Adam22 (ADAM metallopeptidase domain 22)

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Gene: Adam22 (ADAM metallopeptidase domain 22) Rattus norvegicus

Analyze

Symbol:

Adam22

Name:

ADAM metallopeptidase domain 22

RGD ID:

1585016

Description:

Predicted to enable metalloendopeptidase activity. Involved in positive regulation of protein localization. Located in axon initial segment. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

a disintegrin and metalloprotease domain (ADAM) 22; a disintegrin and metalloprotease domain (ADAM) 22 (mapped); a disintegrin and metalloprotease domain 22; Adam22_mapped; disintegrin and metalloproteinase domain-containing protein 22; disintegrin and metalloproteinase domain-containing protein 22-like; LOC108350662; LOC683655; MDC2; similar to ADAM 22 precursor (A disintegrin and metalloproteinase domain 22)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADAM22 (ADAM metallopeptidase domain 22)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Adam22 (a disintegrin and metallopeptidase domain 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adam22 (ADAM metallopeptidase domain 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADAM22 (ADAM metallopeptidase domain 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADAM22 (ADAM metallopeptidase domain 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adam22 (ADAM metallopeptidase domain 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADAM22 (ADAM metallopeptidase domain 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADAM22 (ADAM metallopeptidase domain 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adam22 (ADAM metallopeptidase domain 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ADAM22 (ADAM metallopeptidase domain 22)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Adam22 (a disintegrin and metallopeptidase domain 22)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	adam22 (ADAM metallopeptidase domain 22)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	mmd	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	unc-71	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	adam22	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	25,716,055 - 25,970,932 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	25,715,990 - 25,964,962 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	4	22,864,485 - 23,002,969 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	22,859,622 - 22,996,645 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	22,873,544 - 22,935,588 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	4	22,632,816 - 22,827,454 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	22,332,086 - 22,507,086 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	21,356,458 - 21,453,378 (+)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 61 (ISO)

epilepsy (ISO)

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

clofibrate (EXP)

clotrimazole (EXP)

crocidolite asbestos (ISO)

diazinon (ISO)

dioxygen (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

fenofibrate (EXP)

fenvalerate (EXP)

gentamycin (EXP)

isoprenaline (ISO)

maneb (ISO)

methapyrilene (ISO)

methimazole (EXP)

methotrexate (ISO)

methylmercury chloride (ISO)

methylseleninic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel atom (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (ISO)

paraquat (ISO)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenylmercury acetate (ISO)

pirinixic acid (EXP)

pyridaben (ISO)

raloxifene (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tremolite asbestos (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult locomotory behavior (ISO)

gliogenesis (ISO)

myelination in peripheral nervous system (ISO)

neurotransmitter receptor localization to postsynaptic specialization membrane (ISO)

positive regulation of protein localization (IMP)

proteolysis (IBA)

Schwann cell differentiation (ISO)

Cellular Component

axon (ISO)

axon initial segment (IDA)

glutamatergic synapse (ISO)

membrane (ISO)

plasma membrane (ISO)

postsynaptic density membrane (ISO)

Molecular Function

metalloendopeptidase activity (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Normalization and subtraction: two approaches to facilitate gene discovery.	Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment.	Hivert B, etal., J Cell Sci. 2019 Jan 16;132(2). pii: jcs.219774. doi: 10.1242/jcs.219774.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries.	Poindexter K, etal., Gene 1999 Sep 3;237(1):61-70.
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15876356	PMID:16990550	PMID:20089912	PMID:20133599	PMID:20220021	PMID:21068328	PMID:21700703	PMID:23525710	PMID:27066583	PMID:29358191

Genomics

Comparative Map Data

Adam22
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	25,716,055 - 25,970,932 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	25,715,990 - 25,964,962 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	4	22,864,485 - 23,002,969 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	22,859,622 - 22,996,645 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	22,873,544 - 22,935,588 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	4	22,632,816 - 22,827,454 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	22,332,086 - 22,507,086 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	21,356,458 - 21,453,378 (+)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI

