Cacna2d3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3) - Rat Genome Database

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Gene: Cacna2d3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3) Rattus norvegicus
Analyze
Symbol: Cacna2d3
Name: calcium voltage-gated channel auxiliary subunit alpha2delta 3
RGD ID: 631361
Description: Enables voltage-gated calcium channel activity. Involved in calcium ion transport and cellular response to insulin-like growth factor stimulus. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium channel, voltage dependent, alpha2/delta subunit 3; calcium channel, voltage-dependent, alpha 2/delta 3 subunit; calcium channel, voltage-dependent, alpha2/delta subunit 3; LOC108353110; uncharacterized LOC108353110; voltage-dependent calcium channel subunit alpha-2/delta-3; voltage-gated calcium channel subunit alpha-2/delta-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2164,098,439 - 4,912,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl164,098,445 - 4,912,351 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx164,098,664 - 4,922,074 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0165,244,103 - 6,067,511 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0164,103,589 - 4,923,173 (-)NCBIRnor_WKY
Rnor_6.0164,871,348 - 5,795,825 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,871,650 - 5,795,825 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0164,812,761 - 5,730,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4164,173,412 - 5,059,574 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1164,173,409 - 4,856,843 (-)NCBI
Celera1610,267,421 - 11,074,133 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of calcium channel alpha(2)delta-subunits from rat atria and the differential regulation of their expression by IGF-1. Chu PJ and Best PM, J Mol Cell Cardiol 2003 Feb;35(2):207-15.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20080692   PMID:25631988   PMID:33986433  


Genomics

Comparative Map Data
Cacna2d3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2164,098,439 - 4,912,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl164,098,445 - 4,912,351 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx164,098,664 - 4,922,074 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0165,244,103 - 6,067,511 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0164,103,589 - 4,923,173 (-)NCBIRnor_WKY
Rnor_6.0164,871,348 - 5,795,825 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,871,650 - 5,795,825 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0164,812,761 - 5,730,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4164,173,412 - 5,059,574 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1164,173,409 - 4,856,843 (-)NCBI
Celera1610,267,421 - 11,074,133 (+)NCBICelera
Cytogenetic Map16p16NCBI
CACNA2D3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38354,122,552 - 55,074,557 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl354,122,547 - 55,074,557 (+)EnsemblGRCh38hg38GRCh38
GRCh37354,156,579 - 55,108,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36354,131,733 - 55,083,624 (+)NCBINCBI36Build 36hg18NCBI36
Build 34354,131,732 - 55,083,622NCBI
Celera354,123,406 - 55,075,102 (+)NCBICelera
Cytogenetic Map3p21.1-p14.3NCBI
HuRef354,205,841 - 55,158,072 (+)NCBIHuRef
CHM1_1354,108,246 - 55,059,854 (+)NCBICHM1_1
T2T-CHM13v2.0354,156,427 - 55,108,831 (+)NCBIT2T-CHM13v2.0
Cacna2d3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391428,626,900 - 29,444,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1428,626,900 - 29,443,821 (-)EnsemblGRCm39 Ensembl
GRCm381428,904,943 - 29,722,775 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1428,904,943 - 29,721,864 (-)EnsemblGRCm38mm10GRCm38
MGSCv371429,718,129 - 30,535,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361427,731,954 - 28,548,875 (-)NCBIMGSCv36mm8
Celera1425,158,028 - 25,975,723 (-)NCBICelera
Cytogenetic Map14A3NCBI
Cacna2d3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554304,091,272 - 4,939,967 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554304,091,308 - 4,939,899 (+)NCBIChiLan1.0ChiLan1.0
