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GENE - TERM ANNOTATION REPORT

RGD ID: 10967
Species: Mus musculus
RGD Object: Gene
Symbol: Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Acc ID: GO:0061630
Term: ubiquitin protein ligase activity
Definition: Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
Definition Source(s): GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAFB:FBgn0259174, MGI:MGI:1861728, MGI:MGI:1914144, MGI:MGI:1933754, MGI:MGI:97297, PANTHER:PTN000134256, PomBase:SPAC11G7.02, PomBase:SPAC1805.15c, UniProtKB:P46934, UniProtKB:Q96J02, UniProtKB:Q9HCE72290270GO_Central (PMID:21873635)

PMID:21873635
 IDA 2290270MGI (MGI:MGI:4835039, PMID:11717310), (MGI:MGI:892833, PMID:9182527)

MGI:MGI:4835039, MGI:MGI:892833, PMID:11717310, PMID:9182527
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