Senp8 (SUMO peptidase family member, NEDD8 specific)

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Gene: Senp8 (SUMO peptidase family member, NEDD8 specific) Rattus norvegicus

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Symbol:

Senp8

Name:

SUMO peptidase family member, NEDD8 specific

RGD ID:

1309955

Description:

Predicted to enable deNEDDylase activity. Predicted to be involved in protein deneddylation. Orthologous to human SENP8 (SUMO peptidase family member, NEDD8 specific); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

deneddylase-1; LOC315723; MGC109243; NEDD8-specific protease 1; sentrin-specific protease 8; sentrin/SUMO-specific protease SENP8; SUMO/sentrin peptidase family member, NEDD8 specific; SUMO/sentrin specific peptidase 8; SUMO/sentrin specific peptidase family member 8; SUMO/sentrin specific protease family member 8; Sumo1/sentrin/SMT3 specific peptidase 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	69,031,230 - 69,044,616 (-)	NCBI		GRCr8
mRatBN7.2	8	60,135,446 - 60,148,836 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	60,121,714 - 60,148,928 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	65,657,681 - 65,671,085 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	63,930,607 - 63,944,011 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	61,800,059 - 61,813,464 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	64,558,994 - 64,572,850 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	64,559,015 - 64,572,850 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	64,321,165 - 64,335,616 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	63,564,217 - 63,577,603 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	63,583,288 - 63,596,657 (-)	NCBI
Celera	8	59,578,328 - 59,591,716 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

Neurodevelopmental Disorders (ISO)

Tay-Sachs disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

6-propyl-2-thiouracil (EXP)

alpha-Zearalanol (EXP)

amitrole (EXP)

bisphenol A (EXP)

C60 fullerene (EXP)

CGP 52608 (ISO)

cisplatin (ISO)

clotrimazole (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cypermethrin (ISO)

decabromodiphenyl ether (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

fluoranthene (ISO)

formaldehyde (ISO)

gentamycin (EXP)

methimazole (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

potassium chloride (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulfadimethoxine (EXP)

Tesaglitazar (EXP)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein deneddylation (IBA)

proteolysis (IEA)

Molecular Function

cysteine-type peptidase activity (IEA)

deNEDDylase activity (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:36847487

Genomics

Comparative Map Data

Senp8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	69,031,230 - 69,044,616 (-)	NCBI		GRCr8
mRatBN7.2	8	60,135,446 - 60,148,836 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	60,121,714 - 60,148,928 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	65,657,681 - 65,671,085 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	63,930,607 - 63,944,011 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	61,800,059 - 61,813,464 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	64,558,994 - 64,572,850 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	64,559,015 - 64,572,850 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	64,321,165 - 64,335,616 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	63,564,217 - 63,577,603 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	63,583,288 - 63,596,657 (-)	NCBI
Celera	8	59,578,328 - 59,591,716 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

SENP8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	72,114,258 - 72,143,692 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	72,114,258 - 72,143,692 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	72,406,599 - 72,436,033 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	70,197,808 - 70,220,358 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	70,197,807 - 70,220,357	NCBI
Celera	15	49,292,931 - 49,319,646 (+)	NCBI		Celera
Cytogenetic Map	15	q23	NCBI
HuRef	15	49,236,929 - 49,263,850 (+)	NCBI		HuRef
CHM1_1	15	72,524,572 - 72,551,468 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	69,930,994 - 69,960,429 (+)	NCBI		T2T-CHM13v2.0

Senp8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	59,641,542 - 59,657,932 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	59,641,542 - 59,657,993 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	59,734,259 - 59,750,649 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	59,734,259 - 59,750,710 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	59,582,066 - 59,598,456 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	59,533,891 - 59,548,614 (-)	NCBI		MGSCv36	mm8
Celera	9	56,961,580 - 56,977,968 (-)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	32.11	NCBI

Senp8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	4,978,767 - 5,001,678 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	4,978,767 - 5,001,678 (-)	NCBI	ChiLan1.0	ChiLan1.0

