Crisp1 (cysteine-rich secretory protein 1) - Rat Genome Database

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Gene: Crisp1 (cysteine-rich secretory protein 1) Rattus norvegicus
Analyze
Symbol: Crisp1
Name: cysteine-rich secretory protein 1
RGD ID: 1590757
Description: Predicted to enable calcium channel regulator activity. Predicted to be involved in binding activity of sperm to zona pellucida. Predicted to act upstream of or within regulation of acrosome reaction. Predicted to be active in extracellular space. Orthologous to human CRISP1 (cysteine rich secretory protein 1); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Crisp4; cysteine-rich secretory protein 4
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8928,238,326 - 28,265,344 (-)NCBIGRCr8
mRatBN7.2920,741,775 - 20,768,796 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl920,741,777 - 20,768,796 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx929,272,264 - 29,299,315 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0934,375,604 - 34,415,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0932,686,420 - 32,726,441 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0924,356,577 - 24,383,679 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl924,356,579 - 24,383,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0923,218,716 - 23,245,318 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4916,975,151 - 17,002,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera918,378,604 - 18,405,902 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16467491   PMID:21482758   PMID:21630459   PMID:21865554  


Genomics

Comparative Map Data
Crisp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8928,238,326 - 28,265,344 (-)NCBIGRCr8
mRatBN7.2920,741,775 - 20,768,796 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl920,741,777 - 20,768,796 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx929,272,264 - 29,299,315 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0934,375,604 - 34,415,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0932,686,420 - 32,726,441 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0924,356,577 - 24,383,679 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl924,356,579 - 24,383,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0923,218,716 - 23,245,318 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4916,975,151 - 17,002,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera918,378,604 - 18,405,902 (-)NCBICelera
Cytogenetic Map9q13NCBI
CRISP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38649,834,257 - 49,877,096 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl649,834,257 - 49,877,096 (-)EnsemblGRCh38hg38GRCh38
GRCh37649,801,970 - 49,844,809 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36649,909,929 - 49,942,177 (-)NCBINCBI36Build 36hg18NCBI36
Celera651,358,053 - 51,390,301 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef649,532,400 - 49,575,243 (-)NCBIHuRef
CHM1_1649,804,885 - 49,847,721 (-)NCBICHM1_1
T2T-CHM13v2.0649,676,220 - 49,719,057 (-)NCBIT2T-CHM13v2.0
Crisp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39118,185,113 - 18,216,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl118,185,415 - 18,216,126 (-)EnsemblGRCm39 Ensembl
GRCm38118,114,889 - 18,145,902 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl118,115,191 - 18,145,902 (-)EnsemblGRCm38mm10GRCm38
MGSCv37118,105,272 - 18,127,132 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36118,100,405 - 18,122,265 (-)NCBIMGSCv36mm8
Celera118,019,226 - 18,041,066 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.65NCBI
CRISP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2564,319,223 - 64,358,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1660,184,866 - 60,221,060 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0649,404,220 - 49,452,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1650,665,193 - 50,712,092 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl650,665,204 - 50,712,092 (-)Ensemblpanpan1.1panPan2
CRISP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11217,659,446 - 17,696,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1217,555,565 - 17,595,087 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01218,153,788 - 18,193,483 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.01217,779,242 - 17,812,493 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01217,909,484 - 17,942,885 (-)NCBIUU_Cfam_GSD_1.0
Crisp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494653,207,268 - 53,230,604 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647610,729,610 - 10,752,933 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647610,729,598 - 10,753,000 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRISP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl743,883,539 - 43,911,664 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1743,883,536 - 43,911,877 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2750,275,809 - 50,303,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRISP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11722,539,467 - 22,581,428 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1722,551,309 - 22,579,116 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604449,798,950 - 49,845,592 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Crisp1
231 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:51
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000040542
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat

Markers in Region
D9Wox38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2920,454,551 - 20,454,691 (+)MAPPERmRatBN7.2
Rnor_6.0924,069,953 - 24,070,092NCBIRnor6.0
Rnor_5.0922,930,514 - 22,930,653UniSTSRnor5.0
RGSC_v3.4916,677,062 - 16,677,201UniSTSRGSC3.4
Celera918,102,515 - 18,102,654UniSTS
Cytogenetic Map9q12UniSTS
BI281439  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2920,471,932 - 20,472,043 (+)MAPPERmRatBN7.2
Rnor_6.0924,087,334 - 24,087,444NCBIRnor6.0
Rnor_5.0922,947,909 - 22,948,019UniSTSRnor5.0
RGSC_v3.4916,697,307 - 16,697,417UniSTSRGSC3.4
Celera918,114,644 - 18,114,754UniSTS
RH 3.4 Map9173.3UniSTS
Cytogenetic Map9q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system
High
Medium
Low 2
Below cutoff 4 7

Sequence


RefSeq Acc Id: ENSRNOT00000040542   ⟹   ENSRNOP00000048038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl920,741,777 - 20,768,796 (-)Ensembl
Rnor_6.0 Ensembl924,356,579 - 24,383,679 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119419   ⟹   ENSRNOP00000084611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl920,741,777 - 20,757,302 (-)Ensembl
RefSeq Acc Id: NM_001039393   ⟹   NP_001034482
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8928,238,326 - 28,265,344 (-)NCBI
mRatBN7.2920,741,775 - 20,768,796 (-)NCBI
Rnor_6.0924,356,577 - 24,383,679 (-)NCBI
Rnor_5.0923,218,716 - 23,245,318 (-)NCBI
RGSC_v3.4916,975,151 - 17,002,149 (-)RGD
Celera918,378,604 - 18,405,902 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001034482 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABB29311 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048038
  ENSRNOP00000048038.5
  ENSRNOP00000084611.1
RefSeq Acc Id: NP_001034482   ⟸   NM_001039393
- Peptide Label: precursor
- UniProtKB: Q2I7M7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000048038   ⟸   ENSRNOT00000040542
RefSeq Acc Id: ENSRNOP00000084611   ⟸   ENSRNOT00000119419
Protein Domains
ShKT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTT8-F1-model_v2 AlphaFold E9PTT8 1-254 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696571
Promoter ID:EPDNEW_R7094
Type:single initiation site
Name:Crisp1_1
Description:cysteine-rich secretory protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0924,383,580 - 24,383,640EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590757 AgrOrtholog
BioCyc Gene G2FUF-28060 BioCyc
Ensembl Genes ENSRNOG00000013612 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040542 ENTREZGENE
  ENSRNOT00000040542.5 UniProtKB/TrEMBL
  ENSRNOT00000119419.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.740 UniProtKB/TrEMBL
  3.40.33.10 UniProtKB/TrEMBL
InterPro Allrgn_V5/Tpx1 UniProtKB/TrEMBL
  CAP_domain UniProtKB/TrEMBL
  CAP_sf UniProtKB/TrEMBL
  Crisp-like_dom UniProtKB/TrEMBL
  Cysteine_rich_secretory UniProtKB/TrEMBL
  SCP_CRISP UniProtKB/TrEMBL
  ShKT_dom UniProtKB/TrEMBL
KEGG Report rno:654517 UniProtKB/TrEMBL
NCBI Gene 654517 ENTREZGENE
PANTHER Allrgn_V5/Tpx1 UniProtKB/TrEMBL
  CYSTEINE-RICH SECRETORY PROTEIN 1 UniProtKB/TrEMBL
Pfam Crisp UniProtKB/TrEMBL
  SCP UniProtKB/TrEMBL
PhenoGen Crisp1 PhenoGen
PRINTS V5TPXLIKE UniProtKB/TrEMBL
PROSITE SHKT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013612 RatGTEx
SMART SCP UniProtKB/TrEMBL
Superfamily-SCOP Crisp domain-like UniProtKB/TrEMBL
  SCP-like_extracellular UniProtKB/TrEMBL
UniProt A0A8I6A1P2_RAT UniProtKB/TrEMBL
  E9PTT8_RAT UniProtKB/TrEMBL
  Q2I7M7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-15 Crisp1  cysteine-rich secretory protein 1  Crisp4  cysteine-rich secretory protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 Crisp4  cysteine-rich secretory protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL