Azi2 (5-azacytidine induced 2) - Rat Genome Database

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Gene: Azi2 (5-azacytidine induced 2) Rattus norvegicus
Analyze
Symbol: Azi2
Name: 5-azacytidine induced 2
RGD ID: 1310530
Description: Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including T cell activation; dendritic cell differentiation; and dendritic cell proliferation. Predicted to be active in cytoplasm. Orthologous to human AZI2 (5-azacytidine induced 2); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5-azacytidine induced gene 2; 5-azacytidine-induced protein 2; LOC316051; MGC112644
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88126,651,268 - 126,674,795 (+)NCBIGRCr8
mRatBN7.28117,773,248 - 117,797,844 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8117,773,279 - 117,797,847 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8123,374,021 - 123,397,592 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08121,572,920 - 121,596,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08119,404,200 - 119,427,730 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08126,411,030 - 126,435,581 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8126,411,829 - 126,434,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08125,653,616 - 125,677,500 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48122,961,302 - 122,985,601 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18122,981,038 - 123,005,338 (+)NCBI
Celera8116,962,225 - 116,985,730 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8043507   PMID:10580148   PMID:12477932   PMID:15489334   PMID:23610142   PMID:25691576  


Genomics

Comparative Map Data
Azi2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88126,651,268 - 126,674,795 (+)NCBIGRCr8
mRatBN7.28117,773,248 - 117,797,844 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8117,773,279 - 117,797,847 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8123,374,021 - 123,397,592 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08121,572,920 - 121,596,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08119,404,200 - 119,427,730 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08126,411,030 - 126,435,581 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8126,411,829 - 126,434,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08125,653,616 - 125,677,500 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48122,961,302 - 122,985,601 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18122,981,038 - 123,005,338 (+)NCBI
Celera8116,962,225 - 116,985,730 (+)NCBICelera
Cytogenetic Map8q32NCBI
AZI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38328,321,047 - 28,348,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl328,315,003 - 28,349,050 (-)EnsemblGRCh38hg38GRCh38
GRCh37328,362,538 - 28,390,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36328,339,090 - 28,365,579 (-)NCBINCBI36Build 36hg18NCBI36
Celera328,300,308 - 28,327,081 (-)NCBICelera
Cytogenetic Map3p24.1NCBI
HuRef328,305,512 - 28,332,278 (-)NCBIHuRef
CHM1_1328,313,857 - 28,340,631 (-)NCBICHM1_1
T2T-CHM13v2.0328,323,113 - 28,350,880 (-)NCBIT2T-CHM13v2.0
Azi2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399117,869,510 - 117,898,866 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9117,869,567 - 117,898,862 (+)EnsemblGRCm39 Ensembl
GRCm389118,040,442 - 118,069,798 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9118,040,499 - 118,069,794 (+)EnsemblGRCm38mm10GRCm38
MGSCv379117,949,617 - 117,973,025 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369117,889,390 - 117,912,535 (+)NCBIMGSCv36mm8
Celera9118,515,161 - 118,538,329 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map969.86NCBI
Azi2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543019,802,106 - 19,829,566 (-)NCBIChiLan1.0ChiLan1.0
AZI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2228,271,266 - 28,297,934 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1328,276,033 - 28,302,799 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0328,211,139 - 28,239,073 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1328,534,050 - 28,560,944 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl328,534,050 - 28,560,944 (-)Ensemblpanpan1.1panPan2
AZI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12315,911,663 - 15,947,713 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2315,911,942 - 15,946,265 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2315,906,374 - 15,942,764 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02316,207,283 - 16,243,687 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2316,207,516 - 16,243,696 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12316,032,365 - 16,068,753 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02316,145,790 - 16,182,202 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02316,209,779 - 16,246,190 (+)NCBIUU_Cfam_GSD_1.0
Azi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118186,169,671 - 186,196,177 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647319,309,933 - 19,334,681 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647319,306,809 - 19,334,826 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AZI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1314,757,279 - 14,785,419 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11314,757,281 - 14,785,422 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21316,456,822 - 16,474,657 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AZI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11572,860,482 - 72,883,323 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1572,858,073 - 72,877,516 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604146,053,326 - 46,077,021 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Azi2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247886,183,405 - 6,209,941 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Azi2
125 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:564
Count of miRNA genes:262
Interacting mature miRNAs:325
Transcripts:ENSRNOT00000013450
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
1599689Iddm24Insulin dependent diabetes mellitus QTL 244.720.001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)8112834440118649220Rat

Markers in Region
RH131074  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28117,797,556 - 117,797,742 (+)MAPPERmRatBN7.2
Rnor_6.08126,435,294 - 126,435,479NCBIRnor6.0
Rnor_5.08125,677,709 - 125,677,894UniSTSRnor5.0
RGSC_v3.48122,986,315 - 122,986,500UniSTSRGSC3.4
Celera8116,986,444 - 116,986,629UniSTS
RH 3.4 Map81296.4UniSTS
Cytogenetic Map8q32UniSTS
RH125933  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28117,797,521 - 117,797,771 (+)MAPPERmRatBN7.2
Rnor_6.08126,435,259 - 126,435,508NCBIRnor6.0
Rnor_5.08125,677,674 - 125,677,923UniSTSRnor5.0
RGSC_v3.48122,986,280 - 122,986,529UniSTSRGSC3.4
Celera8116,986,409 - 116,986,658UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000013450   ⟹   ENSRNOP00000013449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8117,773,279 - 117,797,847 (+)Ensembl
Rnor_6.0 Ensembl8126,411,829 - 126,434,579 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092142   ⟹   ENSRNOP00000074198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8126,414,220 - 126,434,361 (+)Ensembl
RefSeq Acc Id: NM_001025705   ⟹   NP_001020876
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88126,651,268 - 126,674,795 (+)NCBI
mRatBN7.28117,773,313 - 117,796,843 (+)NCBI
Rnor_6.08126,411,829 - 126,434,580 (+)NCBI
Rnor_5.08125,653,616 - 125,677,500 (+)NCBI
RGSC_v3.48122,961,302 - 122,985,601 (+)RGD
Celera8116,962,225 - 116,985,730 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244032   ⟹   XP_006244094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88126,651,491 - 126,674,795 (+)NCBI
mRatBN7.28117,773,248 - 117,797,844 (+)NCBI
Rnor_6.08126,411,030 - 126,435,581 (+)NCBI
Rnor_5.08125,653,616 - 125,677,500 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063265650   ⟹   XP_063121720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88126,651,625 - 126,674,795 (+)NCBI
RefSeq Acc Id: NP_001020876   ⟸   NM_001025705
- UniProtKB: Q4KMA0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006244094   ⟸   XM_006244032
- Peptide Label: isoform X1
- UniProtKB: F1LQL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074198   ⟸   ENSRNOT00000092142
RefSeq Acc Id: ENSRNOP00000013449   ⟸   ENSRNOT00000013450
RefSeq Acc Id: XP_063121720   ⟸   XM_063265650
- Peptide Label: isoform X1
- UniProtKB: F1LQL4 (UniProtKB/TrEMBL)
Protein Domains
Tbk1/Ikki binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KMA0-F1-model_v2 AlphaFold Q4KMA0 1-404 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696360
Promoter ID:EPDNEW_R6885
Type:initiation region
Name:Azi2_1
Description:5-azacytidine induced 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08126,411,782 - 126,411,842EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310530 AgrOrtholog
BioCyc Gene G2FUF-28831 BioCyc
Ensembl Genes ENSRNOG00000010096 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013450.8 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7384893 IMAGE-MGC_LOAD
InterPro TBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:316051 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112644 IMAGE-MGC_LOAD
NCBI Gene 316051 ENTREZGENE
PANTHER 5-AZACYTIDINE-INDUCED PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROSAPIP2 PROTEIN/5-AZACYTIDINE INDUCED GENE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Azi2 PhenoGen
RatGTEx ENSRNOG00000010096 RatGTEx
UniProt A6I3T4_RAT UniProtKB/TrEMBL
  A6I3T5_RAT UniProtKB/TrEMBL
  A6I3T6_RAT UniProtKB/TrEMBL
  AZI2_RAT UniProtKB/Swiss-Prot
  F1LQL4 ENTREZGENE, UniProtKB/TrEMBL
  Q4KMA0 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Azi2  5-azacytidine induced 2  Azi2  5-azacytidine induced gene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Azi2  5-azacytidine induced gene 2  Azi2_predicted  5-azacytidine induced gene 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Azi2_predicted  5-azacytidine induced gene 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED