 (+)EnsemblGRCm39 Ensembl
GRCm38972,662,331 - 72,749,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl972,662,346 - 72,749,852 (+)EnsemblGRCm38mm10GRCm38
MGSCv37972,510,154 - 72,597,655 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36972,460,914 - 72,548,414 (+)NCBIMGSCv36mm8
Celera969,852,010 - 69,939,539 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map940.08NCBI
Nedd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8882,264,751 - 82,349,642 (+)NCBIGRCr8
mRatBN7.2873,384,095 - 73,468,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl873,383,695 - 73,468,951 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx878,909,673 - 78,994,418 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0877,182,291 - 77,267,035 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0875,019,698 - 75,104,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0879,323,408 - 79,408,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl879,323,408 - 79,408,833 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0873,679,012 - 73,764,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4877,252,500 - 77,337,402 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1877,271,630 - 77,353,830 (+)NCBI
Celera868,281,153 - 68,365,646 (-)NCBICelera
Cytogenetic Map8q24NCBI
Nedd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955409183,545 - 281,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955409183,645 - 281,252 (+)NCBIChiLan1.0ChiLan1.0
NEDD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21645,093,131 - 45,258,171 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11549,273,091 - 49,441,071 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01534,798,880 - 34,963,823 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11553,118,400 - 53,283,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1553,118,411 - 53,283,076 (-)Ensemblpanpan1.1panPan2
NEDD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13021,123,333 - 21,229,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3021,126,043 - 21,229,870 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3021,088,774 - 21,211,642 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03021,272,328 - 21,395,438 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3021,274,704 - 21,395,561 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13021,215,729 - 21,338,560 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03021,299,239 - 21,422,293 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03021,433,575 - 21,556,459 (-)NCBIUU_Cfam_GSD_1.0
Nedd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864099,406,714 - 99,526,684 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647117,252,234 - 17,374,804 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647117,254,777 - 17,374,725 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,941,940 - 116,070,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,941,945 - 116,069,884 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21128,545,541 - 128,557,317 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEDD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12627,487,652 - 27,655,742 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2627,487,796 - 27,655,992 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048113,632,934 - 113,801,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000018595   ⟹   ENSHGLP00000018411
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247315,862,626 - 5,951,421 (+)Ensembl
RefSeq Acc Id: XM_004835344   ⟹   XP_004835401
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247315,890,106 - 5,954,119 (+)NCBI
RefSeq Acc Id: XM_004835346   ⟹   XP_004835403
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247315,855,678 - 5,954,117 (+)NCBI
RefSeq Acc Id: XM_013074193   ⟹   XP_012929647
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247315,855,678 - 5,954,117 (+)NCBI
RefSeq Acc Id: XM_021260718   ⟹   XP_021116377
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247315,888,578 - 5,954,119 (+)NCBI
RefSeq Acc Id: XM_021260737   ⟹   XP_021116396
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247315,888,574 - 5,933,763 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004835401 (Get FASTA)   NCBI Sequence Viewer  
  XP_004835403 (Get FASTA)   NCBI Sequence Viewer  
  XP_012929647 (Get FASTA)   NCBI Sequence Viewer  
  XP_021116377 (Get FASTA)   NCBI Sequence Viewer  
  XP_021116396 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000018411
RefSeq Acc Id: XP_012929647   ⟸   XM_013074193
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004835403   ⟸   XM_004835346
- Peptide Label: isoform X4
RefSeq Acc Id: XP_021116396   ⟸   XM_021260737
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021116377   ⟸   XM_021260718
- Peptide Label: isoform X1
- UniProtKB: G5B2Q3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004835401   ⟸   XM_004835344
- Peptide Label: isoform X2
- UniProtKB: G5B2Q3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000018411   ⟸   ENSHGLT00000018595


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013198 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000018595 ENTREZGENE
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro E3_ubiq-protein_ligase UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene Nedd4 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE NEDD4 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  WW domain UniProtKB/TrEMBL
UniProt G5B2Q3 ENTREZGENE, UniProtKB/TrEMBL