Srpx (sushi-repeat-containing protein, X-linked)

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Gene: Srpx (sushi-repeat-containing protein, X-linked) Rattus norvegicus

Analyze

Symbol:

Srpx

Name:

sushi-repeat-containing protein, X-linked

RGD ID:

70950

Description:

Predicted to be involved in several processes, including negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to localize to autophagosome and endoplasmic reticulum. Orthologous to human SRPX (sushi repeat containing protein X-linked); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

down-regulated by v-src; down-regulated by v-src gene; Drs; MGC105430; sushi repeat-containing protein SRPX; sushi-repeat-containing protein; sushi-repeat-containing protein X chromosome; sushi-repeat-containing protein, X chromosome

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	12,676,984 - 12,751,296 (+)	NCBI
Rnor_6.0 Ensembl	X	14,150,038 - 14,220,662 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	X	14,146,618 - 14,220,756 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	X	14,932,352 - 15,003,129 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	24,833,279 - 24,904,349 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	X	24,886,676 - 24,957,818 (+)	NCBI
Celera	X	13,286,935 - 13,357,502 (+)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Dwarfism (ISO)

hepatocellular carcinoma (ISO)

Neurodevelopmental Disorders (ISO)

ornithine carbamoyltransferase deficiency (ISO)

retinitis pigmentosa 3 (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked chronic granulomatous disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-azacytidine (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

aflatoxin B1 (ISO)

alachlor (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

carbamazepine (ISO)

chloropicrin (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

dexamethasone (EXP,ISO)

diarsenic trioxide (ISO)

diuron (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

fenvalerate (EXP)

folic acid (ISO)

furan (EXP)

indometacin (ISO)

irinotecan (EXP)

L-methionine (ISO)

medroxyprogesterone acetate (ISO)

methamphetamine (EXP)

mifepristone (ISO)

oxaliplatin (EXP)

pentanal (ISO)

pioglitazone (ISO)

pirinixic acid (ISO)

progesterone (EXP,ISO)

propanal (ISO)

quercetin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tert-butyl hydroperoxide (ISO)

testosterone enanthate (ISO)

topotecan (EXP)

trichostatin A (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vorinostat (ISO)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagy (ISO)

negative regulation of cell proliferation involved in contact inhibition (ISO)

phagolysosome assembly (ISO)

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (ISO)

response to endoplasmic reticulum stress (ISO)

Cellular Component

autophagosome (ISO)

endoplasmic reticulum (ISO)

Molecular Function

protein binding (ISO)

References

References - curated


1.	GOA data from the GO Consortium
2.	MGD Curation, June 12, 2002
3.	MGD data from the GO Consortium
4.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Pan J, etal., FEBS Lett 1996 Mar 25;383(1-2):21-5.
6.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12049817	PMID:12152160	PMID:12477932	PMID:15489334	PMID:17088259	PMID:19368996

Genomics

Comparative Map Data

Srpx
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	12,676,984 - 12,751,296 (+)	NCBI
Rnor_6.0 Ensembl	X	14,150,038 - 14,220,662 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	X	14,146,618 - 14,220,756 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	X	14,932,352 - 15,003,129 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	24,833,279 - 24,904,349 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	X	24,886,676 - 24,957,818 (+)	NCBI
Celera	X	13,286,935 - 13,357,502 (+)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

SRPX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	X	38,149,336 - 38,220,924 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	X	38,149,339 - 38,220,881 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	X	38,008,592 - 38,080,124 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	37,893,536 - 37,965,075 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	X	37,764,808 - 37,836,348	NCBI
Celera	X	42,146,231 - 42,217,816 (-)	NCBI
Cytogenetic Map	X	p11.4	NCBI
HuRef	X	35,753,942 - 35,824,499 (-)	NCBI		HuRef
CHM1_1	X	38,039,638 - 38,111,226 (-)	NCBI		CHM1_1

Srpx
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	9,904,216 - 9,983,879 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	X	9,904,216 - 9,983,948 (-)	Ensembl
GRCm38	X	10,037,977 - 10,117,640 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	10,037,977 - 10,117,709 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	9,615,103 - 9,694,787 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	X	9,194,936 - 9,274,620 (-)	NCBI			mm8
MGSCv36	X	7,112,076 - 7,194,962 (-)	NCBI			mm8
Celera	X	7,749,827 - 7,822,706 (-)	NCBI		Celera
Cytogenetic Map	X	A1.1	NCBI

Srpx
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955601	286,069 - 364,235 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955601	286,092 - 364,235 (-)	NCBI	ChiLan1.0	ChiLan1.0

SRPX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	X	38,306,862 - 38,378,770 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	38,303,313 - 38,378,770 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	X	30,598,574 - 30,670,464 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

SRPX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	X	32,745,020 - 33,330,841 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	X	32,905,380 - 33,017,642 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Srpx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936502	5,010,692 - 5,107,221 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRPX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	34,075,577 - 34,198,467 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	34,075,577 - 34,198,462 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	37,892,766 - 38,008,122 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103247472
(Chlorocebus sabaeus - African green monkey)

No map positions available.

Srpx
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624762	17,240,899 - 17,347,430 (+)	NCBI

Position Markers

RH138665

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	X	14,150,111 - 14,150,255	NCBI	Rnor6.0
Rnor_5.0	X	14,932,432 - 14,932,576	UniSTS	Rnor5.0
RGSC_v3.4	X	24,904,132 - 24,904,276	UniSTS	RGSC3.4
Celera	X	13,357,285 - 13,357,429	UniSTS
RH 3.4 Map	X	115.0	UniSTS
Cytogenetic Map	X	q13	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	44092703	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1662453	21592783	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1662609	33443848	Rat
631204	Gluco15	Glucose level QTL 15		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	1838166	24331837	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	4282140	49282140	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	5954078	50954078	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	67
Count of miRNA genes:	56
Interacting mature miRNAs:	65
Transcripts:	ENSRNOT00000045753
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	32	8	4	13	4	5	8		18	28	11	5
Low		11	49	37	6	37	3	3	74	17	13		3
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC133696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D78359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000045753 ⟹ ENSRNOP00000048924

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	14,150,038 - 14,220,662 (-)	Ensembl

RefSeq Acc Id:

NM_022524 ⟹ NP_071969

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	12,677,091 - 12,747,876 (+)	NCBI
Rnor_6.0	X	14,150,038 - 14,220,662 (-)	NCBI
Rnor_5.0	X	14,932,352 - 15,003,129 (-)	NCBI
RGSC_v3.4	X	24,833,279 - 24,904,349 (+)	RGD
Celera	X	13,286,935 - 13,357,502 (+)	RGD

Sequence:

show sequence

ATCTTGGCCTCCTCCAGCCCCTTAGTGCTGCGCAGCCTGCCCGGCGGGGGAAGCGCCGGCTCGC
CATGGGGAGCCCGGGACTCCGGCCCACGCTGCTGCTGCCTCAAGTACTGTTGCTGTTGCTGGCG
CTGCTGCACGTCCCGCCGAGCCAGGGCTTCCCAGGCTCTGGAGACTCACCACTAGAAGACGATG
GAGTCTGGTCTTCACACTCTCTCTATAAAGACACTCCGTGGTGCTCTCCCATCAAGGTGAAATA
TGGGGATGTGTACTGCAGGGCTCCTCCTGGGGGATATTACAAAACAGCCCTGGGGACCAGGTGT
GACATTCGCTGCAGGAAGGGCTACGAGCTTCATGGCTCTTCCCAGCTCGTCTGCCAGTCAAACA
GGCGCTGGTCGGATAAGGTCATCTGCAAACAAAAGCGATGTCCTACCCTCACCATGCCAGCAAA
TGGAGGGTTTAAGTGTGTCGATGGCGCCTACTTTAACTCTCGGTGTGAGTACTATTGCTCACCA
GGATATACATTGAAAGGGGAACGGACAGTCACATGTATGGACAACAAGGCCTGGAGTGGCCGAC
CAGCCTCCTGTGTAGATATGGAACCTCCTAGAATCAAGTGCCCAAGTGTGAAAGAACGGATAGC
TGAGCCTAATAAGCTGACAGTCCGCGTGTCCTGGGAAACCCCAGAGGGAAGAGATACAGCAGAT
GGGATTCTTACTGATGTTATTCTGAGAGGTCTTCCTCCAGGCTCGAATTTTCCAGAAGGAGACC
ACAAGATTGAGTACACTGTCTATGACAGAGCCGAGAACAAGGGAACTTGCAAGTTCCGAGTTAA
AGTAAGAGTCAGACGTTGTGGCAAGCTCAATGCCCCAGAGAATGGTTACATGAAGTGTTCCAGC
GATGGTGACAATTATGGGGCCACCTGTGAGTTCTCCTGTATCGGTGGCTATGAGCTTCAGGGTA
GTCCTGCCCGAGTATGCCAATCCAATCTGGCTTGGTCTGGTACAGAGCCTAGCTGTGCAGCGAT
GAATGTCAATGTTGGTGTCAGAACCGCAGCTGCACTTTTGGATCAGTTTTATGAGAAAAGACGA
CTCCTCATTGTGTCTACACCCACAGCTCGAAACCTCCTCTACAGACTGCAGCTGGGAATGCTAC
AGCAAGCACAGTGTGGTCTGGATCTCCGACATATCACCGTGGTGGAGCTGGTCGGAGTCTTCCC
AACCCTCATCGGCAGGATCAGAGCAAAGATTATGCCCCCAGCCCTAGCTCTGCAGCTCAGGTTG
TTGCTTCGAATCCCACTCTACTCCTTCAGCATGGTTTTAGTGGATAAGCATGGCATGGATAAAG
AACGTTATGTCTCCTTAGTGACACCCATGGCTCTCTTCAACCTCATTGACACTTTCCCCCTGAG
AAAAGAAGAGATGATCCTTCAGGCTGAGATGGGCCAGTCTTGCAACACCTGATGTGCTGTTCCA
TTTCCTGGTGCTTTCTCACCTCTTATCATAGAGTATATCATGTAGTATACTACAGTGCCTGTGG
GAAGGCCTTAAAAATACCTTTGATGTACAGATTTTCATTTGTAATTTTTAAAGTCTATTTTATT
ATGTGCTTCCTTTGCTCTTAAACATTGGCACAATGCCTTTTAAACTTTGAAATGTTAAAAAAAA
AGTACGAATATATCTATTCTAACTCTCCCTTTAGGCCATTGTGGCTGATGAAATTAGAAGTGAC
AGCCACGCCCATGCTTTCAGAATATTATTCAGTGTGAAACACATTTTCCTTTTCTCTTATTGTT
TATATAAGTCTTTTGTTAATAAAATATTTTGAAGC

hide sequence

RefSeq Acc Id:

XM_006256683 ⟹ XP_006256745

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	12,676,984 - 12,751,296 (+)	NCBI
Rnor_6.0	X	14,146,618 - 14,220,756 (-)	NCBI
Rnor_5.0	X	14,932,352 - 15,003,129 (-)	NCBI

Sequence:

show sequence

CCCCTGACTGGAGGGAGGGAAAGAAGGAAGCCGCCAAGGAGGAGTTTTCCAGCCTGGCTTTAGA
GGCTCTGGCTCACTACACAACCCCTCGGTCTCTTGGCCTCCTCCAGCCCCTTAGTGCTGCGCAG
CCTGCCCGGCGGGGGAAGCGCCGGCTCGCCATGGGGAGCCCGGGACTCCGGCCCACGCTGCTGC
TGCCTCAAGTACTGTTGCTGTTGCTGGCGCTGCTGCACGTCCCGCCGAGCCAGGGCTTCCCAGA
CACTCCGTGGTGCTCTCCCATCAAGGTGAAATATGGGGATGTGTACTGCAGGGCTCCTCCTGGG
GGATATTACAAAACAGCCCTGGGGACCAGGTGTGACATTCGCTGCAGGAAGGGCTACGAGCTTC
ATGGCTCTTCCCAGCTCGTCTGCCAGTCAAACAGGCGCTGGTCGGATAAGGTCATCTGCAAACA
AAAGCGATGTCCTACCCTCACCATGCCAGCAAATGGAGGGTTTAAGTGTGTCGATGGCGCCTAC
TTTAACTCTCGGTGTGAGTACTATTGCTCACCAGGATATACATTGAAAGGGGAACGGACAGTCA
CATGTATGGACAACAAGGCCTGGAGTGGCCGACCAGCCTCCTGTGTAGATATGGAACCTCCTAG
AATCAAGTGCCCAAGTGTGAAAGAACGGATAGCTGAGCCTAATAAGCTGACAGTCCGCGTGTCC
TGGGAAACCCCAGAGGGAAGAGATACAGCAGATGGGATTCTTACTGATGTTATTCTGAGAGGTC
TTCCTCCAGGCTCGAATTTTCCAGAAGGAGACCACAAGATTGAGTACACTGTCTATGACAGAGC
CGAGAACAAGGGAACTTGCAAGTTCCGAGTTAAAGTAAGAGTCAGACGTTGTGGCAAGCTCAAT
GCCCCAGAGAATGGTTACATGAAGTGTTCCAGCGATGGTGACAATTATGGAGCCACCTGTGAGT
TCTCCTGTATCGGTGGCTATGAGCTTCAGGGTAGTCCTGCCCGAGTATGCCAATCCAATCTGGC
TTGGTCTGGTACAGAGCCTAGCTGTGCAGCGATGAATGTCAATGTTGGTGTCAGAACCGCAGCT
GCACTTTTGGATCAGTTTTATGAGAAAAGACGACTCCTCATTGTGTCTACACCCACAGCTCGAA
ACCTCCTCTACAGACTGCAGCTGGGAATGCTACAGCAAGCACAGTGTGGTCTGGATCTCCGACA
TATCACCGTGGTGGAGCTGGTCGGAGTCTTCCCAACCCTCATCGGCAGGATCAGAGCAAAGATT
ATGCCCCCAGCCCTAGCTCTGCAGCTCAGGTTGTTGCTTCGAATCCCACTCTACTCCTTCAGCA
TGGTTTTAGTGGATAAGCATGGCATGGATAAAGAACGTTATGTCTCCTTAGTGACACCCATGGC
TCTCTTCAACCTCATTGACACTTTCCCCCTGAGAAAAGAAGAGATGATCCTTCAGGCTGAGATG
GGCCAGTCTTGCAACACCTGATGTGCTGTTCCATTTCCTGGTGCTTTCTCACCTCTTATCATAG
AGTATATCATGTAGTATACTACAGTGCCTGTGGGAAGGCCTTAAAAATACCTTTGATGTACAGA
TTTTCATTTGTAATTTTTAAAGTCTATTTTATTATGTGCTTCCTTTGCTCTTAAACATTGGCAC
AATGCCTTTTAAACTTTGAAATGTTAAAAAAAAGTACGAATATATCTATTCTAACTCTCCCTTT
AGTCCATTGTGGCTGATGAAATTAGAAGTGACAGCCACGCCCATGCTTTCAGAATATTATTCAG
TGTGAAACACATTTTCCTTTTCTCTTATTGTTTATATAAGTCTTTTGTTAATAAAATATTTTGA
AGCAAACTTACTAAAACTCACCTTTAAAAAATAATCAGGCACCAGGCTTATTTGCTTGGCATGA
