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Gene: Adamts12 (ADAM metallopeptidase with thrombospondin type 1 motif, 12) Rattus norvegicus

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Symbol:

Adamts12

Name:

ADAM metallopeptidase with thrombospondin type 1 motif, 12

RGD ID:

1307323

Description:

Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of cellular response to growth factor stimulus; protein catabolic process; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

A disintegrin and metalloproteinase with thrombospondin motifs 12; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; LOC294809

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	61,759,975 - 62,054,716 (+)	NCBI		GRCr8
mRatBN7.2	2	60,032,873 - 60,327,629 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	60,032,873 - 60,327,629 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	67,143,918 - 67,451,709 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	65,265,431 - 65,573,247 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	60,266,812 - 60,574,625 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	61,039,072 - 61,340,687 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	61,039,053 - 61,340,697 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	83,352,798 - 83,650,251 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	60,427,824 - 60,717,617 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	60,349,718 - 60,645,857 (+)	NCBI
Celera	2	58,357,418 - 58,652,079 (-)	NCBI		Celera
Cytogenetic Map	2	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adamts12	Rat	Stroke	susceptibility	ISO	ADAMTS12 (Homo sapiens)	9681739	DNA:SNP::rs1364044(human)	RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adamts12	Rat	Neurodevelopmental Disorders		ISO	ADAMTS12 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adamts12	Rat	(-)-epigallocatechin 3-gallate	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ADAMTS12 mRNA	CTD	PMID:22079256
Adamts12	Rat	1,2-dichloroethane	decreases expression	ISO	Adamts12 (Mus musculus)	6480464	ethylene dichloride results in decreased expression of ADAMTS12 mRNA	CTD	PMID:28960355
Adamts12	Rat	17beta-estradiol	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[Estradiol co-treated with TGFB1 protein] results in increased expression of ADAMTS12 mRNA	CTD	PMID:30165855
Adamts12	Rat	17beta-estradiol	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ADAMTS12 mRNA	CTD	PMID:32741896
Adamts12	Rat	17beta-estradiol 3-benzoate	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ADAMTS12 mRNA	CTD	PMID:32741896
Adamts12	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of ADAMTS12 mRNA	CTD	PMID:34747641
Adamts12	Rat	3-methylcholanthrene	decreases expression	ISO	Adamts12 (Mus musculus)	6480464	Methylcholanthrene results in decreased expression of ADAMTS12 mRNA	CTD	PMID:20713471
Adamts12	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	Adamts12 (Mus musculus)	6480464	bisphenol S results in increased expression of ADAMTS12 mRNA	CTD	PMID:30951980
Adamts12	Rat	4,4'-sulfonyldiphenol	decreases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	bisphenol S results in decreased expression of ADAMTS12 mRNA	CTD	PMID:30616060
Adamts12	Rat	4-hydroxyphenyl retinamide	decreases expression	ISO	Adamts12 (Mus musculus)	6480464	Fenretinide results in decreased expression of ADAMTS12 mRNA	CTD	PMID:28973697
Adamts12	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of ADAMTS12 mRNA	CTD	PMID:24780913
Adamts12	Rat	acetamide	decreases expression	EXP		6480464	acetamide results in decreased expression of ADAMTS12 mRNA	CTD	PMID:31881176
Adamts12	Rat	aflatoxin B1	decreases methylation	ISO	ADAMTS12 (Homo sapiens)	6480464	Aflatoxin B1 results in decreased methylation of ADAMTS12 gene	CTD	PMID:27153756
Adamts12	Rat	aflatoxin B1	increases methylation	ISO	ADAMTS12 (Homo sapiens)	6480464	Aflatoxin B1 results in increased methylation of ADAMTS12 intron	CTD	PMID:30157460
Adamts12	Rat	Aflatoxin B2 alpha	increases methylation	ISO	ADAMTS12 (Homo sapiens)	6480464	aflatoxin B2 results in increased methylation of ADAMTS12 intron	CTD	PMID:30157460
Adamts12	Rat	amphotericin B	increases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	Amphotericin B analog results in increased expression of ADAMTS12 mRNA	CTD	PMID:28534445
Adamts12	Rat	arsane	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of ADAMTS12 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of ADAMTS12 mRNA	CTD	PMID:39836092
Adamts12	Rat	arsenic atom	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of ADAMTS12 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of ADAMTS12 mRNA	CTD	PMID:39836092
Adamts12	Rat	atrazine	affects methylation	EXP		6480464	Atrazine affects the methylation of ADAMTS12 gene	CTD	PMID:28931070 and PMID:35440735
Adamts12	Rat	benzo[a]pyrene	decreases expression	ISO	Adamts12 (Mus musculus)	6480464	Benzo(a)pyrene results in decreased expression of ADAMTS12 mRNA	CTD	PMID:20713471
Adamts12	Rat	benzo[a]pyrene	increases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased expression of ADAMTS12 mRNA	CTD	PMID:32234424
Adamts12	Rat	benzo[a]pyrene	affects methylation	ISO	ADAMTS12 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of ADAMTS12 promoter	CTD	PMID:27901495
Adamts12	Rat	beta-lapachone	decreases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	beta-lapachone results in decreased expression of ADAMTS12 mRNA	CTD	PMID:38218311
Adamts12	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	Adamts12 (Mus musculus)	6480464	Diethylhexyl Phthalate results in decreased expression of ADAMTS12 mRNA	CTD	PMID:34319233
Adamts12	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of ADAMTS12 mRNA	CTD	PMID:25181051 more ...
Adamts12	Rat	bisphenol A	increases methylation	ISO	ADAMTS12 (Homo sapiens)	6480464	bisphenol A results in increased methylation of ADAMTS12 gene	CTD	PMID:31601247
Adamts12	Rat	bisphenol A	increases expression	ISO	Adamts12 (Mus musculus)	6480464	bisphenol A results in increased expression of ADAMTS12 mRNA	CTD	PMID:30951980 and PMID:32370801
Adamts12	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of ADAMTS12 gene	CTD	PMID:28505145
Adamts12	Rat	bisphenol F	increases expression	ISO	Adamts12 (Mus musculus)	6480464	bisphenol F results in increased expression of ADAMTS12 mRNA	CTD	PMID:30951980
Adamts12	Rat	CGP 52608	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	CGP 52608 promotes the reaction [RORA protein binds to ADAMTS12 gene]	CTD	PMID:28238834
Adamts12	Rat	choline	multiple interactions	ISO	Adamts12 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS12 mRNA	CTD	PMID:20938992
Adamts12	Rat	clotrimazole	decreases expression	EXP		6480464	Clotrimazole results in decreased expression of ADAMTS12 mRNA	CTD	PMID:30047161
Adamts12	Rat	clozapine	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein	CTD	PMID:34122009
Adamts12	Rat	Cuprizon	increases expression	EXP		6480464	Cuprizone results in increased expression of ADAMTS12 mRNA	CTD	PMID:26577399
Adamts12	Rat	Cuprizon	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein	CTD	PMID:34122009
Adamts12	Rat	dorsomorphin	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...	CTD	PMID:27188386
Adamts12	Rat	doxorubicin	increases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	Doxorubicin results in increased expression of ADAMTS12 mRNA	CTD	PMID:29803840
Adamts12	Rat	endosulfan	decreases expression	EXP		6480464	Endosulfan results in decreased expression of ADAMTS12 mRNA	CTD	PMID:29391264
Adamts12	Rat	ethanol	multiple interactions	ISO	Adamts12 (Mus musculus)	6480464	[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of ADAMTS12 mRNA	CTD	PMID:30517762
Adamts12	Rat	folic acid	multiple interactions	ISO	Adamts12 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS12 mRNA	CTD	PMID:20938992
Adamts12	Rat	L-methionine	multiple interactions	ISO	Adamts12 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS12 mRNA	CTD	PMID:20938992
Adamts12	Rat	lead(0)	affects methylation	ISO	ADAMTS12 (Homo sapiens)	6480464	Lead affects the methylation of ADAMTS12 gene	CTD	PMID:31636367
Adamts12	Rat	malathion	decreases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	Malathion results in decreased expression of ADAMTS12 mRNA	CTD	PMID:37047231
Adamts12	Rat	manganese atom	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of ADAMTS12 mRNA	CTD	PMID:39836092
Adamts12	Rat	manganese(0)	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of ADAMTS12 mRNA	CTD	PMID:39836092
Adamts12	Rat	manganese(II) chloride	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of ADAMTS12 mRNA	CTD	PMID:39836092
Adamts12	Rat	mercury dibromide	increases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	mercuric bromide results in increased expression of ADAMTS12 mRNA	CTD	PMID:26272509
Adamts12	Rat	mercury dibromide	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS12 mRNA	CTD	PMID:27188386
Adamts12	Rat	methimazole	decreases expression	EXP		6480464	Methimazole results in decreased expression of ADAMTS12 mRNA	CTD	PMID:30047161
Adamts12	Rat	methoxychlor	affects methylation	EXP		6480464	Methoxychlor affects the methylation of ADAMTS12 gene	CTD	PMID:35440735
Adamts12	Rat	microcystin-LR	increases expression	EXP		6480464	cyanoginosin LR results in increased expression of ADAMTS12 mRNA	CTD	PMID:34740672
Adamts12	Rat	nickel sulfate	decreases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	nickel sulfate results in decreased expression of ADAMTS12 mRNA	CTD	PMID:22714537
Adamts12	Rat	ozone	multiple interactions	ISO	Adamts12 (Mus musculus)	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of ADAMTS12 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of ADAMTS12 mRNA	CTD	PMID:34911549
Adamts12	Rat	paracetamol	decreases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	Acetaminophen results in decreased expression of ADAMTS12 mRNA	CTD	PMID:22230336 and PMID:26690555
Adamts12	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of ADAMTS12 mRNA	CTD	PMID:33387578
Adamts12	Rat	perfluorooctane-1-sulfonic acid	affects expression	ISO	Adamts12 (Mus musculus)	6480464	perfluorooctane sulfonic acid affects the expression of ADAMTS12 mRNA	CTD	PMID:19429403
Adamts12	Rat	perfluorooctanoic acid	affects expression	ISO	Adamts12 (Mus musculus)	6480464	perfluorooctanoic acid affects the expression of ADAMTS12 mRNA	CTD	PMID:19429403
Adamts12	Rat	phenylmercury acetate	increases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	Phenylmercuric Acetate results in increased expression of ADAMTS12 mRNA	CTD	PMID:26272509
Adamts12	Rat	phenylmercury acetate	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS12 mRNA	CTD	PMID:27188386
Adamts12	Rat	potassium chromate	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ADAMTS12 mRNA	CTD	PMID:22079256
Adamts12	Rat	potassium chromate	decreases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	potassium chromate(VI) results in decreased expression of ADAMTS12 mRNA	CTD	PMID:22079256
Adamts12	Rat	resveratrol	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[Plant Extracts co-treated with Resveratrol] results in decreased expression of ADAMTS12 mRNA	CTD	PMID:23557933
Adamts12	Rat	rotenone	increases expression	EXP		6480464	Rotenone results in increased expression of ADAMTS12 mRNA	CTD	PMID:28374803
Adamts12	Rat	rotenone	increases expression	ISO	Adamts12 (Mus musculus)	6480464	Rotenone results in increased expression of ADAMTS12 mRNA	CTD	PMID:32937126
Adamts12	Rat	SB 431542	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...	CTD	PMID:27188386
Adamts12	Rat	sodium arsenite	increases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	sodium arsenite results in increased expression of ADAMTS12 mRNA	CTD	PMID:38568856
Adamts12	Rat	sodium arsenite	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of ADAMTS12 mRNA more ...	CTD	PMID:33939924 and PMID:39836092
Adamts12	Rat	sodium arsenite	decreases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	sodium arsenite results in decreased expression of ADAMTS12 mRNA	CTD	PMID:34032870
Adamts12	Rat	sulfadimethoxine	decreases expression	EXP		6480464	Sulfadimethoxine results in decreased expression of ADAMTS12 mRNA	CTD	PMID:30047161
Adamts12	Rat	sunitinib	decreases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	Sunitinib results in decreased expression of ADAMTS12 mRNA	CTD	PMID:31533062
Adamts12	Rat	testosterone	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ADAMTS12 mRNA	CTD	PMID:32741896
Adamts12	Rat	tetrachloromethane	increases expression	ISO	Adamts12 (Mus musculus)	6480464	Carbon Tetrachloride results in increased expression of ADAMTS12 mRNA	CTD	PMID:17484886
Adamts12	Rat	tetrachloromethane	multiple interactions	ISO	Adamts12 (Mus musculus)	6480464	[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of ADAMTS12 mRNA	CTD	PMID:30517762
Adamts12	Rat	titanium dioxide	decreases expression	ISO	Adamts12 (Mus musculus)	6480464	titanium dioxide results in decreased expression of ADAMTS12 mRNA	CTD	PMID:35295148
Adamts12	Rat	triclosan	decreases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	Triclosan results in decreased expression of ADAMTS12 mRNA	CTD	PMID:30510588
Adamts12	Rat	troglitazone	increases expression	ISO	Adamts12 (Mus musculus)	6480464	troglitazone results in increased expression of ADAMTS12 mRNA	CTD	PMID:28973697
Adamts12	Rat	valproic acid	increases expression	ISO	ADAMTS12 (Homo sapiens)	6480464	Valproic Acid results in increased expression of ADAMTS12 mRNA	CTD	PMID:23179753 more ...
Adamts12	Rat	valproic acid	multiple interactions	ISO	ADAMTS12 (Homo sapiens)	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS12 mRNA	CTD	PMID:27188386

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adamts12	Rat	biological_process		ND		1598407	12/2014:no relevant rat data	RGD
Adamts12	Rat	cell migration	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:21494557	RGD	PMID:21494557
Adamts12	Rat	cell migration	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	cell-matrix adhesion	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:21494557	RGD	PMID:21494557
Adamts12	Rat	cell-matrix adhesion	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	cellular response to BMP stimulus	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:22247065	RGD	PMID:22247065
Adamts12	Rat	cellular response to BMP stimulus	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	cellular response to interleukin-1	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:18485748	RGD	PMID:18485748
Adamts12	Rat	cellular response to interleukin-1	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	cellular response to tumor necrosis factor	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:18485748	RGD	PMID:18485748
Adamts12	Rat	cellular response to tumor necrosis factor	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	chondrocyte differentiation	involved_in	ISO	Adamts12 (Mus musculus)	1624291	MGI:1347346 PMID:29618652	RGD	PMID:29618652
Adamts12	Rat	chondrocyte differentiation	involved_in	IEA	UniProtKB:Q811B3 and ensembl:ENSMUSP00000057796	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	collagen fibril organization	involved_in	IEA	UniProtKB:Q811B3 and ensembl:ENSMUSP00000057796	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	collagen fibril organization	involved_in	ISO	Adamts12 (Mus musculus)	1624291	MGI:1347346 more ...	RGD	PMID:29618652
Adamts12	Rat	extracellular matrix organization	involved_in	IBA	FB:FBgn0003137 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adamts12	Rat	extracellular matrix organization	involved_in	IEA	InterPro:IPR013273	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adamts12	Rat	negative regulation of cellular response to hepatocyte growth factor stimulus	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:17895370	RGD	PMID:17895370
Adamts12	Rat	negative regulation of cellular response to hepatocyte growth factor stimulus	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	negative regulation of cellular response to vascular endothelial growth factor stimulus	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:17895370	RGD	PMID:17895370
Adamts12	Rat	negative regulation of cellular response to vascular endothelial growth factor stimulus	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	negative regulation of chondrocyte differentiation	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:22247065	RGD	PMID:22247065
Adamts12	Rat	negative regulation of chondrocyte differentiation	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	negative regulation of hepatocyte growth factor receptor signaling pathway	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:17895370	RGD	PMID:17895370
Adamts12	Rat	negative regulation of hepatocyte growth factor receptor signaling pathway	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	ossification	involved_in	ISO	Adamts12 (Mus musculus)	1624291	MGI:1347346 PMID:29618652	RGD	PMID:29618652
Adamts12	Rat	ossification	involved_in	IEA	UniProtKB:Q811B3 and ensembl:ENSMUSP00000057796	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	ossification involved in bone maturation	involved_in	IEA	UniProtKB:Q811B3 and ensembl:ENSMUSP00000057796	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	ossification involved in bone maturation	involved_in	ISO	Adamts12 (Mus musculus)	1624291	MGI:1347346 more ...	RGD	PMID:29618652
Adamts12	Rat	proteoglycan catabolic process	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:17895370	RGD	PMID:17895370
Adamts12	Rat	proteoglycan catabolic process	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	proteoglycan metabolic process	involved_in	ISO	Adamts12 (Mus musculus)	1624291	MGI:1347346 PMID:29618652	RGD	PMID:29618652
Adamts12	Rat	proteoglycan metabolic process	involved_in	IEA	UniProtKB:Q811B3 and ensembl:ENSMUSP00000057796	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	proteolysis	involved_in	IBA	MGI:1339949 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adamts12	Rat	proteolysis	involved_in	IEA	UniProtKB-KW:KW-0645	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Adamts12	Rat	proteolysis	involved_in	IEA	InterPro:IPR001590	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adamts12	Rat	proteolysis involved in protein catabolic process	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:16611630 and PMID:18485748	RGD	PMID:16611630 and PMID:18485748
Adamts12	Rat	proteolysis involved in protein catabolic process	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	regulation of endothelial tube morphogenesis	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:17895370	RGD	PMID:17895370
Adamts12	Rat	regulation of endothelial tube morphogenesis	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	regulation of inflammatory response	involved_in	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:23019333	RGD	PMID:23019333
Adamts12	Rat	regulation of inflammatory response	involved_in	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adamts12	Rat	extracellular matrix	is_active_in	IBA	FB:FBgn0003137 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adamts12	Rat	extracellular region	located_in	IEA	UniProtKB-KW:KW-0964	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adamts12	Rat	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Adamts12	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Adamts12	Rat	metalloendopeptidase activity	enables	IBA	MGI:109249 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adamts12	Rat	metalloendopeptidase activity	enables	IEA	UniProtKB:P58397 and ensembl:ENSP00000422554	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adamts12	Rat	metalloendopeptidase activity	enables	IEA	InterPro:IPR001590	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adamts12	Rat	metalloendopeptidase activity	enables	ISO	ADAMTS12 (Homo sapiens)	1624291	PMID:16611630 more ...	RGD	PMID:16611630 more ...
Adamts12	Rat	metallopeptidase activity	enables	IEA	UniProtKB-KW:KW-0482	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Adamts12	Rat	metallopeptidase activity	enables	IEA	InterPro:IPR024079	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adamts12	Rat	peptidase activity	enables	IEA	UniProtKB-KW:KW-0645	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Adamts12	Rat	protein binding	enables	ISO	ADAMTS12 (Homo sapiens)	1624291	UniProtKB:B4DJ51 more ...	RGD	PMID:16611630 more ...
Adamts12	Rat	protein binding	enables	ISO	ADAMTS12 (Homo sapiens) and UniProtKB:P58397-3	1624291	UniProtKB:P38432 more ...	RGD	PMID:32296183

#	Reference Title	Reference Citation
1.	A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.	Arning A, etal., Blood. 2012 Dec 20;120(26):5231-6. doi: 10.1182/blood-2012-07-442038. Epub 2012 Sep 18.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

