SENP8 (SUMO peptidase family member, NEDD8 specific)

Gene: SENP8 (SUMO peptidase family member, NEDD8 specific) Pan paniscus

Analyze

Symbol:

SENP8

Name:

SUMO peptidase family member, NEDD8 specific

RGD ID:

11718854

Description:

ENCODES a protein that exhibits cysteine-type peptidase activity (inferred); deNEDDylase activity (inferred); INVOLVED IN protein deneddylation (inferred); proteolysis (inferred); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); genetic disease (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sentrin-specific protease 8; SUMO/sentrin peptidase family member, NEDD8 specific; SUMO/sentrin specific peptidase family member 8

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	61,383,614 - 61,406,709 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	65,547,834 - 65,578,310 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	51,069,863 - 51,092,561 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	69,833,803 - 69,856,280 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	69,854,934 - 69,855,572 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

Tay-Sachs disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein deneddylation (IEA)

proteolysis (IEA)

Molecular Function

cysteine-type peptidase activity (IEA)

deNEDDylase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SENP8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	61,383,614 - 61,406,709 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	65,547,834 - 65,578,310 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	51,069,863 - 51,092,561 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	69,833,803 - 69,856,280 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	69,854,934 - 69,855,572 (+)	Ensembl	panpan1.1		panPan2

SENP8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	72,114,258 - 72,143,692 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	72,114,258 - 72,143,692 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	72,406,599 - 72,436,033 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	70,197,808 - 70,220,358 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	70,197,807 - 70,220,357	NCBI
Celera	15	49,292,931 - 49,319,646 (+)	NCBI		Celera
Cytogenetic Map	15	q23	NCBI
HuRef	15	49,236,929 - 49,263,850 (+)	NCBI		HuRef
CHM1_1	15	72,524,572 - 72,551,468 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	69,930,994 - 69,960,429 (+)	NCBI		T2T-CHM13v2.0

Senp8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	59,641,542 - 59,657,932 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	59,641,542 - 59,657,993 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	59,734,259 - 59,750,649 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	59,734,259 - 59,750,710 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	59,582,066 - 59,598,456 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	59,533,891 - 59,548,614 (-)	NCBI		MGSCv36	mm8
Celera	9	56,961,580 - 56,977,968 (-)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	32.11	NCBI

Senp8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	69,031,230 - 69,044,616 (-)	NCBI		GRCr8
mRatBN7.2	8	60,135,446 - 60,148,836 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	60,121,714 - 60,148,928 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	65,657,681 - 65,671,085 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	63,930,607 - 63,944,011 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	61,800,059 - 61,813,464 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	64,558,994 - 64,572,850 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	64,559,015 - 64,572,850 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	64,321,165 - 64,335,616 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	63,564,217 - 63,577,603 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	63,583,288 - 63,596,657 (-)	NCBI
Celera	8	59,578,328 - 59,591,716 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Senp8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	4,978,767 - 5,001,678 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	4,978,767 - 5,001,678 (-)	NCBI	ChiLan1.0	ChiLan1.0

SENP8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	35,649,636 - 35,663,873 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	35,662,155 - 35,662,793 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	35,585,858 - 35,600,915 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	35,852,869 - 35,868,212 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	35,853,010 - 35,868,209 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	35,805,986 - 35,821,702 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	35,834,395 - 35,849,508 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	36,088,402 - 36,104,350 (+)	NCBI		UU_Cfam_GSD_1.0

Senp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	113,668,430 - 113,689,910 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	31,517,000 - 31,536,201 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	31,516,486 - 31,539,214 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SENP8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	169,596,200 - 169,616,138 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	169,596,816 - 169,615,498 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SENP8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	11,318,094 - 11,338,876 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	11,318,800 - 11,319,438 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	130,235,173 - 130,256,687 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Senp8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624781	1,877,576 - 1,900,518 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003818549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008971880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000004357 ⟹ ENSPPAP00000000959

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	15	69,854,934 - 69,855,572 (+)	Ensembl

RefSeq Acc Id:

XM_003818549 ⟹ XP_003818597

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	61,394,536 - 61,406,709 (+)	NCBI
NHGRI_mPanPan1	15	65,564,283 - 65,578,310 (+)	NCBI
Mhudiblu_PPA_v0	15	51,090,974 - 51,092,561 (+)	NCBI
PanPan1.1	15	69,854,717 - 69,856,280 (+)	NCBI

