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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3157
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nedd4
Name: NEDD4 E3 ubiquitin protein ligase
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nedd4affects response to substanceISONedd4 (Mus musculus)6480464CTD[NEDD4 protein affects the susceptibility to Oxygen deficiency] which affects the susceptibility to MelatoninPMID:31325559
Nedd4decreases expressionISONedd4 (Mus musculus)6480464CTDMelatonin results in decreased expression of NEDD4 proteinPMID:31325559
Nedd4multiple interactionsISONedd4 (Mus musculus)6480464CTDMelatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of NEDD4 protein]; Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein]; Melatonin promotes the reaction [Cycloheximide results in decreased expression of NEDD4 protein]; Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein]PMID:31325559
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