Tafazzin (tafazzin, phospholipid-lysophospholipid transacylase) - Rat Genome Database

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Gene: Tafazzin (tafazzin, phospholipid-lysophospholipid transacylase) Rattus norvegicus
Analyze
Symbol: Tafazzin
Name: tafazzin, phospholipid-lysophospholipid transacylase
RGD ID: 1588532
Description: Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity. Involved in positive regulation of ATP biosynthetic process and positive regulation of cardiolipin metabolic process. Predicted to be located in mitochondrial inner membrane and mitochondrial outer membrane. Predicted to be active in mitochondrial membrane. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Orthologous to human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase); PARTICIPATES IN cardiolipin metabolic pathway; glycerophospholipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Barth syndrome); cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; MGC116399; tafazzin (cardiomyopathy, dilated 3A (X-linked); tafazzin (cardiomyopathy, dilated 3A (X-linked), endocardial fibroelastosis 2, Barth syndrome); Taz; Taz_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: Some orthologs of Taz (Gene ID: 363521) and Wwtr1 (Gene ID: 295062), such as the human and mouse orthologs, share the Taz symbol/alias in common. Taz is a widely used alternative name for WW domain-containing transcription regulator protein 1 (Wwtr1), which can be confused with the official symbol for tafazzin (Taz). [20 Dec 2019]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X152,065,539 - 152,076,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX152,065,609 - 152,074,001 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX154,207,544 - 154,215,129 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,770,777 - 157,778,362 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,442,576 - 155,450,161 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,421,006 - 156,429,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,421,009 - 156,428,593 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,161,153 - 152,169,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,319,389 - 160,326,974 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1135,822,755 - 135,830,340 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Infantile dilated X-linked cardiomyopathy, G4.5 mutations, altered lipids, and ultrastructural malformations of mitochondria in heart, liver, and skeletal muscle. Bissler JJ, etal., Lab Invest. 2002 Mar;82(3):335-44.
2. TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Di Palma T, etal., Exp Cell Res. 2009 Jan 15;315(2):162-75. doi: 10.1016/j.yexcr.2008.10.016. Epub 2008 Oct 28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes. He Q, Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H210-6. doi: 10.1152/ajpheart.00098.2010. Epub 2010 Mar 26.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Metabolism and function of mitochondrial cardiolipin. Ren M, etal., Prog Lipid Res. 2014 Jul;55:1-16. doi: 10.1016/j.plipres.2014.04.001. Epub 2014 Apr 24.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Information Derived from GenBank Report RGD, Sept. 2003
13. Only one splice variant of the human TAZ gene encodes a functional protein with a role in cardiolipin metabolism. Vaz FM, etal., J Biol Chem 2003 Oct 31;278(44):43089-94. Epub 2003 Aug 20.
Additional References at PubMed
PMID:11118295   PMID:12477932   PMID:15304507   PMID:16857210   PMID:16873891   PMID:17043667   PMID:19164547   PMID:21474562   PMID:23997105   PMID:29325722   PMID:30639735   PMID:34726504  


Genomics

Comparative Map Data
Tafazzin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X152,065,539 - 152,076,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX152,065,609 - 152,074,001 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX154,207,544 - 154,215,129 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,770,777 - 157,778,362 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,442,576 - 155,450,161 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,421,006 - 156,429,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,421,009 - 156,428,593 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,161,153 - 152,169,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,319,389 - 160,326,974 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1135,822,755 - 135,830,340 (-)NCBICelera
Cytogenetic MapXq37NCBI
TAFAZZIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,411,539 - 154,421,726 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,411,524 - 154,421,726 (+)EnsemblGRCh38hg38GRCh38
GRCh37X153,639,875 - 153,650,065 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,293,071 - 153,303,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X153,160,723 - 153,170,908NCBI
CeleraX153,800,935 - 153,811,119 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,217,267 - 142,227,597 (+)NCBIHuRef
CHM1_1X153,551,525 - 153,561,710 (+)NCBICHM1_1
T2T-CHM13v2.0X152,648,045 - 152,658,233 (+)NCBIT2T-CHM13v2.0
Tafazzin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,325,498 - 73,340,182 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,325,518 - 73,333,757 (+)EnsemblGRCm39 Ensembl
GRCm38X74,281,900 - 74,295,319 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,281,912 - 74,290,151 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X71,528,036 - 71,535,490 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,535,482 - 70,542,868 (+)NCBIMGSCv36mm8
CeleraX65,536,488 - 65,543,942 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.95NCBI
Tafazzin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580915,188 - 922,791 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580915,668 - 921,703 (+)NCBIChiLan1.0ChiLan1.0
TAFAZZIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X154,389,806 - 154,399,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,853,054 - 143,863,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,725,299 - 153,734,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,725,294 - 153,734,046 (+)Ensemblpanpan1.1panPan2
TAFAZZIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,111,608 - 122,125,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,111,434 - 122,125,506 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X125,253,464 - 125,267,405 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX125,253,122 - 125,267,404 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X121,022,538 - 121,036,427 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,537,418 - 123,551,342 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,299,313 - 123,313,250 (+)NCBIUU_Cfam_GSD_1.0
Tafazzin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,422,492 - 119,431,185 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368091,160,247 - 1,171,097 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368091,160,265 - 1,168,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAFAZZIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,940,031 - 124,946,273 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,940,036 - 124,946,275 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TAFAZZIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606566,638,292 - 66,648,540 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tafazzin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946871,901 - 879,508 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946871,618 - 885,331 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tafazzin
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:509
Count of miRNA genes:254
Interacting mature miRNAs:305
Transcripts:ENSRNOT00000056290
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
BE109508  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,074,020 - 152,074,177 (-)MAPPERmRatBN7.2
Rnor_6.0X156,420,830 - 156,420,986NCBIRnor6.0
Rnor_5.01152,160,977 - 152,161,133UniSTSRnor5.0
RGSC_v3.4X160,319,211 - 160,319,367UniSTSRGSC3.4
Celera1135,822,577 - 135,822,733UniSTS
Cytogenetic MapXq37UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 34 11 8
Low 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000089778   ⟹   ENSRNOP00000071612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX152,065,609 - 152,074,001 (+)Ensembl
Rnor_6.0 EnsemblX156,421,009 - 156,428,593 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094406   ⟹   ENSRNOP00000089301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX152,065,609 - 152,073,996 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110015   ⟹   ENSRNOP00000080949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX152,065,609 - 152,074,001 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111059   ⟹   ENSRNOP00000085243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX152,065,609 - 152,074,001 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112223   ⟹   ENSRNOP00000089690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX152,065,609 - 152,073,003 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118070   ⟹   ENSRNOP00000090548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX152,065,609 - 152,073,003 (+)Ensembl
RefSeq Acc Id: NM_001025748   ⟹   NP_001020919
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,066,416 - 152,073,999 (+)NCBI
Rnor_6.0X156,421,008 - 156,428,593 (-)NCBI
Rnor_5.01152,161,153 - 152,169,569 (-)NCBI
RGSC_v3.4X160,319,389 - 160,326,974 (-)RGD
Celera1135,822,755 - 135,830,340 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229599   ⟹   XP_006229661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,065,539 - 152,074,001 (+)NCBI
Rnor_6.0X156,421,006 - 156,429,420 (-)NCBI
Rnor_5.01152,161,153 - 152,169,569 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099918   ⟹   XP_038955846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,065,539 - 152,074,001 (+)NCBI
RefSeq Acc Id: XM_039099919   ⟹   XP_038955847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,065,539 - 152,074,001 (+)NCBI
RefSeq Acc Id: XM_039099920   ⟹   XP_038955848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,065,539 - 152,076,178 (+)NCBI
RefSeq Acc Id: XM_039099921   ⟹   XP_038955849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,065,541 - 152,074,001 (+)NCBI
RefSeq Acc Id: XM_039099923   ⟹   XP_038955851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,067,310 - 152,074,001 (+)NCBI
RefSeq Acc Id: XM_039099924   ⟹   XP_038955852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,067,309 - 152,074,001 (+)NCBI
RefSeq Acc Id: NP_001020919   ⟸   NM_001025748
- UniProtKB: Q4KLG6 (UniProtKB/TrEMBL),   A0A8I6A188 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229661   ⟸   XM_006229599
- Peptide Label: isoform X2
- UniProtKB: Q4KLG6 (UniProtKB/TrEMBL),   A0A8I6A188 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071612   ⟸   ENSRNOT00000089778
RefSeq Acc Id: XP_038955848   ⟸   XM_039099920
- Peptide Label: isoform X3
- UniProtKB: A6KRR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955846   ⟸   XM_039099918
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0X0 (UniProtKB/TrEMBL),   A0A8I6A188 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955847   ⟸   XM_039099919
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0X0 (UniProtKB/TrEMBL),   A0A8I6A188 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955849   ⟸   XM_039099921
- Peptide Label: isoform X4
- UniProtKB: A6KRR6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955852   ⟸   XM_039099924
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038955851   ⟸   XM_039099923
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000080949   ⟸   ENSRNOT00000110015
RefSeq Acc Id: ENSRNOP00000085243   ⟸   ENSRNOT00000111059
RefSeq Acc Id: ENSRNOP00000089301   ⟸   ENSRNOT00000094406
RefSeq Acc Id: ENSRNOP00000090548   ⟸   ENSRNOT00000118070
RefSeq Acc Id: ENSRNOP00000089690   ⟸   ENSRNOT00000112223
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLG6-F1-model_v2 AlphaFold Q4KLG6 1-262 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702046
Promoter ID:EPDNEW_R12570
Type:initiation region
Name:Taz_1
Description:tafazzin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,428,601 - 156,428,661EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588532 AgrOrtholog
BioCyc Gene G2FUF-631 BioCyc
Ensembl Genes ENSRNOG00000053023 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089778 ENTREZGENE
  ENSRNOT00000089778.2 UniProtKB/TrEMBL
  ENSRNOT00000094406 ENTREZGENE
  ENSRNOT00000094406.1 UniProtKB/TrEMBL
  ENSRNOT00000110015.1 UniProtKB/TrEMBL
  ENSRNOT00000111059.1 UniProtKB/TrEMBL
  ENSRNOT00000112223.1 UniProtKB/TrEMBL
  ENSRNOT00000118070.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7387882 IMAGE-MGC_LOAD
InterPro Acyltransferase UniProtKB/TrEMBL
  Tafazzin UniProtKB/TrEMBL
KEGG Report rno:363521 UniProtKB/TrEMBL
MGC_CLONE MGC:116399 IMAGE-MGC_LOAD
NCBI Gene 363521 ENTREZGENE
PANTHER Tafazzin UniProtKB/TrEMBL
  TAFAZZIN UniProtKB/TrEMBL
Pfam Acyltransferase UniProtKB/TrEMBL
PhenoGen Tafazzin PhenoGen
PRINTS TAFAZZIN UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053023 RatGTEx
SMART PlsC UniProtKB/TrEMBL
Superfamily-SCOP Glycerol-3-phosphate (1)-acyltransferase UniProtKB/TrEMBL
UniProt A0A0G2K0X0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZU36_RAT UniProtKB/TrEMBL
  A0A8I6A188 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AB32_RAT UniProtKB/TrEMBL
  A0A8I6ABG2_RAT UniProtKB/TrEMBL
  A0A8I6ACA3_RAT UniProtKB/TrEMBL
  A6KRR5 ENTREZGENE, UniProtKB/TrEMBL
  A6KRR6 ENTREZGENE, UniProtKB/TrEMBL
  A6KRR8_RAT UniProtKB/TrEMBL
  Q4KLG6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-18 Tafazzin  tafazzin, phospholipid-lysophospholipid transacylase  Taz  tafazzin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Taz  tafazzin  Taz  tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome)  Taz  tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) (mapped)  Name updated 737654 APPROVED
2007-04-12 Taz  tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) (mapped)  Taz_mapped  tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) (mapped)  Data merged from RGD:3822 737654 APPROVED
2006-11-19 Taz  tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Taz_mapped  tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) (mapped)      Symbol and Name updated 1556543 APPROVED
2004-09-10 Taz  tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome)    tafazzin  Name updated 1299863 APPROVED
2002-06-10 Taz  Tafazzin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes Barth syndrome (BTHS), which is characterized by cardiomyopathy, growth retardation, neutropenia, and 3-methylglutaconic aciduria 1300481