Nedd4 (NEDD4 E3 ubiquitin protein ligase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Nedd4 (NEDD4 E3 ubiquitin protein ligase) Chinchilla lanigera
Analyze
Symbol: Nedd4
Name: NEDD4 E3 ubiquitin protein ligase
RGD ID: 8990732
Description: ENCODES a protein that exhibits beta-2 adrenergic receptor binding (ortholog); enzyme binding (ortholog); ionotropic glutamate receptor binding (ortholog); INVOLVED IN adaptive immune response (ortholog); blood vessel morphogenesis (ortholog); cellular response to UV (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colon cancer (ortholog); Keloid (ortholog); FOUND IN cell cortex (ortholog); chromatin (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: E3 ubiquitin-protein ligase NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955409183,545 - 281,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955409183,645 - 281,252 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO)
blood vessel morphogenesis  (ISO)
cellular response to UV  (ISO)
endocardial cushion development  (ISO)
formation of structure involved in a symbiotic process  (ISO)
glucocorticoid receptor signaling pathway  (ISO)
immune response  (ISO)
lysosomal transport  (ISO)
negative regulation of sodium ion transmembrane transporter activity  (ISO)
negative regulation of sodium ion transport  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  (ISO)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
neuromuscular junction development  (ISO)
neuron projection development  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of nucleocytoplasmic transport  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein catabolic process  (ISO)
progesterone receptor signaling pathway  (ISO)
protein K63-linked ubiquitination  (ISO)
protein monoubiquitination  (ISO)
protein targeting to lysosome  (ISO)
protein ubiquitination  (ISO)
receptor catabolic process  (ISO)
receptor internalization  (ISO)
regulation of dendrite morphogenesis  (ISO)
regulation of ion transmembrane transport  (ISO)
regulation of membrane potential  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of potassium ion transmembrane transporter activity  (ISO)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (ISO)
regulation of synapse organization  (ISO)
response to denervation involved in regulation of muscle adaptation  (ISO)
T cell activation  (ISO)
ubiquitin-dependent protein catabolic process  (ISO)
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  (ISO)
viral budding  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Nedd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955409183,545 - 281,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955409183,645 - 281,252 (+)NCBIChiLan1.0ChiLan1.0
NEDD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1555,826,922 - 55,993,660 (-)EnsemblGRCh38hg38GRCh38
GRCh381555,826,917 - 55,993,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371556,119,115 - 56,285,810 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361553,906,412 - 54,073,127 (-)NCBINCBI36hg18NCBI36
Build 341553,906,420 - 53,996,621NCBI
Celera1533,007,634 - 33,174,352 (-)NCBI
Cytogenetic Map15q21.3NCBI
HuRef1532,943,160 - 33,109,724 (-)NCBIHuRef
CHM1_11556,237,527 - 56,404,286 (-)NCBICHM1_1
Nedd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39972,569,613 - 72,657,133 (+)NCBIGRCm39mm39
GRCm39 Ensembl972,569,628 - 72,657,134 (+)Ensembl
GRCm38972,662,331 - 72,749,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl972,662,346 - 72,749,852 (+)EnsemblGRCm38mm10GRCm38
MGSCv37972,510,154 - 72,597,655 (+)NCBIGRCm37mm9NCBIm37
MGSCv36972,460,914 - 72,548,414 (+)NCBImm8
Celera969,852,010 - 69,939,539 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map940.08NCBI
Nedd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2873,384,095 - 73,468,951 (+)NCBI
Rnor_6.0 Ensembl879,323,408 - 79,408,833 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0879,323,408 - 79,408,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0873,679,012 - 73,764,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4877,252,500 - 77,337,402 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1877,271,630 - 77,353,830 (+)NCBI
Celera868,281,153 - 68,365,646 (-)NCBICelera
Cytogenetic Map8q24NCBI
NEDD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11553,118,400 - 53,283,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1553,118,411 - 53,283,076 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01534,798,880 - 34,963,823 (-)NCBIMhudiblu_PPA_v0panPan3
NEDD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13021,123,333 - 21,229,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3021,126,043 - 21,229,870 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3021,088,774 - 21,211,642 (-)NCBI
ROS_Cfam_1.03021,272,328 - 21,395,438 (-)NCBI
UMICH_Zoey_3.13021,215,729 - 21,338,560 (-)NCBI
UNSW_CanFamBas_1.03021,299,239 - 21,422,293 (-)NCBI
UU_Cfam_GSD_1.03021,433,575 - 21,556,459 (-)NCBI
Nedd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864099,406,714 - 99,526,684 (-)NCBI
SpeTri2.0NW_00493647117,254,777 - 17,374,725 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,941,937 - 116,070,317 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,941,945 - 116,069,884 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21128,545,541 - 128,557,317 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEDD4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12627,487,652 - 27,655,742 (+)NCBI
ChlSab1.1 Ensembl2627,487,796 - 27,655,992 (+)Ensembl
Vero_WHO_p1.0NW_023666048113,632,934 - 113,801,674 (-)NCBI
Nedd4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247315,855,678 - 5,954,119 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000020678   ⟹   ENSCLAP00000020480
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955409183,545 - 281,318 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000020679   ⟹   ENSCLAP00000020481
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955409183,545 - 281,318 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000020680   ⟹   ENSCLAP00000020482
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955409187,400 - 278,356 (+)Ensembl
RefSeq Acc Id: XM_005376602   ⟹   XP_005376659
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955409212,467 - 281,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005376604   ⟹   XP_005376661
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955409183,645 - 281,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005376605   ⟹   XP_005376662
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955409183,645 - 281,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005376606   ⟹   XP_005376663
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955409249,011 - 281,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013510263   ⟹   XP_013365717
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955409212,466 - 281,252 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005376661   ⟸   XM_005376604
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005376662   ⟸   XM_005376605
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005376659   ⟸   XM_005376602
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005376663   ⟸   XM_005376606
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_013365717   ⟸   XM_013510263
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000020482   ⟸   ENSCLAT00000020680
RefSeq Acc Id: ENSCLAP00000020480   ⟸   ENSCLAT00000020678
RefSeq Acc Id: ENSCLAP00000020481   ⟸   ENSCLAT00000020679


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014035 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000020480 ENTREZGENE
  ENSCLAP00000020481 ENTREZGENE
Ensembl Transcript ENSCLAT00000020678 ENTREZGENE
  ENSCLAT00000020679 ENTREZGENE
NCBI Gene Nedd4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-09 Nedd4  NEDD4 E3 ubiquitin protein ligase    neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase  Symbol and/or name change 5135510 APPROVED