CACNA2D3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1355,282,940 - 56,234,050 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl355,282,935 - 56,233,723 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0354,061,565 - 55,012,985 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CACNA2D3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12035,097,185 - 36,043,562 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2035,097,182 - 35,956,774 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2035,028,187 - 35,974,772 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02035,371,704 - 36,317,653 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2035,371,705 - 36,204,746 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12034,813,915 - 35,646,853 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02035,172,910 - 36,118,982 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02035,388,688 - 36,335,412 (-)NCBIUU_Cfam_GSD_1.0
Cacna2d3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118171,617,423 - 172,496,330 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364734,757,893 - 5,634,576 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364734,757,797 - 5,634,896 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA2D3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1336,222,295 - 37,019,801 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11336,222,295 - 37,025,119 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21340,167,102 - 40,325,457 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNA2D3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12215,506,289 - 16,433,892 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2215,700,522 - 16,433,899 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041150,452,156 - 151,384,152 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna2d3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248222,218,995 - 3,080,863 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248222,218,675 - 3,080,874 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cacna2d3
5213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:56
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000048043
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
12903955Kidm69Kidney mass QTL 690.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)168323804227609Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
D16Mit2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2164,227,609 - 4,227,730 (+)MAPPERmRatBN7.2
Rnor_6.0165,098,584 - 5,098,704NCBIRnor6.0
Rnor_6.0165,013,802 - 5,013,922NCBIRnor6.0
Rnor_5.0164,954,192 - 4,954,312UniSTSRnor5.0
Rnor_5.0165,038,686 - 5,038,806UniSTSRnor5.0
RGSC_v3.4164,304,396 - 4,304,517RGDRGSC3.4
RGSC_v3.4164,304,397 - 4,304,517UniSTSRGSC3.4
RGSC_v3.1164,304,394 - 4,304,515RGD
Celera1610,945,533 - 10,945,653UniSTS
RH 3.4 Map168.3RGD
RH 3.4 Map168.3UniSTS
SHRSP x BN Map161.1599UniSTS
SHRSP x BN Map161.1599RGD
FHH x ACI Map163.1999RGD
Cytogenetic Map16p16UniSTS
D16Rat86  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2164,824,836 - 4,824,985 (+)MAPPERmRatBN7.2
Rnor_6.0165,706,424 - 5,706,572NCBIRnor6.0
Rnor_5.0165,643,859 - 5,644,007UniSTSRnor5.0
RGSC_v3.4164,970,173 - 4,970,322RGDRGSC3.4
RGSC_v3.4164,970,174 - 4,970,322UniSTSRGSC3.4
RGSC_v3.1164,970,172 - 4,970,320RGD
Celera1610,353,106 - 10,353,250UniSTS
RH 3.4 Map1616.3UniSTS
RH 3.4 Map1616.3RGD
SHRSP x BN Map161.74UniSTS
SHRSP x BN Map161.74RGD
Cytogenetic Map16p16UniSTS
RH133095  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2164,242,690 - 4,242,899 (+)MAPPERmRatBN7.2
Rnor_6.0165,113,667 - 5,113,875NCBIRnor6.0
Rnor_6.0165,029,227 - 5,029,435NCBIRnor6.0
Rnor_5.0165,053,769 - 5,053,977UniSTSRnor5.0
Rnor_5.0164,969,617 - 4,969,825UniSTSRnor5.0
RGSC_v3.4164,319,480 - 4,319,688UniSTSRGSC3.4
Celera1610,930,364 - 10,930,572UniSTS
RH 3.4 Map168.8UniSTS
Cytogenetic Map16p16UniSTS
AU048102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2164,120,279 - 4,120,492 (+)MAPPERmRatBN7.2
Rnor_6.0164,893,190 - 4,893,402NCBIRnor6.0
Rnor_5.0164,834,301 - 4,834,513UniSTSRnor5.0
RGSC_v3.4164,194,952 - 4,195,164UniSTSRGSC3.4
Celera1611,052,395 - 11,052,607UniSTS
Cytogenetic Map16p16UniSTS
AU048875  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2164,474,140 - 4,474,347 (+)MAPPERmRatBN7.2
Rnor_6.0165,353,076 - 5,353,282NCBIRnor6.0
Rnor_5.0165,292,211 - 5,292,417UniSTSRnor5.0
RGSC_v3.4164,587,366 - 4,587,572UniSTSRGSC3.4
Celera1610,701,066 - 10,701,285UniSTS
Cytogenetic Map16p16UniSTS
D2S339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2164,255,279 - 4,256,041 (+)MAPPERmRatBN7.2
Rnor_6.0165,126,487 - 5,127,248NCBIRnor6.0
Rnor_5.0165,065,439 - 5,066,200UniSTSRnor5.0
RGSC_v3.4164,331,150 - 4,331,911UniSTSRGSC3.4
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64 9
Low 2 18 15 18 8 10 8 32 30 11 8
Below cutoff 1 25 29 28 1 28 1 2 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000048043   ⟹   ENSRNOP00000042602
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl164,098,741 - 4,912,351 (-)Ensembl
Rnor_6.0 Ensembl164,871,650 - 5,795,825 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096713   ⟹   ENSRNOP00000084398
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl164,233,179 - 4,912,351 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110691   ⟹   ENSRNOP00000080630
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl164,098,741 - 4,912,351 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117613   ⟹   ENSRNOP00000097929
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl164,098,445 - 4,746,315 (-)Ensembl
RefSeq Acc Id: NM_175595   ⟹   NP_783185
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2164,098,741 - 4,912,351 (-)NCBI
Rnor_6.0164,871,650 - 5,795,825 (-)NCBI
Rnor_5.0164,812,761 - 5,730,476 (-)NCBI
RGSC_v3.4164,173,412 - 5,059,574 (-)RGD
Celera1610,267,421 - 11,074,133 (+)RGD
Sequence:
RefSeq Acc Id: XM_017600077   ⟹   XP_017455566
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2164,098,439 - 4,912,351 (-)NCBI
Rnor_6.0164,871,348 - 5,795,825 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094442   ⟹   XP_038950370
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2164,098,759 - 4,912,254 (-)NCBI
RefSeq Acc Id: XR_005494605
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2164,098,439 - 4,912,498 (-)NCBI
RefSeq Acc Id: XR_005494606
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2164,249,143 - 4,912,498 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_783185   ⟸   NM_175595
- Peptide Label: precursor
- UniProtKB: Q8CFG5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455566   ⟸   XM_017600077
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G6W1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042602   ⟸   ENSRNOT00000048043
RefSeq Acc Id: XP_038950370   ⟸   XM_039094442
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000080630   ⟸   ENSRNOT00000110691
RefSeq Acc Id: ENSRNOP00000097929   ⟸   ENSRNOT00000117613
RefSeq Acc Id: ENSRNOP00000084398   ⟸   ENSRNOT00000096713
Protein Domains
Cache   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CFG5-F1-model_v2 AlphaFold Q8CFG5 1-1085 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631361 AgrOrtholog
BioCyc Gene G2FUF-12219 BioCyc
Ensembl Genes ENSRNOG00000031287 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000042602 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000080630.1 UniProtKB/TrEMBL
  ENSRNOP00000084398.1 UniProtKB/TrEMBL
  ENSRNOP00000097929 ENTREZGENE
  ENSRNOP00000097929.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048043 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000096713 ENTREZGENE
  ENSRNOT00000096713.1 UniProtKB/TrEMBL
  ENSRNOT00000110691.1 UniProtKB/TrEMBL
  ENSRNOT00000117613 ENTREZGENE
  ENSRNOT00000117613.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro VDCC_a2/dsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:306243 UniProtKB/Swiss-Prot
NCBI Gene 306243 ENTREZGENE
Pfam VGCC_alpha2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacna2d3 PhenoGen
PROSITE VWFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZZ76_RAT UniProtKB/TrEMBL
  A0A8I6AST9_RAT UniProtKB/TrEMBL
  A0A8I6G6W1 ENTREZGENE, UniProtKB/TrEMBL
  CA2D3_RAT UniProtKB/Swiss-Prot
  F1LSR8_RAT UniProtKB/TrEMBL
  Q8CFG5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cacna2d3  calcium voltage-gated channel auxiliary subunit alpha2delta 3  LOC108353110  uncharacterized LOC108353110  Data Merged 737654 PROVISIONAL
2016-08-02 LOC108353110  uncharacterized LOC108353110      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-02-11 Cacna2d3  calcium voltage-gated channel auxiliary subunit alpha2delta 3  Cacna2d3  calcium channel, voltage-dependent, alpha2/delta subunit 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Cacna2d3  calcium voltage-gated channel auxiliary subunit alpha2delta 3  Cacna2d3  calcium voltage-gated channel auxiliary subunit alpha2delta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Cacna2d3  calcium channel, voltage-dependent, alpha2/delta subunit 3  Cacna2d3  calcium channel, voltage-dependent, alpha 2/delta 3 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cacna2d3  calcium channel, voltage-dependent, alpha 2/delta 3 subunit    calcium channel, voltage dependent, alpha2/delta subunit 3  Name updated 1299863 APPROVED
2004-02-11 Cacna2d3  calcium channel, voltage dependent, alpha2/delta subunit 3      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is increased by IGF-1 632381