RGD Reference Report - Vitamin D Signaling Pathways Confer the Susceptibility of Esophageal Squamous Cell Carcinoma in a Northern Chinese Population. - Rat Genome Database

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Vitamin D Signaling Pathways Confer the Susceptibility of Esophageal Squamous Cell Carcinoma in a Northern Chinese Population.

Authors: Yang, Jianzhou  Wang, Haili  Ji, Aifang  Ma, Liang  Wang, Jinsheng  Lian, Changhong  Wei, Zibai  Wang, Lidong 
Citation: Yang J, etal., Nutr Cancer. 2017 May-Jun;69(4):593-600. doi: 10.1080/01635581.2017.1299873. Epub 2017 Mar 31.
RGD ID: 151665500
Pubmed: PMID:28362172   (View Abstract at PubMed)
DOI: DOI:10.1080/01635581.2017.1299873   (Journal Full-text)

Experimental studies have determined the chemopreventive effects of vitamin D against the esophageal squamous cell carcinoma (ESCC); however, results from the epidemiological studies are not yet well established. The current study aimed to evaluate the associations between plasma vitamin D levels and variants on vitamin D metabolic-related genes with the risks for ESCC. A hospital-based case-control study was performed. Five hundred eighty-two ESCC patients and 569 controls were recruited in a Northern Chinese population. Common variants on vitamin D metabolism-related genes CYP24A1, DHCR7, GC, CYP27B1, and vitamin D receptor (VDR) and the plasma 25(OH)D level were determined. The unconditional logistic regression method was applied to determine the associations between the variants and vitamin D level and ESCC. Higher plasma 25(OH)D was associated with a reduced risk for ESCC, especially for rs2296241, rs11568820, and rs4646536. The variants rs2296241 on CYP24A1 and rs11568820 on VDR are significantly associated with ESCC cancer. Vitamin D signaling pathways may participate in the ESCC development. Further studies with larger sample size are warranted to confirm the results. Intervention studies are needed to determine whether vitamin D supplementation may reduce the ESCC risk in the Chinese population.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
CYP24A1Humanesophagus squamous cell carcinoma susceptibilityIAGP DNA:SNP:CDS: (rs2296241) (human)RGD 
Cyp24a1Ratesophagus squamous cell carcinoma susceptibilityISOCYP24A1 (Homo sapiens)DNA:SNP:CDS: (rs2296241) (human)RGD 
Cyp24a1Mouseesophagus squamous cell carcinoma susceptibilityISOCYP24A1 (Homo sapiens)DNA:SNP:CDS: (rs2296241) (human)RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
CYP24A1HumanEsophageal carcinoma susceptibilityIAGP DNA:SNP:CDS: (rs2296241) RGD 

Genes (Rattus norvegicus)
Cyp24a1  (cytochrome P450, family 24, subfamily a, polypeptide 1)

Genes (Mus musculus)
Cyp24a1  (cytochrome P450, family 24, subfamily a, polypeptide 1)

Genes (Homo sapiens)
CYP24A1  (cytochrome P450 family 24 subfamily A member 1)