TGAGTAGTTTTTAAACCGTGATTCTTTATTCATCTTAAGAAAGGGAAACAATAGTCCTGTCGGG
GGATAAACTGAGATGAGAGAGAGCTACATTCTTAACTGGAGAATAACAAATTGAAAATATTCAA
ACAAAGCTACATGATGTCCATACTGAAATGATGCAGACTTTTTCCCCACATTGTTCCCCAACCA
ATGCAGTATAAAAACTATTTACAAATCACTTCCCTCATATGAGGTACTGTAAGTAATCCAGAGA
GGTTTCAAGTATACAAGGGGATACACATGGATTACAGGTAGGTACTGTACCATTTTATATCACA
AGGTGAGTGACTTTTGGGGCCCTGGAACCAATCATTCCTGAGTTTGTAAATGAAAAAGCGTGAT
GGGCCAGTAGGGCTGAATTCGAGACTGTACCCCACCCAGAGAGGTTGCAATTCCCAGGTTGTCC
ATCAGATCACTTTTCAGAGAGGTCAGCTTTATTTATGGAGGCTGCATTTGTATTTGTAAATGGT
TAAGCATAGAAAACCACACCTTGGCATTTAATGAAGAATTGGATTATACTCATAGGCATACATT
TCTAAACATTTCCGGTATCGGATTGGCCCATAATCTATTCTTAAACAAAATAGTGAAATGATAG
AAAGTCCAAGTTCCAATACGTAGTGCTTTAAAACAGGAGGTAGGATGAATGGTATTCTTACAAA
AGATTAGACAGAGTAAACACCAACCCTTGAATAGATTGACATTCTATGTAGAAAAATTTACTGT
TTCCCTCTTTTATAGTAAAAACCACTCTTTAACTACTGCAGCATTCATATGTATCAGATTGAAG
GAAAAAGCACAAATGGAGAGGAATGTCAAATGATAATGACCTTTACCAACTACCCTGTGCCTAT
GGGATAATAGCAGGAAAGGAACTTACCTCATTTATTCAAAGCACTCTTTCTGGTCACTTTGAAT
TATTGTTGCACTTTGACCCTCCCCCCCAAACAAATACACAGATTACTTGAAAATGAATGAAGGC
ATGAGTGAATGACCTTTGACGTTTCAAAATTAAAACTCTATTAAAAAAAAACATGGGAGACACT
TGAAAATTATCAATTGCTATCTCTAGGATACAGATTTCTCCATGAGCAGTTCACAGGGTTTTTT
TTTTAAATACACATTTCAAACTGCTACAAAGAAATAGCTAGAACTAGGGAGTCAGATCAAATCA
ATTGGTAAAGTGCTTGTTGTATAAACTTGGGAAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAG
AGAGAGAGAGAGAGAGAGAGAGAGAGAGAACTAAAAGACACATGGATACGCTCTTGGGCACATG
GATACAGAGAAGAACTAGACAGTTAAATGAGCTGGTCAAATAGAAAACAGCATCTGCTCAGTAG
GCGACAGCCGAAATCCCAGTTCAATTTCTTATGGTTAGCAGGCCTGCTTACAACCTGTCAGGAC
TCCCAGACCACACCTGCCTGACTCAGTGATCAATTAGAAAGGCAAACAGTTTGTTTACAGAATC
TGGGTCACCCCATCTGGTTCTTTTTGAGACTTACCTCATCACATTTCGGTTGCTACACTTTTTC
TGACGTCTTCATCTTTTAAAGCAAAAAGACTATACATTTTGTATTTTCCTTTAAGCCCCCTCTC
AGCTCTAACCCCACACAGGTCTGTATTATAATTTGTCCTTAATTAAAGCCCCCAAATCTGAAGT
TTATTTAAGTGATGACTGTTTTCTAGTTTGCTCATCTTTTGACTGTCCTTAATCTTTAAGAAGG
TGTTTTCTTTTTAATCCAAATATGGTGATTTTCTATAGGAGATTAGTTAGAAAGAAGTTTCTTT
TTTTTTTTTCTTTTTTTTTGGAGCTGGGGACCGAACCCAGGGCCTTGAGCTTGGAACTCTTTAC
CTCCTTCTGAATTGTTTCCTCTAGCTTTGACATGAGGATTTGTATCTAGTCTTGTCATAACTTA
TTATGCCATATTCAGTTGATATCCCTGGGAGGTCTTCCCAGTTTTATTGAAAGTAAATGGAGGA
GGAATGAGTCTCGGGGAAGGAAGTGGAGGGGAATTTGAGGTAAGAATGCATGATAAAACAATAC
TAACAATAATAAAAAGAATAGCCCATAGGGTCATATATCTGAATGCTTAGTCACTAGGGAGTGG
CACTATTTGTGAAGGATTAGGAGGTGCCCTTCCTTTCAAATGTTAAAGTCTCTTAGTTGAAAGT
TAATAGCAAGTCTTTCCCAGTTTTACACCTTCTTTTATAATCTGTAATTCTTTCCTTGCTCATG
GAAAGCCTCTCTTGTTTTTGATCACCTGGGTCATTTACCCTAGAAGAAACCACCTGTCATGTTC
TAAGACTAATACAGCACTTTGTAATTAAGTCCGTGTGGGCAAGAACAGAGGAACCTTCCAAAAA
CCAGTCATGTGATAGCCGCCATGAAGTCCATTCCCTAGCCCAGCCAAGTCTTCAGATGACTGCC
ATAGCAGAAGTGACTGTAGCGTTACCAGAGACCTCAGTACAGACTTGGCAAGCTAAGACTCCCC
TAAAACCTCTAGCCCACAGAAATTGTGAGATAATAAAACAATTGCTACTTCAGGCCACTAAGTT
TAGGAGTAATGCAATTAATAGTAAAGGACCAATATGGATAGCCATGCCCTGGACTTTGTCCAAC
AAGCTTTAAACGACTTTACTGCCTTTCTTCTCCATCATCCATGGGAAATCATACAATCATACAT
GTATACGGAGGACATAGTTTAGACCCATACAGCCCTCATGCTTTTGGCTTCAGTCTCTGTGAAG
CCTTATGAGCCCTTCATACTTGATTCTGTGGGCTGTGTTCTCCATGGTGTCTTGGCCCTCTGGC
TCCTATAGTCCTTCCTCCTCCTGTATTGCAGGCTTGCCCTGGCTCCCAAAGCAAAGTGCTTTGC
TTTGGGTCTCTGCATCTGCTCCCATCAGTTGCTGGATGATGCCTCTCTGATGTCAATTGGGCTA
GAAACTGATCTGTGAGTATAGGAGAATATCTTTAGGAATCATTTCATTGACAGCTTTTTCTAAT
TAGCAATATTTTAATTAAAATAAGCAGATATGTTTGTCTGATGATTTAATACCTTGACTATTCA
TTTTGTGTGAAAATTGTTCTTTTTTGTTTCCAAGTTCAAATTATGTTTATATTATTTCAGATTT
TGGACTATAATGACTAAATATTTTCTCAATTAGCATATTGTTATTTGCATTTTGAAAGTCTATT
CTAGCATAATATTGCTATAATGGATTGTCAATATTTTGCCTTTTCCAGTACTGGCCCTTATTTT
ATGATAACATAAATTTTACATTTACCAATGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_071969	(Get FASTA)	NCBI Sequence Viewer
	XP_006256745	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87639	(Get FASTA)	NCBI Sequence Viewer
	BAA11371	(Get FASTA)	NCBI Sequence Viewer
	EDL97614	(Get FASTA)	NCBI Sequence Viewer
	EDL97615	(Get FASTA)	NCBI Sequence Viewer
	Q63769	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_071969 ⟸ NM_022524
- Peptide Label:	precursor
- UniProtKB:	Q63769 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGSPGLRPTLLLPQVLLLLLALLHVPPSQGFPGSGDSPLEDDGVWSSHSLYKDTPWCSPIKVKY GDVYCRAPPGGYYKTALGTRCDIRCRKGYELHGSSQLVCQSNRRWSDKVICKQKRCPTLTMPAN GGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIA EPNKLTVRVSWETPEGRDTADGILTDVILRGLPPGSNFPEGDHKIEYTVYDRAENKGTCKFRVK VRVRRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSCAAM NVNVGVRTAAALLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFP TLIGRIRAKIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVSLVTPMALFNLIDTFPLR KEEMILQAEMGQSCNT hide sequence

RefSeq Acc Id:	XP_006256745 ⟸ XM_006256683
- Peptide Label:	isoform X1
- UniProtKB:	Q63769 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGSPGLRPTLLLPQVLLLLLALLHVPPSQGFPDTPWCSPIKVKYGDVYCRAPPGGYYKTALGTR CDIRCRKGYELHGSSQLVCQSNRRWSDKVICKQKRCPTLTMPANGGFKCVDGAYFNSRCEYYCS PGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTA DGILTDVILRGLPPGSNFPEGDHKIEYTVYDRAENKGTCKFRVKVRVRRCGKLNAPENGYMKCS SDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSCAAMNVNVGVRTAAALLDQFYEKR RLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFPTLIGRIRAKIMPPALALQLR LLLRIPLYSFSMVLVDKHGMDKERYVSLVTPMALFNLIDTFPLRKEEMILQAEMGQSCNT hide sequence

RefSeq Acc Id:

ENSRNOP00000048924 ⟸ ENSRNOT00000045753

Protein Domains

HYR Sushi

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701720

Promoter ID:

EPDNEW_R12244

Type:

initiation region

Name:

Srpx_1

Description:

sushi-repeat-containing protein, X-linked

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	14,220,681 - 14,220,741	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
X	14150556	14150557	T	A	snv	SBN/Ygl (RGD)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70950	AgrOrtholog
Ensembl Genes	ENSRNOG00000039666	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000048924	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000045753	ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7309360	IMAGE-MGC_LOAD
InterPro	DUF4174	UniProtKB/Swiss-Prot
	HYR_dom	UniProtKB/Swiss-Prot
	SRPX	UniProtKB/Swiss-Prot
	SRPX-like	UniProtKB/Swiss-Prot
	Sushi/SCR/CCP_sf	UniProtKB/Swiss-Prot
	Sushi_SCR_CCP_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:64316	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105430	IMAGE-MGC_LOAD
NCBI Gene	64316	ENTREZGENE
PANTHER	PTHR46343	UniProtKB/Swiss-Prot
	PTHR46343:SF1	UniProtKB/Swiss-Prot
Pfam	DUF4174	UniProtKB/Swiss-Prot
	HYR	UniProtKB/Swiss-Prot
	Sushi	UniProtKB/Swiss-Prot
PhenoGen	Srpx	PhenoGen
PROSITE	HYR	UniProtKB/Swiss-Prot
	SUSHI	UniProtKB/Swiss-Prot
SMART	CCP	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF57535	UniProtKB/Swiss-Prot
UniProt	Q63769	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q5PPK5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-23	Srpx	sushi-repeat-containing protein, X-linked	Srpx	sushi-repeat-containing protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Srpx	sushi-repeat-containing protein			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD