Top2b (DNA topoisomerase II beta) - Rat Genome Database

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Gene: Top2b (DNA topoisomerase II beta) Rattus norvegicus
Analyze
Symbol: Top2b
Name: DNA topoisomerase II beta
RGD ID: 1586156
Description: Enables ribonucleoprotein complex binding activity. Involved in several processes, including cellular response to ATP; cellular response to hydrogen peroxide; and positive regulation of double-strand break repair via nonhomologous end joining. Predicted to be located in cytosol; heterochromatin; and nuclear lumen. Predicted to be active in nucleus. Orthologous to human TOP2B (DNA topoisomerase II beta); PARTICIPATES IN doxorubicin pharmacodynamics pathway; doxorubicin response pathway; etoposide pharmacodynamics pathway; INTERACTS WITH (+)-dexrazoxane; all-trans-retinoic acid; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA topoisomerase 2-beta; LOC361100; similar to topoisomerase (DNA) II beta; topoisomerase (DNA) II beta; topoisomerase II beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81511,482,089 - 11,542,464 (-)NCBIGRCr8
mRatBN7.2159,051,340 - 9,111,721 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl159,051,341 - 9,112,085 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1511,194,159 - 11,253,909 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01512,106,947 - 12,166,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01510,407,427 - 10,467,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01510,262,972 - 10,319,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1510,262,651 - 10,320,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01514,308,369 - 14,366,373 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera159,095,127 - 9,153,091 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,4-benzoquinone  (ISO)
1,4-naphthoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
acetaldehyde  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alternariol  (ISO)
amphetamine  (EXP)
amsacrine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
bortezomib  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
curcumin  (ISO)
dehydroepiandrosterone  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ellipticine  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
etoposide  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glafenine  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
m-xylene  (EXP)
menadione  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
naphthalene-1,2-diol  (ISO)
nitrates  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
razoxane  (EXP,ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
sodium dichromate  (EXP)
tamibarotene  (ISO)
tannic acid  (EXP)
tetrachloroethene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (ISO)
cytosol  (IEA,ISO)
heterochromatin  (ISO)
nucleolus  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cultured cerebellar granule neurons as an in vitro aging model: topoisomerase IIß as an additional biomarker in DNA repair and aging. Bhanu MU, etal., Toxicol In Vitro. 2010 Oct;24(7):1935-45. doi: 10.1016/j.tiv.2010.08.003. Epub 2010 Aug 12.
2. Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U). Kawano S, etal., J Biol Chem. 2010 Aug 20;285(34):26451-60. doi: 10.1074/jbc.M110.112979. Epub 2010 Jun 16.
3. Regional differences in the expression of DNA topoisomerase IIbeta in the pyramidal neurons of the rat hippocampus. Maeda Y, etal., Neurosci Res. 2000 Apr;36(4):291-6.
4. Topoisomerase IIß associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons. Mandraju R, etal., Arch Biochem Biophys. 2011 Dec 15;516(2):128-37. doi: 10.1016/j.abb.2011.09.017. Epub 2011 Oct 10.
5. Nuclear dynamics of topoisomerase IIß reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain. Onoda A, etal., Nucleic Acids Res. 2014 Aug;42(14):9005-20. doi: 10.1093/nar/gku640. Epub 2014 Jul 17.
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms. Rochette L, etal., Trends Pharmacol Sci. 2015 Jun;36(6):326-48. doi: 10.1016/j.tips.2015.03.005. Epub 2015 Apr 17.
10. Doxorubicin, DNA torsion, and chromatin dynamics. Yang F, etal., Biochim Biophys Acta. 2014 Jan;1845(1):84-9. doi: 10.1016/j.bbcan.2013.12.002. Epub 2013 Dec 19.
Additional References at PubMed
PMID:8395528   PMID:9049244   PMID:9224616   PMID:10473615   PMID:10615047   PMID:10666337   PMID:10684600   PMID:11062478   PMID:11106659   PMID:11136718   PMID:11835579   PMID:12773624  
PMID:15607978   PMID:16611985   PMID:16712776   PMID:16973621   PMID:17567603   PMID:19116664   PMID:22082260   PMID:22433436   PMID:24116135   PMID:30930055  


Genomics

Comparative Map Data
Top2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81511,482,089 - 11,542,464 (-)NCBIGRCr8
mRatBN7.2159,051,340 - 9,111,721 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl159,051,341 - 9,112,085 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1511,194,159 - 11,253,909 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01512,106,947 - 12,166,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01510,407,427 - 10,467,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01510,262,972 - 10,319,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1510,262,651 - 10,320,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01514,308,369 - 14,366,373 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera159,095,127 - 9,153,091 (-)NCBICelera
Cytogenetic Map15p16NCBI
TOP2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38325,597,905 - 25,664,907 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl325,597,978 - 25,664,909 (-)EnsemblGRCh38hg38GRCh38
GRCh37325,639,396 - 25,706,398 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36325,614,479 - 25,680,792 (-)NCBINCBI36Build 36hg18NCBI36
Build 34325,614,478 - 25,680,792NCBI
Celera325,576,353 - 25,642,666 (-)NCBICelera
Cytogenetic Map3p24.2NCBI
HuRef325,584,872 - 25,651,422 (-)NCBIHuRef
CHM1_1325,589,386 - 25,655,854 (-)NCBICHM1_1
T2T-CHM13v2.0325,600,752 - 25,667,754 (-)NCBIT2T-CHM13v2.0
Top2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39146,038,976 - 6,104,585 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl146,034,301 - 6,104,584 (-)EnsemblGRCm39 Ensembl
GRCm381416,365,206 - 16,430,787 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1416,365,179 - 16,435,462 (+)EnsemblGRCm38mm10GRCm38
MGSCv371417,197,720 - 17,263,301 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361415,158,473 - 15,224,054 (+)NCBIMGSCv36mm8
Celera1412,058,636 - 12,125,106 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map147.08NCBI
Top2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543017,457,603 - 17,507,012 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543017,457,603 - 17,523,115 (-)NCBIChiLan1.0ChiLan1.0
TOP2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2225,558,594 - 25,625,391 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1325,563,361 - 25,630,147 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0325,499,239 - 25,566,029 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1325,830,424 - 25,877,870 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl325,828,879 - 25,896,912 (-)Ensemblpanpan1.1panPan2
TOP2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12318,159,521 - 18,206,413 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2318,146,095 - 18,206,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2318,145,151 - 18,204,187 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02318,450,639 - 18,509,671 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2318,462,741 - 18,509,662 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12318,269,373 - 18,328,309 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02318,372,171 - 18,431,166 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02318,486,061 - 18,545,078 (+)NCBIUU_Cfam_GSD_1.0
Top2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118184,007,995 - 184,050,993 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647317,143,894 - 17,189,605 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647317,146,576 - 17,189,589 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1312,507,138 - 12,575,583 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11312,507,738 - 12,575,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21314,119,707 - 14,187,251 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOP2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11570,266,267 - 70,332,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1570,266,601 - 70,332,824 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604143,404,940 - 43,471,152 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Top2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247883,493,188 - 3,590,138 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Top2b
373 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:73
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000075125
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000075125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl159,051,341 - 9,112,085 (-)Ensembl
Rnor_6.0 Ensembl1510,262,972 - 10,319,741 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1510,287,371 - 10,291,644 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1510,262,651 - 10,274,950 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1510,292,922 - 10,320,233 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1510,280,895 - 10,281,963 (-)Ensembl
RefSeq Acc Id: NM_001100858   ⟹   NP_001094328
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81511,482,089 - 11,542,464 (-)NCBI
mRatBN7.2159,051,340 - 9,111,721 (-)NCBI
Rnor_6.01510,262,972 - 10,319,741 (-)NCBI
Rnor_5.01514,308,369 - 14,366,373 (-)NCBI
Celera159,095,127 - 9,153,091 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001094328 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA03133 (Get FASTA)   NCBI Sequence Viewer  
  BAE96971 (Get FASTA)   NCBI Sequence Viewer  
  EDL94093 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077482
  ENSRNOP00000077482.1
RefSeq Acc Id: NP_001094328   ⟸   NM_001100858
- UniProtKB: A0A8I5Y7L4 (UniProtKB/TrEMBL),   Q14TE9 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
DNA topoisomerase type IIA   Toprim

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586156 AgrOrtholog
BioCyc Gene G2FUF-14431 BioCyc
Ensembl Genes ENSRNOG00000048795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075125 ENTREZGENE
  ENSRNOT00000075125.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.268.10 UniProtKB/TrEMBL
  3.30.1360.40 UniProtKB/TrEMBL
  3.30.1490.30 UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
  3.40.50.670 UniProtKB/TrEMBL
  3.90.199.10 UniProtKB/TrEMBL
InterPro ATPase-like_ATP-bd UniProtKB/TrEMBL
  DNA_Topoisomerase_II UniProtKB/TrEMBL
  DTHCT UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
  Topo_IIA UniProtKB/TrEMBL
  Topo_IIA_A/C UniProtKB/TrEMBL
  Topo_IIA_A/C_ab UniProtKB/TrEMBL
  Topo_IIA_A_a UniProtKB/TrEMBL
  Topo_IIA_bsu_dom2 UniProtKB/TrEMBL
  Topo_IIA_cen UniProtKB/TrEMBL
  Topo_IIA_cen_dom UniProtKB/TrEMBL
  TopoII_euk UniProtKB/TrEMBL
  TopoIIA_CS UniProtKB/TrEMBL
  TOPRIM_C UniProtKB/TrEMBL
  Toprim_domain UniProtKB/TrEMBL
  TOPRIM_TopoII UniProtKB/TrEMBL
KEGG Report rno:361100 UniProtKB/TrEMBL
NCBI Gene 361100 ENTREZGENE
PANTHER DNA TOPOISOMERASE/GYRASE UniProtKB/TrEMBL
  PTHR10169:SF36 UniProtKB/TrEMBL
Pfam DNA_gyraseB UniProtKB/TrEMBL
  DNA_topoisoIV UniProtKB/TrEMBL
  DTHCT UniProtKB/TrEMBL
  HATPase_c UniProtKB/TrEMBL
  Toprim UniProtKB/TrEMBL
  TOPRIM_C UniProtKB/TrEMBL
PhenoGen Top2b PhenoGen
PRINTS TOPISMRASEII UniProtKB/TrEMBL
  TPI2FAMILY UniProtKB/TrEMBL
PROSITE TOPOISOMERASE_II UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048795 RatGTEx
SMART TOP2c UniProtKB/TrEMBL
  TOP4c UniProtKB/TrEMBL
Superfamily-SCOP ATP_bd_ATPase UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Topo_IIA_cen UniProtKB/TrEMBL
UniProt A0A8I5Y7L4 ENTREZGENE, UniProtKB/TrEMBL
  Q14TE9 ENTREZGENE, UniProtKB/TrEMBL
  Q63177_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Top2b  DNA topoisomerase II beta  Top2b  topoisomerase (DNA) II beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-12-09 Top2b  topoisomerase (DNA) II beta  LOC361100  similar to topoisomerase (DNA) II beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC361100  similar to topoisomerase (DNA) II beta      Symbol and Name status set to provisional 70820 PROVISIONAL