PMID:16611630	PMID:17895370	PMID:18485748	PMID:21494557	PMID:21869572	PMID:22247065	PMID:23019333	PMID:37400752

Adamts12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	61,759,975 - 62,054,716 (+)	NCBI		GRCr8
mRatBN7.2	2	60,032,873 - 60,327,629 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	60,032,873 - 60,327,629 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	67,143,918 - 67,451,709 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	65,265,431 - 65,573,247 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	60,266,812 - 60,574,625 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	61,039,072 - 61,340,687 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	61,039,053 - 61,340,697 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	83,352,798 - 83,650,251 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	60,427,824 - 60,717,617 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	60,349,718 - 60,645,857 (+)	NCBI
Celera	2	58,357,418 - 58,652,079 (-)	NCBI		Celera
Cytogenetic Map	2	q16	NCBI

ADAMTS12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	33,523,535 - 33,891,990 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	33,523,535 - 33,892,019 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	33,523,640 - 33,892,095 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	33,563,043 - 33,927,881 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	33,563,042 - 33,927,881	NCBI
Celera	5	33,408,303 - 33,780,613 (-)	NCBI		Celera
Cytogenetic Map	5	p13.3-p13.2	NCBI
HuRef	5	33,495,595 - 33,870,040 (-)	NCBI		HuRef
CHM1_1	5	33,528,883 - 33,893,746 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	33,638,143 - 34,013,900 (-)	NCBI		T2T-CHM13v2.0

Adamts12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	11,064,781 - 11,349,321 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	11,064,876 - 11,349,317 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	11,064,773 - 11,349,232 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	11,064,790 - 11,349,231 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	10,994,545 - 11,276,622 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	11,009,756 - 11,290,402 (+)	NCBI		MGSCv36	mm8
Celera	15	10,855,060 - 11,130,577 (+)	NCBI		Celera
Cytogenetic Map	15	A1	NCBI
cM Map	15	5.43	NCBI

Adamts12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	19,150,343 - 19,471,534 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955426	19,146,288 - 19,471,880 (-)	NCBI	ChiLan1.0	ChiLan1.0

ADAMTS12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	76,399,984 - 76,784,157 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	74,561,166 - 74,937,839 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	76,442,053 - 76,818,726 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	81,828,264 - 82,203,497 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	81,827,560 - 82,199,840 (+)	Ensembl	panpan1.1		panPan2

ADAMTS12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	73,887,959 - 74,188,909 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	73,887,924 - 74,001,984 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	73,503,678 - 73,767,544 (+)	NCBI		Dog10K_Boxer_Tasha
Dog10K_Boxer_Tasha	4	73,777,238 - 73,812,152 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	74,394,459 - 74,697,683 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	74,379,341 - 74,696,853 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	74,140,285 - 74,398,310 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	74,264,326 - 74,571,548 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	74,798,493 - 75,101,600 (+)	NCBI		UU_Cfam_GSD_1.0

Adamts12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	223,889,032 - 224,191,694 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936518	7,180,428 - 7,480,802 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936518	7,180,262 - 7,483,416 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAMTS12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	19,547,011 - 19,920,513 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	19,547,003 - 19,920,780 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	20,237,769 - 20,454,645 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAMTS12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	32,757,699 - 33,129,116 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	32,757,684 - 33,129,059 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	23,035,326 - 23,424,713 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adamts12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	20,898,761 - 21,088,838 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624759	20,749,548 - 21,092,816 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Adamts12
2096 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	713
Count of miRNA genes:	306
Interacting mature miRNAs:	381
Transcripts:	ENSRNOT00000025693
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	59846005	104846005	Rat
6480225	Gdil1	Gastrointestinal dilation QTL 1			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	56660879	74786777	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
2293676	Bmd19	Bone mineral density QTL 19	10.7	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	43162366	111362592	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
2293682	Bmd24	Bone mineral density QTL 24	8.9	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	43162366	111362592	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	20304672	65304672	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	38573329	122609194	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
10402051	Gdil2	Gastrointestinal dilation QTL 2			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	24903853	74786777	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	40067944	102785628	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	43171017	83575226	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	42804607	60653831	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	59324377	103795077	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
2300168	Bmd47	Bone mineral density QTL 47	6.6	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	2	20662448	65662448	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1357990	Ael1	Aortic elastin QTL 1	3.1	0.00091	aorta elastin amount (VT:0003905)	aortic elastin	2	19076825	64076825	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	16491740	61491740	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	35134841	88029593	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	57605612	76539510	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	59324719	102755241	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	22384627	67384627	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	35023117	80023117	Rat
10755434	Coatc7	Coat color QTL 7		0.04794	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	30648065	75648065	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	59324377	103795077	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	27157160	72157160	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	81754745	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1354592	Rf50	Renal function QTL 50	3.5		urine output (VT:0003620)	timed urine volume (CMO:0000260)	2	53822747	74786777	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	28484589	169504100	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	28484589	169504100	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat

D2Rat271

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	60,305,234 - 60,305,371 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	61,318,079 - 61,318,215	NCBI	Rnor6.0
Rnor_5.0	2	83,375,215 - 83,375,351	UniSTS	Rnor5.0
RGSC_v3.4	2	60,697,816 - 60,697,953	RGD	RGSC3.4
RGSC_v3.4	2	60,697,817 - 60,697,953	UniSTS	RGSC3.4
RGSC_v3.1	2	60,625,871 - 60,626,340	RGD
Celera	2	58,379,219 - 58,379,355	UniSTS
SHRSP x BN Map	2	27.4398	RGD
SHRSP x BN Map	2	27.4398	UniSTS
Cytogenetic Map	2	q16	UniSTS

D2Got315

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	60,277,511 - 60,277,618 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	61,290,038 - 61,290,144	NCBI	Rnor6.0
Rnor_5.0	2	83,403,286 - 83,403,392	UniSTS	Rnor5.0
RGSC_v3.4	2	60,670,084 - 60,670,190	UniSTS	RGSC3.4
Celera	2	58,406,792 - 58,406,898	UniSTS
Cytogenetic Map	2	q16	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001106420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025693 ⟹ ENSRNOP00000025693

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	60,032,873 - 60,327,629 (+)	Ensembl
Rnor_6.0 Ensembl	2	61,039,053 - 61,340,697 (+)	Ensembl

RefSeq Acc Id:

NM_001106420 ⟹ NP_001099890

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	61,759,987 - 62,054,716 (+)	NCBI
mRatBN7.2	2	60,032,873 - 60,327,629 (+)	NCBI
Rnor_6.0	2	61,039,072 - 61,340,687 (+)	NCBI
Rnor_5.0	2	83,352,798 - 83,650,251 (-)	NCBI
RGSC_v3.4	2	60,427,824 - 60,717,617 (+)	RGD
Celera	2	58,357,418 - 58,652,079 (-)	NCBI

Sequence:

show sequence

CAGAAAGCAGAAGCTGTCAGCTCATTCACTCCCCTTTCAGGAAAGGGAGAGCAGAGAAGTTCTCTGGTCCTGTCTACTTCAAAAGGCCACTAGAGCTCTTGGGCAGCTAGCGGGCCGCTCCCTTCCCA
CGCCTGGACCATGCTCCGCTGCGGCTTCCTGCGCGGCCACGGGCGAGGACTCGGTATCTGCAGCTGAGAGCTAACACTGTTTTGACTTTTCTTCTCCCCAACAACCGAACCATGCCATGTGCTCAGGG
GAACTGGATGGCAAAGCTCTCCATGGTGGCCCAGCTTCTTAACTTTGGGGCTTTTTGCCATGGGAGACAAGCTCAGCCCTGGCCGGTTCGCTTCCCAGACCCGAAGCAAGAACATTTTATCAAGTCCC
TGCCAGAATACCACATAGTGAGTCCTGTCCAAGTAGATGCCAGTGGCCACTTTCTGTCCTATGGCCTGCATCACCCTGTCACTGGCAGCAGGAAGAAGAGAGCTGCAGGTGGTTCTGGGGACCAGGTG
TACTACAGGATTTCACACGAAGAAAAAAACCTGTTTTTCAATCTGACAGTCAACTGGGAATTTCTTTCCAATGGCTATGTCGTGGAGAGGAGATATGGGAACCTTTCCCATGTGAAGATGGCGGCTTC
CTCAGGGCAGCCCTGCCATCTCAGGGGCACAGTTCTGCAACAGGGCCCCACAATCAGGATGGGGACAGCAGCTCTTAGTGCCTGCCAAGGACTGACTGGATTTTTCCATCTACCACATGGAGACTTTT
TCATTGAGCCTGTTAAAAAGCATCCACTGACCGAGGAAGGTTACCAGCCTCATGTCATATACAGGAGGCAGAGCTACAGAGTTCCAGAGACAAAGGAGCCCACCTGCGGATTAAAGGACAGCCTTGAT
AACTCTGTGAAGCAAGAGCTCCAGCGGGAGAAGTGGGAGAGGAAGAACTGGCCAAGCAGAAGCCTCTCCCGACGCTCCATAAGCAAGGAGAGATGGGTGGAGACCCTCGTGGTAGCTGACACGAAGAT
GGTAGAGTACCATGGAAGTGAGAACGTGGAGTCGTACATCCTCACTATCATGAATATGGTCACTGGGTTGTTTCATAACCCAAGCATTGGAAACGCAGTGCACATTGTTGTGGTTCGGCTCATTCTAC
TTGAAGAAGAGGAGCAAGGATTGAAAATAGTTCACCATGCAGAGAAGACACTGTCCAGCTTCTGCAAGTGGCAGAAGAGCATCAATCCCAAGAGTGACCTCAACCCTGTCCATCATGATGTGGCTGTC
CTTATCACCAGAAAGGACATCTGTGCTGGTGTCAATCGCCCTTGTGAGACTCTGGGGCTGTCCCAGCTGTCAGGAATGTGCCAGCCTCACAGGAGCTGTAACATCAACGAAGACTCCGGTCTCCCCCT
GGCTTTCACCATTGCGCATGAACTTGGGCACAGCTTCGGCATCCAACATGATGGGAAGGAAAATGACTGTGAGCCCGTGGGCAGACACCCATACATCATGTCCCAACAAATTCAGTATGACCCAACTC
CACTGACATGGTCGAAATGCAGCAAGGAGTACATCACTCGCTTCTTGGACCGAGGCAGGGGGTTCTGTCTTGATGACGTCCCCAGAAAGAAAGGCTTAAAGTCCAATGTCATTGCCCCTGGAGTGATT
TATGATGTTCATCACCAGTGCCAGCTCCAATACGGCCCAAATGCTACATTCTGCCAGGAAGTGGAAAATGTTTGCCAGACACTGTGGTGCTCAGTGAAAGGCTTCTGTCGCTCTAAGCTGGATGCTGC
TGCAGATGGGACACGTTGTGGTGAGAAGAAGTGGTGTATGGCTGGAAAGTGTATCACAGTGGGGAAGAAACCAGAGAGCATCCCTGGAGGCTGGGGACGCTGGTCACCCTGGTCACACTGTTCGAGGA
CATGTGGGGCAGGAGCTCAGAGCGCAGAGAGGCTCTGCAACAACCCAGAACCAAAGTTTGGAGGGAAATACTGCACCGGAGAAAGAAAACGCTATCGCTTATGCAATGTCCACCCCTGCCGCTCAGAC
ACTCCAACTTTCCGACAGATGCAGTGCAGTGAATTTGACACAGTCCCCTACAAAAACCAATTCTACCGCTGGTTCCCAGTGTTTAATCCAGCACATCCTTGTGAGCTGTACTGCAGACCCATAGATGA
ACAGTTTTCTGAGAGAATGCTGGAAGCCGTCATTGATGGCACCCCGTGCTTTGAAGGTGGCAACAGCAGAAATGTCTGTATTAATGGCATATGTAAGAGGGTTGGCTGTGACTATGAGATTGATTCCA
ATGCTACAGAGGATCGCTGTGGCGTGTGCCTTGGAGATGGCTCTGCCTGCCAGACTGTGAAGAAGGTGTTTAGACAGAAGGAAGGATCCGGTTACATTGACATCGGACTTATTCCCAAAGGTGCAAGG
GATATAAGAGTGATGGAAATCAAGGCAGCCGGCAATTTCCTGGCCATTAGGAGTGAAGATCCAGAAAAATATTACCTCAACGGAGGATTTATCATCCAGTGGAATGGAAACTATAAACTGGCAGGGAC
CGTCTTCCAGTATGACAGGAAAGGAGATCTGGAGAGACTTATGGCTCCAGGCCCCACCAACGAGTCAGTGTGGCTCCAGCTACTATTCCAGGTGACTAACCCCGGTATCAAGTATGAGTACACAGTCC
GGAAAGATGGCCTTGACAATGATGTGGAGAAGTTGCTGTACTTCTGGCAATTTGGCCGCTGGACAGAGTGCAGTGTAACATGTGGAACAGGTATCCGCCGGCAGACTGCTCATTGTGTCAAGAAGGGC
CATGGGATAGTGAAAACTACCTTCTGCAACCCAGAAACACAGCCCAGCGTGAGACAGAAAAAGTGCTATGAAAAGGACTGTCCACCCAGGTGGTGGGCCGGAGAGTGGGAAGCATGTTCAATGACATG
TGGGCCGTACGGAGAAAAAAAGAGAACAGTGCTGTGCATCCAGACCATGGGCTCTGATGAGCAGGCTCTCCCAGCTACAGACTGCCAGCACCTGCTGAAGCCCAAGACACTGGTTTCCTGCAACAGAG
ACATTCTGTGTCCATCAGATTGGACAGTAGGCAACTGGAGTGAGTGCTCTGTTTCCTGTGGTGGTGGAGTGCGGATTCGCAGTGTCACATGTGCCAAGAACCTTAATGAACCCTGTGACAAGACACGG
AAACCCAACAGTCGAGCTCTGTGTGGCCTCCAGCAGTGCCCATTCAGCCGTAGAGTTCTGAAACCCAATAAAGATACAGTTCCCAGTGGGAAAAATCCAACAACATCAGAACATGACCACTTCAAGCC
CATCCCAGCATCTACATCCAGGCCCACGCCACTGTCCACACCCACAGTGCCTGAGTCTGTGAGCACAAGTACCCCCACAATCAACAGCCTTGGCTCCACCATAACATCCCAAGAAGAACCAGATGGGA
TAGGATGGCAGAATAATTCAACCCAAGCTGAAGAGGACTCCCACATCCCTACTTCTGTTGGAAGCACTTCCCAGACTCCCCTCACTTCCTGGTCTTGGAGTATGCAGCCTGATGATGAAAACGTTTCC
AGTTCAGCTATAGGTCCAACTTCAGAGAGTGACTTTTGGGCAACCACAAGTGATTCTGGCTTATCATCTAGCAATGCTATGACTTGGCAGGTAACTCCATTTTATAGCACTGCGACCACAGAACCGGA
AGTGGAGATACATAGTGGCTCAGGGGAAGACAGTGACCAGCCTTTGAACAAGGAGGAAAACAACTCTGTGCTATGGAACAAGATCAGAGTACCTGAACGTGATGCTCCCATGGAGATGGATGCAGAAA
TACCACTTGGACCTCCACCAACATCTTATGTGACAGAAGAGTCCTCATGGCCTCCCTTCAGTACAATGATGAAAAGCTCACTACCTGCCTGGTCCTTCAAAAATGAGACACCCAGGGATGAGGGGATG
ATCACTGAAAAATCAGGGAATATTCCACTCCCTCTTGGAGGAGACCACCAGACAACATCCCCAGAGAAGTTAGGAAACAATGACCAACTGGCATCAGCAAATAGTACAAATCCAACCCAAGGCTCTGG
GCCTGTCCTGACTGAGGAAGATGCCTCCACTCTGATTGAGGAGGGATTTTTGCTAAATGCTTCCAATTACAAGCATCTCATGAAGGACCACAGCCCTGCACACTGGATTGTTGGAAATTGGAGTAAAT
GCTCTACCACCTGTGGGCTGGGGGCCTACTGGAGGAGTGTGGAGTGTAGCACCGGGATGAACGCTGACTGCGCCGCCATTCAGAGGCCAGACCCTGCTAAGAAGTGCCACCTGCGCCCCTGTGCTGGC
TGGCGAGTGGGAAACTGGAGCAAGTGCTCTCGAAACTGCAGTGGAGGTTTCAAGATTCGTGAGGTTCAGTGCATGGACGGCGTGGACCATCACCGGAGCCTGAGGCCATTTCACTGTCAGTTCCTGGC
CGGCGTTCCTCCTCCGCTGAGTATGAGCTGTAATCTGGAGCCTTGCGAAGAGTGGAAAGTGGAACCCTGGAGCCAGTGTTCTAGGTCCTGTGGAGGCGGTGTTCAGGAGAGAGGAGTGTTTTGCCCAG
GAGGTCTCTGCGACTGGACAAAAAGACCTGCATCCACTGTGCCCTGCAACAGACACCTTTGCTGTCACTGGGCCACTGGGAACTGGGAACTGTGCACCACTTCCTGTGGTGGTGGCTCTCAGAAGAGG
ACCGTTCATTGCATCCCTTCAGAAAACAGTACAACTGAAGATCAAGACCAGTGTTTCTGTGACCACCAAGCCAGACCCCCAGAATTCCAAAACTGCAACCAGCAAGCCTGCCGGAAGAGTGCTGATTT
AACTTGCACGAAGGACAGACTTTCAACCAGCTTCTGCCAGACACTAAAATCCATGAAGAAGTGCTCGGTGCCATCAGTACGAGTCCAGTGCTGTCTCTCGTGTCCACAGACACAGAGCATCCACACCC
AGAGGCAAAGAAAACAGCAGATGCTCCAAAATCATGACACGCTCTAGGTTCAGAAAGAAGCCACCATCATGGGCTTCCACAGCCTGATACCCAAGAACATGGTCCAGAAGGCCACTTCACTAATATTT
CACTTTGTACATTCTAGGTTCAACTTTGGGTCATAACAAAACAAAACGCAATGTGTGTGTCTAGTCACTAAATGTTTCTCACAGAAAGCTTGGGGCTGGCTGCTCCCCAATAGGAAGACGAAGTATTT
GAGAGAATGATGCTGCAGCAGTTGAGATGAGTTCCTTGGGAAAGTGCCAGATTAGGCAAGTCTGTGAAAATATGTCTTTCCCCCTTTAAAGATGAAAATAGAAACCTGTTTTTTTCCCAAACTACCTC
AAGAAACAGAGACACACTTACCCAGGAAACAGATAATCTTTTAAATTTGTCTTCATGAATATATCCCCCTTAGGTGCCTTGGGTAGCCACTGTTTAAAAGCCATGAGGCAAGTTTTAGGACCATCTAT
CTCAGTAGTCAATAAGGACAGGAAAAAGATGCTAGCTATGGTGCCCTGTCTGTTCTCCATCACTGTAGGACTTCACAACTGGAAACCTAGAATCTTGGGACAAACCATGGAGATTTGAGATTAAGGAG