SENP8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	61,383,614 - 61,406,709 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	65,547,834 - 65,578,310 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	51,069,863 - 51,092,561 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	69,833,803 - 69,856,280 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	69,854,934 - 69,855,572 (+)	Ensembl	panpan1.1		panPan2

SENP8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	35,649,636 - 35,663,873 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	35,662,155 - 35,662,793 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	35,585,858 - 35,600,915 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	35,852,869 - 35,868,212 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	35,853,010 - 35,868,209 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	35,805,986 - 35,821,702 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	35,834,395 - 35,849,508 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	36,088,402 - 36,104,350 (+)	NCBI		UU_Cfam_GSD_1.0

Senp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	113,668,430 - 113,689,910 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	31,517,000 - 31,536,201 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	31,516,486 - 31,539,214 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SENP8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	169,596,200 - 169,616,138 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	169,596,816 - 169,615,498 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SENP8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	11,318,094 - 11,338,876 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	11,318,800 - 11,319,438 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	130,235,173 - 130,256,687 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Senp8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624781	1,877,576 - 1,900,518 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Senp8
18 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	26
Count of miRNA genes:	26
Interacting mature miRNAs:	26
Transcripts:	ENSRNOT00000015415
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30856404	75856404	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	30848154	101699754	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	41866876	86866876	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	30848154	61290444	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	42692684	90165460	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	30848154	101699754	Rat
1582222	Epfw2	Epididymal fat weight QTL 2	3.2	0.0005	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	8	31737729	76737729	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	35582032	80582032	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	50095249	82460899	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	30848154	101699754	Rat
1300146	Rf17	Renal function QTL 17	2.9		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	8	28242912	73242912	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	28242912	99525068	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	30848154	82460899	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	27205715	99103503	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	29502665	70386295	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	30848154	61290444	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	22662330	67662330	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	40713066	82925667	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	30848154	61290444	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	41866876	75097878	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	35551938	80551938	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	40713066	93965294	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	27205715	99103503	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30848259	105647037	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	54237644	85365202	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	27205715	99103503	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	41867010	70386132	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	50095249	82460899	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	54237644	85365202	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	16290444	61290444	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	30848154	82460899	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	43296169	98968765	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	54259986	100382532	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	30188867	94457446	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	43296169	98968765	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	30848154	82460899	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	43296169	98968765	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	43296169	98968765	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	43296169	98968765	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	43296169	98968765	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	51351728	107062046	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	50095249	82460899	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	54043744	98968765	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	46531722	99083736	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	36469535	99083736	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
2303564	Gluco43	Glucose level QTL 43	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	26130187	71130187	Rat
2303570	Gluco48	Glucose level QTL 48	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	49805831	94805831	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	30848154	82460899	Rat
2303572	Insul13	Insulin level QTL 13	2		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	8	26130187	71130187	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	54237644	99103503	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC089939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015415 ⟹ ENSRNOP00000062239

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	60,131,596 - 60,136,381 (-)	Ensembl
Rnor_6.0 Ensembl	8	64,559,015 - 64,572,850 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095899 ⟹ ENSRNOP00000086291

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	60,126,482 - 60,148,928 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111287 ⟹ ENSRNOP00000086922

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	60,133,863 - 60,148,834 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117148 ⟹ ENSRNOP00000093886

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	60,131,554 - 60,136,559 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117798 ⟹ ENSRNOP00000076855

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	60,121,714 - 60,148,878 (-)	Ensembl

RefSeq Acc Id:

NM_001012355 ⟹ NP_001012355

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	69,031,230 - 69,044,616 (-)	NCBI
mRatBN7.2	8	60,135,446 - 60,148,836 (-)	NCBI
Rnor_6.0	8	64,558,994 - 64,572,850 (-)	NCBI
Rnor_5.0	8	64,321,165 - 64,335,616 (-)	NCBI
RGSC_v3.4	8	63,564,217 - 63,577,603 (-)	RGD
Celera	8	59,578,328 - 59,591,716 (-)	RGD

Sequence:

show sequence

TACCGAGATCCCTGAAGGCTGGTTGGGCTGGTGAGGCCTGAGGAATAGAAGTACTGCTGAGTGG
CCAGCTTCTGGAATTTCTGAGAAGCCCTGCTCAATACAAGATGGACCCTGTGGTCTTGAGTTAT
ATGGACAGTCTATTGCGACAATCAGATGTCTCACTATTGGACCCTCCAAACTGGCTCAACGACC
ACATTATTGGGTTTGCCTTTGAATACTTTGCCAGTAGTCAGTTTCATGATTGCTCAGACCATGT
CTGCTTCATCAGCCCTGAAGTCACCCAGTTCATTAAGTGCACCAGCAGCCCTGCAGAGATTGCC
ATGTTCCTTGAACCCCTGGATCTTCCCCACAAAAGAGTGGTATTTTTAGCCATCAATGATAATT
CTAACCAGGCAGCCGGAGGTACCCACTGGAGTTTGTTGGTTTATCTCCAAGATAAAAATAGCTT
CTTTCATTATGATTCCCATAGCAGGAGCAACTCAATCCATGCAAAACAGGTAGCAGAGAAACTG
AAGGCTTTCTTAGGGAGCAAAGGAGACAAACTGGTCTTTGTGGAAGAGAAAGCCCCAGCTCAAC
AGAACAGCTATGACTGTGGGATGTACGTGATATGTAACACCGAGGCCTTGTGTCAAAATCTCTT
TAGACGACAGCCAGAATCCCCACTGCAGCTCCTCACCCCGACATACATCACAAAGAAGAGGGGA
GAATGGAAAGATCTAATTGCCAGACTTGCTAAAAAAAACCGAAGTAGCTACTGAAGAATGCTTG
TGATGTTTGAAGTCTGGTCTTTCTGCCTTTCTCTATGGTGACAGCCTCAGTGCCTGAGGGAAAA
ACACTAGTAGATGAAAGTTTACTATTCCTGCTTCTTTATTGTTCTGAAAGAATGTCATCCTCTG
CGTTCTCTGAATGGGAAGTTTCACTGTAACCCTGAGGAGAGCAGTGCATTCTGTGAAAATGTCT
GGAACTTATGTACCAAAACCTTAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001012355	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89939	(Get FASTA)	NCBI Sequence Viewer
	EDL95710	(Get FASTA)	NCBI Sequence Viewer
	EDL95711	(Get FASTA)	NCBI Sequence Viewer
	EDL95712	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000062239.1
	ENSRNOP00000076855.1
	ENSRNOP00000086291.1
	ENSRNOP00000086922.1
	ENSRNOP00000093886.1
	ENSRNOP00055038901
	ENSRNOP00055038912
	ENSRNOP00055038918
	ENSRNOP00055038924
	ENSRNOP00060023308
	ENSRNOP00060023324
	ENSRNOP00060023341
	ENSRNOP00060023360
	ENSRNOP00060023364
	ENSRNOP00065008588
	ENSRNOP00065008592
	ENSRNOP00065008596
	ENSRNOP00065008600
GenBank Protein	Q5FVJ8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012355 ⟸ NM_001012355

- UniProtKB:

Q5FVJ8 (UniProtKB/Swiss-Prot), A6J539 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDPVVLSYMDSLLRQSDVSLLDPPNWLNDHIIGFAFEYFASSQFHDCSDHVCFISPEVTQFIKC
TSSPAEIAMFLEPLDLPHKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSIH
AKQVAEKLKAFLGSKGDKLVFVEEKAPAQQNSYDCGMYVICNTEALCQNLFRRQPESPLQLLTP
TYITKKRGEWKDLIARLAKKNRSSY

hide sequence

Ensembl Acc Id:

ENSRNOP00000062239 ⟸ ENSRNOT00000015415

Ensembl Acc Id:

ENSRNOP00000086291 ⟸ ENSRNOT00000095899

Ensembl Acc Id:

ENSRNOP00000076855 ⟸ ENSRNOT00000117798

Ensembl Acc Id:

ENSRNOP00000093886 ⟸ ENSRNOT00000117148

Ensembl Acc Id:

ENSRNOP00000086922 ⟸ ENSRNOT00000111287

Protein Domains

Ubiquitin-like protease family profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5FVJ8-F1-model_v2	AlphaFold	Q5FVJ8	1-217	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696043

Promoter ID:

EPDNEW_R6567

Type:

multiple initiation site

Name:

Senp8_1

Description:

SUMO/sentrin peptidase family member, NEDD8 specific

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	64,572,863 - 64,572,923	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309955	AgrOrtholog
BioCyc Gene	G2FUF-30230	BioCyc
Ensembl Genes	ENSRNOG00000011595	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055027353	UniProtKB/Swiss-Prot
	ENSRNOG00060016940	UniProtKB/Swiss-Prot
	ENSRNOG00065007511	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000015415.8	UniProtKB/Swiss-Prot
	ENSRNOT00000095899.1	UniProtKB/Swiss-Prot
	ENSRNOT00000111287.1	UniProtKB/Swiss-Prot
	ENSRNOT00000117148.1	UniProtKB/Swiss-Prot
	ENSRNOT00000117798.1	UniProtKB/Swiss-Prot
	ENSRNOT00055047322	UniProtKB/Swiss-Prot
	ENSRNOT00055047332	UniProtKB/Swiss-Prot
	ENSRNOT00055047337	UniProtKB/Swiss-Prot
	ENSRNOT00055047345	UniProtKB/Swiss-Prot
	ENSRNOT00060028952	UniProtKB/Swiss-Prot
	ENSRNOT00060028969	UniProtKB/Swiss-Prot
	ENSRNOT00060028988	UniProtKB/Swiss-Prot
	ENSRNOT00060029010	UniProtKB/Swiss-Prot
	ENSRNOT00060029016	UniProtKB/Swiss-Prot
	ENSRNOT00065011745	UniProtKB/Swiss-Prot
	ENSRNOT00065011749	UniProtKB/Swiss-Prot
	ENSRNOT00065011753	UniProtKB/Swiss-Prot
	ENSRNOT00065011757	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7310036	IMAGE-MGC_LOAD
InterPro	Nep1/2-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Papain-like_cys_pep_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_C48_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:315723	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:109243	IMAGE-MGC_LOAD
NCBI Gene	315723	ENTREZGENE
PANTHER	SENTRIN-SPECIFIC PROTEASE 8	UniProtKB/Swiss-Prot
	SENTRIN-SPECIFIC PROTEASE 8	UniProtKB/Swiss-Prot
	SENTRIN-SPECIFIC PROTEASE 8	UniProtKB/TrEMBL
	SENTRIN-SPECIFIC PROTEASE 8	UniProtKB/TrEMBL
Pfam	Peptidase_C48	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Senp8	PhenoGen
PROSITE	ULP_PROTEASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011595	RatGTEx
	ENSRNOG00055027353	RatGTEx
	ENSRNOG00060016940	RatGTEx
	ENSRNOG00065007511	RatGTEx
Superfamily-SCOP	Cysteine proteinases	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	A6J539	ENTREZGENE, UniProtKB/TrEMBL
	Q5FVJ8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-03-01	Senp8	SUMO peptidase family member, NEDD8 specific	Senp8	SUMO/sentrin peptidase family member, NEDD8 specific	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-06-26	Senp8	SUMO/sentrin peptidase family member, NEDD8 specific	Senp8	SUMO/sentrin specific peptidase family member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-05	Senp8	SUMO/sentrin specific peptidase family member 8	Senp8	Sumo1/sentrin/SMT3 specific peptidase 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-12-15	Senp8	Sumo1/sentrin/Smt3 specific peptidase 8	Senp8	SUMO/sentrin specific peptidase family member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-12-15	Senp8	Sumo1/sentrin/SMT3 specific peptidase 8	Senp8	Sumo1/sentrin/Smt3 specific peptidase 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-20	Senp8	SUMO/sentrin specific peptidase family member 8	Senp8	SUMO/sentrin specific peptidase 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Senp8	SUMO/sentrin specific peptidase 8	Senp8	SUMO/sentrin specific protease family member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Senp8	SUMO/sentrin specific protease family member 8	Senp8_predicted	SUMO/sentrin specific protease family member 8 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Senp8_predicted	SUMO/sentrin specific protease family member 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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