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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:3764
Term: clotrimazole
Definition: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
Chemical ID: MESH:D003022
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3increases expressionISOABCC3 (Homo sapiens)6480464CTDClotrimazole results in increased expression of ABCC3 mRNAPMID:27507784
Abcc3multiple interactionsISOABCC3 (Homo sapiens)6480464CTDMAPK14 promotes the reaction [Clotrimazole results in increased expression of ABCC3 mRNA]; SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ABCC3 mRNA]PMID:27507784
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