Mark3 (microtubule affinity regulating kinase 3) - Rat Genome Database

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Gene: Mark3 (microtubule affinity regulating kinase 3) Rattus norvegicus
Analyze
Symbol: Mark3
Name: microtubule affinity regulating kinase 3
RGD ID: 619883
Description: Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; peptidyl-serine autophosphorylation; and positive regulation of protein binding activity. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MAP/microtubule affinity-regulating kinase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26130,626,612 - 130,716,245 (+)NCBI
Rnor_6.0 Ensembl6136,041,777 - 136,129,661 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06136,040,957 - 136,129,780 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06144,286,952 - 144,375,010 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,348,832 - 136,438,667 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16136,355,018 - 136,444,854 (+)NCBI
Celera6128,183,127 - 128,271,232 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
dendrite  (IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

Additional References at PubMed
PMID:16980613   PMID:18570454   PMID:21145462   PMID:23666762   PMID:25931508   PMID:28087714  


Genomics

Comparative Map Data
Mark3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26130,626,612 - 130,716,245 (+)NCBI
Rnor_6.0 Ensembl6136,041,777 - 136,129,661 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06136,040,957 - 136,129,780 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06144,286,952 - 144,375,010 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,348,832 - 136,438,667 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16136,355,018 - 136,444,854 (+)NCBI
Celera6128,183,127 - 128,271,232 (+)NCBICelera
Cytogenetic Map6q32NCBI
MARK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14103,385,377 - 103,503,831 (+)EnsemblGRCh38hg38GRCh38
GRCh3814103,385,394 - 103,503,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714103,851,752 - 103,970,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614102,921,524 - 103,039,921 (+)NCBINCBI36hg18NCBI36
Build 3414102,921,523 - 103,039,917NCBI
Celera1483,905,890 - 84,024,379 (+)NCBI
Cytogenetic Map14q32.32-q32.33NCBI
HuRef1484,029,889 - 84,148,541 (+)NCBIHuRef
CHM1_114103,789,889 - 103,908,361 (+)NCBICHM1_1
Mark3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,540,929 - 111,622,661 (+)NCBIGRCm39mm39
GRCm39 Ensembl12111,540,957 - 111,622,655 (+)Ensembl
GRCm3812111,574,505 - 111,656,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,574,523 - 111,656,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712112,812,721 - 112,894,438 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612112,022,777 - 112,104,031 (+)NCBImm8
Celera12112,768,826 - 112,852,637 (+)NCBICelera
Cytogenetic Map12F1NCBI
Mark3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555382,273,221 - 2,371,154 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555382,273,221 - 2,370,204 (+)NCBIChiLan1.0ChiLan1.0
MARK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.114103,823,900 - 103,941,529 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14103,823,900 - 103,941,529 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01484,012,076 - 84,130,136 (+)NCBIMhudiblu_PPA_v0panPan3
MARK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,148,263 - 71,269,717 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl871,102,690 - 71,270,399 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,659,869 - 70,780,993 (+)NCBI
ROS_Cfam_1.0871,424,060 - 71,545,499 (+)NCBI
UMICH_Zoey_3.1871,113,816 - 71,234,630 (+)NCBI
UNSW_CanFamBas_1.0871,153,195 - 71,274,345 (+)NCBI
UU_Cfam_GSD_1.0871,552,492 - 71,673,590 (+)NCBI
Mark3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086402,798,889 - 2,904,084 (-)NCBI
SpeTri2.0NW_0049366211,627,846 - 1,733,041 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARK3
(Sus scrofa - pig)
No map positions available.
MARK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12481,364,316 - 81,452,115 (+)NCBI
ChlSab1.1 Ensembl2481,364,361 - 81,455,070 (+)Ensembl
Vero_WHO_p1.0NW_02366605368,632,588 - 68,747,799 (+)NCBI
Mark3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247341,362,263 - 1,469,930 (-)NCBI

Position Markers
BE120426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,706,394 - 130,706,552 (+)MAPPER
Rnor_6.06136,119,992 - 136,120,149NCBIRnor6.0
Rnor_5.06144,296,583 - 144,296,740UniSTSRnor5.0
RGSC_v3.46136,429,586 - 136,429,743UniSTSRGSC3.4
Celera6128,261,857 - 128,262,014UniSTS
RH 3.4 Map6780.11UniSTS
Cytogenetic Map6q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)675623277136143011Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)675623277136426962Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)675623393136142742Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)675623393136142742Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)688996335139410483Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)691703409136703409Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)692879510137879510Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)699273921144273921Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)699273921144792678Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)6101207574147991367Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6104363890147991367Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6104381930138066274Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6111134524138065254Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6117355600147991367Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6127286494144745573Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6127286494147249902Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6127286494147991367Rat
2312560Pur20Proteinuria QTL 202.10.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6130561943144745573Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6132652096138068606Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000014395
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_130749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF465412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000014395   ⟹   ENSRNOP00000014395
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6136,041,777 - 136,129,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080304   ⟹   ENSRNOP00000068972
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6136,050,422 - 136,129,661 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088784   ⟹   ENSRNOP00000073297
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6136,042,059 - 136,129,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092806   ⟹   ENSRNOP00000075961
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6136,084,605 - 136,129,631 (+)Ensembl
RefSeq Acc Id: NM_130749   ⟹   NP_570105
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,627,482 - 130,715,874 (+)NCBI
Rnor_6.06136,042,059 - 136,129,409 (+)NCBI
Rnor_5.06144,286,952 - 144,375,010 (-)NCBI
RGSC_v3.46136,348,832 - 136,438,667 (+)RGD
Celera6128,183,127 - 128,271,232 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240563   ⟹   XP_006240625
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,627,035 - 130,716,245 (+)NCBI
Rnor_6.06136,041,926 - 136,129,780 (+)NCBI
Rnor_5.06144,286,952 - 144,375,010 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594008   ⟹   XP_017449497
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,627,031 - 130,716,245 (+)NCBI
Rnor_6.06136,040,957 - 136,129,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594009   ⟹   XP_017449498
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,627,031 - 130,716,245 (+)NCBI
Rnor_6.06136,040,957 - 136,129,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594010   ⟹   XP_017449499
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,627,030 - 130,716,245 (+)NCBI
Rnor_6.06136,040,957 - 136,129,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594011   ⟹   XP_017449500
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,627,031 - 130,716,245 (+)NCBI
Rnor_6.06136,040,957 - 136,129,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594016   ⟹   XP_017449505
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,627,030 - 130,716,245 (+)NCBI
Rnor_6.06136,040,957 - 136,129,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111713   ⟹   XP_038967641
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,645,098 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111714   ⟹   XP_038967642
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,645,098 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111715   ⟹   XP_038967643
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,645,098 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111716   ⟹   XP_038967644
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,645,098 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111717   ⟹   XP_038967645
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,645,098 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111718   ⟹   XP_038967646
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,634,574 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111719   ⟹   XP_038967647
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,645,098 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111720   ⟹   XP_038967648
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,645,098 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111721   ⟹   XP_038967649
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,627,035 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111722   ⟹   XP_038967650
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,626,612 - 130,688,688 (+)NCBI
RefSeq Acc Id: XM_039111723   ⟹   XP_038967651
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,626,612 - 130,688,688 (+)NCBI
RefSeq Acc Id: XM_039111724   ⟹   XP_038967652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,671,150 - 130,716,245 (+)NCBI
RefSeq Acc Id: XM_039111725   ⟹   XP_038967653
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,671,150 - 130,716,245 (+)NCBI
Protein Sequences
Protein RefSeqs NP_570105 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240625 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449497 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449498 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449499 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449500 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449505 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967641 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967642 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967643 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967644 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967645 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967646 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967647 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967648 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967649 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967650 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967651 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967652 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967653 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL69981 (Get FASTA)   NCBI Sequence Viewer  
  EDL97458 (Get FASTA)   NCBI Sequence Viewer  
  EDL97459 (Get FASTA)   NCBI Sequence Viewer  
  EDL97460 (Get FASTA)   NCBI Sequence Viewer  
  EDL97461 (Get FASTA)   NCBI Sequence Viewer  
  EDL97462 (Get FASTA)   NCBI Sequence Viewer  
  Q8VHF0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_570105   ⟸   NM_130749
- UniProtKB: Q8VHF0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240625   ⟸   XM_006240563
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_017449497   ⟸   XM_017594008
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017449498   ⟸   XM_017594009
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449500   ⟸   XM_017594011
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017449499   ⟸   XM_017594010
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017449505   ⟸   XM_017594016
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: ENSRNOP00000068972   ⟸   ENSRNOT00000080304
RefSeq Acc Id: ENSRNOP00000075961   ⟸   ENSRNOT00000092806
RefSeq Acc Id: ENSRNOP00000014395   ⟸   ENSRNOT00000014395
RefSeq Acc Id: ENSRNOP00000073297   ⟸   ENSRNOT00000088784
RefSeq Acc Id: XP_038967650   ⟸   XM_039111722
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038967651   ⟸   XM_039111723
- Peptide Label: isoform X17
RefSeq Acc Id: XP_038967649   ⟸   XM_039111721
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038967646   ⟸   XM_039111718
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038967641   ⟸   XM_039111713
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038967642   ⟸   XM_039111714
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038967644   ⟸   XM_039111716
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038967643   ⟸   XM_039111715
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038967645   ⟸   XM_039111717
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038967647   ⟸   XM_039111719
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038967648   ⟸   XM_039111720
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038967652   ⟸   XM_039111724
- Peptide Label: isoform X18
RefSeq Acc Id: XP_038967653   ⟸   XM_039111725
- Peptide Label: isoform X19
Protein Domains
KA1   Protein kinase   UBA

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619883 AgrOrtholog
Ensembl Genes ENSRNOG00000010330 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014395 UniProtKB/TrEMBL
  ENSRNOP00000068972 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000073297 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000075961 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014395 UniProtKB/TrEMBL
  ENSRNOT00000080304 UniProtKB/TrEMBL
  ENSRNOT00000088784 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000092806 UniProtKB/TrEMBL
InterPro KA1/Ssp2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KA1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MARK3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170577 UniProtKB/Swiss-Prot
NCBI Gene 170577 ENTREZGENE
PANTHER PTHR24346:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mark3 PhenoGen
PROSITE KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JU56_RAT UniProtKB/TrEMBL
  A0A1B0GWN5_RAT UniProtKB/TrEMBL
  F1M836_RAT UniProtKB/TrEMBL
  MARK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Mark3  microtubule affinity regulating kinase 3  Mark3  MAP/microtubule affinity-regulating kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Mark3  MAP/microtubule affinity-regulating kinase 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mark3  MAP/microtubule affinity-regulating kinase 3      Symbol and Name status set to provisional 70820 PROVISIONAL