LOC102013768 (1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial) - Rat Genome Database

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Gene: LOC102013768 (1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial) Chinchilla lanigera
Analyze
Symbol: LOC102013768 (Ensembl: CYP24A1)
Name: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (Ensembl:cytochrome P450 family 24 subfamily A member 1)
RGD ID: 8770414
Description: ENCODES a protein that exhibits 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity (ortholog); 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity (ortholog); 25-hydroxycholecalciferol-23-hydroxylase activity (ortholog); INVOLVED IN cellular response to vitamin D (ortholog); osteoblast differentiation (ortholog); response to vitamin D (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); breast carcinoma (ortholog); Breast Neoplasms (ortholog); FOUND IN mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554454,873,942 - 4,891,780 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554454,874,583 - 4,891,723 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 47 rows

  
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Original Reference(s)
LOC102013768Chinchillabreast carcinoma  ISOCYP24A1 (Homo sapiens)9068941mRNA:decreased expression:breast (human)RGDPMID:16180015 and REF_RGD_ID:151361183
LOC102013768Chinchillacholangiocarcinoma  ISOCYP24A1 (Homo sapiens)9068941protein:increased expression:intrahepatic bile and extrahepatic bile duct (human)RGDPMID:23375797 and REF_RGD_ID:151361187
LOC102013768ChinchillaColitis-Associated Neoplasms treatmentISOCyp24a1 (Mus musculus)9068941 RGDPMID:31877961 and REF_RGD_ID:151665341
LOC102013768Chinchillacolon adenocarcinoma  ISOCYP24A1 (Homo sapiens)9068941mRNA:increased expression:colonic mucosa (human)RGDPMID:27793774 and REF_RGD_ID:151665173
LOC102013768Chinchillacolon adenocarcinoma  ISOCYP24A1 (Homo sapiens)9068941mRNA:increased expression:colon (human)RGDPMID:33791222 and REF_RGD_ID:151665790
LOC102013768Chinchillacolon cancer susceptibilityISOCYP24A1 (Homo sapiens)9068941DNA:SNPs:introns: (rs4809960 and rs6022999) (human)RGDPMID:31740231 and REF_RGD_ID:151665338
LOC102013768Chinchillacolon cancer susceptibilityISOCYP24A1 (Homo sapiens)9068941DNA:SNP:intron: IVS4-66T>G and (rs4809958) (human)RGDPMID:19706847 and REF_RGD_ID:151665174
LOC102013768Chinchillacolon cancer  ISOCYP24A1 (Homo sapiens)9068941mRNA:increased expression:colon (human)RGDPMID:16180015 and REF_RGD_ID:151361183
LOC102013768Chinchillacolon cancer susceptibilityISOCYP24A1 (Homo sapiens)9068941DNA:SNPs:multiple (human)RGDPMID:28811712 and REF_RGD_ID:151665177
LOC102013768ChinchillaColonic Polyps susceptibilityISOCYP24A1 (Homo sapiens)9068941DNA:SNPs:multiple (human)RGDPMID:28811712 and REF_RGD_ID:151665177
LOC102013768Chinchillacolorectal adenocarcinoma susceptibilityISOCYP24A1 (Homo sapiens)9068941DNA:SNPs:enhancers: (rs6013897 more ...RGDPMID:28009432 and REF_RGD_ID:151665179
LOC102013768Chinchillacolorectal adenoma treatmentISOCYP24A1 (Homo sapiens)9068941DNA:SNP:CDS: (rs2296241) (human)RGDPMID:27978548 and REF_RGD_ID:152025254
LOC102013768Chinchillacolorectal adenoma severityISOCYP24A1 (Homo sapiens)9068941DNA:SNPs:intron and CDS: (rs927650), (rs35051736) (human)RGDPMID:26241700 and REF_RGD_ID:11521055
LOC102013768Chinchillacolorectal cancer susceptibilityISOCYP24A1 (Homo sapiens)9068941DNA:SNP:enhancer: (rs6013897) (human)RGDPMID:33504116 and REF_RGD_ID:151708714
LOC102013768Chinchillacolorectal cancer disease_progressionISOCYP24A1 (Homo sapiens)9068941mRNA:increased expression:colon (human)RGDPMID:26260259 and REF_RGD_ID:151665788
LOC102013768Chinchillacolorectal cancer susceptibilityISOCYP24A1 (Homo sapiens)9068941DNA:missense mutation:CDS: (rs6022990) (human)RGDPMID:24562971 and REF_RGD_ID:151665501
LOC102013768Chinchillacolorectal cancer  ISOCYP24A1 (Homo sapiens)9068941circRNA:increased expression:colorectum (human)RGDPMID:32803502 and REF_RGD_ID:151665496
LOC102013768Chinchillacolorectal cancer  ISOCYP24A1 (Homo sapiens)9068941mRNA:increased expression:colorectal mucosa (human)RGDPMID:23463632 more ...
LOC102013768Chinchillacolorectal cancer susceptibilityISOCYP24A1 (Homo sapiens)9068941DNA:SNP:intron: (rs4809960) (human)RGDPMID:31802707 and REF_RGD_ID:151665172
LOC102013768Chinchillacolorectal cancer sexual_dimorphismISOCYP24A1 (Homo sapiens)9068941mRNA:splice variants:colorectal mucosa (human)RGDPMID:20398751 and REF_RGD_ID:151361186
1 to 20 of 47 rows
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Original Reference(s)
LOC102013768Chinchillagenetic disease  ISOCYP24A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
LOC102013768ChinchillaHypercalcemia, Infantile, 1  ISOCYP24A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypercalcemia more ...ClinVarPMID:19961857 more ...
LOC102013768ChinchillaInfantile Hypercalcemia  ISOCYP24A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Infantile hypercalcemiaClinVarPMID:25741868
LOC102013768ChinchillaSpasm  ISOCYP24A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Muscle spasmClinVarPMID:21675912 more ...
1 to 9 of 9 rows
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Original Reference(s)
LOC102013768Chinchillaautism spectrum disorder  ISOCYP24A1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:35663546
LOC102013768ChinchillaBreast Neoplasms  ISOCYP24A1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16280049
LOC102013768Chinchillahypercalcemia  ISOCYP24A1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22337913
LOC102013768ChinchillaHypercalciuria  ISOCYP24A1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22337913
LOC102013768Chinchillakidney failure  ISOCYP24A1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:8164439
LOC102013768ChinchillaLung Neoplasms  ISOCYP24A1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22797725
LOC102013768Chinchillanephrolithiasis  ISOCYP24A1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22337913
LOC102013768Chinchillaosteoporosis  ISOCYP24A1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22337913
LOC102013768ChinchillaSpontaneous Abortions  ISOCYP24A1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18539642
1 to 9 of 9 rows
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Original Reference(s)
LOC102013768ChinchillaHypercalcemia, Infantile, 1  ISOCYP24A1 (Homo sapiens)7240710 OMIM 


