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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of WDR6 mRNA] | CTD | PMID:31150632 | 1,2-dichloroethane | decreases expression | ISO | RGD:1316963 | 6480464 | ethylene dichloride results in decreased expression of WDR6 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | RGD:1316963 | 6480464 | 1, 2-Dimethylhydrazine results in increased expression of WDR6 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:1316963 | 6480464 | Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of WDR6 mRNA] | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | RGD:1316962 | 6480464 | Estradiol results in increased expression of WDR6 mRNA | CTD | PMID:19167446 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1316963 | 6480464 | Tetrachlorodibenzodioxin affects the expression of WDR6 mRNA | CTD | PMID:21570461, PMID:24680724 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of WDR6 mRNA | CTD | PMID:33387578 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 4-dinitrotoluene affects the expression of WDR6 mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | RGD:1316962 | 6480464 | beta-methylcholine affects the expression of WDR6 mRNA | CTD | PMID:21179406 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | RGD:1316963 | 6480464 | tetrabromobisphenol A results in decreased expression of WDR6 mRNA | CTD | PMID:25172293 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of WDR6 protein | CTD | PMID:34915118 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of WDR6 mRNA | CTD | PMID:24780913 | acrolein | multiple interactions | ISO | RGD:1316962 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of WDR6 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of WDR6 mRNA | CTD | PMID:32699268 | alpha-pinene | multiple interactions | ISO | RGD:1316962 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of WDR6 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of WDR6 mRNA | CTD | PMID:32699268 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of WDR6 mRNA | CTD | PMID:30779732 | arsane | affects methylation | ISO | RGD:1316962 | 6480464 | Arsenic affects the methylation of WDR6 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RGD:1316962 | 6480464 | Arsenic affects the methylation of WDR6 gene | CTD | PMID:25304211 | benzo[a]pyrene | decreases expression | ISO | RGD:1316962 | 6480464 | Benzo(a)pyrene results in decreased expression of WDR6 mRNA | CTD | PMID:20498004 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of WDR6 mRNA | CTD | PMID:25181051, PMID:30903817 | bisphenol A | increases expression | ISO | RGD:1316963 | 6480464 | bisphenol A results in increased expression of WDR6 mRNA | CTD | PMID:33221593 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of WDR6 mRNA | CTD | PMID:30816183, PMID:34947998 | butanal | decreases expression | ISO | RGD:1316962 | 6480464 | butyraldehyde results in decreased expression of WDR6 mRNA | CTD | PMID:26079696 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of WDR6 mRNA | CTD | PMID:19167457 | cadmium atom | multiple interactions | ISO | RGD:1316962 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of WDR6 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | RGD:1316962 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of WDR6 mRNA | CTD | PMID:35301059 | carbamazepine | affects expression | ISO | RGD:1316962 | 6480464 | Carbamazepine affects the expression of WDR6 mRNA | CTD | PMID:25979313 | carbon nanotube | decreases expression | ISO | RGD:1316963 | 6480464 | Nanotubes, Carbon results in decreased expression of WDR6 mRNA | CTD | PMID:25620056 | CGP 52608 | multiple interactions | ISO | RGD:1316962 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to WDR6 gene] | CTD | PMID:28238834 | chloropicrin | affects expression | ISO | RGD:1316962 | 6480464 | chloropicrin affects the expression of WDR6 mRNA | CTD | PMID:26352163 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of WDR6 mRNA | CTD | PMID:17602206 | cobalt dichloride | decreases expression | ISO | RGD:1316962 | 6480464 | cobaltous chloride results in decreased expression of WDR6 mRNA | CTD | PMID:19320972 | copper(II) sulfate | decreases expression | ISO | RGD:1316962 | 6480464 | Copper Sulfate results in decreased expression of WDR6 mRNA | CTD | PMID:19549813 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of WDR6 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | RGD:1316963 | 6480464 | Cyclosporine results in decreased expression of WDR6 mRNA | CTD | PMID:19770486 | diazinon | increases methylation | ISO | RGD:1316962 | 6480464 | Diazinon results in increased methylation of WDR6 gene | CTD | PMID:22964155 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of WDR6 mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:1316963 | 6480464 | Dibutyl Phthalate results in decreased expression of WDR6 mRNA | CTD | PMID:21266533 | diethyl maleate | decreases expression | EXP | | 6480464 | diethyl maleate results in decreased expression of WDR6 mRNA | CTD | PMID:21161181 | dioxygen | multiple interactions | ISO | RGD:1316963 | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of WDR6 mRNA | CTD | PMID:30529165 | disodium selenite | increases expression | ISO | RGD:1316962 | 6480464 | Sodium Selenite results in increased expression of WDR6 mRNA | CTD | PMID:18175754 | elemental selenium | increases expression | ISO | RGD:1316962 | 6480464 | Selenium results in increased expression of WDR6 mRNA | CTD | PMID:19244175 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of WDR6 mRNA | CTD | PMID:29391264 | ethanol | affects splicing | ISO | RGD:1316963 | 6480464 | Ethanol affects the splicing of WDR6 mRNA | CTD | PMID:30319688 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of WDR6 mRNA | CTD | PMID:24136188 | folic acid | increases expression | ISO | RGD:1316963 | 6480464 | Folic Acid results in increased expression of WDR6 mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | RGD:1316963 | 6480464 | Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of WDR6 mRNA] | CTD | PMID:22206623 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of WDR6 mRNA | CTD | PMID:33387578 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of WDR6 mRNA | CTD | PMID:24136188 | ivermectin | decreases expression | ISO | RGD:1316962 | 6480464 | Ivermectin results in decreased expression of WDR6 protein | CTD | PMID:32959892 | leflunomide | decreases expression | ISO | RGD:1316962 | 6480464 | leflunomide results in decreased expression of WDR6 mRNA | CTD | PMID:28988120 | methidathion | increases expression | ISO | RGD:1316963 | 6480464 | methidathion results in increased expression of WDR6 mRNA | CTD | PMID:34813904 | miconazole | increases expression | ISO | RGD:1316963 | 6480464 | Miconazole results in increased expression of WDR6 mRNA | CTD | PMID:27462272 | mono(2-ethylhexyl) phthalate | affects expression | ISO | RGD:1316963 | 6480464 | mono-(2-ethylhexyl)phthalate affects the expression of WDR6 mRNA | CTD | PMID:21195148 | Monobutylphthalate | affects expression | ISO | RGD:1316963 | 6480464 | monobutyl phthalate affects the expression of WDR6 mRNA | CTD | PMID:21195148 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:1316963 | 6480464 | Ethylnitrosourea results in increased mutagenesis of WDR6 gene | CTD | PMID:27776689 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of WDR6 mRNA | CTD | PMID:17602206 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:1316963 | 6480464 | [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of WDR6 gene | CTD | PMID:23968726 | ozone | multiple interactions | ISO | RGD:1316962 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of WDR6 mRNA more ... | CTD | PMID:32699268 | p-toluidine | increases expression | EXP | | 6480464 | 4-toluidine results in increased expression of WDR6 mRNA | CTD | PMID:27638505 | paracetamol | decreases expression | ISO | RGD:1316962 | 6480464 | Acetaminophen results in decreased expression of WDR6 mRNA | CTD | PMID:21420995 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of WDR6 mRNA | CTD | PMID:33387578 | piperonyl butoxide | multiple interactions | ISO | RGD:1316963 | 6480464 | [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of WDR6 gene | CTD | PMID:23968726 | pirinixic acid | decreases expression | ISO | RGD:1316963 | 6480464 | pirinixic acid results in decreased expression of WDR6 mRNA | CTD | PMID:17426115 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of WDR6 mRNA | CTD | PMID:19013527, PMID:28374803 | selenium atom | increases expression | ISO | RGD:1316962 | 6480464 | Selenium results in increased expression of WDR6 mRNA | CTD | PMID:19244175 | sodium arsenite | multiple interactions | ISO | RGD:1316962 | 6480464 | sodium arsenite promotes the reaction [WDR6 protein binds to CAPRIN1 protein] | CTD | PMID:33939924 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of WDR6 mRNA | CTD | PMID:31150632 | tetrachloromethane | decreases expression | ISO | RGD:1316963 | 6480464 | Carbon Tetrachloride results in decreased expression of WDR6 mRNA | CTD | PMID:31919559 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of WDR6 mRNA] | CTD | PMID:31150632 | tetrachloromethane | affects expression | ISO | RGD:1316963 | 6480464 | Carbon Tetrachloride affects the expression of WDR6 mRNA | CTD | PMID:17484886 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of WDR6 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | RGD:1316963 | 6480464 | titanium dioxide results in increased expression of WDR6 mRNA | CTD | PMID:29264374 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of WDR6 mRNA | CTD | PMID:33387578 | troglitazone | increases expression | ISO | RGD:1316963 | 6480464 | troglitazone results in increased expression of WDR6 mRNA | CTD | PMID:28973697 | urethane | decreases expression | ISO | RGD:1316962 | 6480464 | Urethane results in decreased expression of WDR6 mRNA | CTD | PMID:28818685 | valdecoxib | decreases expression | EXP | | 6480464 | valdecoxib results in decreased expression of WDR6 mRNA | CTD | PMID:24136188 | valproic acid | decreases expression | ISO | RGD:1316962 | 6480464 | Valproic Acid results in decreased expression of WDR6 mRNA | CTD | PMID:19101580, PMID:29154799 | valproic acid | affects expression | ISO | RGD:1316962 | 6480464 | Valproic Acid affects the expression of WDR6 mRNA | CTD | PMID:25979313 | valproic acid | affects expression | ISO | RGD:1316963 | 6480464 | Valproic Acid affects the expression of WDR6 mRNA | CTD | PMID:17292431 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of WDR6 mRNA | CTD | PMID:22570695 | |