Syne2 (spectrin repeat containing nuclear envelope protein 2) - Rat Genome Database
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Gene: Syne2 (spectrin repeat containing nuclear envelope protein 2) Rattus norvegicus
Analyze
Symbol: Syne2
Name: spectrin repeat containing nuclear envelope protein 2
RGD ID: 1305248
Description: Predicted to have actin binding activity and cytoskeleton-nuclear membrane anchor activity. Predicted to be involved in several processes, including centrosome localization; fibroblast migration; and nuclear migration. Predicted to colocalize with myofibril. Used to study cryptorchidism. Human ortholog(s) of this gene implicated in autosomal dominant Emery-Dreifuss muscular dystrophy 5. Orthologous to human SYNE2 (spectrin repeat containing nuclear envelope protein 2); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cefaloridine.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC299151; LOC366669; LOW QUALITY PROTEIN: nesprin-2; nesprin 2 long isoform; nesprin-2; RGD1305248; similar to mKIAA1011 protein; similar to nesprin-2; spectrin repeat containing, nuclear envelope 2; synaptic nuclear envelope 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0698,884,269 - 99,153,551 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06108,300,643 - 108,565,625 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,457,147 - 98,601,686 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1698,460,902 - 98,605,226 (+)NCBI
Celera693,001,776 - 93,273,770 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
3-phenylprop-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7beta-aminocephalosporanic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
alpha-pinene  (ISO)
ammonium hexachloroplatinate  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloropicrin  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
coumestrol  (ISO)
DDT  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epichlorohydrin  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
glafenine  (EXP)
glycidol  (EXP)
hexamethylene diisocyanate  (ISO)
hydrogen peroxide  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)

References

Additional References at PubMed
PMID:12118075   PMID:12477932   PMID:15671068   PMID:18396275   PMID:18477613   PMID:18570454   PMID:19596800   PMID:19874786   PMID:20457914   PMID:20724637   PMID:22349700   PMID:25721888  
PMID:26506308  


Genomics

Comparative Map Data
Syne2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0698,884,269 - 99,153,551 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06108,300,643 - 108,565,625 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,457,147 - 98,601,686 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1698,460,902 - 98,605,226 (+)NCBI
Celera693,001,776 - 93,273,770 (+)NCBICelera
Cytogenetic Map6q24NCBI
SYNE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1463,761,899 - 64,226,433 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1463,852,983 - 64,226,433 (+)EnsemblGRCh38hg38GRCh38
GRCh381463,761,904 - 64,226,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371464,319,683 - 64,693,167 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361463,389,436 - 63,762,920 (+)NCBINCBI36hg18NCBI36
Build 341463,612,085 - 63,762,903NCBI
Celera1444,377,022 - 44,750,869 (+)NCBI
Cytogenetic Map14q23.2NCBI
HuRef1444,548,587 - 44,865,749 (+)NCBIHuRef
CHM1_11464,258,594 - 64,632,989 (+)NCBICHM1_1
Syne2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391275,865,092 - 76,157,702 (+)NCBIGRCm39mm39
GRCm381275,818,318 - 76,110,928 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1275,818,134 - 76,110,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv371276,919,305 - 77,211,915 (+)NCBIGRCm37mm9NCBIm37
MGSCv361276,772,909 - 77,029,768 (+)NCBImm8
Celera1276,923,010 - 77,205,661 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.11NCBI
Syne2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554665,646,516 - 5,926,382 (-)NCBIChiLan1.0ChiLan1.0
SYNE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11462,694,928 - 63,064,136 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1462,751,560 - 63,064,136 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01444,438,851 - 44,807,710 (+)NCBIMhudiblu_PPA_v0panPan3
SYNE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl838,373,964 - 38,643,240 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1838,373,900 - 38,643,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Syne2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364957,658,250 - 7,949,417 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYNE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1193,911,965 - 194,264,354 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11193,909,563 - 194,352,550 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,795,839 - 216,243,192 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SYNE2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,054,609 - 41,443,067 (+)NCBI
ChlSab1.1 Ensembl2441,054,621 - 41,443,436 (+)Ensembl
Syne2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473436,832,490 - 37,167,438 (-)NCBI

Position Markers
D6Rat72  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0699,015,382 - 99,015,590NCBIRnor6.0
Rnor_5.06108,431,344 - 108,431,552UniSTSRnor5.0
RGSC_v3.4698,591,094 - 98,591,303RGDRGSC3.4
RGSC_v3.4698,591,095 - 98,591,303UniSTSRGSC3.4
RGSC_v3.1698,594,550 - 98,594,759RGD
Celera693,135,618 - 93,135,828UniSTS
Cytogenetic Map6q24UniSTS
FHH x ACI Map668.04UniSTS
FHH x ACI Map668.04RGD
BI301410  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0699,048,675 - 99,048,828NCBIRnor6.0
Rnor_5.06108,462,531 - 108,462,684UniSTSRnor5.0
Celera693,169,251 - 93,169,404UniSTS
Cytogenetic Map6q24UniSTS
RH 3.4 Map6670.2UniSTS
BF390456  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0699,143,452 - 99,143,639NCBIRnor6.0
Rnor_5.06108,555,526 - 108,555,713UniSTSRnor5.0
Cytogenetic Map6q24UniSTS
RH 3.4 Map6671.1UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)648432758108268790Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)660606431108154445Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)660606431108154445Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)662263348107263348Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)666129520111129520Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)671206251116206251Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)675449871120449871Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)675623277120276465Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)675623277120623277Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)675623277136143011Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)675623277136426962Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)675623393136142742Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)675623393136142742Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)676902247114203334Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)684763275108464097Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)684763275108464097Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)686422697115379601Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)687418448111129520Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)688507712133507712Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)688996335139410483Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)689631358134631358Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)689631358134631358Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)691703409136703409Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (VE) (CMO:0000132)692879510137879510Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)693706176111134673Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)697949772133849286Rat


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_017594540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07064873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07064874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07064875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07064876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07064877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07064878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07064879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07064880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK681779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_017594540   ⟹   XP_017450029
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0698,884,269 - 99,153,551 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017603167   ⟹   XP_017458656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera693,001,776 - 93,273,770 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_017450029 (Get FASTA)   NCBI Sequence Viewer  
  XP_017458656 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98809 (Get FASTA)   NCBI Sequence Viewer  
  EDM03649 (Get FASTA)   NCBI Sequence Viewer  
  QFP98438 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_017458656   ⟸   XM_017603167
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017450029   ⟸   XM_017594540
- Peptide Label: isoform X1
- Sequence:
Protein Domains
Calponin-homology (CH)   KASH


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305248 AgrOrtholog
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  KASH UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
  SYNE2 UniProtKB/TrEMBL
NCBI Gene 366669 ENTREZGENE
PANTHER PTHR14514:SF4 UniProtKB/TrEMBL
Pfam KASH UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PhenoGen Syne2 PhenoGen
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  KASH UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
SMART KASH UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/TrEMBL
UniProt A0A5P8DHK3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 Syne2  spectrin repeat containing nuclear envelope protein 2  Syne2  spectrin repeat containing, nuclear envelope 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-27 Syne2  spectrin repeat containing, nuclear envelope 2  LOC366669  similar to mKIAA1011 protein  Data Merged 737654 APPROVED
2008-11-17 Syne2  spectrin repeat containing, nuclear envelope 2  Syne2  synaptic nuclear envelope 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Syne2  synaptic nuclear envelope 2  RGD1305248_predicted  similar to nesprin-2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC366669  similar to mKIAA1011 protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1305248_predicted  similar to nesprin-2 (predicted)  LOC299151_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC299151_predicted  similar to nesprin-2 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL