Symbol:
Gins2
Name:
GINS complex subunit 2
Description:
Predicted to contribute to 3'-5' DNA helicase activity. Predicted to be involved in double-strand break repair via break-induced replication. Predicted to localize to the GINS complex and replication fork protection complex. Orthologous to human GINS2 (GINS complex subunit 2); INTERACTS WITH 6-propyl-2-thiouracil; atrazine; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
DNA replication complex GINS protein PSF2; GINS complex subunit 2 (Psf2 homolog); hypothetical protein LOC292058; LOC292058; RGD1311055; similar to HSPC037 protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
GINS2 (GINS complex subunit 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Gins2 (GINS complex subunit 2 (Psf2 homolog)) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Gins2 (GINS complex subunit 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
GINS2 (GINS complex subunit 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
GINS2 (GINS complex subunit 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Gins2 (GINS complex subunit 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
GINS2 (GINS complex subunit 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Gins2 (GINS complex subunit 2 (Psf2 homolog))
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
GINS2 (GINS complex subunit 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
gins2 (GINS complex subunit 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
PSF2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Psf2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
psf-2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 19 54,151,048 - 54,163,701 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 54,151,048 - 54,163,608 (-) Ensembl Rnor_5.0 19 64,873,928 - 64,886,729 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 50,915,108 - 50,927,668 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 19 50,923,424 - 50,943,902 (-) NCBI Celera 19 47,880,377 - 47,892,745 (-) NCBI Celera Cytogenetic Map 19 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1,1-dichloroethene increases expression ISO RGD:1322307 6480464 vinylidene chloride results in increased expression of GINS2 mRNA CTD PMID:26682919 17beta-estradiol increases expression ISO RGD:1602113 6480464 Estradiol results in increased expression of GINS2 mRNA CTD PMID:16474171 , PMID:19167446 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1602113 6480464 Tetrachlorodibenzodioxin results in decreased expression of GINS2 mRNA CTD PMID:21802500 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1322307 6480464 Tetrachlorodibenzodioxin affects the expression of GINS2 mRNA CTD PMID:26377647 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1602113 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GINS2 mRNA CTD PMID:28628672 4-hydroxyphenyl retinamide decreases expression ISO RGD:1322307 6480464 Fenretinide results in decreased expression of GINS2 mRNA CTD PMID:28973697 5-fluorouracil affects expression ISO RGD:1602113 6480464 Fluorouracil affects the expression of GINS2 mRNA CTD PMID:16584549 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of GINS2 mRNA CTD PMID:24780913 aflatoxin B1 affects expression ISO RGD:1602113 6480464 Aflatoxin B1 affects the expression of GINS2 protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:1322307 6480464 Aflatoxin B1 results in decreased expression of GINS2 mRNA CTD PMID:19770486 all-trans-retinoic acid decreases expression ISO RGD:1602113 6480464 Tretinoin results in decreased expression of GINS2 mRNA CTD PMID:16249480 antirheumatic drug decreases expression ISO RGD:1602113 6480464 Antirheumatic Agents results in decreased expression of GINS2 mRNA CTD PMID:24449571 arsane affects methylation ISO RGD:1602113 6480464 Arsenic affects the methylation of GINS2 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1602113 6480464 Arsenic affects the methylation of GINS2 gene CTD PMID:25304211 atrazine decreases expression ISO RGD:1602113 6480464 Atrazine results in decreased expression of GINS2 mRNA CTD PMID:22378314 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of GINS2 gene CTD PMID:28931070 azathioprine decreases expression ISO RGD:1602113 6480464 Azathioprine results in decreased expression of GINS2 mRNA CTD PMID:22623647 benzo[a]pyrene decreases expression ISO RGD:1322307 6480464 Benzo(a)pyrene results in decreased expression of GINS2 mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression ISO RGD:1602113 6480464 Benzo(a)pyrene results in decreased expression of GINS2 mRNA CTD PMID:20064835 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1602113 6480464 7 more ... CTD PMID:20382639 bis(2-chloroethyl) sulfide decreases expression ISO RGD:1602113 6480464 Mustard Gas results in decreased expression of GINS2 mRNA CTD PMID:25102026 bisphenol A increases expression ISO RGD:1602113 6480464 bisphenol A results in increased expression of GINS2 mRNA CTD PMID:16474171 bisphenol A decreases expression ISO RGD:1602113 6480464 bisphenol A results in decreased expression of GINS2 mRNA CTD PMID:29275510 bisphenol A affects expression ISO RGD:1602113 6480464 bisphenol A affects the expression of GINS2 mRNA CTD PMID:30903817 bisphenol A multiple interactions ISO RGD:1602113 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GINS2 mRNA CTD PMID:28628672 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GINS2 mRNA CTD PMID:25181051 calcitriol decreases expression ISO RGD:1602113 6480464 Calcitriol results in decreased expression of GINS2 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1602113 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of GINS2 mRNA CTD PMID:21592394 carbamazepine affects expression ISO RGD:1602113 6480464 Carbamazepine affects the expression of GINS2 mRNA CTD PMID:25979313 carbon nanotube increases expression ISO RGD:1322307 6480464 Nanotubes, Carbon analog results in increased expression of GINS2 mRNA, Nanotubes, Carbon results in increased expression of GINS2 mRNA CTD PMID:25554681 cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of GINS2 mRNA CTD PMID:18500788 choline multiple interactions ISO RGD:1322307 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GINS2 gene CTD PMID:20938992 cisplatin multiple interactions ISO RGD:1602113 6480464 Cisplatin affects the reaction [Piroxicam results in decreased expression of GINS2 mRNA] CTD PMID:21858171 cisplatin increases expression ISO RGD:1602113 6480464 Cisplatin results in increased expression of GINS2 mRNA CTD PMID:27594783 cobalt dichloride decreases expression ISO RGD:1602113 6480464 cobaltous chloride results in decreased expression of GINS2 mRNA CTD PMID:19376846 copper atom multiple interactions ISO RGD:1602113 6480464 [NSC 689534 binds to Copper] which results in decreased expression of GINS2 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1602113 6480464 [NSC 689534 binds to Copper] which results in decreased expression of GINS2 mRNA CTD PMID:20971185 copper(II) sulfate decreases expression ISO RGD:1602113 6480464 Copper Sulfate results in decreased expression of GINS2 mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:1602113 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression ISO RGD:1602113 6480464 Coumestrol results in increased expression of GINS2 mRNA CTD PMID:19167446 cyclosporin A decreases expression ISO RGD:1602113 6480464 Cyclosporine results in decreased expression of GINS2 mRNA CTD PMID:20106945 more ... decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of GINS2 mRNA CTD PMID:23640034 dexamethasone multiple interactions ISO RGD:1602113 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GINS2 mRNA CTD PMID:28628672 dibutyl phthalate decreases expression ISO RGD:1322307 6480464 Dibutyl Phthalate results in decreased expression of GINS2 mRNA CTD PMID:21266533 dioxygen decreases expression ISO RGD:1602113 6480464 Oxygen deficiency results in decreased expression of GINS2 mRNA CTD PMID:26516004 doxorubicin decreases expression ISO RGD:1602113 6480464 Doxorubicin results in decreased expression of GINS2 mRNA CTD PMID:29803840 Enterolactone multiple interactions ISO RGD:1602113 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GINS2 mRNA CTD PMID:19167446 Enterolactone increases expression ISO RGD:1602113 6480464 2, 3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of GINS2 mRNA CTD PMID:19167446 folic acid multiple interactions ISO RGD:1322307 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GINS2 gene CTD PMID:20938992 folic acid multiple interactions ISO RGD:1602113 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of GINS2 mRNA CTD PMID:24657277 furan increases methylation EXP 6480464 furan results in increased methylation of GINS2 gene CTD PMID:22079235 furan increases expression EXP 6480464 furan results in increased expression of GINS2 mRNA CTD PMID:25539665 genistein increases expression ISO RGD:1602113 6480464 Genistein results in increased expression of GINS2 mRNA CTD PMID:16474171 indometacin multiple interactions ISO RGD:1602113 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GINS2 mRNA CTD PMID:28628672 L-methionine multiple interactions ISO RGD:1322307 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GINS2 gene CTD PMID:20938992 methotrexate multiple interactions ISO RGD:1602113 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of GINS2 mRNA CTD PMID:24657277 methotrexate decreases expression ISO RGD:1602113 6480464 Methotrexate results in decreased expression of GINS2 mRNA CTD PMID:24657277 methyl methanesulfonate increases expression ISO RGD:1602113 6480464 Methyl Methanesulfonate results in increased expression of GINS2 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:1602113 6480464 methylmercuric chloride results in decreased expression of GINS2 mRNA CTD PMID:28001369 miconazole increases expression ISO RGD:1322307 6480464 Miconazole results in increased expression of GINS2 mRNA CTD PMID:27462272 naphthalene increases expression ISO RGD:1322307 6480464 naphthalene results in increased expression of GINS2 mRNA CTD PMID:18978301 nickel atom increases expression ISO RGD:1602113 6480464 Nickel results in increased expression of GINS2 mRNA CTD PMID:25583101 nickel sulfate increases expression ISO RGD:1602113 6480464 nickel sulfate results in increased expression of GINS2 mRNA CTD PMID:22714537 ozone increases expression ISO RGD:1322307 6480464 Ozone results in increased expression of GINS2 mRNA CTD PMID:25658374 palbociclib decreases expression ISO RGD:1602113 6480464 palbociclib results in decreased expression of GINS2 mRNA CTD PMID:22869556 paracetamol increases expression ISO RGD:1602113 6480464 Acetaminophen results in increased expression of GINS2 mRNA CTD PMID:22230336 paracetamol decreases expression ISO RGD:1602113 6480464 Acetaminophen results in decreased expression of GINS2 mRNA CTD PMID:26690555 phenethyl isothiocyanate decreases expression ISO RGD:1602113 6480464 phenethyl isothiocyanate results in decreased expression of GINS2 mRNA CTD PMID:26678675 phenobarbital affects expression ISO RGD:1602113 6480464 Phenobarbital affects the expression of GINS2 mRNA CTD PMID:19159669 phenobarbital increases expression ISO RGD:1322307 6480464 Phenobarbital results in increased expression of GINS2 mRNA CTD PMID:23091169 pirinixic acid multiple interactions ISO RGD:1602113 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GINS2 mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:1322307 6480464 pirinixic acid results in increased expression of GINS2 mRNA CTD PMID:23811191 piroxicam decreases expression ISO RGD:1602113 6480464 Piroxicam results in decreased expression of GINS2 mRNA CTD PMID:21858171 piroxicam multiple interactions ISO RGD:1602113 6480464 Cisplatin affects the reaction [Piroxicam results in decreased expression of GINS2 mRNA] CTD PMID:21858171 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:1322307 6480464 Pregnenolone Carbonitrile results in increased expression of GINS2 mRNA CTD PMID:22698814 propanal decreases expression ISO RGD:1602113 6480464 propionaldehyde results in decreased expression of GINS2 mRNA CTD PMID:26079696 resveratrol multiple interactions ISO RGD:1602113 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of GINS2 mRNA CTD PMID:19167446 silicon dioxide decreases expression ISO RGD:1602113 6480464 Silicon Dioxide analog results in decreased expression of GINS2 mRNA CTD PMID:23806026 sodium arsenite affects methylation ISO RGD:1602113 6480464 sodium arsenite affects the methylation of GINS2 gene CTD PMID:28589171 sodium arsenite affects expression ISO RGD:1602113 6480464 sodium arsenite affects the expression of GINS2 mRNA CTD PMID:29301061 tacrolimus hydrate increases expression ISO RGD:1322307 6480464 Tacrolimus results in increased expression of GINS2 mRNA CTD PMID:29362864 tert-butyl hydroperoxide decreases expression ISO RGD:1602113 6480464 tert-Butylhydroperoxide results in decreased expression of GINS2 mRNA CTD PMID:15336504 testosterone multiple interactions ISO RGD:1602113 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of GINS2 mRNA CTD PMID:21592394 testosterone decreases expression ISO RGD:1602113 6480464 Testosterone results in decreased expression of GINS2 mRNA CTD PMID:21592394 tetrachloromethane affects expression ISO RGD:1322307 6480464 Carbon Tetrachloride affects the expression of GINS2 mRNA CTD PMID:17484886 tetrachloromethane increases expression ISO RGD:1322307 6480464 Carbon Tetrachloride results in increased expression of GINS2 mRNA CTD PMID:27339419 thapsigargin decreases expression ISO RGD:1602113 6480464 Thapsigargin results in decreased expression of GINS2 mRNA CTD PMID:22378314 triclosan decreases expression ISO RGD:1602113 6480464 Triclosan results in decreased expression of GINS2 mRNA CTD PMID:30510588 trimellitic anhydride increases expression ISO RGD:1322307 6480464 trimellitic anhydride results in increased expression of GINS2 mRNA CTD PMID:19042947 troglitazone decreases expression ISO RGD:1602113 6480464 troglitazone results in decreased expression of GINS2 mRNA CTD PMID:19140230 tungsten increases expression ISO RGD:1322307 6480464 Tungsten results in increased expression of GINS2 mRNA CTD PMID:30912803 tunicamycin decreases expression ISO RGD:1602113 6480464 Tunicamycin results in decreased expression of GINS2 mRNA CTD PMID:22378314 urethane decreases expression ISO RGD:1602113 6480464 Urethane results in decreased expression of GINS2 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1602113 6480464 Valproic Acid affects the expression of GINS2 mRNA CTD PMID:25979313 zoledronic acid decreases expression ISO RGD:1602113 6480464 zoledronic acid results in decreased expression of GINS2 mRNA CTD PMID:24714768 
Gene-Chemical Interaction Annotations
