Clk2 (CDC-like kinase 2) - Rat Genome Database

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Gene: Clk2 (CDC-like kinase 2) Rattus norvegicus
Analyze
Symbol: Clk2 (Ensembl: Scamp3)
Name: CDC-like kinase 2 (Ensembl:secretory carrier membrane protein 3)
RGD ID: 1359711
Description: Predicted to enable identical protein binding activity; protein serine/threonine kinase activity; and protein tyrosine kinase activity. Predicted to be involved in negative regulation of gluconeogenesis; regulation of RNA splicing; and response to ionizing radiation. Predicted to act upstream of or within response to retinoic acid. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to human CLK2 (CDC like kinase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dual specificity protein kinase CLK2; LOC365842; similar to CDC-like kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,868,423 - 176,880,412 (+)NCBIGRCr8
mRatBN7.22174,570,614 - 174,582,645 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,570,653 - 174,588,985 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,716,677 - 181,728,614 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,739,050 - 179,750,987 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,338,924 - 174,350,859 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,476,789 - 188,488,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,476,820 - 188,496,191 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,895,502 - 207,905,134 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,244,665 - 181,257,364 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,199,649 - 181,207,469 (+)NCBI
Celera2168,513,358 - 168,525,076 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9307018   PMID:9637771   PMID:9852100   PMID:10480872   PMID:18400104   PMID:20074525   PMID:20682768   PMID:25416956   PMID:28289210  


Genomics

Comparative Map Data
Clk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,868,423 - 176,880,412 (+)NCBIGRCr8
mRatBN7.22174,570,614 - 174,582,645 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,570,653 - 174,588,985 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,716,677 - 181,728,614 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,739,050 - 179,750,987 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,338,924 - 174,350,859 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,476,789 - 188,488,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,476,820 - 188,496,191 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,895,502 - 207,905,134 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,244,665 - 181,257,364 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,199,649 - 181,207,469 (+)NCBI
Celera2168,513,358 - 168,525,076 (+)NCBICelera
Cytogenetic Map2q34NCBI
CLK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,262,868 - 155,273,504 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,262,868 - 155,278,491 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,232,659 - 155,243,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,499,283 - 153,509,905 (-)NCBINCBI36Build 36hg18NCBI36
Build 341152,045,732 - 152,056,354NCBI
Celera1128,305,910 - 128,316,453 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,594,941 - 126,605,589 (-)NCBIHuRef
CHM1_11156,628,098 - 156,638,722 (-)NCBICHM1_1
T2T-CHM13v2.01154,401,428 - 154,412,064 (-)NCBIT2T-CHM13v2.0
Clk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,072,102 - 89,084,394 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,072,102 - 89,084,228 (+)EnsemblGRCm39 Ensembl
GRCm38389,164,795 - 89,177,087 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,164,795 - 89,176,921 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,968,727 - 88,981,009 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,251,010 - 89,262,516 (+)NCBIMGSCv36mm8
Celera389,198,450 - 89,210,762 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.01NCBI
Clk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,716,294 - 1,725,185 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,716,294 - 1,727,187 (-)NCBIChiLan1.0ChiLan1.0
CLK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,570,716 - 94,581,130 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,301,873 - 94,312,460 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,607,877 - 130,618,461 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,213,237 - 134,223,842 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,213,237 - 134,221,288 (-)Ensemblpanpan1.1panPan2
CLK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,284,869 - 42,294,434 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,284,699 - 42,294,394 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,775,618 - 41,785,257 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,153,896 - 42,163,570 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,154,826 - 42,163,523 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,933,749 - 41,943,406 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,987,720 - 41,997,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,271,531 - 42,281,194 (+)NCBIUU_Cfam_GSD_1.0
Clk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,715,900 - 25,727,832 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,746,276 - 4,756,230 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,746,276 - 4,758,236 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,560,579 - 94,570,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,558,220 - 94,570,084 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,340,518 - 103,352,217 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,562,334 - 8,578,880 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660387,903,697 - 7,914,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,284,953 - 2,296,735 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,285,116 - 2,295,959 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Clk2
50 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:231
Count of miRNA genes:159
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000027793
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2174543008175950118Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
AU041688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,582,333 - 174,582,490 (+)MAPPERmRatBN7.2
Rnor_6.02188,488,498 - 188,488,654NCBIRnor6.0
Rnor_5.02207,904,823 - 207,904,979UniSTSRnor5.0
RGSC_v3.42181,257,053 - 181,257,209UniSTSRGSC3.4
Celera2168,524,765 - 168,524,921UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 53 37 19 37 1 4 74 35 41 11 1
Low 8 4 4 4 7 7 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001014254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010063630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000027793   ⟹   ENSRNOP00000027793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,570,653 - 174,588,979 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000027815   ⟹   ENSRNOP00000027815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,583,198 - 174,588,982 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085817   ⟹   ENSRNOP00000073519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,570,934 - 174,582,644 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111900   ⟹   ENSRNOP00000084600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,583,199 - 174,588,985 (+)Ensembl
RefSeq Acc Id: NM_001014254   ⟹   NP_001014276
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,423 - 176,880,412 (+)NCBI
mRatBN7.22174,570,652 - 174,582,645 (+)NCBI
Rnor_6.02188,476,820 - 188,488,809 (+)NCBI
Rnor_5.02207,895,502 - 207,905,134 (+)NCBI
RGSC_v3.42181,244,665 - 181,257,364 (+)RGD
Celera2168,513,358 - 168,525,076 (+)RGD
Sequence:
RefSeq Acc Id: XM_008761186   ⟹   XP_008759408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,550 - 176,880,412 (+)NCBI
mRatBN7.22174,570,619 - 174,582,645 (+)NCBI
Rnor_6.02188,476,909 - 188,488,809 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761187   ⟹   XP_008759409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,550 - 176,880,412 (+)NCBI
mRatBN7.22174,570,619 - 174,582,645 (+)NCBI
Rnor_6.02188,478,334 - 188,488,809 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761189   ⟹   XP_008759411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,550 - 176,880,412 (+)NCBI
mRatBN7.22174,570,620 - 174,582,645 (+)NCBI
Rnor_6.02188,478,338 - 188,488,809 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761190   ⟹   XP_008759412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,550 - 176,880,412 (+)NCBI
mRatBN7.22174,570,620 - 174,582,645 (+)NCBI
Rnor_6.02188,478,336 - 188,488,809 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761191   ⟹   XP_008759413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,550 - 176,880,412 (+)NCBI
mRatBN7.22174,570,619 - 174,582,645 (+)NCBI
Rnor_6.02188,478,335 - 188,488,809 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761192   ⟹   XP_008759414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,556 - 176,880,412 (+)NCBI
mRatBN7.22174,570,620 - 174,582,645 (+)NCBI
Rnor_6.02188,476,789 - 188,488,809 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102762   ⟹   XP_038958690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,550 - 176,880,412 (+)NCBI
mRatBN7.22174,570,620 - 174,582,645 (+)NCBI
RefSeq Acc Id: XM_063282256   ⟹   XP_063138326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,556 - 176,880,412 (+)NCBI
RefSeq Acc Id: XM_063282257   ⟹   XP_063138327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,556 - 176,880,412 (+)NCBI
RefSeq Acc Id: XR_010063630
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,868,550 - 176,878,774 (+)NCBI
RefSeq Acc Id: NP_001014276   ⟸   NM_001014254
- UniProtKB: Q5XI98 (UniProtKB/TrEMBL),   F1LNQ0 (UniProtKB/TrEMBL),   A0A0G2K5Q8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759414   ⟸   XM_008761192
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_008759408   ⟸   XM_008761186
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008759409   ⟸   XM_008761187
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008759411   ⟸   XM_008761189
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008759412   ⟸   XM_008761190
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008759413   ⟸   XM_008761191
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_038958690   ⟸   XM_039102762
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000084600   ⟸   ENSRNOT00000111900
RefSeq Acc Id: ENSRNOP00000027815   ⟸   ENSRNOT00000027815
RefSeq Acc Id: ENSRNOP00000073519   ⟸   ENSRNOT00000085817
RefSeq Acc Id: ENSRNOP00000027793   ⟸   ENSRNOT00000027793
RefSeq Acc Id: XP_063138326   ⟸   XM_063282256
- Peptide Label: isoform X8
- UniProtKB: A6J6C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138327   ⟸   XM_063282257
- Peptide Label: isoform X9
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5Q8-F1-model_v2 AlphaFold A0A0G2K5Q8 1-799 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691458
Promoter ID:EPDNEW_R1983
Type:initiation region
Name:Scamp3_2
Description:secretory carrier membrane protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1984  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,476,786 - 188,476,846EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359711 AgrOrtholog
BioCyc Gene G2FUF-52450 BioCyc
Ensembl Genes ENSRNOG00000020500 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027793.7 UniProtKB/TrEMBL
  ENSRNOT00000085817 ENTREZGENE
  ENSRNOT00000085817.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7098251 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SCAMP UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:365842 UniProtKB/TrEMBL
MGC_CLONE MGC:94769 IMAGE-MGC_LOAD
NCBI Gene 365842 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE CLK2 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE DOA-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  SCAMP UniProtKB/TrEMBL
PhenoGen Clk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020500 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2K5Q8 ENTREZGENE
  A0A8J8YHW4_RAT UniProtKB/TrEMBL
  A6J6C3 ENTREZGENE, UniProtKB/TrEMBL
  F1LNQ0 ENTREZGENE
  Q5XI98 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2K5Q8 UniProtKB/TrEMBL
  F1LNQ0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Clk2  CDC-like kinase 2  LOC365842  similar to CDC-like kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC365842  similar to CDC-like kinase 2      Symbol and Name status set to provisional 70820 PROVISIONAL