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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10967
Species: Mus musculus
RGD Object: Gene
Symbol: Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7366126480464CTDfulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein], SB 203580 inhibits the reaction [fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]]

PMID:29180066
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