Sequence:

show sequence

GGTGGCAGAGGCAGAAGAAAATCTATGTCTTCTGGAATTTCTGAGCAGCCCTCGTCAGTACAAG
ATGGACCCCGTAGTCTTGAGTTACATGGACAGTCTACTGCGGCAATCAGATGTCTCACTATTGG
ATCCGCCAAGCTGGCTCAATGACCATATTATTGGGTTTGCGTTTGAGTACTTTGCCAACAGTCA
GTTTCATGACTGCTCTGATCACGTCAGTTTCATCAGCCCTGAAGTCACCCAGTTCATCAAGTGC
ACTAGCAACCCAGCAGAGATTGCCATGTTCCTTGAACCTCTGGACCTCCCCCACAAGAGAGTTG
TATTTTTAGCCATCAATGATAACTCCAACCAGGCAGCTGGAGGAACCCACTGGAGTTTATTGGT
CTACCTCCAAGATAAAAATAGCTTTTTTCATTATGATTCCCATAGCAGGAGCAACTCAGTTCAC
GCAAAGCAGGTAGCAGAGAAACTGGAGGCTTTCTTAGGCAGAAAAGGAGACAAACTGGCCTTTG
TGGAAGAGAAAGCCCCTGCCCAACAAAACAGCTATGACTGTGGGATGTACGTGATATGTAACAC
TGAGGCCTTGTGTCAGAACTTCTTTAGGCAACAGACAGAATCACTGCTGCAGCTACTCACCCCT
GCATACATCACAAAGAAGAGGGGAGAATGGAAAGATCTCATTGCCACACTTGCTAAAAAGTAGC
TATTGAAGTATATTTGCGACTTTTGAAGGCTCCTCTTTCTGCCCTTCCCCATTTGTTGGATGGC
TGCAATCTCAGTGCCTGAGGGAAGATGCCTAGTAGAGGAAAGCTTAATACTCTTTTTCCTGAAA
GAATATCATCCTCTGCATTATCCCCATGGAACGTTTCACTTTAACCCTGACTGGGGAGCAATAT
GTTCTGTGAAAATATCTTGAAATTGTACACCAAAACCTTACAACCAACTTATTTGAACATTTAT
TACACACAAGGTTTAAGTAAGACTTTTCTTATTGGTATATAATTAATTTCCTTTGGTCTCCCTT
ATCCACATTGGCTTATTCTGGAGGAAAAGCAGTGATCTATAAAACAAATCAAGAATATATTAAA
TCTAGAGGAATGCAGAGAAGAAAACTATAAAACAGAACCAAAAACTTGTGGCACAGCCTACATA
ATTAAGAGATCAACTGGCTGGAAGCAGATCAAGGCCTAACTTCATTCAAGACCTAAATATTATG
AGACTCAGTTATTCAGTTTTATGTGATATCTCTTCCATTCACCATGCACAGGCTTTTCCAGCTA
TCTATATAATGTTTGCAAATATTTGATAAAGATGATGTTACCCTATCTTCCTCCATCTGATTCC
TGGAATGCTTGAAGAAAGGGGAAATCTTGAGTAACCTCATTAAAATTAATGTCTGGTGGACCTC
TCA

hide sequence

RefSeq Acc Id:

XM_008971880 ⟹ XP_008970128

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	61,383,614 - 61,406,709 (+)	NCBI
NHGRI_mPanPan1	15	65,547,834 - 65,578,310 (+)	NCBI
Mhudiblu_PPA_v0	15	51,069,863 - 51,092,561 (+)	NCBI
PanPan1.1	15	69,833,804 - 69,856,280 (+)	NCBI

Sequence:

