Kcnj1 (potassium inwardly-rectifying channel, subfamily J, member 1) - Rat Genome Database

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Gene: Kcnj1 (potassium inwardly-rectifying channel, subfamily J, member 1) Rattus norvegicus
Analyze
Symbol: Kcnj1
Name: potassium inwardly-rectifying channel, subfamily J, member 1
RGD ID: 2957
Description: Exhibits several functions, including ATP binding activity; ATP-activated inward rectifier potassium channel activity; and potassium ion binding activity. Involved in several processes, including cellular response to magnesium ion; potassium ion transport; and response to potassium ion. Localizes to plasma membrane. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1); PARTICIPATES IN aldosterone signaling pathway; INTERACTS WITH (S)-amphetamine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-regulated potassium channel; ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; inward rectifier K(+) channel Kir1.1; K+ channel protein; KAB-1; Kcnj; Kcnj1_v1; Kcnj1_v3; kir1.1; potassium channel, inwardly rectifying subfamily J member 1; potassium channel, inwardly rectifying subfamily J, member 1; Potassium inwardly-rectifying channel subfamily J; potassium voltage-gated channel subfamily J member 1, variant 1; potassium voltage-gated channel subfamily J member 1, variant 3; ROMK1; ROMK2; ROMK3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcnj1em1Kasu  
Genetic Models: SS-Kcnj1em1Kasu-/- SS-Kcnj1em1Kasu+/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2830,779,883 - 30,808,607 (+)NCBI
Rnor_6.0 Ensembl833,514,042 - 33,518,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0833,490,280 - 33,519,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0833,453,597 - 33,454,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4832,158,243 - 32,162,370 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1832,167,008 - 32,171,135 (+)NCBI
Celera832,231,456 - 32,260,138 (+)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Beesley AH, etal., Am J Physiol 1999 Mar;276(3 Pt 1):C585-92.
2. Boim MA, etal., Am J Physiol. 1995 Jun;268(6 Pt 2):F1132-40.
3. Cao K, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):463-9.
4. Cho JT and Guay-Woodford LM, J Korean Med Sci. 2003 Feb;18(1):65-8.
5. Dong K, etal., J Biol Chem 2001 Nov 23;276(47):44347-53.
6. Dong K, etal., J Biol Chem 2002 Dec 20;277(51):49366-73.
7. Felix JP, etal., Biochemistry. 2006 Aug 22;45(33):10129-39.
8. Fila M, etal., J Physiol. 2011 Jul 15;589(Pt 14):3611-21. doi: 10.1113/jphysiol.2011.209692. Epub 2011 May 23.
9. Foster DB, etal., Circ Res. 2012 Aug 3;111(4):446-54. doi: 10.1161/CIRCRESAHA.112.266445. Epub 2012 Jul 17.
10. Frindt G and Palmer LG, Am J Physiol Renal Physiol. 2010 Oct;299(4):F890-7. doi: 10.1152/ajprenal.00323.2010. Epub 2010 Aug 11.
11. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. GOA data from the GO Consortium
13. Ho K, etal., Nature 1993 Mar 4;362(6415):31-8.
14. Lin DH, etal., Am J Physiol Renal Physiol 2002 Oct;283(4):F671-7.
15. MGD data from the GO Consortium
16. NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline
18. Pipeline to import KEGG annotations from KEGG into RGD
19. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. RGD automated import pipeline for gene-chemical interactions
21. Vanoye CG, etal., J Biol Chem. 2002 Jun 28;277(26):23260-70. doi: 10.1074/jbc.M112004200. Epub 2002 Apr 15.
22. Yang L, etal., J Am Soc Nephrol. 2010 Dec;21(12):2109-16. doi: 10.1681/ASN.2010060617. Epub 2010 Oct 28.
23. Zhou X, etal., Hypertension. 2013 Aug;62(2):288-94. doi: 10.1161/HYPERTENSIONAHA.111.01051. Epub 2013 Jun 10.
Additional References at PubMed
PMID:8166245   PMID:11927600   PMID:12086641   PMID:12122007   PMID:12130653   PMID:12911542   PMID:12952855   PMID:14623317   PMID:14967839   PMID:15075184   PMID:15644319   PMID:15653740  
PMID:15767585   PMID:15775962   PMID:16118216   PMID:16428287   PMID:17003571   PMID:18184875   PMID:18211905   PMID:18391953   PMID:18799551   PMID:19170254   PMID:19202345   PMID:19221509  
PMID:19349416   PMID:19710010   PMID:20458182   PMID:22357918   PMID:23678039   PMID:23874410   PMID:24980796   PMID:28228405   PMID:28252570   PMID:28630040  


