![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of CACNA2D3 mRNA | CTD | PMID:30723492 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1331982 | 6480464 | Tetrachlorodibenzodioxin affects the expression of CACNA2D3 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CACNA2D3 mRNA | CTD | PMID:32109520 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of CACNA2D3 protein | CTD | PMID:26597043 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | RGD:1349571 | 6480464 | [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in decreased methylation of CACNA2D3 gene | CTD | PMID:31601247 | 4,4'-sulfonyldiphenol | increases methylation | ISO | RGD:1349571 | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased methylation of CACNA2D3 gene | CTD | PMID:31601247 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of CACNA2D3 mRNA | CTD | PMID:24780913 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of CACNA2D3 mRNA | CTD | PMID:31881176 | aflatoxin B1 | decreases methylation | ISO | RGD:1349571 | 6480464 | Aflatoxin B1 results in decreased methylation of CACNA2D3 gene | CTD | PMID:27153756 | aflatoxin B1 | affects methylation | ISO | RGD:1349571 | 6480464 | Aflatoxin B1 affects the methylation of CACNA2D3 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | RGD:1349571 | 6480464 | aflatoxin B2 results in increased methylation of CACNA2D3 intron | CTD | PMID:30157460 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CACNA2D3 mRNA | CTD | PMID:16483693 | androgen antagonist | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA2D3 mRNA | CTD | PMID:25607892 | aristolochic acid A | decreases expression | ISO | RGD:1349571 | 6480464 | aristolochic acid I results in decreased expression of CACNA2D3 mRNA | CTD | PMID:33212167 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of CACNA2D3 gene | CTD | PMID:28931070 | benzo[a]pyrene | decreases methylation | ISO | RGD:1331982 | 6480464 | Benzo(a)pyrene results in decreased methylation of CACNA2D3 intron | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | RGD:1349571 | 6480464 | Benzo(a)pyrene results in decreased expression of CACNA2D3 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | RGD:1349571 | 6480464 | Benzo(a)pyrene results in increased methylation of CACNA2D3 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | RGD:1349571 | 6480464 | Benzo(a)pyrene affects the methylation of CACNA2D3 intron | CTD | PMID:30157460 | benzo[e]pyrene | increases methylation | ISO | RGD:1349571 | 6480464 | benzo(e)pyrene results in increased methylation of CACNA2D3 intron | CTD | PMID:30157460 | bexarotene | multiple interactions | EXP | | 6480464 | [bexarotene co-treated with Tamoxifen] results in increased expression of CACNA2D3 mRNA | CTD | PMID:17630414 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CACNA2D3 mRNA | CTD | PMID:25607892 | bis(2-ethylhexyl) phthalate | increases expression | ISO | RGD:1349571 | 6480464 | Diethylhexyl Phthalate results in increased expression of CACNA2D3 mRNA | CTD | PMID:31163220 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA2D3 mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNA2D3 mRNA | CTD | PMID:25607892 | bisphenol A | increases methylation | ISO | RGD:1349571 | 6480464 | bisphenol A results in increased methylation of CACNA2D3 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CACNA2D3 mRNA | CTD | PMID:34947998 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of CACNA2D3 gene | CTD | PMID:28505145 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CACNA2D3 mRNA | CTD | PMID:25181051 | Butylparaben | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA2D3 mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNA2D3 mRNA | CTD | PMID:25607892 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of CACNA2D3 mRNA | CTD | PMID:19167457 | carbon nanotube | decreases expression | ISO | RGD:1349571 | 6480464 | Nanotubes, Carbon results in decreased expression of CACNA2D3 mRNA | CTD | PMID:15585362 | CGP 52608 | multiple interactions | ISO | RGD:1349571 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CACNA2D3 gene] | CTD | PMID:28238834 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of CACNA2D3 mRNA | CTD | PMID:32741897 | DDE | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CACNA2D3 mRNA | CTD | PMID:25607892 | DDT | decreases methylation | EXP | | 6480464 | DDT results in decreased methylation of CACNA2D3 gene | CTD | PMID:30207508 | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CACNA2D3 mRNA | CTD | PMID:25607892 | disodium selenite | increases expression | ISO | RGD:1349571 | 6480464 | Sodium Selenite results in increased expression of CACNA2D3 mRNA | CTD | PMID:18175754 | dorsomorphin | multiple interactions | ISO | RGD:1349571 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D3 mRNA | CTD | PMID:27188386 | enzacamene | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA2D3 mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNA2D3 mRNA | CTD | PMID:25607892 | epoxiconazole | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CACNA2D3 mRNA | CTD | PMID:25607892 | ethanol | affects splicing | ISO | RGD:1331982 | 6480464 | Ethanol affects the splicing of CACNA2D3 mRNA | CTD | PMID:30319688 | fenofibrate | increases expression | EXP | | 6480464 | Fenofibrate results in increased expression of CACNA2D3 mRNA | CTD | PMID:32741897 | fulvestrant | multiple interactions | ISO | RGD:1349571 | 6480464 | [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in decreased methylation of CACNA2D3 gene | CTD | PMID:31601247 | fulvestrant | increases methylation | ISO | RGD:1349571 | 6480464 | Fulvestrant results in increased methylation of CACNA2D3 gene | CTD | PMID:31601247 | glyphosate | increases methylation | EXP | | 6480464 | glyphosate results in increased methylation of CACNA2D3 gene | CTD | PMID:31011160 | ibuprofen | affects expression | ISO | RGD:1349571 | 6480464 | Ibuprofen affects the expression of CACNA2D3 mRNA | CTD | PMID:17070997 | linuron | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CACNA2D3 mRNA | CTD | PMID:25607892 | lipopolysaccharide | decreases expression | ISO | RGD:1349571 | 6480464 | Lipopolysaccharides results in decreased expression of CACNA2D3 mRNA | CTD | PMID:18192897 | lipopolysaccharide | multiple interactions | ISO | RGD:1349571 | 6480464 | [S-(1, 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of CACNA2D3 mRNA | CTD | PMID:35811015 | methapyrilene | increases methylation | ISO | RGD:1349571 | 6480464 | Methapyrilene results in increased methylation of CACNA2D3 intron | CTD | PMID:30157460 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of CACNA2D3 gene | CTD | PMID:33148267 | O-methyleugenol | decreases expression | ISO | RGD:1349571 | 6480464 | methyleugenol results in decreased expression of CACNA2D3 mRNA | CTD | PMID:32234424 | paracetamol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] affects the expression of CACNA2D3 mRNA | CTD | PMID:25607892 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of CACNA2D3 gene | CTD | PMID:33148267 | pioglitazone | multiple interactions | ISO | RGD:1331982 | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CACNA2D3 mRNA | CTD | PMID:27935865 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of CACNA2D3 mRNA | CTD | PMID:32741897 | prochloraz | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CACNA2D3 mRNA | CTD | PMID:25607892 | procymidone | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CACNA2D3 mRNA | CTD | PMID:25607892 | rofecoxib | decreases expression | ISO | RGD:1349571 | 6480464 | rofecoxib results in decreased expression of CACNA2D3 mRNA | CTD | PMID:17070997 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | RGD:1349571 | 6480464 | S-(1, 2-dichlorovinyl)cysteine results in decreased expression of CACNA2D3 mRNA | CTD | PMID:35811015 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | RGD:1349571 | 6480464 | [S-(1, 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of CACNA2D3 mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | RGD:1349571 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D3 mRNA | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | RGD:1349571 | 6480464 | Silicon Dioxide results in decreased expression of CACNA2D3 mRNA | CTD | PMID:22300531 | tamoxifen | multiple interactions | EXP | | 6480464 | [bexarotene co-treated with Tamoxifen] results in increased expression of CACNA2D3 mRNA | CTD | PMID:17630414 | trichostatin A | increases expression | ISO | RGD:1349571 | 6480464 | trichostatin A results in increased expression of CACNA2D3 mRNA | CTD | PMID:24935251 | trimellitic anhydride | decreases expression | ISO | RGD:1331982 | 6480464 | trimellitic anhydride results in decreased expression of CACNA2D3 mRNA | CTD | PMID:19042947 | valproic acid | affects expression | ISO | RGD:1331982 | 6480464 | Valproic Acid affects the expression of CACNA2D3 mRNA | CTD | PMID:17292431 | valproic acid | multiple interactions | ISO | RGD:1349571 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D3 mRNA | CTD | PMID:27188386 | valproic acid | affects expression | ISO | RGD:1349571 | 6480464 | Valproic Acid affects the expression of CACNA2D3 mRNA | CTD | PMID:25979313 | vinclozolin | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CACNA2D3 mRNA | CTD | PMID:25607892 | vinclozolin | decreases methylation | EXP | | 6480464 | vinclozolin results in decreased methylation of CACNA2D3 gene | CTD | PMID:31079544 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of CACNA2D3 mRNA | CTD | PMID:19015723 | zoledronic acid | increases expression | ISO | RGD:1349571 | 6480464 | zoledronic acid results in increased expression of CACNA2D3 mRNA | CTD | PMID:24714768 | |