Cellular Component

  
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Original Reference(s)
LOC102013768Chinchillamitochondrion located_inISOCYP24A1 (Homo sapiens)9068941 PMID:34800366FlyBasePMID:34800366

Molecular Function
1 to 12 of 12 rows

  
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Original Reference(s)
LOC102013768Chinchilla1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity enablesISOCYP24A1 (Homo sapiens)9068941 PMID:16617161 more ...UniProtPMID:16617161 more ...
LOC102013768Chinchilla1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity enablesISOCYP24A1 (Homo sapiens)9068941 PMID:16617161 more ...UniProtPMID:16617161 more ...
LOC102013768Chinchilla1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity enablesISOCyp24a1 (Rattus norvegicus)9068941PMID:10231362UniProtPMID:10231362 and REF_RGD_ID:14995316
LOC102013768Chinchilla1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity enablesISOCyp24a1 (Rattus norvegicus)9068941PMID:16617161UniProtPMID:16617161 and REF_RGD_ID:14995311
LOC102013768Chinchilla25-hydroxycholecalciferol-23-hydroxylase activity enablesISOCYP24A1 (Homo sapiens)9068941 PMID:11012668 more ...UniProtPMID:11012668 more ...
LOC102013768Chinchilla25-hydroxycholecalciferol-24-hydroxylase activity  ISOCyp24a1 (Rattus norvegicus)9068941 RGDPMID:1991512 and REF_RGD_ID:1298844
LOC102013768Chinchilla25-hydroxycholecalciferol-24-hydroxylase activity enablesISOMGI:21823389068941 PMID:15225763MGIPMID:15225763
LOC102013768Chinchilla25-hydroxycholecalciferol-24-hydroxylase activity enablesISOCyp24a1 (Rattus norvegicus)9068941PMID:10231362UniProtPMID:10231362 and REF_RGD_ID:14995316
LOC102013768Chinchilla25-hydroxycholecalciferol-24-hydroxylase activity enablesISOCYP24A1 (Homo sapiens)9068941 PMID:24893882 and PMID:8679605UniProtPMID:24893882 and PMID:8679605
LOC102013768Chinchillavitamin D 24-hydroxylase activity enablesISOCyp24a1 (Rattus norvegicus)9068941PMID:25727742UniProtPMID:25727742 and REF_RGD_ID:14995325
LOC102013768Chinchillavitamin D3 25-hydroxylase activity enablesISOCyp24a1 (Rattus norvegicus)9068941PMID:25727742UniProtPMID:25727742 and REF_RGD_ID:14995325
LOC102013768Chinchillavitamin D3 25-hydroxylase activity enablesISOCYP24A1 (Homo sapiens)9068941 PMID:25727742UniProtPMID:25727742
1 to 12 of 12 rows


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



LOC102013768
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554454,873,942 - 4,891,780 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554454,874,583 - 4,891,723 (+)NCBIChiLan1.0ChiLan1.0
CYP24A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382054,143,538 - 54,173,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2054,153,446 - 54,173,986 (-)EnsemblGRCh38hg38GRCh38
GRCh372052,769,985 - 52,790,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362052,203,395 - 52,223,931 (-)NCBINCBI36Build 36hg18NCBI36
Celera2049,474,643 - 49,495,166 (-)NCBICelera
Cytogenetic Map20q13.2NCBI
HuRef2049,516,544 - 49,537,045 (-)NCBIHuRef
CHM1_12052,673,171 - 52,693,667 (-)NCBICHM1_1
T2T-CHM13v2.02055,917,843 - 55,948,320 (-)NCBIT2T-CHM13v2.0
Cyp24a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392170,324,877 - 170,339,065 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2170,324,628 - 170,339,065 (-)EnsemblGRCm39 Ensembl
GRCm382170,482,957 - 170,497,145 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2170,482,708 - 170,497,145 (-)EnsemblGRCm38mm10GRCm38
MGSCv372170,308,465 - 170,322,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362170,174,170 - 170,188,343 (-)NCBIMGSCv36mm8
Celera2176,437,445 - 176,451,588 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map291.91NCBI
Cyp24a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83179,694,647 - 179,709,083 (-)NCBIGRCr8
mRatBN7.23159,275,947 - 159,290,383 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3159,275,947 - 159,290,383 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3163,075,289 - 163,089,740 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03171,574,931 - 171,589,382 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03169,316,153 - 169,330,604 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03168,097,484 - 168,111,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3168,097,485 - 168,111,920 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03174,200,349 - 174,214,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43161,542,131 - 161,553,801 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13161,445,746 - 161,460,193 (-)NCBI
Celera3157,820,209 - 157,834,648 (-)NCBICelera
Cytogenetic Map3q42NCBI
CYP24A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22159,906,065 - 59,926,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12059,899,186 - 59,919,783 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02050,500,103 - 50,520,487 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12051,721,895 - 51,742,716 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2051,721,685 - 51,742,716 (-)Ensemblpanpan1.1panPan2
CYP24A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12439,861,018 - 39,878,161 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2439,862,355 - 39,878,216 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2439,106,835 - 39,123,588 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02440,574,274 - 40,591,063 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2440,576,845 - 40,591,462 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12439,809,842 - 39,826,569 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02439,945,173 - 39,961,923 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02440,527,730 - 40,544,495 (-)NCBIUU_Cfam_GSD_1.0
LOC101957714
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640186,013,122 - 186,029,747 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365141,467,261 - 1,480,185 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365141,467,460 - 1,480,185 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP24A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1755,110,590 - 55,130,363 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11755,110,546 - 55,130,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21761,891,352 - 61,912,269 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP24A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.129,868,794 - 9,889,510 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl29,868,678 - 9,885,884 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605057,988,669 - 58,009,485 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101716773
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247902,182,598 - 2,200,425 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247902,183,079 - 2,200,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.





RefSeq Transcripts XM_005392282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01039433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCQ01006441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCLAT00000010146   ⟹   ENSCLAP00000010016
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554454,873,942 - 4,891,780 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000010147   ⟹   ENSCLAP00000010017
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554454,873,942 - 4,891,780 (+)Ensembl
RefSeq Acc Id: XM_005392282   ⟹   XP_005392339
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554454,874,583 - 4,891,723 (+)NCBI
Sequence:
Protein RefSeqs XP_005392339 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000010016.1
  ENSCLAP00000010017
  ENSCLAP00000010017.1
RefSeq Acc Id: XP_005392339   ⟸   XM_005392282
- UniProtKB: A0A8C2V978 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000010016   ⟸   ENSCLAT00000010146
Ensembl Acc Id: ENSCLAP00000010017   ⟸   ENSCLAT00000010147



1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000006942 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000010146.1 UniProtKB/TrEMBL
  ENSCLAT00000010147 ENTREZGENE
  ENSCLAT00000010147.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro CYP11_CYP27_families UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene LOC102013768 ENTREZGENE
PANTHER CYTOCHROME P450 FAMILY 24 SUBFAMILY A MEMBER 1 UniProtKB/TrEMBL
  PTHR24279 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A8C2V978 ENTREZGENE, UniProtKB/TrEMBL
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 LOC102013768  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial    1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial-like  Symbol and/or name change 5135510 APPROVED