Cyp24a1 (cytochrome P450, family 24, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp24a1 (cytochrome P450, family 24, subfamily a, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
RGD ID: 2462
Description: Enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; and vitamin D 25-hydroxylase activity. Involved in cellular response to vitamin D and vitamin D catabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in colorectal adenoma; gastrointestinal system cancer (multiple); hypercalcemia; lung cancer (multiple); and ulcerative colitis. Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24-OHase; 24R-Ohase; 25-hydroxyvitamin D3 24-hydroxylase; 25-hydroxyvitaminD324-hydroxylase; Cyp24; Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase); cytochrome P450 24A1; cytochrome P450, subfamily 24; cytochrome P450-CC24; P450-CC24; vitamin D(3) 24-hydroxylase; VITD12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83179,694,647 - 179,709,083 (-)NCBIGRCr8
mRatBN7.23159,275,947 - 159,290,383 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3159,275,947 - 159,290,383 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3163,075,289 - 163,089,740 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03171,574,931 - 171,589,382 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03169,316,153 - 169,330,604 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03168,097,484 - 168,111,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3168,097,485 - 168,111,920 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03174,200,349 - 174,214,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43161,542,131 - 161,553,801 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13161,445,746 - 161,460,193 (-)NCBI
Celera3157,820,209 - 157,834,648 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,25-Dihydroxy-16-ene-vitamin D3  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP,ISO)
2-palmitoylglycerol  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
aflatoxin B1  (ISO)
alfacalcidol  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-linolenic acid  (ISO)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
ampicillin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bezafibrate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (ISO)
calciol  (EXP,ISO)
calcipotriol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cefaloridine  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flurbiprofen  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hyperforin  (ISO)
itraconazole  (EXP,ISO)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lactacystin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP,ISO)
Maxacalcitol  (ISO)
menadione  (ISO)
nickel atom  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
oxybenzone  (EXP)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
PD 0325901  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
Pramiconazole  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
raloxifene  (ISO)
rifampicin  (ISO)
saracatinib  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
uranium atom  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin D  (EXP,ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Expression of VDR and CYP24A1 mRNA in human tumors. Anderson MG, etal., Cancer Chemother Pharmacol. 2006 Jan;57(2):234-40. doi: 10.1007/s00280-005-0059-7. Epub 2005 Sep 23.
2. Vitamin D Receptor Genotype, Vitamin D3 Supplementation, and Risk of Colorectal Adenomas: A Randomized Clinical Trial. Barry EL, etal., JAMA Oncol. 2017 May 1;3(5):628-635. doi: 10.1001/jamaoncol.2016.5917.
3. Genetic mutation of p53 and suppression of the miR-17∼92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling. Borkowski R, etal., Cancer Res. 2015 Feb 15;75(4):666-75. doi: 10.1158/0008-5472.CAN-14-1329. Epub 2014 Dec 17.
4. Relative Expression of Vitamin D Hydroxylases, CYP27B1 and CYP24A1, and of Cyclooxygenase-2 and Heterogeneity of Human Colorectal Cancer in Relation to Age, Gender, Tumor Location, and Malignancy: Results from Factor and Cluster Analysis. Brozek W, etal., Cancers (Basel). 2012 Jul 26;4(3):763-76. doi: 10.3390/cancers4030763.
5. CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma. Chen G, etal., Clin Cancer Res. 2011 Feb 15;17(4):817-26. doi: 10.1158/1078-0432.CCR-10-1789. Epub 2010 Dec 17.
6. Association between CYP24A1 polymorphisms and the risk of colonic polyps and colon cancer in a Chinese population. Chen XQ, etal., World J Gastroenterol. 2017 Jul 28;23(28):5179-5186. doi: 10.3748/wjg.v23.i28.5179.
7. Constitutively active RAS signaling reduces 1,25 dihydroxyvitamin D-mediated gene transcription in intestinal epithelial cells by reducing vitamin D receptor expression. DeSmet ML and Fleet JC, J Steroid Biochem Mol Biol. 2017 Oct;173:194-201. doi: 10.1016/j.jsbmb.2017.01.008. Epub 2017 Jan 16.
8. Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Dong J, etal., Nat Genet. 2012 Jul 15;44(8):895-9. doi: 10.1038/ng.2351.
9. Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk. Dong LM, etal., Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2540-8. doi: 10.1158/1055-9965.EPI-09-0228. Epub 2009 Aug 25.
10. Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5. Dwivedi PP, etal., J Biol Chem 2002 Aug 16;277(33):29643-53.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Associations between abnormal vitamin D metabolism pathway function and non-small cell lung cancer. Ge N, etal., Oncol Lett. 2017 Dec;14(6):7538-7544. doi: 10.3892/ol.2017.7162. Epub 2017 Oct 10.
13. Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China. Gong C, etal., Sci Rep. 2017 Aug 18;7(1):8827. doi: 10.1038/s41598-017-09356-1.
14. Switching to a Healthy Diet Prevents the Detrimental Effects of Western Diet in a Colitis-Associated Colorectal Cancer Model. Gröschel C, etal., Nutrients. 2019 Dec 23;12(1). pii: nu12010045. doi: 10.3390/nu12010045.
15. Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats. Hamamoto H, etal., Mol Pharmacol. 2006 Jul;70(1):120-8. doi: 10.1124/mol.106.023275. Epub 2006 Apr 14.
16. Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation. Haznadar M, etal., Cancer Med. 2018 Jun;7(6):2764-2775. doi: 10.1002/cam4.1444. Epub 2018 May 3.
17. CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence. Hibler EA, etal., Nutr Cancer. 2015;67(7):1131-41. doi: 10.1080/01635581.2015.1068818. Epub 2015 Aug 4.
18. CYP24A1 splice variants--implications for the antitumorigenic actions of 1,25-(OH)2D3 in colorectal cancer. Horváth HC, etal., J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):76-9. doi: 10.1016/j.jsbmb.2010.03.080. Epub 2010 Apr 14.
19. Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis. Hummel DM, etal., J Steroid Biochem Mol Biol. 2013 Jul;136:284-8. doi: 10.1016/j.jsbmb.2012.09.003. Epub 2012 Sep 11.
20. Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer. Höbaus J, etal., Int J Cancer. 2013 Sep 15;133(6):1380-8. doi: 10.1002/ijc.28143. Epub 2013 Apr 5.
21. Characterization of transgenic rats constitutively expressing vitamin D-24-hydroxylase gene. Kasuga H, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1332-8.
22. Clinical validity of the lung cancer biomarkers identified by bioinformatics analysis of public expression data. Kim B, etal., Cancer Res. 2007 Aug 1;67(15):7431-8. doi: 10.1158/0008-5472.CAN-07-0003.
23. Genetic polymorphisms in the vitamin D pathway in relation to lung cancer risk and survival. Kong J, etal., Oncotarget. 2015 Feb 10;6(4):2573-82. doi: 10.18632/oncotarget.2951.
24. Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility. Li M, etal., Cancer Med. 2019 Aug;8(10):4892-4905. doi: 10.1002/cam4.2367. Epub 2019 Jul 1.
25. Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Ma R, etal., Am J Physiol Endocrinol Metab. 2012 Oct 1;303(7):E928-35. doi: 10.1152/ajpendo.00279.2012. Epub 2012 Aug 7.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer. Mimori K, etal., Ann Oncol. 2004 Feb;15(2):236-41. doi: 10.1093/annonc/mdh056.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
30. Structural characterization of the gene encoding rat 25-hydroxyvitamin D3 24-hydroxylase. Ohyama Y, etal., Biochemistry 1993 Jan 12;32(1):76-82.
31. Cloning and expression of cDNA encoding 25-hydroxyvitamin D3 24-hydroxylase. Ohyama Y, etal., FEBS Lett 1991 Jan 28;278(2):195-8.
32. Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene. Ohyama Y, etal., J Biol Chem 1994 Apr 8;269(14):10545-50.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans. Pibiri F, etal., Cancer Causes Control. 2014 May;25(5):561-70. doi: 10.1007/s10552-014-0361-y. Epub 2014 Feb 23.
35. A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer. Ramnath N, etal., Cancer Chemother Pharmacol. 2013 May;71(5):1173-82. doi: 10.1007/s00280-013-2109-x. Epub 2013 Feb 23.
36. Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma. Ramnath N, etal., J Thorac Oncol. 2014 Apr;9(4):473-82. doi: 10.1097/JTO.0000000000000114.
37. GOA pipeline RGD automated data pipeline
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. A novel circular RNA hsa_circ_0060927 may serve as a potential diagnostic biomarker for human colorectal cancer. Sadeghi H and Heiat M, Mol Biol Rep. 2020 Sep;47(9):6649-6655. doi: 10.1007/s11033-020-05716-9. Epub 2020 Aug 14.
41. A candidate intronic CYP24A1 gene variant affects the risk of colorectal cancer. Sadeghi H, etal., Biomark Med. 2020 Jan;14(1):23-29. doi: 10.2217/bmm-2019-0189. Epub 2019 Dec 5.
42. Metabolic studies using recombinant escherichia coli cells producing rat mitochondrial CYP24 CYP24 can convert 1alpha,25-dihydroxyvitamin D3 to calcitroic acid. Sakaki T, etal., Eur J Biochem. 1999 May;262(1):43-8. doi: 10.1046/j.1432-1327.1999.00375.x.
43. Microbiome as Mediator of Diet on Colorectal Cancer Risk: The Role of Vitamin D, Markers of Inflammation and Adipokines. Serrano D, etal., Nutrients. 2021 Jan 25;13(2). pii: nu13020363. doi: 10.3390/nu13020363.
44. Oncogenic Potential of CYP24A1 in Lung Adenocarcinoma. Shiratsuchi H, etal., J Thorac Oncol. 2017 Feb;12(2):269-280. doi: 10.1016/j.jtho.2016.10.010. Epub 2016 Oct 26.
45. Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma. Singhal S, etal., J Gastrointest Cancer. 2019 Dec;50(4):867-878. doi: 10.1007/s12029-018-0164-6.
46. The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. St-Arnaud R, etal., J Bone Miner Res 1997 Oct;12(10):1552-9.
47. CYP24A1 is a potential biomarker for the progression and prognosis of human colorectal cancer. Sun H, etal., Hum Pathol. 2016 Apr;50:101-8. doi: 10.1016/j.humpath.2015.11.008. Epub 2015 Nov 28.
48. Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1. Tieu EW, etal., J Steroid Biochem Mol Biol. 2015 May;149:153-65. doi: 10.1016/j.jsbmb.2015.02.010. Epub 2015 Feb 26.
49. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
50. Genetic polymorphisms of vitamin D receptor (VDR), CYP27B1 and CYP24A1 genes and the risk of colorectal cancer. Vidigal VM, etal., Int J Biol Markers. 2017 May 4;32(2):e224-e230. doi: 10.5301/jbm.5000248.
51. Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture. Wierzbicka JM, etal., Int J Oncol. 2015 Sep;47(3):1084-96. doi: 10.3892/ijo.2015.3088. Epub 2015 Jul 17.
52. Vitamin D-Related Gene Polymorphisms, Plasma 25-Hydroxy-Vitamin D, Cigarette Smoke and Non-Small Cell Lung Cancer (NSCLC) Risk. Wu X, etal., Int J Mol Sci. 2016 Sep 22;17(10). pii: ijms17101597. doi: 10.3390/ijms17101597.
53. Vitamin D Signaling Pathways Confer the Susceptibility of Esophageal Squamous Cell Carcinoma in a Northern Chinese Population. Yang J, etal., Nutr Cancer. 2017 May-Jun;69(4):593-600. doi: 10.1080/01635581.2017.1299873. Epub 2017 Mar 31.
54. Association study between CYP24A1 gene polymorphisms and cancer risk. Yi C, etal., Pathol Res Pract. 2020 Jan;216(1):152735. doi: 10.1016/j.prp.2019.152735. Epub 2019 Nov 11.
55. Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival. Zeljic K, etal., J Oral Pathol Med. 2012 Nov;41(10):779-87. doi: 10.1111/j.1600-0714.2012.01164.x. Epub 2012 May 22.
Additional References at PubMed
PMID:8036172   PMID:8506296   PMID:8679605   PMID:11012668   PMID:12477932   PMID:12846736   PMID:12914530   PMID:14651853   PMID:14765994   PMID:15078099   PMID:15225763   PMID:15358094  
PMID:15836435   PMID:16720713   PMID:17023519   PMID:17535892   PMID:18614015   PMID:19667159   PMID:19961857   PMID:23816829   PMID:24893882   PMID:25614971   PMID:26729468   PMID:27173620  
PMID:31907922   PMID:33596463  


Genomics

Comparative Map Data
Cyp24a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83179,694,647 - 179,709,083 (-)NCBIGRCr8
mRatBN7.23159,275,947 - 159,290,383 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3159,275,947 - 159,290,383 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3163,075,289 - 163,089,740 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03171,574,931 - 171,589,382 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03169,316,153 - 169,330,604 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03168,097,484 - 168,111,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3168,097,485 - 168,111,920 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03174,200,349 - 174,214,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43161,542,131 - 161,553,801 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13161,445,746 - 161,460,193 (-)NCBI
Celera3157,820,209 - 157,834,648 (-)NCBICelera
Cytogenetic Map3q42NCBI
CYP24A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382054,143,538 - 54,173,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2054,153,446 - 54,173,986 (-)EnsemblGRCh38hg38GRCh38
GRCh372052,769,985 - 52,790,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362052,203,395 - 52,223,931 (-)NCBINCBI36Build 36hg18NCBI36
Celera2049,474,643 - 49,495,166 (-)NCBICelera
Cytogenetic Map20q13.2NCBI
HuRef2049,516,544 - 49,537,045 (-)NCBIHuRef
CHM1_12052,673,171 - 52,693,667 (-)NCBICHM1_1
T2T-CHM13v2.02055,917,843 - 55,948,320 (-)NCBIT2T-CHM13v2.0
Cyp24a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392170,324,877 - 170,339,065 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2170,324,628 - 170,339,065 (-)EnsemblGRCm39 Ensembl
GRCm382170,482,957 - 170,497,145 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2170,482,708 - 170,497,145 (-)EnsemblGRCm38mm10GRCm38
MGSCv372170,308,465 - 170,322,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362170,174,170 - 170,188,343 (-)NCBIMGSCv36mm8
Celera2176,437,445 - 176,451,588 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map291.91NCBI
LOC102013768
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554454,873,942 - 4,891,780 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554454,874,583 - 4,891,723 (+)NCBIChiLan1.0ChiLan1.0
CYP24A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22159,906,065 - 59,926,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12059,899,186 - 59,919,783 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02050,500,103 - 50,520,487 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12051,721,895 - 51,742,716 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2051,721,685 - 51,742,716 (-)Ensemblpanpan1.1panPan2
CYP24A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12439,861,018 - 39,878,161 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2439,862,355 - 39,878,216 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2439,106,835 - 39,123,588 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02440,574,274 - 40,591,063 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2440,576,845 - 40,591,462 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12439,809,842 - 39,826,569 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02439,945,173 - 39,961,923 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02440,527,730 - 40,544,495 (-)NCBIUU_Cfam_GSD_1.0
LOC101957714
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640186,013,122 - 186,029,747 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365141,467,261 - 1,480,185 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365141,467,460 - 1,480,185 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP24A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1755,110,590 - 55,130,363 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11755,110,546 - 55,130,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21761,891,352 - 61,912,269 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP24A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.129,868,794 - 9,889,510 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl29,868,678 - 9,885,884 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605057,988,669 - 58,009,485 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101716773
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247902,182,598 - 2,200,425 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247902,183,079 - 2,200,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp24a1
139 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:150
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000046011
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
PMC61082P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23159,290,046 - 159,290,250 (+)MAPPERmRatBN7.2
Rnor_6.03168,111,584 - 168,111,787NCBIRnor6.0
Rnor_5.03174,214,449 - 174,214,652UniSTSRnor5.0
RGSC_v3.43161,553,810 - 161,554,013UniSTSRGSC3.4
Celera3157,834,312 - 157,834,515UniSTS
Cytogenetic Map3q42UniSTS
Cyp24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23159,289,779 - 159,290,035 (+)MAPPERmRatBN7.2
Rnor_6.03168,111,317 - 168,111,572NCBIRnor6.0
Rnor_5.03174,214,182 - 174,214,437UniSTSRnor5.0
RGSC_v3.43161,553,543 - 161,553,798UniSTSRGSC3.4
Celera3157,834,045 - 157,834,300UniSTS
Cytogenetic Map3q42UniSTS
Cyp24a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23159,278,719 - 159,279,542 (+)MAPPERmRatBN7.2
Rnor_6.03168,100,258 - 168,101,080NCBIRnor6.0
Rnor_5.03174,203,123 - 174,203,945UniSTSRnor5.0
RGSC_v3.43161,542,484 - 161,543,306UniSTSRGSC3.4
Celera3157,822,983 - 157,823,805UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system renal system reproductive system respiratory system
High
Medium 10
Low 13 7
Below cutoff 1 2 6 2 4 2 1 12 15 1

Sequence


Ensembl Acc Id: ENSRNOT00000046011   ⟹   ENSRNOP00000043298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3159,275,947 - 159,290,383 (-)Ensembl
Rnor_6.0 Ensembl3168,097,485 - 168,111,920 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100624   ⟹   ENSRNOP00000089650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3159,275,947 - 159,290,383 (-)Ensembl
RefSeq Acc Id: NM_201635   ⟹   NP_963966
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83179,694,647 - 179,709,083 (-)NCBI
mRatBN7.23159,275,947 - 159,290,383 (-)NCBI
Rnor_6.03168,097,484 - 168,111,920 (-)NCBI
Rnor_5.03174,200,349 - 174,214,780 (-)NCBI
RGSC_v3.43161,542,131 - 161,553,801 (-)RGD
Celera3157,820,209 - 157,834,648 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_963966 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42340 (Get FASTA)   NCBI Sequence Viewer  
  AAI00060 (Get FASTA)   NCBI Sequence Viewer  
  BAA04618 (Get FASTA)   NCBI Sequence Viewer  
  EDL96333 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043298.2
  ENSRNOP00000089650.1
GenBank Protein Q09128 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_963966   ⟸   NM_201635
- Peptide Label: precursor
- UniProtKB: Q498V4 (UniProtKB/Swiss-Prot),   Q63685 (UniProtKB/Swiss-Prot),   Q09128 (UniProtKB/Swiss-Prot),   A6JXS6 (UniProtKB/TrEMBL),   A0A8I6A8M6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043298   ⟸   ENSRNOT00000046011
Ensembl Acc Id: ENSRNOP00000089650   ⟸   ENSRNOT00000100624

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q09128-F1-model_v2 AlphaFold Q09128 1-514 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692701
Promoter ID:EPDNEW_R3226
Type:single initiation site
Name:Cyp24a1_1
Description:cytochrome P450, family 24, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03168,111,930 - 168,111,990EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2462 AgrOrtholog
BioCyc Gene G2FUF-46616 BioCyc
Ensembl Genes ENSRNOG00000013062 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046011.3 UniProtKB/Swiss-Prot
  ENSRNOT00000100624.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7129117 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_CYP24A_mit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25279 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:112576 IMAGE-MGC_LOAD
NCBI Gene 25279 ENTREZGENE
PANTHER CYTOCHROME P450 FAMILY 24 SUBFAMILY A MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24279 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp24a1 PhenoGen
PRINTS MITP450CC24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013062 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A8M6 ENTREZGENE, UniProtKB/TrEMBL
  A6JXS6 ENTREZGENE, UniProtKB/TrEMBL
  CP24A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q498V4 ENTREZGENE
  Q63685 ENTREZGENE
UniProt Secondary Q498V4 UniProtKB/Swiss-Prot
  Q63685 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp24a1  cytochrome P450, family 24, subfamily a, polypeptide 1  Cyp24a1  cytochrome P450, subfamily 24  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cyp24a1  cytochrome P450, subfamily 24  Cyp24    Symbol and Name updated 1299863 APPROVED
2002-11-06 Cyp24  cytochrome P450, subfamily 24    Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase)  Name updated 625702 APPROVED
2002-06-10 Cyp24  Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease linked to albuminuria, hyperlipidemia and atherosclerotic aorta lesions, which suggests a dual role for enzyme 1298844
gene_process actively degrades vitamin D3 1298843
gene_regulation transcription may be regulated by DNA binding proteins at CCAAT (possibly by CREB) and vitamin D promoter enhancer elements (VDREs; possibly by vitamin D3) 1298845