Mcfd2 (multiple coagulation factor deficiency 2, ER cargo receptor complex subunit) - Rat Genome Database

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Gene: Mcfd2 (multiple coagulation factor deficiency 2, ER cargo receptor complex subunit) Rattus norvegicus
Analyze
Symbol: Mcfd2
Name: multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
RGD ID: 628690
Description: Predicted to enable calcium ion binding activity. Acts upstream of or within carboxylic acid metabolic process. Located in extracellular region. Biomarker of transient cerebral ischemia. Orthologous to human MCFD2 (multiple coagulation factor deficiency 2, ER cargo receptor complex subunit); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: multiple coagulation factor deficiency 2; multiple coagulation factor deficiency protein 2 homolog; neural stem cell-derived neuronal survival protein; Sdnsf; stem cell derived neuronal survival protein; stem cell derived neuronal survival protein precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,028,036 - 13,039,388 (+)NCBIGRCr8
mRatBN7.267,274,469 - 7,285,841 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,274,469 - 7,285,841 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx67,555,619 - 7,566,928 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,865,043 - 7,876,352 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,392,168 - 7,403,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0610,887,303 - 10,899,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,887,288 - 10,899,200 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0620,875,389 - 20,887,306 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,763,516 - 10,774,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1610,763,515 - 10,774,854 (-)NCBI
Celera67,023,091 - 7,034,429 (+)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
gentamycin  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
ozone  (ISO)
paracetamol  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mutations in the MCFD2 gene are predominant among patients with hereditary combined FV and FVIII deficiency (F5F8D) in India. Jayandharan G, etal., Haemophilia. 2007 Jul;13(4):413-9.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells. Toda H, etal., J Biol Chem 2003 Sep 12;278(37):35491-500.
Additional References at PubMed
PMID:17612595  


Genomics

Comparative Map Data
Mcfd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,028,036 - 13,039,388 (+)NCBIGRCr8
mRatBN7.267,274,469 - 7,285,841 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,274,469 - 7,285,841 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx67,555,619 - 7,566,928 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,865,043 - 7,876,352 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,392,168 - 7,403,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0610,887,303 - 10,899,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,887,288 - 10,899,200 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0620,875,389 - 20,887,306 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,763,516 - 10,774,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1610,763,515 - 10,774,854 (-)NCBI
Celera67,023,091 - 7,034,429 (+)NCBICelera
Cytogenetic Map6q12NCBI
MCFD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38246,901,870 - 46,941,855 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl246,901,870 - 46,941,855 (-)EnsemblGRCh38hg38GRCh38
GRCh37247,129,009 - 47,168,994 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36246,982,517 - 46,996,453 (-)NCBINCBI36Build 36hg18NCBI36
Build 34247,040,667 - 47,054,600NCBI
Celera246,967,630 - 47,007,856 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef246,866,270 - 46,906,310 (-)NCBIHuRef
CHM1_1247,059,303 - 47,099,278 (-)NCBICHM1_1
T2T-CHM13v2.0246,906,646 - 46,946,631 (-)NCBIT2T-CHM13v2.0
Mcfd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,561,871 - 87,573,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,561,871 - 87,573,363 (-)EnsemblGRCm39 Ensembl
GRCm381787,254,443 - 87,265,947 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,254,443 - 87,265,935 (-)EnsemblGRCm38mm10GRCm38
MGSCv371787,653,783 - 87,665,287 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361787,162,769 - 87,174,241 (-)NCBIMGSCv36mm8
Celera1791,645,568 - 91,657,364 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.06NCBI
Mcfd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544113,764,144 - 13,777,628 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544113,766,683 - 13,776,305 (-)NCBIChiLan1.0ChiLan1.0
MCFD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21279,473,963 - 79,488,153 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A79,477,946 - 79,492,124 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A47,012,550 - 47,031,725 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A47,950,679 - 47,962,005 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A47,950,679 - 47,987,407 (-)Ensemblpanpan1.1panPan2
MCFD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,091,466 - 49,101,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,092,908 - 49,101,775 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1048,944,989 - 48,955,352 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01049,961,866 - 49,972,101 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1049,961,874 - 50,001,189 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11049,669,845 - 49,680,077 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01049,959,594 - 49,969,896 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01050,143,441 - 50,153,684 (-)NCBIUU_Cfam_GSD_1.0
Mcfd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,963,670 - 33,991,418 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365085,410,674 - 5,420,012 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365085,392,275 - 5,419,267 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCFD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,620,936 - 93,633,015 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1393,620,921 - 93,633,018 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,712,888 - 99,719,379 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCFD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,273,274 - 60,283,919 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1460,273,296 - 60,287,200 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604551,560,975 - 51,572,057 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcfd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473828,324,894 - 28,337,730 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473828,325,154 - 28,333,241 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcfd2
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:97
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000020328
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat

Markers in Region
RH128627  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X119,708,403 - 119,708,611 (-)MAPPERmRatBN7.2
mRatBN7.267,285,551 - 7,285,759 (-)MAPPERmRatBN7.2
mRatBN7.267,285,551 - 7,285,759 (+)MAPPERmRatBN7.2
mRatBN7.2X119,708,403 - 119,708,611 (+)MAPPERmRatBN7.2
Rnor_6.0610,887,385 - 10,887,592NCBIRnor6.0
Rnor_6.0X127,036,271 - 127,036,478NCBIRnor6.0
Rnor_5.0620,875,471 - 20,875,678UniSTSRnor5.0
Rnor_5.0X127,131,618 - 127,131,825UniSTSRnor5.0
RGSC_v3.4X4,288,794 - 4,289,001UniSTSRGSC3.4
RGSC_v3.4610,763,598 - 10,763,805UniSTSRGSC3.4
Celera67,034,140 - 7,034,347UniSTS
CeleraX118,844,147 - 118,844,354UniSTS
Cytogenetic Map6q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000020328   ⟹   ENSRNOP00000020328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl610,889,069 - 10,891,146 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089104   ⟹   ENSRNOP00000069872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl67,274,469 - 7,285,841 (+)Ensembl
Rnor_6.0 Ensembl610,887,288 - 10,899,200 (-)Ensembl
RefSeq Acc Id: NM_139253   ⟹   NP_640346
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8613,028,050 - 13,039,388 (+)NCBI
mRatBN7.267,274,502 - 7,285,841 (+)NCBI
Rnor_6.0610,887,303 - 10,899,183 (-)NCBI
Rnor_5.0620,875,389 - 20,887,306 (-)NCBI
RGSC_v3.4610,763,516 - 10,774,854 (-)RGD
Celera67,023,091 - 7,034,429 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239711   ⟹   XP_006239773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8613,028,036 - 13,039,388 (+)NCBI
mRatBN7.267,274,469 - 7,285,841 (+)NCBI
Rnor_6.0610,888,768 - 10,899,202 (-)NCBI
Rnor_5.0620,875,389 - 20,887,306 (-)NCBI
Sequence:
RefSeq Acc Id: NP_640346   ⟸   NM_139253
- Peptide Label: precursor
- UniProtKB: Q8K5B3 (UniProtKB/Swiss-Prot),   Q6GQY2 (UniProtKB/TrEMBL),   A0A0G2JWG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239773   ⟸   XM_006239711
- Peptide Label: isoform X1
- UniProtKB: Q8K5B3 (UniProtKB/Swiss-Prot),   Q6GQY2 (UniProtKB/TrEMBL),   A0A0G2JWG5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069872   ⟸   ENSRNOT00000089104
Ensembl Acc Id: ENSRNOP00000020328   ⟸   ENSRNOT00000020328
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K5B3-F1-model_v2 AlphaFold Q8K5B3 1-145 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694392
Promoter ID:EPDNEW_R4917
Type:multiple initiation site
Name:Mcfd2_1
Description:multiple coagulation factor deficiency 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0610,899,160 - 10,899,220EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628690 AgrOrtholog
BioCyc Gene G2FUF-38717 BioCyc
Ensembl Genes ENSRNOG00000015059 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089104.2 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100216 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ER-Golgi_Adhesion_Reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91471 IMAGE-MGC_LOAD
NCBI Gene 246117 ENTREZGENE
PANTHER MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mcfd2 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015059 RatGTEx
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWG5 ENTREZGENE, UniProtKB/TrEMBL
  A6H9D9_RAT UniProtKB/TrEMBL
  A6H9E3_RAT UniProtKB/TrEMBL
  MCFD2_RAT UniProtKB/Swiss-Prot
  Q6GQY2 ENTREZGENE, UniProtKB/TrEMBL
  Q8K5B3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-19 Mcfd2  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit  Mcfd2  multiple coagulation factor deficiency 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-04-25 Mcfd2  multiple coagulation factor deficiency 2  Mcfd2  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit  Name changed 629549 APPROVED
2019-11-11 Mcfd2  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit  Mcfd2  multiple coagulation factor deficiency 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Mcfd2  multiple coagulation factor deficiency 2  Sdnsf  stem cell derived neuronal survival protein precursor  Symbol and Name updated 1299863 APPROVED
2003-02-27 Sdnsf  stem cell derived neuronal survival protein precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is upregulated by induced neurogenesis status seen in ischemically treated hippocampus 724668