Genomics

Comparative Map Data
Kcnj1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2830,779,883 - 30,808,607 (+)NCBI
Rnor_6.0 Ensembl833,514,042 - 33,518,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0833,490,280 - 33,519,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0833,453,597 - 33,454,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4832,158,243 - 32,162,370 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1832,167,008 - 32,171,135 (+)NCBI
Celera832,231,456 - 32,260,138 (+)NCBICelera
Cytogenetic Map8q21NCBI
KCNJ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11128,836,315 - 128,867,373 (-)EnsemblGRCh38hg38GRCh38
GRCh3811128,838,020 - 128,867,296 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711128,707,915 - 128,737,191 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611128,213,125 - 128,242,478 (-)NCBINCBI36hg18NCBI36
Build 3411128,213,124 - 128,242,478NCBI
Celera11125,874,052 - 125,903,407 (-)NCBI
Cytogenetic Map11q24.3NCBI
HuRef11124,655,619 - 124,684,981 (-)NCBIHuRef
CHM1_111128,593,943 - 128,623,302 (-)NCBICHM1_1
Kcnj1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39932,283,714 - 32,310,493 (+)NCBIGRCm39mm39
GRCm39 Ensembl932,283,789 - 32,310,493 (+)Ensembl
GRCm38932,372,418 - 32,399,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl932,372,493 - 32,399,197 (+)EnsemblGRCm38mm10GRCm38
MGSCv37932,180,003 - 32,206,782 (+)NCBIGRCm37mm9NCBIm37
MGSCv36932,143,550 - 32,148,762 (+)NCBImm8
Celera929,635,143 - 29,662,007 (+)NCBICelera
Cytogenetic Map9A4NCBI
Kcnj1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541229,801,022 - 29,829,674 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541229,801,022 - 29,832,153 (-)NCBIChiLan1.0ChiLan1.0
KCNJ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111127,553,327 - 127,582,738 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11127,553,327 - 127,557,860 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011123,649,466 - 123,680,149 (-)NCBIMhudiblu_PPA_v0panPan3
KCNJ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.155,783,242 - 5,813,961 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl55,809,118 - 5,812,794 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha55,843,322 - 5,875,020 (+)NCBI
ROS_Cfam_1.055,743,108 - 5,773,951 (+)NCBI
UMICH_Zoey_3.155,802,733 - 5,834,432 (+)NCBI
UNSW_CanFamBas_1.055,780,635 - 5,811,375 (+)NCBI
UU_Cfam_GSD_1.055,814,725 - 5,846,437 (+)NCBI
Kcnj1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947111,024,514 - 111,054,032 (-)NCBI
SpeTri2.0NW_0049365723,396,329 - 3,425,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl955,780,257 - 55,785,556 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1955,779,020 - 55,812,761 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2961,870,166 - 61,903,920 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11119,971,282 - 120,040,752 (-)NCBI
ChlSab1.1 Ensembl1119,969,370 - 119,986,411 (-)Ensembl
Kcnj1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248123,160,684 - 3,192,323 (-)NCBI

Position Markers
BE100526  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0833,434,142 - 33,434,295NCBIRnor6.0
Rnor_5.0833,451,757 - 33,451,910UniSTSRnor5.0
RGSC_v3.4832,077,188 - 32,077,341UniSTSRGSC3.4
Celera832,176,780 - 32,176,933UniSTS
RH 3.4 Map8244.6UniSTS
Cytogenetic Map8q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8210812847108128Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8210812847108128Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8210812847108128Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8210812847108128Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8736807652368076Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8736807652368076Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8736807652368076Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8873867753738677Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)81038843955388439Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)81038843955388439Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81137326757541668Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81137350945712344Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81137350945712344Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81144825156448251Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81144825156448251Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81766655562666555Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)82071759265717592Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82784149672841496Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82816802350708951Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82986798359908353Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83014480075144800Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)83014480075144800Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)83084545033558764Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)83091811258858224Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)83091811275918112Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83220198154065241Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83220198175971421Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat


Genetic Models
This gene Kcnj1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:511
Count of miRNA genes:219
Interacting mature miRNAs:259
Transcripts:ENSRNOT00000011698, ENSRNOT00000042493, ENSRNOT00000060543
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 29 1
Low 20 1 1 11 1 2 2
Below cutoff 2 16 33 19 8 19 8 8 20 4 16 11 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001309297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001309298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001309299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001309301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S69385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X72341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000081525   ⟹   ENSRNOP00000072157
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl833,514,042 - 33,518,165 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081614   ⟹   ENSRNOP00000070813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl833,514,042 - 33,518,165 (+)Ensembl
RefSeq Acc Id: NM_001309297   ⟹   NP_001296226
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2830,779,883 - 30,808,607 (+)NCBI
Rnor_6.0833,490,306 - 33,519,116 (+)NCBI
Celera832,231,456 - 32,260,138 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001309298   ⟹   NP_001296227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2830,803,533 - 30,808,607 (+)NCBI
Rnor_6.0833,514,042 - 33,519,116 (+)NCBI
Celera832,255,061 - 32,260,138 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001309299   ⟹   NP_001296228
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2830,779,883 - 30,808,607 (+)NCBI
Rnor_6.0833,490,306 - 33,519,116 (+)NCBI
Celera832,231,456 - 32,260,138 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001309301   ⟹   NP_001296230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2830,803,533 - 30,808,607 (+)NCBI
Rnor_6.0833,514,042 - 33,519,116 (+)NCBI
Celera832,255,061 - 32,260,138 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017023   ⟹   NP_058719
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2830,803,533 - 30,808,607 (+)NCBI
Rnor_6.0833,514,042 - 33,519,116 (+)NCBI
Rnor_5.0833,453,597 - 33,454,750 (+)NCBI
RGSC_v3.4832,158,243 - 32,162,370 (+)RGD
Celera832,255,061 - 32,260,138 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766044   ⟹   XP_008764266
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0833,490,280 - 33,519,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766047   ⟹   XP_008764269
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0833,515,210 - 33,519,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595458   ⟹   XP_017450947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0833,490,280 - 33,519,127 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058719   ⟸   NM_017023
- Peptide Label: isoform 1
- UniProtKB: A0A0G2JYW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764266   ⟸   XM_008766044
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008764269   ⟸   XM_008766047
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001296228   ⟸   NM_001309299
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: NP_001296226   ⟸   NM_001309297
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: NP_001296227   ⟸   NM_001309298
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: NP_001296230   ⟸   NM_001309301
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: XP_017450947   ⟸   XM_017595458
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000070813   ⟸   ENSRNOT00000081614
RefSeq Acc Id: ENSRNOP00000072157   ⟸   ENSRNOT00000081525
Protein Domains
IRK   IRK_C

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695837
Promoter ID:EPDNEW_R6355
Type:single initiation site
Name:Kcnj1_1
Description:potassium voltage-gated channel subfamily J member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0833,514,016 - 33,514,076EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2957 AgrOrtholog
Ensembl Genes ENSRNOG00000059005 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070813 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072157 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081525 UniProtKB/TrEMBL
  ENSRNOT00000081614 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir1.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kir_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24521 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11767:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnj1 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS KIRCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYW2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K298_RAT UniProtKB/TrEMBL
  KCNJ1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O88639 UniProtKB/Swiss-Prot
  O88640 UniProtKB/Swiss-Prot
  Q9QUR5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-06 Kcnj1  potassium voltage-gated channel subfamily J member 1  Kcnj1_v3  potassium voltage-gated channel subfamily J member 1, variant 3  Data Merged 737654 PROVISIONAL
2018-09-06 Kcnj1  potassium voltage-gated channel subfamily J member 1  Kcnj1_v1  potassium voltage-gated channel subfamily J member 1, variant 1  Data Merged 737654 PROVISIONAL
2016-02-11 Kcnj1  potassium voltage-gated channel subfamily J member 1  Kcnj1  potassium channel, inwardly rectifying subfamily J, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj1  potassium channel, inwardly rectifying subfamily J, member 1  Kcnj1  potassium inwardly-rectifying channel, subfamily J, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Kcnj1_v3  potassium inwardly-rectifying channel, subfamily J, member 1, variant 3    potassium inwardly-rectifying channel, subfamily J, variant 3  Name updated 1299863 APPROVED
2004-12-14 Kcnj1_v1  potassium inwardly-rectifying channel, subfamily J, member 1, variant 1    potassium inwardly-rectifying channel, subfamily J, variant 1  Name updated 1299863 APPROVED
2001-10-23 Kcnj1  Potassium inwardly-rectifying channel, subfamily J, member 1      Name withdrawn 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two potential membrane-spanning helices and a proposed ATP-binding domain 729173
gene_expression ROMK1 is expressed only in the cortical collecting duct of kidney 70578
gene_expression ROMK3 is expressed only in the thick ascending limb (TAL)of the loop of Henle cells 70578
gene_function ROMK1 associates with Cftr and Abcc9 to form K+ ATP channels 70578
gene_function IRA triplet in the NH2-terminal extensions of ROMK3 may play a role in subunit assembly of the renal secretary KATP channel 70578
gene_function ROMK3 associates with Cftr and Abcc9 to form K-ATP channels 70578
gene_process ROMK1 does not form glibenclamide-sensitive K+ channels when co-expressed with Abcc9, but ROMK2 does 70578
gene_process ROMK1 mediates K(+) secretion into urine 70578
gene_process ROMK3 does not form glibenclamide-sensitive K+ channels when co-expressed with Abcc9, but ROMK2 does 70578
gene_process ROMK3 mediates K(+) secretion into urine 70578
gene_protein amino acids 13-19 ROMK1 are identical to 20-26 in ROMK3 70578
gene_protein ROMK1 shares the core polypeptide of ROMK2 but with distinct NH2-terminal extension of 19 amino acids 70578
gene_protein amino-terminal extension of ROMK1 plays a role in inhibiting subunit assembly with Abcc9 70578
gene_protein ROMK3 amino acids 20-26 in the NH2-terminal extensions are identical to amino acids 13-19 in ROMK1 70578
gene_protein ROMK3 shares the core polypeptide of ROMK2 but with distinct NH2-terminal extensions of 26 amino acids 70578