show sequence

TACGGCAGAGCAGGGAACTCAGCTTTAGATTCTCCCTGTACTGGAAAGGGATGTCGCAAGGTTG
GGGGAAGAAACCTCTGAGTTTGCGACCGTAGCTGTCGCTTTCCGGCCAATACAGAGGTGCCTGA
AGGCTGGTTGGGGTGGTGAGGCCCGAGGCAGCTTCTGGAATTTCTGAGCAGCCCTCGTCAGTAC
AAGATGGACCCCGTAGTCTTGAGTTACATGGACAGTCTACTGCGGCAATCAGATGTCTCACTAT
TGGATCCGCCAAGCTGGCTCAATGACCATATTATTGGGTTTGCGTTTGAGTACTTTGCCAACAG
TCAGTTTCATGACTGCTCTGATCACGTCAGTTTCATCAGCCCTGAAGTCACCCAGTTCATCAAG
TGCACTAGCAACCCAGCAGAGATTGCCATGTTCCTTGAACCTCTGGACCTCCCCCACAAGAGAG
TTGTATTTTTAGCCATCAATGATAACTCCAACCAGGCAGCTGGAGGAACCCACTGGAGTTTATT
GGTCTACCTCCAAGATAAAAATAGCTTTTTTCATTATGATTCCCATAGCAGGAGCAACTCAGTT
CACGCAAAGCAGGTAGCAGAGAAACTGGAGGCTTTCTTAGGCAGAAAAGGAGACAAACTGGCCT
TTGTGGAAGAGAAAGCCCCTGCCCAACAAAACAGCTATGACTGTGGGATGTACGTGATATGTAA
CACTGAGGCCTTGTGTCAGAACTTCTTTAGGCAACAGACAGAATCACTGCTGCAGCTACTCACC
CCTGCATACATCACAAAGAAGAGGGGAGAATGGAAAGATCTCATTGCCACACTTGCTAAAAAGT
AGCTATTGAAGTATATTTGCGACTTTTGAAGGCTCCTCTTTCTGCCCTTCCCCATTTGTTGGAT
GGCTGCAATCTCAGTGCCTGAGGGAAGATGCCTAGTAGAGGAAAGCTTAATACTCTTTTTCCTG
AAAGAATATCATCCTCTGCATTATCCCCATGGAACGTTTCACTTTAACCCTGACTGGGGAGCAA
TATGTTCTGTGAAAATATCTTGAAATTGTACACCAAAACCTTACAACCAACTTATTTGAACATT
TATTACACACAAGGTTTAAGTAAGACTTTTCTTATTGGTATATAATTAATTTCCTTTGGTCTCC
CTTATCCACATTGGCTTATTCTGGAGGAAAAGCAGTGATCTATAAAACAAATCAAGAATATATT
AAATCTAGAGGAATGCAGAGAAGAAAACTATAAAACAGAACCAAAAACTTGTGGCACAGCCTAC
ATAATTAAGAGATCAACTGGCTGGAAGCAGATCAAGGCCTAACTTCATTCAAGACCTAAATATT
ATGAGACTCAGTTATTCAGTTTTATGTGATATCTCTTCCATTCACCATGCACAGGCTTTTCCAG
CTATCTATATAATGTTTGCAAATATTTGATAAAGATGATGTTACCCTATCTTCCTCCATCTGAT
TCCTGGAATGCTTGAAGAAAGGGGAAATCTTGAGTAACCTCATTAAAATTAATGTCTGGTGGAC
CTCTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003818597	(Get FASTA)	NCBI Sequence Viewer
	XP_008970128	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000000959
	ENSPPAP00000000959.1

RefSeq Acc Id:

XP_008970128 ⟸ XM_008971880

- UniProtKB:

A0A2R8Z824 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKC
TSNPAEIAMFLEPLDLPHKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVH
AKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTP
AYITKKRGEWKDLIATLAKK

hide sequence

RefSeq Acc Id:

XP_003818597 ⟸ XM_003818549

- UniProtKB:

A0A2R8Z824 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKC
TSNPAEIAMFLEPLDLPHKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVH
AKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTP
AYITKKRGEWKDLIATLAKK

hide sequence

RefSeq Acc Id:

ENSPPAP00000000959 ⟸ ENSPPAT00000004357

Protein Domains

Ubiquitin-like protease family profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000003990	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000004357.1	UniProtKB/TrEMBL
InterPro	Nep1/2-like	UniProtKB/TrEMBL
	Papain-like_cys_pep_sf	UniProtKB/TrEMBL
	Peptidase_C48_C	UniProtKB/TrEMBL
KEGG Report	pps:100982993	UniProtKB/TrEMBL
NCBI Gene	SENP8	ENTREZGENE
PANTHER	SENTRIN-SPECIFIC PROTEASE 8	UniProtKB/TrEMBL
	SENTRIN-SPECIFIC PROTEASE 8	UniProtKB/TrEMBL
Pfam	Peptidase_C48	UniProtKB/TrEMBL
PROSITE	ULP_PROTEASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54001	UniProtKB/TrEMBL
UniProt	A0A2R8Z824	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-02-27	SENP8	SUMO peptidase family member, NEDD8 specific		SUMO/sentrin peptidase family member, NEDD8 specific	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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