Gene: Kcnj1 (potassium voltage-gated channel subfamily J member 1) Rattus norvegicus
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Symbol: Kcnj1
Name: potassium voltage-gated channel subfamily J member 1
Description: ENCODES a protein that exhibits ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; peptide binding; INVOLVED IN cellular response to magnesium ion; negative regulation of apoptotic process; potassium ion transport; PARTICIPATES IN aldosterone signaling pathway; ASSOCIATED WITH decreased body weight; decreased circulating bicarbonate level; decreased susceptibility to hypertension; ASSOCIATED WITH nephrotic syndrome; Bartter disease (ortholog); Bartter disease type 2 (ortholog); FOUND IN plasma membrane; INTERACTS WITH (S)-amphetamine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil
AGR Description: Exhibits ATP-activated inward rectifier potassium channel activity, peptide binding activity, and potassium ion binding activity; involved in several processes, including cellular response to magnesium ion, negative regulation of apoptotic process, and potassium ion transport; localizes to the plasma membrane; biomarker of nephrotic syndrome; orthologous to human KCNJ1 (potassium voltage-gated channel subfamily J member 1).
Merged Description: Exhibits ATP-activated inward rectifier potassium channel activity, peptide binding activity, and potassium ion binding activity; involved in several processes, including cellular response to magnesium ion, negative regulation of apoptotic process, and potassium ion transport; localizes to the plasma membrane; biomarker of nephrotic syndrome; orthologous to human KCNJ1 (potassium voltage-gated channel subfamily J member 1); PARTICIPATES IN aldosterone signaling pathway; INTERACTS WITH (S)-amphetamine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-regulated potassium channel; ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; inward rectifier K(+) channel Kir1.1; K+ channel protein; KAB-1; Kcnj; Kcnj1_v1; Kcnj1_v3; kir1.1; potassium channel, inwardly rectifying subfamily J member 1; potassium channel, inwardly rectifying subfamily J, member 1; Potassium inwardly-rectifying channel subfamily J; potassium inwardly-rectifying channel, subfamily J, member 1; potassium voltage-gated channel subfamily J member 1, variant 1; potassium voltage-gated channel subfamily J member 1, variant 3; ROMK1; ROMK2; ROMK3
Orthologs:
Allele / Splice: Kcnj1em1Kasu  
Genetic Models: SS-Kcnj1em1Kasu-/- SS-Kcnj1em1Kasu+/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0833,490,280 - 33,519,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0833,453,597 - 33,454,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4832,158,243 - 32,162,370 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1832,167,008 - 32,171,135 (+)NCBI
Celera832,231,456 - 32,260,138 (+)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

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QTLs in Region (Rnor_6.0)
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Sequence

Nucleotide Sequences
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
RGD Curation Notes
 
More on Kcnj1
Alliance Gene
NCBI Gene
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RGD Object Information
RGD ID: 2957
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.