RGD Reference Report - A novel circular RNA hsa_circ_0060927 may serve as a potential diagnostic biomarker for human colorectal cancer. - Rat Genome Database

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A novel circular RNA hsa_circ_0060927 may serve as a potential diagnostic biomarker for human colorectal cancer.

Authors: Sadeghi, Hossein  Heiat, Mohammad 
Citation: Sadeghi H and Heiat M, Mol Biol Rep. 2020 Sep;47(9):6649-6655. doi: 10.1007/s11033-020-05716-9. Epub 2020 Aug 14.
RGD ID: 151665496
Pubmed: PMID:32803502   (View Abstract at PubMed)
DOI: DOI:10.1007/s11033-020-05716-9   (Journal Full-text)

CYP24A1 plays a role in strictly regulated vitamin D metabolism pathway and has been nominated as a prognostic biomarker for colorectal cancer (CRC). Increasing evidence suggests that circular RNAs (circRNAs) are involved in cancer initiation and progression; however, their diagnostic values in cancers as the new potential biomarkers are still not fully understood. In the present study, by using quantitative real-time polymerase chain reaction (qRT-PCR), we demonstrated that CYP24A1 and hsa_circ_0060927 were only transcribed in 33 and 25 out of 83 CRC tissues, respectively. In these samples, we demonstrated that CYP24A1 was up-regulated in both linear and circular forms (P < 0.05). Furthermore, we showed that CYP24A1and hsa_circ_0060927 transcription were induced after vitamin D treatment in HCT-116 and HT-29 colon cancer cell lines. Importantly, analysis of the ROC curve in expressed samples indicated that CYP24A1 and hsa_circ_0060927 could serve as the potential diagnostic markers of CRC, but due to the fact that these transcripts are not expressed in many samples, the diagnostic role of these transcripts could be rejected. Taken together, for the first time, the results of our study illustrated the expression levels hsa_circ_0060927 in CRC; however, further studies are required to validate the present results.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CYP24A1Humancolorectal cancer  IEP circRNA:increased expression:colorectum (human)RGD 
Cyp24a1Ratcolorectal cancer  ISOCYP24A1 (Homo sapiens)circRNA:increased expression:colorectum (human)RGD 
Cyp24a1Mousecolorectal cancer  ISOCYP24A1 (Homo sapiens)circRNA:increased expression:colorectum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp24a1  (cytochrome P450, family 24, subfamily a, polypeptide 1)

Genes (Mus musculus)
Cyp24a1  (cytochrome P450, family 24, subfamily a, polypeptide 1)

Genes (Homo sapiens)
CYP24A1  (cytochrome P450 family 24 subfamily A member 1)


Additional Information