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Gene: Kcnj1 (potassium inwardly-rectifying channel, subfamily J, member 1) Rattus norvegicus
Symbol: Kcnj1
Name: potassium inwardly-rectifying channel, subfamily J, member 1
Description: Exhibits several functions, including ATP binding activity; ATP-activated inward rectifier potassium channel activity; and potassium ion binding activity. Involved in several processes, including cellular response to magnesium ion; potassium ion transport; and response to potassium ion. Localizes to plasma membrane. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1); PARTICIPATES IN aldosterone signaling pathway; INTERACTS WITH (S)-amphetamine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-regulated potassium channel; ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; inward rectifier K(+) channel Kir1.1; K+ channel protein; KAB-1; Kcnj; Kcnj1_v1; Kcnj1_v3; kir1.1; potassium channel, inwardly rectifying subfamily J member 1; potassium channel, inwardly rectifying subfamily J, member 1; Potassium inwardly-rectifying channel subfamily J; potassium voltage-gated channel subfamily J member 1, variant 1; potassium voltage-gated channel subfamily J member 1, variant 3; ROMK1; ROMK2; ROMK3
Allele / Splice: Kcnj1em1Kasu  
Genetic Models: SS-Kcnj1em1Kasu-/- SS-Kcnj1em1Kasu+/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0833,490,280 - 33,519,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,514,042 - 33,518,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0833,453,597 - 33,454,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4832,158,243 - 32,162,370 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1832,167,008 - 32,171,135 (+)NCBI
Celera832,231,456 - 32,260,138 (+)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Kcnj1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2957
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.