ACAGGGGCATCAGATGCAGCCTAGGGGCATTAGATTGGCGGTCAAGAAGTCATTTTTTACTTTACTTCAATTTCTATTAAAAGTCCTTAAAATGCAAATGAACAGAATCAACTTCTAGCTAGCATAAG
AAAGAAAATGGTCCTTGTCCCTCAAACTTTACTGGCTTTGTTAGCTTGTCACAGAACAAATGTGTGTTCCTGTCTGCCAGTGCCCTGTCCCTTTCGGAGTCATGACCTCAGGTCTTCCCATCATCCCT
GTGCAGAAAGATTACACACAAACCTGCTACAAGTAGGGTTAGGGCTGTCTGCACACCCTGTTTCTCTCCTGAGAGAAAAAGTGAAGTTATAGGCCAAACCACTTTTAAAAATCAGGTAAATTGTACTA
AGTCTAGGAATTTAGTAGAAATTTATAGTTTAGAAGAAAAAAGTTCTAAAAAGTGTGCCTTAGTGTGTCTATTAGTAACTTTTAAAAGAGATAAAGAGCTGGGGTAGAATGCATATTTATCACAGTTG
TGCAAGGCTGTAAGTTTGGTGTCTAGCAACACACGTGCATGCGTATACACATACACACAGAATCAAAAATGGAGGCTAACTAACCTTATGGAGAGCAAGCAAGTCAAGAGGGTCCAGAACACTGAAAC
AGAAGTGAAATAGAACACTAAAACATGCTTGTTTTAGAATCACCCCGCCTCACTGATGTCAGTAGGCTGTGAGCACAAACGCAGAGCAGATTTCCAGGTGAGCCTGTAGACTGAACCTTGAGTGAAAA
ATGGATGTGTGGAGAGATGCAAGCCCCAGGGAAAGACCCCAGAACCAGCTCTTGACAGGATAGGAGGCAATGTATGTCTTCCGGTGGGACTCAAGGCTTATGCACCAATATGAATCTTCATTCTGGAG
TGCAGTGTCCCTCAGCTCCCTGTAGTTATCTGTCCATTCAGCAGAATGGTGCTATTGAACTTGGTGCTAATATCTAGATGGTGGCAAAGCTAACAGAATGTTAACAAATAGTCATGTGAAAGGCTAGG
TGTCTATGAACTTCCTTATAGACATATGCTTTGTGTGAGATGGTATTGCTGGCCAATGCCAGTTTTATTTGTTCTGAGACCATGAACATAGCATTATATAGGATGCACTTTTAAACTCTTTCAAGACA
CTAGCATGGATTATTCTGATCGATTCCTGTGGAAAGTAAAACACTGGGATTTGGATAAAATTCAAGGTATACCAGAAATAGGAGAAAATACACATTTACTGAAGCCAGGGAATTATGTATAGTTAAGC
ATACATTCTTGCATTCTGTCTTTACATAAACACATTGCTGGCCAATGACAATCTCTGATGAAATAGCTATTTTAGAGAAATGCTTACATTAATCTGTTAGTGGCAGAAATGGAGAAAAAAGTAGAGGA
GAACTTGACCTTCTAATGAGGAATTTTGCAAGGGCTAGTAGTATAGGCTTTCAAAAGTGTTAATTAATAAGCCATGTGTACTGTTCTACAGCAGAATAAAGAACATGACACCAGAGTCCTGGGTATGA
CCAGGCTTACAAAACTCAGGAACAAACTTGGATTTCTACTGACCTCAACAAACTAAAAGTAGGCCAGATTTTCCAGTGCAAAAAAAATAGACCATGTCATTTGGGACCCATGTGGTTGAGCACAACAT
GAGCCTCGGGGGAGAGTCTGGCCAGGTGCTCCATTCTAGATCTTTCTCCATTTTCTTAAGTACAGGAAATAGGTCTCTGATCATGCATCATGGACATCCTCTTCTTCTACCACGGTGAGACTGTCCTA
TGCCATGTGTCATTAGTGTTTGCTGTAGGAGTCATTGGTCAGCTGCTCAGCTGTGGGCTATCAGTGTTTCCATGGATCTTTAATGCTTGAGATGCTGGAAGAACCTTGAATAGCAGGATGACACTGAC
AGCAAGAGCTGGATAGTATCTTCACGGGGTCAAATGTGAAGGCTTGGTTTATTTCATCCATCTCCTCCTTCACATCAACACCTTGAAGGTGTGAACAAGAAGCTCAGCAAGAGACACTAGAGTCGTAC
TCTGAGCCAGACAGATCCACCATGGAGCCTTGTACTTACATTCATCATGTTGGGTTTACATTGCTTTTCAGAGTGATAGACTTAGTTCTTCTCCAAAAAGTTATAAGCTACTTAATTTTAACATCAGA
AAAGTGTTATGCCATAAGAAAACAATATTCCTAGAAACTTTATAGTGAACACTTTGTTCAAGTCATGAATCATGTCCTGTAACAAAGGATTGCTTTCCTTTGCAGGAATAACTATTGAGTCATAGGTC
TTCCTAAACAAGAGCACAGGCACTTTCCTCTGGTCTCCTGAGACAGCATGTCTTCGCTGGCTGTCCAATGCAATGCTCTGAGAGTCTTTTGAGCAACCGCCACCAAGAATCTGAAGCAATTTGAGAGA
TTACATAATTTCAGACCCTAATTTCCCATCCAGTTAGCTGAAGTTCTCTGACAGCTACATATTGCAAACCTAGAAAAGTGCAAAGTCTTAGTTTTCTCCTTTCTCACTTCAAGATGAAGCTCTGGGAC
AGCTTTTCTGGTGCTCAATCCACAGTGATCCACTCTCACAGGCCACATGTCTTGAGTTTCCTGGTGCTATAACCAATCTAATACATTTGATGCTACTCCTGTTGTTAATGCAAGTATTTTTTTTAATT
CAAGTATTTTTTTAAGTTCTGTCACTAAAAATAATGTGATGGGGGAAAATGCATTTCTCCCTACCATTGTCCTCCAAAATAATGGCGTGACATAACATGGCTAACTCATTGTCTCCCCTGTGTTTCTA
TATTGCTGCTTCACCAGCTGATTCCTACACTCCTCCTGTACCCCATTAGTAAGTACCTCAGTATTAAAACCAGATTGTAATCACAGGCTGTCTCTGTGTGGCATCAATAAATGGCCAAACCCA

hide sequence

RefSeq Acc Id:

XM_039101948 ⟹ XP_038957876

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	61,759,975 - 62,025,462 (+)	NCBI
mRatBN7.2	2	60,032,885 - 60,298,374 (+)	NCBI


Protein RefSeqs	NP_001099890	(Get FASTA)	NCBI Sequence Viewer
	XP_038957876	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL82979	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025693
	ENSRNOP00000025693.6

RefSeq Acc Id:	NP_001099890 ⟸ NM_001106420
- Peptide Label:	precursor
- UniProtKB:	D3ZTJ3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPCAQGNWMAKLSMVAQLLNFGAFCHGRQAQPWPVRFPDPKQEHFIKSLPEYHIVSPVQVDASGHFLSYGLHHPVTGSRKKRAAGGSGDQVYYRISHEEKNLFFNLTVNWEFLSNGYVVERRYGNLSH VKMAASSGQPCHLRGTVLQQGPTIRMGTAALSACQGLTGFFHLPHGDFFIEPVKKHPLTEEGYQPHVIYRRQSYRVPETKEPTCGLKDSLDNSVKQELQREKWERKNWPSRSLSRRSISKERWVETLV VADTKMVEYHGSENVESYILTIMNMVTGLFHNPSIGNAVHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLITRKDICAGVNRPCETLGLSQLSGMCQPHRSCNINE DSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSQQIQYDPTPLTWSKCSKEYITRFLDRGRGFCLDDVPRKKGLKSNVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCR SKLDAAADGTRCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGAQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSDTPTFRQMQCSEFDTVPYKNQFYRWFPVFNPAHPCELY CRPIDEQFSERMLEAVIDGTPCFEGGNSRNVCINGICKRVGCDYEIDSNATEDRCGVCLGDGSACQTVKKVFRQKEGSGYIDIGLIPKGARDIRVMEIKAAGNFLAIRSEDPEKYYLNGGFIIQWNGN YKLAGTVFQYDRKGDLERLMAPGPTNESVWLQLLFQVTNPGIKYEYTVRKDGLDNDVEKLLYFWQFGRWTECSVTCGTGIRRQTAHCVKKGHGIVKTTFCNPETQPSVRQKKCYEKDCPPRWWAGEWE ACSMTCGPYGEKKRTVLCIQTMGSDEQALPATDCQHLLKPKTLVSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNLNEPCDKTRKPNSRALCGLQQCPFSRRVLKPNKDTVPSGKNPTTSE HDHFKPIPASTSRPTPLSTPTVPESVSTSTPTINSLGSTITSQEEPDGIGWQNNSTQAEEDSHIPTSVGSTSQTPLTSWSWSMQPDDENVSSSAIGPTSESDFWATTSDSGLSSSNAMTWQVTPFYST ATTEPEVEIHSGSGEDSDQPLNKEENNSVLWNKIRVPERDAPMEMDAEIPLGPPPTSYVTEESSWPPFSTMMKSSLPAWSFKNETPRDEGMITEKSGNIPLPLGGDHQTTSPEKLGNNDQLASANSTN PTQGSGPVLTEEDASTLIEEGFLLNASNYKHLMKDHSPAHWIVGNWSKCSTTCGLGAYWRSVECSTGMNADCAAIQRPDPAKKCHLRPCAGWRVGNWSKCSRNCSGGFKIREVQCMDGVDHHRSLRPF HCQFLAGVPPPLSMSCNLEPCEEWKVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPASTVPCNRHLCCHWATGNWELCTTSCGGGSQKRTVHCIPSENSTTEDQDQCFCDHQARPPEFQNCNQQAC RKSADLTCTKDRLSTSFCQTLKSMKKCSVPSVRVQCCLSCPQTQSIHTQRQRKQQMLQNHDTL hide sequence

Ensembl Acc Id:

ENSRNOP00000025693 ⟸ ENSRNOT00000025693

RefSeq Acc Id:	XP_038957876 ⟸ XM_039101948
- Peptide Label:	isoform X1

Protein Domains

Peptidase M12B PLAC

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZTJ3-F1-model_v2	AlphaFold	D3ZTJ3	1-1599	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13691189

Promoter ID:

EPDNEW_R1714

Type:

initiation region

Name:

Adamts12_1

Description:

ADAM metallopeptidase with thrombospondin type 1 motif, 12

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	61,039,073 - 61,039,133	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-54063	BioCyc
Ensembl Genes	ENSRNOG00000018865	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025693	ENTREZGENE
	ENSRNOT00000025693.8	UniProtKB/TrEMBL
Gene3D-CATH	2.20.100.10	UniProtKB/TrEMBL
	2.60.120.830	UniProtKB/TrEMBL
	3.40.1620.60	UniProtKB/TrEMBL
	3.40.390.10	UniProtKB/TrEMBL
InterPro	ADAM_CR_2	UniProtKB/TrEMBL
	ADAM_spacer1	UniProtKB/TrEMBL
	ADAMTS/ADAMTS-like	UniProtKB/TrEMBL
	ADAMTS_ADAMTS-like	UniProtKB/TrEMBL
	ADAMTS_CR_3	UniProtKB/TrEMBL
	MetalloPept_cat_dom	UniProtKB/TrEMBL
	Peptidase_M12B	UniProtKB/TrEMBL
	Peptidase_M12B_N	UniProtKB/TrEMBL
	PLAC	UniProtKB/TrEMBL
	Thrombospondin_1_rpt	UniProtKB/TrEMBL
	TSP1_rpt_sf	UniProtKB/TrEMBL
KEGG Report	rno:294809	UniProtKB/TrEMBL
NCBI Gene	294809	ENTREZGENE
PANTHER	A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 12	UniProtKB/TrEMBL
	ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE	UniProtKB/TrEMBL
Pfam	ADAM_CR_2	UniProtKB/TrEMBL
	ADAM_CR_3	UniProtKB/TrEMBL
	ADAM_spacer1	UniProtKB/TrEMBL
	Pep_M12B_propep	UniProtKB/TrEMBL
	Reprolysin	UniProtKB/TrEMBL
	TSP1_ADAMTS	UniProtKB/TrEMBL
	TSP_1	UniProtKB/TrEMBL
PhenoGen	Adamts12	PhenoGen
PRINTS	ADAMTSFAMILY	UniProtKB/TrEMBL
PROSITE	ADAM_MEPRO	UniProtKB/TrEMBL
	PLAC	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018865	RatGTEx
SMART	TSP1	UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
UniProt	D3ZTJ3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-18	Adamts12	ADAM metallopeptidase with thrombospondin type 1 motif, 12	Adamts12	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Adamts12	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12	Adamts12_predicted	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Adamts12_predicted	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 (predicted)		a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 (predicted)	Name updated	1299863	APPROVED
2005-01-12	Adamts12_predicted	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Disease Annotations - ClinVar