ADAM22
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	87,934,251 - 88,202,889 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	87,934,143 - 88,202,889 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	87,563,566 - 87,832,204 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	87,401,638 - 87,664,390 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	87,208,352 - 87,471,098	NCBI
Celera	7	82,268,261 - 82,531,056 (+)	NCBI		Celera
Cytogenetic Map	7	q21.12	NCBI
HuRef	7	82,173,445 - 82,442,057 (+)	NCBI		HuRef
CHM1_1	7	87,493,737 - 87,762,729 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	89,184,170 - 89,453,378 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	86,894,883 - 87,163,561 (+)	NCBI

Adam22
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	8,122,353 - 8,418,312 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	8,122,352 - 8,418,160 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	8,072,347 - 8,368,312 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	8,072,352 - 8,368,160 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	8,072,352 - 8,368,081 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	8,098,266 - 8,374,087 (-)	NCBI		MGSCv36	mm8
Celera	5	8,005,837 - 8,298,614 (-)	NCBI		Celera
Cytogenetic Map	5	A1	NCBI
cM Map	5	3.39	NCBI

Adam22
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	5,305,611 - 5,536,282 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	5,306,018 - 5,536,282 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADAM22
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	7	154,080,277 - 154,349,357 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	79,930,613 - 80,197,498 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	93,578,988 - 93,846,903 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	93,579,306 - 93,840,484 (+)	Ensembl	panpan1.1		panPan2

ADAM22
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	14,032,434 - 14,256,835 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	14,032,475 - 14,250,554 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	13,603,791 - 13,828,940 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	13,797,440 - 14,021,747 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	13,797,158 - 14,021,623 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	14,001,060 - 14,231,713 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	13,726,826 - 13,951,335 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	14,012,429 - 14,236,782 (+)	NCBI		UU_Cfam_GSD_1.0

Adam22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	27,048,939 - 27,263,377 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936763	739,629 - 952,435 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936763	738,051 - 952,435 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAM22
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	68,253,065 - 68,487,619 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	68,253,023 - 68,490,327 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	74,687,666 - 74,925,672 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAM22
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	60,753,344 - 60,999,283 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	60,759,980 - 60,998,600 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	43,076,021 - 43,348,892 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adam22
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624809	5,197,147 - 5,448,283 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624809	5,190,974 - 5,448,317 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Adam22
1296 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	477
Count of miRNA genes:	86
Interacting mature miRNAs:	91
Transcripts:	ENSRNOT00000068410, ENSRNOT00000070872, ENSRNOT00000071635, ENSRNOT00000071921, ENSRNOT00000072068, ENSRNOT00000073044, ENSRNOT00000073501, ENSRNOT00000073723, ENSRNOT00000074832, ENSRNOT00000074918
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	27716890	Rat
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	27716890	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	27716890	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	1	29494328	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	30372989	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	31934116	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	31934116	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	31934116	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	31934116	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	32584199	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	33250345	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	33250345	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	39505420	Rat
634323	Hc2	Hypercalciuria QTL 2	2.15		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	4	210796	45210796	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	57114705	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
1358201	Gluco12	Glucose level QTL12	1.6		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake (CMO:0000870)	4	5218392	29593287	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5219178	56647776	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	9940885	44463908	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10024901	39524530	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	10084089	55084089	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	10084089	55084089	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	10084089	55084089	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	10084089	55084089	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	10084089	55084089	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	10084089	55084089	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	14678065	59678065	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	17933508	62933508	Rat
70222	Eae2	Experimental allergic encephalomyelitis QTL 2	4.3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	4	21333343	39505420	Rat
1354665	Stl10	Serum triglyceride level QTL 10	3.57		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	21333343	44463908	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	21333343	62278020	Rat
8552803	Bw144	Body weight QTL 144	16		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	22710685	34430484	Rat

Markers in Region

D4Got302

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	25,727,841 - 25,728,107 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	22,931,319 - 22,931,584	NCBI	Rnor6.0
Rnor_6.0	4	22,712,288 - 22,712,533	NCBI	Rnor6.0
Rnor_5.0	4	22,644,273 - 22,644,518	UniSTS	Rnor5.0
Rnor_5.0	4	22,866,183 - 22,866,448	UniSTS	Rnor5.0
RGSC_v3.4	4	22,495,335 - 22,495,600	UniSTS	RGSC3.4
Celera	4	21,213,806 - 21,214,071	UniSTS
Cytogenetic Map	4		RGD

RH142562

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	25,839,092 - 25,839,324 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	22,826,418 - 22,826,649	NCBI	Rnor6.0
Rnor_5.0	4	22,759,764 - 22,759,995	UniSTS	Rnor5.0
RGSC_v3.4	4	22,388,493 - 22,388,724	UniSTS	RGSC3.4
Celera	4	21,323,301 - 21,323,532	UniSTS
RH 3.4 Map	4	156.0	UniSTS

RH137701

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	25,948,216 - 25,948,430 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	22,979,966 - 22,980,179	NCBI	Rnor6.0
Rnor_5.0	4	22,912,585 - 22,912,798	UniSTS	Rnor5.0
Celera	4	21,430,668 - 21,430,881	UniSTS
RH 3.4 Map	4	156.0	UniSTS

RH137892

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	25,737,633 - 25,737,858 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	22,721,516 - 22,721,740	NCBI	Rnor6.0
Rnor_5.0	4	22,653,501 - 22,653,725	UniSTS	Rnor5.0
RGSC_v3.4	4	22,485,585 - 22,485,809	UniSTS	RGSC3.4
Celera	4	21,223,600 - 21,223,824	UniSTS
RH 3.4 Map	4	169.4	UniSTS

Adam22

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	25,897,112 - 25,897,445 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	22,889,134 - 22,889,466	NCBI	Rnor6.0
Rnor_5.0	4	22,824,848 - 22,825,180	UniSTS	Rnor5.0
Celera	4	21,381,100 - 21,381,432	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									60	5	1
Low		24	23	8	10	8	8	10	14	30	38	11	8
Below cutoff	3	18	19	18	9	18		1			2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_017592940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602738	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602739	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108567	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001837516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001843290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005503424	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AI029994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000068410 ⟹ ENSRNOP00000059289

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	25,716,044 - 25,964,962 (+)	Ensembl
Rnor_6.0 Ensembl	4	22,859,622 - 22,996,645 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000073501 ⟹ ENSRNOP00000064723

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	25,864,422 - 25,961,471 (+)	Ensembl
Rnor_6.0 Ensembl	4	22,859,622 - 22,996,645 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094468 ⟹ ENSRNOP00000093947

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	25,716,044 - 25,964,962 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099765 ⟹ ENSRNOP00000077847

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	25,716,122 - 25,964,962 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101856 ⟹ ENSRNOP00000094391

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	25,716,044 - 25,951,817 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108037 ⟹ ENSRNOP00000081703

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	25,716,044 - 25,964,962 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111685 ⟹ ENSRNOP00000094323

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	25,715,990 - 25,964,962 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114747 ⟹ ENSRNOP00000085571

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	25,715,990 - 25,964,962 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000115124 ⟹ ENSRNOP00000081419

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	25,715,990 - 25,964,962 (+)	Ensembl

RefSeq Acc Id:

XM_039108561 ⟹ XP_038964489

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,056 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108562 ⟹ XP_038964490

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,055 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108563 ⟹ XP_038964491

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,056 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108564 ⟹ XP_038964492

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,056 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108565 ⟹ XP_038964493

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,056 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108566 ⟹ XP_038964494

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,056 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108567 ⟹ XP_038964495

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,057 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108568 ⟹ XP_038964496

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,058 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108569 ⟹ XP_038964497

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,057 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108570 ⟹ XP_038964498

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,059 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108571 ⟹ XP_038964499

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,058 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108572 ⟹ XP_038964500

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,059 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108573 ⟹ XP_038964501

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,058 - 25,970,932 (+)	NCBI

RefSeq Acc Id:

XM_039108574 ⟹ XP_038964502

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,058 - 25,951,265 (+)	NCBI

RefSeq Acc Id:

XR_005503424

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	25,716,057 - 25,961,372 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038964489	(Get FASTA)	NCBI Sequence Viewer
	XP_038964490	(Get FASTA)	NCBI Sequence Viewer
	XP_038964491	(Get FASTA)	NCBI Sequence Viewer
	XP_038964492	(Get FASTA)	NCBI Sequence Viewer
	XP_038964493	(Get FASTA)	NCBI Sequence Viewer
	XP_038964494	(Get FASTA)	NCBI Sequence Viewer
	XP_038964495	(Get FASTA)	NCBI Sequence Viewer
	XP_038964496	(Get FASTA)	NCBI Sequence Viewer
	XP_038964497	(Get FASTA)	NCBI Sequence Viewer
	XP_038964498	(Get FASTA)	NCBI Sequence Viewer
	XP_038964499	(Get FASTA)	NCBI Sequence Viewer
	XP_038964500	(Get FASTA)	NCBI Sequence Viewer
	XP_038964501	(Get FASTA)	NCBI Sequence Viewer
	XP_038964502	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000064723 ⟸ ENSRNOT00000073501

RefSeq Acc Id:

ENSRNOP00000059289 ⟸ ENSRNOT00000068410

RefSeq Acc Id:	XP_038964490 ⟸ XM_039108562
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6G7Y5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964489 ⟸ XM_039108561
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6G7Y5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964492 ⟸ XM_039108564
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5Y6E8 (UniProtKB/TrEMBL), A0A8I6G7Y5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964491 ⟸ XM_039108563
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6G7Y5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964493 ⟸ XM_039108565
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I6G7Y5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964494 ⟸ XM_039108566
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I6G7Y5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964495 ⟸ XM_039108567
- Peptide Label:	isoform X7
- UniProtKB:	A0A8I6GKI4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964497 ⟸ XM_039108569
- Peptide Label:	isoform X9
- UniProtKB:	A0A8I6GKI4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964496 ⟸ XM_039108568
- Peptide Label:	isoform X8
- UniProtKB:	A0A8I6AMW2 (UniProtKB/TrEMBL), A0A8I6G7Y5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964499 ⟸ XM_039108571
- Peptide Label:	isoform X11
- UniProtKB:	F1M542 (UniProtKB/TrEMBL), A0A8I6GKI4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964501 ⟸ XM_039108573
- Peptide Label:	isoform X13
- UniProtKB:	A0A8I6GKI4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964502 ⟸ XM_039108574
- Peptide Label:	isoform X14
- UniProtKB:	A0A8I6ARH6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964498 ⟸ XM_039108570
- Peptide Label:	isoform X10
- UniProtKB:	A0A8I6G7Y5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964500 ⟸ XM_039108572
- Peptide Label:	isoform X12
- UniProtKB:	A0A8I6GKI4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000081419 ⟸ ENSRNOT00000115124

RefSeq Acc Id:

ENSRNOP00000094391 ⟸ ENSRNOT00000101856

RefSeq Acc Id:

ENSRNOP00000077847 ⟸ ENSRNOT00000099765

RefSeq Acc Id:

ENSRNOP00000094323 ⟸ ENSRNOT00000111685

RefSeq Acc Id:

ENSRNOP00000093947 ⟸ ENSRNOT00000094468

RefSeq Acc Id:

ENSRNOP00000081703 ⟸ ENSRNOT00000108037

RefSeq Acc Id:

ENSRNOP00000085571 ⟸ ENSRNOT00000114747

Protein Domains

Disintegrin EGF-like Peptidase M12B

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0R5P8-F1-model_v2	AlphaFold	M0R5P8	1-775	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1585016	AgrOrtholog
BioCyc Gene	G2FUF-45821	BioCyc
Ensembl Genes	ENSRNOG00000042478	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000059289	ENTREZGENE
	ENSRNOP00000059289.4	UniProtKB/TrEMBL
	ENSRNOP00000064723.3	UniProtKB/TrEMBL
	ENSRNOP00000077847	ENTREZGENE
	ENSRNOP00000077847.1	UniProtKB/TrEMBL
	ENSRNOP00000081419.1	UniProtKB/TrEMBL
	ENSRNOP00000081703.1	UniProtKB/TrEMBL
	ENSRNOP00000085571.1	UniProtKB/TrEMBL
	ENSRNOP00000093947.1	UniProtKB/TrEMBL
	ENSRNOP00000094323	ENTREZGENE
	ENSRNOP00000094323.1	UniProtKB/TrEMBL
	ENSRNOP00000094391	ENTREZGENE
	ENSRNOP00000094391.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000068410	ENTREZGENE
	ENSRNOT00000068410.5	UniProtKB/TrEMBL
	ENSRNOT00000073501.4	UniProtKB/TrEMBL
	ENSRNOT00000094468.1	UniProtKB/TrEMBL
	ENSRNOT00000099765	ENTREZGENE
	ENSRNOT00000099765.1	UniProtKB/TrEMBL
	ENSRNOT00000101856	ENTREZGENE
	ENSRNOT00000101856.1	UniProtKB/TrEMBL
	ENSRNOT00000108037.1	UniProtKB/TrEMBL
	ENSRNOT00000111685	ENTREZGENE
	ENSRNOT00000111685.1	UniProtKB/TrEMBL
	ENSRNOT00000114747.1	UniProtKB/TrEMBL
	ENSRNOT00000115124.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.390.10	UniProtKB/TrEMBL
	4.10.70.10	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	ADAM_Cys-rich	UniProtKB/TrEMBL
	Blood-coag_inhib_Disintegrin	UniProtKB/TrEMBL
	Disintegrin_CS	UniProtKB/TrEMBL
	Disintegrin_dom_sf	UniProtKB/TrEMBL
	EG-like_dom	UniProtKB/TrEMBL
	EGF_extracell	UniProtKB/TrEMBL
	MetalloPept_cat_dom	UniProtKB/TrEMBL
	Peptidase_M12B	UniProtKB/TrEMBL
	Peptidase_M12B_N	UniProtKB/TrEMBL
	Reprolysin_adamalysin	UniProtKB/TrEMBL
NCBI Gene	57033	ENTREZGENE
PANTHER	ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN	UniProtKB/TrEMBL
	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 22	UniProtKB/TrEMBL
Pfam	ADAM_CR	UniProtKB/TrEMBL
	Disintegrin	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	Pep_M12B_propep	UniProtKB/TrEMBL
	Reprolysin	UniProtKB/TrEMBL
PhenoGen	Adam22	PhenoGen
PRINTS	DISINTEGRIN	UniProtKB/TrEMBL
PROSITE	ADAM_MEPRO	UniProtKB/TrEMBL
	DISINTEGRIN_1	UniProtKB/TrEMBL
	DISINTEGRIN_2	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
SMART	ACR	UniProtKB/TrEMBL
	DISIN	UniProtKB/TrEMBL
Superfamily-SCOP	Disintegrin	UniProtKB/TrEMBL
	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
UniProt	A0A8I5Y6E8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A0F9_RAT	UniProtKB/TrEMBL
	A0A8I6AMW2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ARH6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G6D0_RAT	UniProtKB/TrEMBL
	A0A8I6G7Y5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GKI4	ENTREZGENE, UniProtKB/TrEMBL
	F1M542	ENTREZGENE, UniProtKB/TrEMBL
	M0R5P8_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Adam22	ADAM metallopeptidase domain 22	LOC108350662	disintegrin and metalloproteinase domain-containing protein 22-like	Data Merged	737654	PROVISIONAL
2016-08-02	LOC108350662	disintegrin and metalloproteinase domain-containing protein 22-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2013-04-17	Adam22	ADAM metallopeptidase domain 22	LOC683655	similar to ADAM 22 precursor (A disintegrin and metalloproteinase domain 22)	Data Merged	737654	PROVISIONAL
2012-07-13	Adam22	ADAM metallopeptidase domain 22	Adam22	a disintegrin and metalloprotease domain (ADAM) 22	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-04-10	Adam22	a disintegrin and metalloprotease domain (ADAM) 22	Adam22_mapped	a disintegrin and metalloprotease domain (ADAM) 22 (mapped)	Data Merged	737654	APPROVED
2006-11-19	Adam22_mapped	a disintegrin and metalloprotease domain (ADAM) 22(mapped)	Adam22	a disintegrin and metalloprotease domain (ADAM) 22	Symbol set to symbol_mapped, name set to name (mapped)	1582166	APPROVED
2006-11-19	Adam22	a disintegrin and metalloprotease domain (ADAM) 22			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC683655	similar to ADAM 22 precursor (A disintegrin and metalloproteinase domain 22)			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-08-07	Adam22	a disintegrin and metalloprotease domain (ADAM) 22			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM