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Gene: Cct3 (chaperonin containing TCP1 subunit 3) Rattus norvegicus

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Symbol:

Cct3

Name:

chaperonin containing TCP1 subunit 3

RGD ID:

735038

Description:

Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in several processes, including chaperone mediated protein folding independent of cofactor; positive regulation of protein localization to Cajal body; and positive regulation of telomerase RNA localization to Cajal body. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in cell body and microtubule. Predicted to be part of chaperonin-containing T-complex and zona pellucida receptor complex. Orthologous to human CCT3 (chaperonin containing TCP1 subunit 3); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CCT-gamma; chaperonin containing Tcp1, subunit 3 (gamma); chaperonin subunit 3 (gamma); MGC72950; T-complex protein 1 subunit gamma; TCP-1-gamma

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CCT3 (chaperonin containing TCP1 subunit 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cct3 (chaperonin containing TCP1 subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cct3 (chaperonin containing TCP1 subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CCT3 (chaperonin containing TCP1 subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CCT3 (chaperonin containing TCP1 subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cct3 (chaperonin containing TCP1 subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CCT3 (chaperonin containing TCP1 subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CCT3 (chaperonin containing TCP1 subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cct3 (chaperonin containing TCP1 subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ASAH1 (N-acylsphingosine amidohydrolase 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CCT3 (chaperonin containing TCP1 subunit 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cct3 (chaperonin containing TCP1 subunit 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cct3 (chaperonin containing TCP1, subunit 3 (gamma))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CCT3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CCT3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cct-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cct3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Related Pseudogenes:

Cct3-ps2 Cct3-ps3

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	176,063,529 - 176,088,180 (+)	NCBI		GRCr8
mRatBN7.2	2	173,765,701 - 173,790,353 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	173,765,698 - 173,790,757 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	180,910,314 - 180,934,758 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	178,932,672 - 178,957,116 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	173,532,533 - 173,557,196 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	187,669,051 - 187,693,610 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	187,668,796 - 187,693,610 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	207,072,068 - 207,096,553 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	180,381,044 - 180,434,152 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	180,331,149 - 180,384,258 (+)	NCBI
Celera	2	167,711,584 - 167,735,276 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cct3	Rat	Charcot-Marie-Tooth disease type 2		ISO	RGD:1342982	8554872	ClinVar Annotator: match by term: Charcot-Marie-Tooth disease type 2	ClinVar	PMID:18585512\|PMID:18926329\|PMID:28492532\|PMID:29845577
Cct3	Rat	gastrointestinal stromal tumor		ISO	RGD:1342982	8554872	ClinVar Annotator: match by term: Gastrointestinal stromal tumor	ClinVar	PMID:28492532
Cct3	Rat	immunodeficiency 42		ISO	RGD:1342982	8554872	ClinVar Annotator: match by term: Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete more ...	ClinVar	PMID:28492532
Cct3	Rat	MHC class II deficiency		ISO	RGD:1342982	8554872	ClinVar Annotator: match by term: MHC class II deficiency	ClinVar	PMID:28492532
Cct3	Rat	NEURODEVELOPMENTAL DISORDER WITH SPEECH OR VISUAL IMPAIRMENT AND BRAIN HYPOMYELINATION		ISO	RGD:1342982	8554872	ClinVar Annotator: match by term: NEURODEVELOPMENTAL DISORDER WITH SPEECH OR VISUAL IMPAIRMENT AND BRAIN HYPOMYELINATION	ClinVar	PMID:25741868\|PMID:39480921
Cct3	Rat	parathyroid carcinoma		ISO	RGD:1342982	8554872	ClinVar Annotator: match by term: Parathyroid carcinoma	ClinVar	PMID:28492532
Cct3	Rat	severe congenital neutropenia 3		ISO	RGD:1342982	8554872	ClinVar Annotator: match by term: Kostmann syndrome	ClinVar	PMID:28492532
Cct3	Rat	severe congenital neutropenia 5		ISO	RGD:1342982	8554872	ClinVar Annotator: match by term: Congenital neutropenia-myelofibrosis-nephromegaly syndrome	ClinVar	PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cct3	Rat	Chemical and Drug Induced Liver Injury		ISO	RGD:1342982	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:25231249
Cct3	Rat	human immunodeficiency virus infectious disease		ISO	RGD:1342982	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:15308739

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cct3	Rat	NEURODEVELOPMENTAL DISORDER WITH SPEECH OR VISUAL IMPAIRMENT AND BRAIN HYPOMYELINATION		ISO	RGD:1342982	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cct3	Rat	(+)-schisandrin B	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CCT3 mRNA]	CTD	PMID:31150632
Cct3	Rat	(1->4)-beta-D-glucan	multiple interactions	ISO	RGD:1551227	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CCT3 mRNA	CTD	PMID:36331819
Cct3	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1551227	6480464	Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCT3 mRNA]	CTD	PMID:22206623
Cct3	Rat	1,2-dimethylhydrazine	increases expression	ISO	RGD:1551227	6480464	1,2-Dimethylhydrazine results in increased expression of CCT3 mRNA	CTD	PMID:22206623
Cct3	Rat	1-chloro-2,4-dinitrobenzene	affects binding	ISO	RGD:1342982	6480464	Dinitrochlorobenzene binds to CCT3 protein	CTD	PMID:32991956
Cct3	Rat	17alpha-ethynylestradiol	affects expression	ISO	RGD:1551227	6480464	Ethinyl Estradiol affects the expression of CCT3 mRNA	CTD	PMID:17555576
Cct3	Rat	17alpha-ethynylestradiol	increases expression	EXP		6480464	Ethinyl Estradiol results in increased expression of CCT3 mRNA	CTD	PMID:16174780
Cct3	Rat	17alpha-ethynylestradiol	multiple interactions	ISO	RGD:1551227	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCT3 mRNA	CTD	PMID:17942748
Cct3	Rat	17alpha-ethynylestradiol	increases expression	ISO	RGD:1551227	6480464	Ethinyl Estradiol results in increased expression of CCT3 mRNA	CTD	PMID:16174780\|PMID:17942748
Cct3	Rat	17beta-estradiol	affects expression	ISO	RGD:1551227	6480464	Estradiol affects the expression of CCT3 mRNA	CTD	PMID:15598610
Cct3	Rat	17beta-estradiol	increases expression	ISO	RGD:1551227	6480464	Estradiol results in increased expression of CCT3 mRNA	CTD	PMID:39298647
Cct3	Rat	17beta-estradiol	increases expression	EXP		6480464	Estradiol results in increased expression of CCT3 protein	CTD	PMID:32145629
Cct3	Rat	2,2',4,4'-Tetrabromodiphenyl ether	affects expression	ISO	RGD:1551227	6480464	2,2',4,4'-tetrabromodiphenyl ether affects the expression of CCT3 mRNA	CTD	PMID:30294300
Cct3	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1551227	6480464	Tetrachlorodibenzodioxin results in increased expression of CCT3 mRNA	CTD	PMID:17942748\|PMID:18796159
Cct3	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1551227	6480464	Tetrachlorodibenzodioxin affects the expression of CCT3 mRNA	CTD	PMID:21570461
Cct3	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of CCT3 protein	CTD	PMID:16548065\|PMID:19201780
Cct3	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1551227	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCT3 mRNA; Tetrachlorodibenzodioxin promotes the more ...	CTD	PMID:17942748\|PMID:19654925
Cct3	Rat	2,4-dibromophenyl 2,4,5-tribromophenyl ether	increases expression	EXP		6480464	2,2',4,4',5-brominated diphenyl ether results in increased expression of CCT3 protein	CTD	PMID:19954255
Cct3	Rat	2,4-dibromophenyl 2,4,5-tribromophenyl ether	decreases expression	EXP		6480464	2,2',4,4',5-brominated diphenyl ether results in decreased expression of CCT3 protein	CTD	PMID:19954255
Cct3	Rat	2,4-dinitrotoluene	affects expression	EXP		6480464	2,4-dinitrotoluene affects the expression of CCT3 mRNA	CTD	PMID:21346803
Cct3	Rat	2,6-dimethoxyphenol	multiple interactions	ISO	RGD:1342982	6480464	[Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether] results in decreased expression of and affects the more ...	CTD	PMID:38598786
Cct3	Rat	2,6-dinitrotoluene	affects expression	EXP		6480464	2,6-dinitrotoluene affects the expression of CCT3 mRNA	CTD	PMID:21346803
Cct3	Rat	2-nitrofluorene	increases expression	EXP		6480464	2-nitrofluorene results in increased expression of CCT3 mRNA	CTD	PMID:15890375
Cct3	Rat	3-chloropropane-1,2-diol	decreases expression	EXP		6480464	alpha-Chlorohydrin results in decreased expression of CCT3 protein	CTD	PMID:26072098
Cct3	Rat	3H-1,2-dithiole-3-thione	increases expression	ISO	RGD:1551227	6480464	1,2-dithiol-3-thione results in increased expression of CCT3 mRNA	CTD	PMID:15375163
Cct3	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1551227	6480464	bisphenol S results in increased expression of CCT3 mRNA	CTD	PMID:39298647
Cct3	Rat	4,4'-sulfonyldiphenol	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Cct3	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1342982	6480464	bisphenol S results in increased expression of CCT3 protein	CTD	PMID:34186270
Cct3	Rat	4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one	increases expression	EXP		6480464	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCT3 mRNA	CTD	PMID:15890375
Cct3	Rat	4-amino-2,6-dinitrotoluene	affects expression	EXP		6480464	4-amino-2,6-dinitrotoluene affects the expression of CCT3 mRNA	CTD	PMID:21346803
Cct3	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of CCT3 mRNA	CTD	PMID:36843608
Cct3	Rat	acrolein	multiple interactions	ISO	RGD:1342982	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in decreased expression of CCT3 mRNA	CTD	PMID:32845096
Cct3	Rat	acrylamide	increases expression	ISO	RGD:1342982	6480464	Acrylamide results in increased expression of CCT3 mRNA	CTD	PMID:32763439
Cct3	Rat	aflatoxin B1	increases expression	EXP		6480464	Aflatoxin B1 results in increased expression of CCT3 mRNA	CTD	PMID:15890375
Cct3	Rat	aflatoxin B1	decreases expression	EXP		6480464	Aflatoxin B1 results in decreased expression of CCT3 mRNA	CTD	PMID:33354967
Cct3	Rat	aflatoxin B1	decreases expression	ISO	RGD:1551227	6480464	Aflatoxin B1 results in decreased expression of CCT3 mRNA	CTD	PMID:19770486
Cct3	Rat	albendazole	multiple interactions	ISO	RGD:1342982	6480464	[Ivermectin co-treated with Albendazole] results in increased expression of CCT3 mRNA	CTD	PMID:16861626
Cct3	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1342982	6480464	Tretinoin results in decreased expression of CCT3 mRNA	CTD	PMID:33167477
Cct3	Rat	arsenous acid	increases expression	ISO	RGD:1342982	6480464	Arsenic Trioxide results in increased expression of CCT3 protein	CTD	PMID:19364129
Cct3	Rat	atrazine	increases expression	ISO	RGD:1342982	6480464	Atrazine results in increased expression of CCT3 mRNA	CTD	PMID:18585445
Cct3	Rat	atrazine	decreases expression	ISO	RGD:1342982	6480464	Atrazine results in decreased expression of CCT3 mRNA	CTD	PMID:22378314
Cct3	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1342982	6480464	Benzo(a)pyrene results in increased methylation of CCT3 promoter	CTD	PMID:27901495
Cct3	Rat	beta-lapachone	increases expression	ISO	RGD:1342982	6480464	beta-lapachone results in increased expression of CCT3 mRNA	CTD	PMID:38218311
Cct3	Rat	beta-naphthoflavone	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCT3 mRNA	CTD	PMID:18164116
Cct3	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1551227	6480464	Diethylhexyl Phthalate results in increased expression of CCT3 mRNA	CTD	PMID:21318169
Cct3	Rat	bis(2-ethylhexyl) phthalate	increases expression	EXP		6480464	Diethylhexyl Phthalate results in increased expression of CCT3 mRNA	CTD	PMID:21318169
Cct3	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of CCT3 mRNA	CTD	PMID:25181051
Cct3	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Cct3	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of CCT3 mRNA	CTD	PMID:34947998
Cct3	Rat	bisphenol A	decreases expression	ISO	RGD:1342982	6480464	bisphenol A results in decreased expression of CCT3 mRNA; bisphenol A results in decreased expression more ...	CTD	PMID:29275510\|PMID:33024228\|PMID:34186270
Cct3	Rat	bisphenol AF	increases expression	ISO	RGD:1342982	6480464	bisphenol AF results in increased expression of CCT3 protein	CTD	PMID:34186270
Cct3	Rat	Bisphenol B	increases expression	ISO	RGD:1342982	6480464	bisphenol B results in increased expression of CCT3 protein	CTD	PMID:34186270
Cct3	Rat	bisphenol F	increases expression	ISO	RGD:1342982	6480464	bisphenol F results in increased expression of CCT3 protein	CTD	PMID:34186270
Cct3	Rat	bisphenol F	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Cct3	Rat	Brodifacoum	increases expression	EXP		6480464	bromfenacoum results in increased expression of CCT3 protein	CTD	PMID:28903499
Cct3	Rat	cadmium acetate	decreases expression	ISO	RGD:1342982	6480464	cadmium acetate results in decreased expression of CCT3 mRNA	CTD	PMID:18155341
Cct3	Rat	caffeine	decreases phosphorylation	ISO	RGD:1342982	6480464	Caffeine results in decreased phosphorylation of CCT3 protein	CTD	PMID:35688186
Cct3	Rat	carbon nanotube	increases expression	ISO	RGD:1551227	6480464	Nanotubes, Carbon analog results in increased expression of CCT3 mRNA; Nanotubes, Carbon results in increased more ...	CTD	PMID:25554681
Cct3	Rat	chromium(6+)	affects expression	ISO	RGD:1551227	6480464	chromium hexavalent ion affects the expression of CCT3 mRNA	CTD	PMID:28472532
Cct3	Rat	Cinobufagin	decreases expression	ISO	RGD:1342982	6480464	cinobufagin results in decreased expression of CCT3 mRNA	CTD	PMID:35447139
Cct3	Rat	clobetasol	increases expression	ISO	RGD:1551227	6480464	Clobetasol results in increased expression of CCT3 mRNA	CTD	PMID:27462272
Cct3	Rat	clofibrate	increases expression	EXP		6480464	Clofibrate results in increased expression of CCT3 mRNA	CTD	PMID:21318169
Cct3	Rat	clofibric acid	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CCT3 mRNA	CTD	PMID:17602206
Cct3	Rat	coumarin	increases phosphorylation	ISO	RGD:1342982	6480464	coumarin results in increased phosphorylation of CCT3 protein	CTD	PMID:35688186
Cct3	Rat	CU-O LINKAGE	decreases expression	ISO	RGD:1342982	6480464	cupric oxide results in decreased expression of CCT3 protein	CTD	PMID:25470785
Cct3	Rat	cyclophosphamide	decreases expression	EXP		6480464	Cyclophosphamide results in decreased expression of CCT3 mRNA	CTD	PMID:11906922
Cct3	Rat	diarsenic trioxide	increases expression	ISO	RGD:1342982	6480464	Arsenic Trioxide results in increased expression of CCT3 protein	CTD	PMID:19364129
Cct3	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1342982	6480464	di-n-butylphosphoric acid affects the expression of CCT3 mRNA	CTD	PMID:37042841
Cct3	Rat	dibutyl phthalate	decreases expression	ISO	RGD:1551227	6480464	Dibutyl Phthalate results in decreased expression of CCT3 mRNA	CTD	PMID:17361019\|PMID:21266533
Cct3	Rat	diethylstilbestrol	increases expression	EXP		6480464	Diethylstilbestrol results in increased expression of CCT3 mRNA	CTD	PMID:15890375
Cct3	Rat	dihydroartemisinin	affects binding	ISO	RGD:1342982	6480464	artenimol analog binds to CCT3 protein modified form	CTD	PMID:26340163
Cct3	Rat	dioxygen	multiple interactions	ISO	RGD:1551227	6480464	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CCT3 mRNA	CTD	PMID:30529165
Cct3	Rat	disodium selenite	increases expression	ISO	RGD:1342982	6480464	Sodium Selenite results in increased expression of CCT3 mRNA	CTD	PMID:18175754
Cct3	Rat	doxorubicin	increases expression	ISO	RGD:1342982	6480464	Doxorubicin results in increased expression of CCT3 mRNA	CTD	PMID:29803840
Cct3	Rat	enzyme inhibitor	multiple interactions	ISO	RGD:1342982	6480464	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ...	CTD	PMID:23301498
Cct3	Rat	fenvalerate	decreases expression	EXP		6480464	fenvalerate results in decreased expression of CCT3 protein	CTD	PMID:33656234
Cct3	Rat	finasteride	increases expression	EXP		6480464	Finasteride results in increased expression of CCT3 mRNA	CTD	PMID:24136188
Cct3	Rat	flutamide	increases expression	EXP		6480464	Flutamide results in increased expression of CCT3 mRNA	CTD	PMID:24136188
Cct3	Rat	folic acid	multiple interactions	ISO	RGD:1551227	6480464	Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCT3 mRNA]	CTD	PMID:22206623
Cct3	Rat	FR900359	decreases phosphorylation	ISO	RGD:1342982	6480464	FR900359 results in decreased phosphorylation of CCT3 protein	CTD	PMID:37730182
Cct3	Rat	furfural	multiple interactions	ISO	RGD:1342982	6480464	[Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of more ...	CTD	PMID:38598786
Cct3	Rat	gentamycin	increases expression	EXP		6480464	Gentamicins results in increased expression of CCT3 mRNA; Gentamicins results in increased expression of CCT3 more ...	CTD	PMID:22061828\|PMID:33387578
Cct3	Rat	hydrogen peroxide	affects expression	ISO	RGD:1342982	6480464	Hydrogen Peroxide affects the expression of CCT3 mRNA	CTD	PMID:21179406
Cct3	Rat	ivermectin	multiple interactions	ISO	RGD:1342982	6480464	[Ivermectin co-treated with Albendazole] results in increased expression of CCT3 mRNA	CTD	PMID:16861626
Cct3	Rat	ivermectin	decreases expression	ISO	RGD:1342982	6480464	Ivermectin results in decreased expression of CCT3 protein	CTD	PMID:32959892
Cct3	Rat	lead(0)	affects expression	ISO	RGD:1342982	6480464	Lead affects the expression of CCT3 mRNA	CTD	PMID:28903495
Cct3	Rat	methapyrilene	increases expression	EXP		6480464	Methapyrilene results in increased expression of CCT3 mRNA	CTD	PMID:15890375
Cct3	Rat	methidathion	increases expression	ISO	RGD:1551227	6480464	methidathion results in increased expression of CCT3 mRNA	CTD	PMID:34813904
Cct3	Rat	miconazole	increases expression	ISO	RGD:1551227	6480464	Miconazole results in increased expression of CCT3 mRNA	CTD	PMID:27462272
Cct3	Rat	N-nitrosodiethylamine	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCT3 mRNA; [Diethylnitrosamine co-treated with Clofibric more ...	CTD	PMID:17602206\|PMID:18164116
Cct3	Rat	N-nitrosodimethylamine	increases expression	EXP		6480464	Dimethylnitrosamine results in increased expression of CCT3 mRNA	CTD	PMID:15890375
Cct3	Rat	nefazodone	increases expression	EXP		6480464	nefazodone results in increased expression of CCT3 mRNA	CTD	PMID:24136188
Cct3	Rat	nimesulide	increases expression	EXP		6480464	nimesulide results in increased expression of CCT3 mRNA	CTD	PMID:24136188
Cct3	Rat	nitrates	multiple interactions	ISO	RGD:1551227	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of CCT3 more ...	CTD	PMID:35964746
Cct3	Rat	okadaic acid	increases expression	ISO	RGD:1342982	6480464	Okadaic Acid results in increased expression of CCT3 mRNA	CTD	PMID:38832940
Cct3	Rat	ozone	multiple interactions	ISO	RGD:1551227	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ...	CTD	PMID:34911549
Cct3	Rat	ozone	multiple interactions	ISO	RGD:1342982	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in decreased expression of CCT3 mRNA; [Air more ...	CTD	PMID:32845096\|PMID:35430440
Cct3	Rat	paracetamol	affects expression	ISO	RGD:1551227	6480464	Acetaminophen affects the expression of CCT3 mRNA	CTD	PMID:17562736
Cct3	Rat	pentachlorophenol	increases expression	ISO	RGD:1551227	6480464	Pentachlorophenol results in increased expression of CCT3 mRNA	CTD	PMID:23892564
Cct3	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1551227	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CCT3 mRNA	CTD	PMID:36331819
Cct3	Rat	perfluorooctanoic acid	increases expression	ISO	RGD:1551227	6480464	perfluorooctanoic acid results in increased expression of CCT3 mRNA	CTD	PMID:21318169
Cct3	Rat	perfluorooctanoic acid	increases expression	EXP		6480464	perfluorooctanoic acid results in increased expression of CCT3 mRNA	CTD	PMID:19162173\|PMID:21318169
Cct3	Rat	perfluorooctanoic acid	multiple interactions	ISO	RGD:1551227	6480464	PPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of CCT3 mRNA]	CTD	PMID:21318169
Cct3	Rat	phenobarbital	affects expression	ISO	RGD:1551227	6480464	Phenobarbital affects the expression of CCT3 mRNA	CTD	PMID:23091169
Cct3	Rat	piperonyl butoxide	increases expression	EXP		6480464	Piperonyl Butoxide results in increased expression of CCT3 mRNA	CTD	PMID:15890375
Cct3	Rat	pirinixic acid	increases expression	ISO	RGD:1551227	6480464	pirinixic acid results in increased expression of CCT3 mRNA	CTD	PMID:15375163\|PMID:18301758\|PMID:20059764
Cct3	Rat	pirinixic acid	multiple interactions	ISO	RGD:1551227	6480464	PPARA protein promotes the reaction [pirinixic acid results in increased expression of CCT3 mRNA]	CTD	PMID:20059764
Cct3	Rat	pirinixic acid	increases expression	EXP		6480464	pirinixic acid results in increased expression of CCT3 mRNA	CTD	PMID:15890375
Cct3	Rat	pregnenolone 16alpha-carbonitrile	increases expression	ISO	RGD:1551227	6480464	Pregnenolone Carbonitrile results in increased expression of CCT3 mRNA	CTD	PMID:28903501
Cct3	Rat	propiconazole	increases expression	ISO	RGD:1551227	6480464	propiconazole results in increased expression of CCT3 mRNA	CTD	PMID:21278054
Cct3	Rat	pyrogallol	increases expression	ISO	RGD:1551227	6480464	Pyrogallol results in increased expression of CCT3 mRNA	CTD	PMID:20362636
Cct3	Rat	rotenone	decreases expression	EXP		6480464	Rotenone results in decreased expression of CCT3 protein	CTD	PMID:35544339
Cct3	Rat	sodium arsenite	increases expression	ISO	RGD:1342982	6480464	sodium arsenite results in increased expression of CCT3 mRNA	CTD	PMID:34032870
Cct3	Rat	sodium arsenite	decreases expression	ISO	RGD:1342982	6480464	sodium arsenite results in decreased expression of CCT3 mRNA; sodium arsenite results in decreased expression more ...	CTD	PMID:30528433\|PMID:38568856
Cct3	Rat	sodium chloride	multiple interactions	ISO	RGD:1342982	6480464	[Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of more ...	CTD	PMID:38598786
Cct3	Rat	sodium dichromate	increases expression	EXP		6480464	sodium bichromate results in increased expression of CCT3 mRNA	CTD	PMID:25993096
Cct3	Rat	tamoxifen	affects expression	ISO	RGD:1551227	6480464	Tamoxifen affects the expression of CCT3 mRNA	CTD	PMID:17555576
Cct3	Rat	tetrachloromethane	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CCT3 mRNA]	CTD	PMID:31150632
Cct3	Rat	tetrachloromethane	increases expression	ISO	RGD:1551227	6480464	Carbon Tetrachloride results in increased expression of CCT3 mRNA	CTD	PMID:31919559
Cct3	Rat	tetrachloromethane	increases expression	EXP		6480464	Carbon Tetrachloride results in increased expression of CCT3 mRNA	CTD	PMID:31150632
Cct3	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of CCT3 mRNA	CTD	PMID:23411599\|PMID:34492290
Cct3	Rat	thiram	decreases expression	ISO	RGD:1342982	6480464	Thiram results in decreased expression of CCT3 mRNA	CTD	PMID:38568856
Cct3	Rat	titanium dioxide	decreases methylation	ISO	RGD:1551227	6480464	titanium dioxide results in decreased methylation of CCT3 gene	CTD	PMID:35295148
Cct3	Rat	trichloroethene	increases expression	ISO	RGD:1551227	6480464	Trichloroethylene results in increased expression of CCT3 mRNA	CTD	PMID:15363585
Cct3	Rat	trimellitic anhydride	increases expression	ISO	RGD:1551227	6480464	trimellitic anhydride results in increased expression of CCT3 mRNA	CTD	PMID:19042947
Cct3	Rat	triphenylstannane	decreases expression	ISO	RGD:1342982	6480464	triphenyltin analog results in decreased expression of CCT3 protein	CTD	PMID:31634547
Cct3	Rat	triptonide	decreases expression	ISO	RGD:1551227	6480464	triptonide results in decreased expression of CCT3 mRNA	CTD	PMID:33045310
Cct3	Rat	ursodeoxycholic acid	affects expression	ISO	RGD:1342982	6480464	Ursodeoxycholic Acid affects the expression of CCT3 mRNA	CTD	PMID:18422935
Cct3	Rat	valdecoxib	increases expression	EXP		6480464	valdecoxib results in increased expression of CCT3 mRNA	CTD	PMID:24136188
Cct3	Rat	valproic acid	decreases methylation	ISO	RGD:1342982	6480464	Valproic Acid results in decreased methylation of CCT3 gene	CTD	PMID:29154799
Cct3	Rat	valproic acid	affects expression	ISO	RGD:1551227	6480464	Valproic Acid affects the expression of CCT3 mRNA	CTD	PMID:17292431

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cct3	Rat	binding of sperm to zona pellucida	acts_upstream_of_or_within	IEA	UniProtKB:P80318\|ensembl:ENSMUSP00000001452	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cct3	Rat	binding of sperm to zona pellucida	acts_upstream_of_or_within	ISO	RGD:1551227	1624291	PMID:21880732	RGD	PMID:21880732
Cct3	Rat	obsolete chaperone mediated protein folding independent of cofactor	involved_in	IEA	UniProtKB:P49368\|ensembl:ENSP00000295688	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cct3	Rat	obsolete chaperone-mediated protein folding	involved_in	ISO	RGD:1342982	1624291	PMID:22133715	RGD	PMID:22133715
Cct3	Rat	obsolete chaperone-mediated protein folding	involved_in	IEA	UniProtKB:P49368\|ensembl:ENSP00000295688	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cct3	Rat	positive regulation of protein localization to Cajal body	involved_in	ISO	RGD:1342982	9068941	PMID:25467444	BHF-UCL	PMID:25467444
Cct3	Rat	positive regulation of telomerase RNA localization to Cajal body	involved_in	ISO	RGD:1342982	9068941	PMID:25467444	BHF-UCL	PMID:25467444
Cct3	Rat	positive regulation of telomere maintenance via telomerase	acts_upstream_of	ISO	RGD:1342982	1624291	PMID:25467444	RGD	PMID:25467444
Cct3	Rat	positive regulation of telomere maintenance via telomerase	acts_upstream_of	IEA	UniProtKB:P49368\|ensembl:ENSP00000295688	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cct3	Rat	protein folding	involved_in	IEA	InterPro:IPR002194\|InterPro:IPR012719	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Cct3	Rat	protein folding	involved_in	ISO	RGD:1342982	1624291	PMID:25467444, PMID:30955883	RGD	PMID:25467444\|PMID:30955883
Cct3	Rat	protein folding	involved_in	IEA	UniProtKB:P49368\|ensembl:ENSP00000295688	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cct3	Rat	protein folding	involved_in	IBA	PANTHER:PTN004253040\|SGD:S000001404\|SGD:S000002302\|SGD:S000002596\|SGD:S000002620\|SGD:S000003545\|SGD:S000003551\|SGD:S000003647\|SGD:S000003825\|UniProtKB:P17987\|UniProtKB:P40227\|UniProtKB:P48643\|UniProtKB:P49368\|UniProtKB:P50990\|UniProtKB:P50991\|UniProtKB:P78371\|UniProtKB:Q92526\|UniProtKB:Q99832	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cct3	Rat	protein stabilization	involved_in	ISO	RGD:1342982	1624291	PMID:25467444	RGD	PMID:25467444
Cct3	Rat	protein stabilization	involved_in	IEA	UniProtKB:P49368\|ensembl:ENSP00000295688	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cct3	Rat	cell body	located_in	ISO	RGD:1551227	1624291	PMID:21880732	RGD	PMID:21880732
Cct3	Rat	cell body	located_in	IEA	UniProtKB:P80318\|ensembl:ENSMUSP00000001452	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cct3	Rat	chaperonin-containing T-complex	part_of	ISO	RGD:1342982	1624291	PMID:22133715, PMID:23011926, PMID:30955883	RGD	PMID:22133715\|PMID:23011926\|PMID:30955883
Cct3	Rat	chaperonin-containing T-complex	part_of	ISO	RGD:1551227	1624291	PMID:7798195, PMID:7828721, PMID:7953530	RGD	PMID:7798195\|PMID:7828721\|PMID:7953530
Cct3	Rat	chaperonin-containing T-complex	part_of	IEA	UniProtKB:P80318\|ensembl:ENSMUSP00000001452	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cct3	Rat	chaperonin-containing T-complex	part_of	IBA	MGI:104708\|PANTHER:PTN000143681\|PomBase:SPBC1A4.08c\|SGD:S000003551\|UniProtKB:P49368\|UniProtKB:Q3T0K2\|UniProtKB:Q8I5C4	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cct3	Rat	chaperonin-containing T-complex	part_of	IEA	UniProtKB:P49368\|ensembl:ENSP00000295688	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cct3	Rat	chaperonin-containing T-complex	part_of	ISS	UniProtKB:Q3T0K2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cct3	Rat	chaperonin-containing T-complex	part_of	IEA	ARBA:ARBA00029273	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Cct3	Rat	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cct3	Rat	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Cct3	Rat	microtubule	located_in	ISO	RGD:1342982	1624291	PMID:21525035	RGD	PMID:21525035
Cct3	Rat	microtubule	located_in	IEA	UniProtKB:P49368\|ensembl:ENSP00000295688	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cct3	Rat	zona pellucida receptor complex	part_of	ISO	RGD:1551227	1624291	PMID:21880732	RGD	PMID:21880732
Cct3	Rat	zona pellucida receptor complex	part_of	IEA	UniProtKB:P80318\|ensembl:ENSMUSP00000001452	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cct3	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cct3	Rat	ATP binding	enables	IEA	InterPro:IPR002194\|InterPro:IPR002423\|InterPro:IPR012719	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Cct3	Rat	ATP hydrolysis activity	enables	IEA	InterPro:IPR002194\|InterPro:IPR012719	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Cct3	Rat	ATP-dependent protein folding chaperone	enables	IEA	InterPro:IPR017998	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Cct3	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cct3	Rat	protein binding	enables	ISO	RGD:1342982	1624291	UniProtKB:O15160\|UniProtKB:O60232\|UniProtKB:O75140-2\|UniProtKB:O75530\|UniProtKB:P04049\|UniProtKB:P57678\|UniProtKB:Q13371\|UniProtKB:Q8TD10\|UniProtKB:Q96M98\|UniProtKB:Q9BUR4\|UniProtKB:Q9H832\|UniProtKB:Q9Y238 PMID:12620389, PMID:14532270, PMID:16189514, PMID:25416956, PMID:25467444, PMID:27705803, PMID:28514442, PMID:30021884, PMID:31980649, PMID:32296183, PMID:33144677, PMID:33961781, PMID:37045861	RGD	PMID:12620389\|PMID:14532270\|PMID:16189514\|PMID:25416956\|PMID:25467444\|PMID:27705803\|PMID:28514442\|PMID:30021884\|PMID:31980649\|PMID:32296183\|PMID:33144677\|PMID:33961781\|PMID:37045861
Cct3	Rat	protein binding	enables	ISO	RGD:1551227	1624291	PR:E9Q9D5\|UniProtKB:P04591-PRO_0000038598\|UniProtKB:Q8R368 PMID:23055941, PMID:23872636, PMID:25416944	RGD	PMID:23055941\|PMID:23872636\|PMID:25416944
Cct3	Rat	protein folding chaperone	enables	ISO	RGD:1342982	1624291	PMID:25467444, PMID:30955883	RGD	PMID:25467444\|PMID:30955883
Cct3	Rat	protein folding chaperone	enables	IEA	UniProtKB:P49368\|ensembl:ENSP00000295688	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cct3	Rat	unfolded protein binding	enables	IEA	InterPro:IPR002194\|InterPro:IPR012719	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Cct3	Rat	unfolded protein binding	enables	IBA	PANTHER:PTN004253040\|SGD:S000001404\|SGD:S000002302\|SGD:S000002596\|SGD:S000002620\|SGD:S000003545\|SGD:S000003551\|SGD:S000003647\|SGD:S000003825	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 2 (ISO)

Chemical and Drug Induced Liver Injury (ISO)

gastrointestinal stromal tumor (ISO)

human immunodeficiency virus infectious disease (ISO)

immunodeficiency 42 (ISO)

MHC class II deficiency (ISO)

NEURODEVELOPMENTAL DISORDER WITH SPEECH OR VISUAL IMPAIRMENT AND BRAIN HYPOMYELINATION (ISO)

parathyroid carcinoma (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

2,4-dinitrotoluene (EXP)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

2-nitrofluorene (EXP)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

4-amino-2,6-dinitrotoluene (EXP)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

albendazole (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

Brodifacoum (EXP)

cadmium acetate (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

Cinobufagin (ISO)

clobetasol (ISO)

clofibrate (EXP)

clofibric acid (EXP)

coumarin (ISO)

CU-O LINKAGE (ISO)

cyclophosphamide (EXP)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (EXP)

dihydroartemisinin (ISO)

dioxygen (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

fenvalerate (EXP)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

furfural (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

ivermectin (ISO)

lead(0) (ISO)

methapyrilene (EXP)

methidathion (ISO)

miconazole (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

nitrates (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

piperonyl butoxide (EXP)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

pyrogallol (ISO)

rotenone (EXP)

sodium arsenite (ISO)

sodium chloride (ISO)

sodium dichromate (EXP)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (ISO)

trimellitic anhydride (ISO)

triphenylstannane (ISO)

triptonide (ISO)

ursodeoxycholic acid (ISO)

valdecoxib (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

binding of sperm to zona pellucida (IEA,ISO)

obsolete chaperone mediated protein folding independent of cofactor (IEA)

obsolete chaperone-mediated protein folding (IEA,ISO)

positive regulation of protein localization to Cajal body (ISO)

positive regulation of telomerase RNA localization to Cajal body (ISO)

positive regulation of telomere maintenance via telomerase (IEA,ISO)

protein folding (IBA,IEA,ISO)

protein stabilization (IEA,ISO)

Cellular Component

cell body (IEA,ISO)

chaperonin-containing T-complex (IBA,IEA,ISO,ISS)

cytoplasm (IEA)

microtubule (IEA,ISO)

zona pellucida receptor complex (IEA,ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATP-dependent protein folding chaperone (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein folding chaperone (IEA,ISO)

unfolded protein binding (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits.	Kubota H, etal., Eur J Biochem 1999 Jun;262(2):492-500.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:7798195	PMID:7828721	PMID:7953530	PMID:15489334	PMID:16854843	PMID:17634366	PMID:19056867	PMID:20193073	PMID:20458337	PMID:21525035	PMID:21880732	PMID:22082260
PMID:22681889	PMID:22871113	PMID:23011926	PMID:23533145	PMID:23716698	PMID:24625528	PMID:25002582	PMID:25467444	PMID:29476059	PMID:31904090	PMID:33450132

Genomics

Comparative Map Data

Cct3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	176,063,529 - 176,088,180 (+)	NCBI		GRCr8
mRatBN7.2	2	173,765,701 - 173,790,353 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	173,765,698 - 173,790,757 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	180,910,314 - 180,934,758 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	178,932,672 - 178,957,116 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	173,532,533 - 173,557,196 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	187,669,051 - 187,693,610 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	187,668,796 - 187,693,610 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	207,072,068 - 207,096,553 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	180,381,044 - 180,434,152 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	180,331,149 - 180,384,258 (+)	NCBI
Celera	2	167,711,584 - 167,735,276 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

CCT3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	156,308,968 - 156,338,292 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	156,308,968 - 156,367,873 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	156,278,759 - 156,308,083 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	154,545,376 - 154,574,819 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	153,091,832 - 153,121,121	NCBI
Celera	1	129,351,733 - 129,381,131 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI
HuRef	1	127,638,812 - 127,668,494 (-)	NCBI		HuRef
CHM1_1	1	157,674,664 - 157,704,561 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	155,447,437 - 155,476,903 (-)	NCBI		T2T-CHM13v2.0

Cct3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	88,204,442 - 88,229,073 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	88,204,423 - 88,229,074 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	88,297,135 - 88,321,766 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	88,297,116 - 88,321,767 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	88,101,057 - 88,125,688 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	88,383,062 - 88,407,693 (+)	NCBI		MGSCv36	mm8
Celera	3	88,336,705 - 88,361,340 (+)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	38.79	NCBI

Cct3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955545	2,444,988 - 2,461,113 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955545	2,444,988 - 2,460,976 (-)	NCBI	ChiLan1.0	ChiLan1.0

CCT3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	93,508,565 - 93,536,333 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	93,240,518 - 93,268,250 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	131,652,058 - 131,679,802 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	135,482,012 - 135,508,983 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	135,481,427 - 135,508,983 (-)	Ensembl	panpan1.1		panPan2

CCT3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	41,566,274 - 41,583,903 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	41,566,292 - 41,584,863 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	41,054,446 - 41,072,072 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	41,431,013 - 41,448,650 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	41,431,096 - 41,449,272 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	41,212,433 - 41,230,036 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	41,265,635 - 41,283,249 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	41,549,686 - 41,567,311 (+)	NCBI		UU_Cfam_GSD_1.0

Cct3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	26,506,956 - 26,523,883 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	5,537,015 - 5,554,384 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	5,537,338 - 5,554,384 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCT3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	93,733,918 - 93,753,340 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	93,733,967 - 93,753,340 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	102,435,570 - 102,453,406 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCT3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	7,518,729 - 7,545,296 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	7,518,846 - 7,545,677 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	6,819,515 - 6,846,680 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cct3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624885	1,575,562 - 1,592,594 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624885	1,575,560 - 1,592,540 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cct3
221 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	187
Count of miRNA genes:	140
Interacting mature miRNAs:	149
Transcripts:	ENSRNOT00000025824
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
6907363	Bp357	Blood pressure QTL 357	4.1	0.002	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	129540907	174540907	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	136445150	202447032	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	122609194	206936711	Rat
70162	Bp63	Blood pressure QTL 63	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	185122374	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	143657411	190602963	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	185122374	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	185122374	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	157142209	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	185122374	Rat
61469	Bp16	Blood pressure QTL 16	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	135552573	202446871	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168354880	185122374	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
12879845	Cm89	Cardiac mass QTL 89		0.008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	175950118	Rat
61473	Bp19	Blood pressure QTL 19	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	172710921	175950118	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
12879846	Cm90	Cardiac mass QTL 90		0.011	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	2	152413072	175950118	Rat
12879847	Am4	Aortic mass QTL 4		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	175950118	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	185122374	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	136916935	189599348	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	157142078	192625452	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150540301	202447032	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150341684	202446871	Rat
2301415	Cm67	Cardiac mass QTL 67		0.003	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	175950118	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	168594495	213594495	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	141596551	202447032	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
11565180	Kidm56	Kidney mass QTL 56		0.003	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	175950118	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150341585	189039377	Rat
11565181	Bw176	Body weight QTL 176		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	175950118	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	143157029	210020885	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	133914684	202447032	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	144599348	189599348	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	150540301	202447032	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147798556	192798556	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	172710921	184114403	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	162765032	207765032	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166539266	211539266	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	160564068	205564068	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	143657569	184114274	Rat
7488904	Bp363	Blood pressure QTL 363		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	172982062	175950118	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat

Markers in Region

RH129532

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	173,790,133 - 173,790,336 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	187,693,391 - 187,693,593	NCBI	Rnor6.0
Rnor_5.0	2	207,096,334 - 207,096,536	UniSTS	Rnor5.0
RGSC_v3.4	2	180,433,933 - 180,434,135	UniSTS	RGSC3.4
Celera	2	167,735,057 - 167,735,259	UniSTS
RH 3.4 Map	2	1152.0	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH129680

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	173,790,132 - 173,790,336 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	187,693,390 - 187,693,593	NCBI	Rnor6.0
Rnor_5.0	2	207,096,333 - 207,096,536	UniSTS	Rnor5.0
RGSC_v3.4	2	180,433,932 - 180,434,135	UniSTS	RGSC3.4
Celera	2	167,735,056 - 167,735,259	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH135214

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	173,769,826 - 173,770,043 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	187,673,086 - 187,673,302	NCBI	Rnor6.0
Rnor_5.0	2	207,076,103 - 207,076,319	UniSTS	Rnor5.0
RGSC_v3.4	2	180,385,079 - 180,385,295	UniSTS	RGSC3.4
Celera	2	167,715,619 - 167,715,835	UniSTS
RH 3.4 Map	2	1148.91	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC063178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025824 ⟹ ENSRNOP00000025824

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	173,765,699 - 173,790,351 (+)	Ensembl
Rnor_6.0 Ensembl	2	187,668,796 - 187,693,610 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092332

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	187,670,722 - 187,675,355 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092396

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	173,765,699 - 173,790,351 (+)	Ensembl
Rnor_6.0 Ensembl	2	187,668,960 - 187,685,721 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092556

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	187,691,761 - 187,692,402 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092682

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	187,668,970 - 187,669,394 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110088 ⟹ ENSRNOP00000076951

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	173,765,698 - 173,790,757 (+)	Ensembl

RefSeq Acc Id:

NM_199091 ⟹ NP_954522

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	176,063,529 - 176,088,180 (+)	NCBI
mRatBN7.2	2	173,765,701 - 173,790,353 (+)	NCBI
Rnor_6.0	2	187,669,051 - 187,693,610 (+)	NCBI
Rnor_5.0	2	207,072,068 - 207,096,553 (+)	NCBI
RGSC_v3.4	2	180,381,044 - 180,434,152 (+)	RGD
Celera	2	167,711,584 - 167,735,276 (+)	RGD

Sequence:

show sequence

GGCTCTTCGTCGTGCCGCCATGATGGGCCACCGTCCAGTGCTCGTGCTCAGTCAGAATACAAAG
CGTGAGTCTGGAAGAAAAGTTCAATCTGGAAATATCAATGCTGCAAAGACAATTGCAGACATCA
TCCGGACCTGTTTGGGACCTAAATCTATGATGAAGATGCTTTTGGATCCAATGGGAGGCATCGT
GATGACCAATGATGGTAATGCCATTCTTCGAGAGATTCAAGTCCAGCATCCCGCAGCAAAATCC
ATGATTGAAATTAGCAGGACCCAGGATGAAGAGGTTGGAGATGGGACCACATCAGTAATTATTC
TTGCTGGAGAAATGCTGTCTGTGGCTGAGCACTTCCTAGAGCAGCAGATGCACCCAACAGTGGT
GATCAGTGCTTACCGCATGGCACTGGATGATATGGTCAGCACTCTGAAGAAAATCAGTACCCCT
GTTGATGTCAATAACCGTGATATGATGTTGAACATCATCAATAGCTCTATTACTACAAAAGTCA
TCAGTCGGTGGTCCTCTTTGGCATGCAACATTGCACTGGATGCTGTTAAGACTGTTCAGTTTGA
AGAGAATGGCAGAAAGGAAATTGATATCAAGAAGTATGCAAGGGTGGAAAAGATACCCGGGGGC
ATCATTGAAGACTCGTGTGTCTTACGTGGAGTTATGATCAACAAGGATGTGACCCATCCAAGAA
TGCGCCGCTATATTAAGAATCCTCGAATTGTTCTACTGGATTCTTCTCTGGAGTACAAGAAAGG
AGAAAGCCAGACTGACATTGAGATTACACGAGAGGAGGATTTCACCCGCATCCTGCAAATGGAA
GAAGAGTACATCCAGCAGTTGTGTGAGGATATTATCCAGCTGAAACCTGACGTAGTCATCACAG
AAAAGGGCATCTCGGATTTAGCTCAGCACTACCTCATGCGGGCCAATGTCACAGCCATTCGTAG
AGTCCGGAAAACAGACAATAATCGCATTGCTAGAGCCTGTGGGGCACGGATAGTCAGCCGACCC
GAGGAACTGAGAGAAGATGATGTTGGTACAGGAGCAGGCTTATTGGAAATCAAGAAGATTGGAG
ATGAGTACTTCACATTCATCACTGACTGCAAAGACCCAAAGGCCTGCACCATTCTTCTTAGAGG
AGCCAGCAAAGAGATACTATCGGAAGTAGAACGCAACCTCCAGGATGCCATGCAAGTGTGCCGC
AATGTTCTCCTGGACCCTCAGCTGGTGCCTGGTGGTGGAGCCTCTGAGATGGCTGTGGCCCATG
CCTTGACAGAAAAATCTAAGGCCATGACTGGTGTGGAACAATGGCCATATAGGGCTGTGGCCCA
GGCTTTAGAGGTCATCCCTCGGACCTTGATCCAGAACTGTGGGGCCAGTACCATTCGTCTGCTT
ACCTCCCTTCGGGCCAAGCACACACAGGAGAATTGTGAGACCTGGGGTGTGAATGGTGAGACTG
GTACCTTAGTGGACATGAAAGAGCTGGGTATTTGGGAGCCATTGGCTGTGAAGCTACAAACATA
CAAAACAGCAGTGGAGACTGCAGTTCTGCTTCTGCGGATTGATGACATTGTCTCTGGCCACAAG
AAGAAGGGTGATGACCAGAACCGGCAAACCGGTGCTCCAGATGCTGGCCAGGAGTGAGTGCTAA
GCAAGGTGGCTGAACCACAGAACCAGCAGTCTCCCCTTTCCTGAGCCAGAGTTCCAGGAACACT
GTGGACATCTTTGTTTGCAAAGGATCAGGTTGAGGGGCAGCCCCCAGTCTGTCCCATCTCGGTT
TGCAAAAAGCACTGACGTGTATCTCTTCTGTTGTAAGCTTCCATTCAGTTTGCTTCCAGTGATT
AAATCTAAGTCATTTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_954522	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH63178	(Get FASTA)	NCBI Sequence Viewer
	EDM00727	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025824.4
	ENSRNOP00000076951
GenBank Protein	Q6P502	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_954522 ⟸ NM_199091

- UniProtKB:

Q6P502 (UniProtKB/Swiss-Prot), A6J662 (UniProtKB/TrEMBL), A0A8I6GKA7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGN
AILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRM
ALDDMVSTLKKISTPVDVNNRDMMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKE
IDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDI
EITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDN
NRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEIL
SEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIP
RTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVET
AVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE

hide sequence

Ensembl Acc Id:

ENSRNOP00000025824 ⟸ ENSRNOT00000025824

Ensembl Acc Id:

ENSRNOP00000076951 ⟸ ENSRNOT00000110088

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P502-F1-model_v2	AlphaFold	Q6P502	1-545	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691433

Promoter ID:

EPDNEW_R1956

Type:

initiation region

Name:

Cct3_1

Description:

chaperonin containing TCP1 subunit 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	187,668,973 - 187,669,033	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735038	AgrOrtholog
BioCyc Gene	G2FUF-52493	BioCyc
Ensembl Genes	ENSRNOG00000019090	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025824.7	UniProtKB/Swiss-Prot
	ENSRNOT00000110088	ENTREZGENE
Gene3D-CATH	1.10.560.10	UniProtKB/Swiss-Prot
	3.30.260.10	UniProtKB/Swiss-Prot
	3.50.7.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:6890550	IMAGE-MGC_LOAD
InterPro	Chap_CCT_gamma	UniProtKB/Swiss-Prot
	Chaperone_TCP-1	UniProtKB/Swiss-Prot
	Chaperonin_TCP-1_CS	UniProtKB/Swiss-Prot
	Cpn60/TCP-1	UniProtKB/Swiss-Prot
	GroEL-like_apical_dom_sf	UniProtKB/Swiss-Prot
	GROEL-like_equatorial_sf	UniProtKB/Swiss-Prot
	TCP-1-like_intermed_sf	UniProtKB/Swiss-Prot
	TCP-1_chaperonin	UniProtKB/Swiss-Prot
	thermosome_alpha	UniProtKB/Swiss-Prot
KEGG Report	rno:295230	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72950	IMAGE-MGC_LOAD
NCBI Gene	295230	ENTREZGENE
PANTHER	PTHR11353	UniProtKB/Swiss-Prot
Pfam	Cpn60_TCP1	UniProtKB/Swiss-Prot
PhenoGen	Cct3	PhenoGen
PRINTS	TCOMPLEXTCP1	UniProtKB/Swiss-Prot
PROSITE	TCP1_1	UniProtKB/Swiss-Prot
	TCP1_2	UniProtKB/Swiss-Prot
	TCP1_3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019090	RatGTEx
Superfamily-SCOP	SSF48592	UniProtKB/Swiss-Prot
	SSF52029	UniProtKB/Swiss-Prot
	SSF54849	UniProtKB/Swiss-Prot
UniProt	A0A8I5Y7A1_RAT	UniProtKB/TrEMBL
	A0A8I6GKA7	ENTREZGENE, UniProtKB/TrEMBL
	A6J662	ENTREZGENE, UniProtKB/TrEMBL
	Q6P502	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-13	Cct3	chaperonin containing TCP1 subunit 3	Cct3	chaperonin containing Tcp1, subunit 3 (gamma)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-29	Cct3	chaperonin containing Tcp1, subunit 3 (gamma)	Cct3	chaperonin subunit 3 (gamma)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-08	Cct3	chaperonin subunit 3 (gamma)		chaperonin containing TCP1, subunit 3 (gamma)	Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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