Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Crls1 | Rat | combined oxidative phosphorylation deficiency 57 | | ISO | CRLS1 (Homo sapiens) | 7240710 | | OMIM | | |
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Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Crls1 | Rat | combined oxidative phosphorylation deficiency 57 | | ISO | CRLS1 (Homo sapiens) | 7240710 | | OMIM | | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Effect of thyroxine on the activity of mitochondrial cardiolipin synthase in rat liver. | Hostetler KY Biochim Biophys Acta. 1991 Oct 15;1086(1):139-40. |
3. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
4. | SMPDB Annotation Import Pipeline | Pipeline to import SMPDB annotations from SMPDB into RGD |
5. | Metabolism and function of mitochondrial cardiolipin. | Ren M, etal., Prog Lipid Res. 2014 Jul;55:1-16. doi: 10.1016/j.plipres.2014.04.001. Epub 2014 Apr 24. |
6. | GOA pipeline | RGD automated data pipeline |
7. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
8. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
9. | Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement. | Schlame M and Hostetler KY, J Biol Chem. 1991 Nov 25;266(33):22398-403. |
10. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
PMID:15489334 | PMID:18454555 | PMID:18614015 | PMID:29325722 | PMID:34800366 |
Crls1 (Rattus norvegicus - Norway rat) |
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CRLS1 (Homo sapiens - human) |
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Crls1 (Mus musculus - house mouse) |
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Crls1 (Chinchilla lanigera - long-tailed chinchilla) |
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CRLS1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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CRLS1 (Canis lupus familiaris - dog) |
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Crls1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CRLS1 (Sus scrofa - pig) |
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CRLS1 (Chlorocebus sabaeus - green monkey) |
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Crls1 (Heterocephalus glaber - naked mole-rat) |
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Variants in Crls1
178 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH136667 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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nervous system
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renal system
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reproductive system
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respiratory system
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9 | 11 | 49 | 113 | 91 | 90 | 59 | 25 | 59 | 6 | 218 | 97 | 93 | 45 | 60 | 31 |
RefSeq Transcripts | NM_001014258 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006235078 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006235079 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006235080 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063284285 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063284286 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | BC085849 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CH473949 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000003 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000028900 ⟹ ENSRNOP00000028900 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_001014258 ⟹ NP_001014280 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006235078 ⟹ XP_006235140 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006235079 ⟹ XP_006235141 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006235080 ⟹ XP_006235142 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_063284285 ⟹ XP_063140355 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063284286 ⟹ XP_063140356 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001014280 | (Get FASTA) | NCBI Sequence Viewer |
XP_006235140 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006235141 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006235142 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063140355 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063140356 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAH85849 | (Get FASTA) | NCBI Sequence Viewer |
EDL80276 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000028900.5 | ||
ENSRNOP00060002451 | |||
ENSRNOP00065017792 | |||
GenBank Protein | Q5U2V5 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001014280 ⟸ NM_001014258 |
- UniProtKB: | Q5U2V5 (UniProtKB/Swiss-Prot), A6HQH5 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006235142 ⟸ XM_006235080 |
- Peptide Label: | isoform X2 |
- Sequence: |
RefSeq Acc Id: | XP_006235140 ⟸ XM_006235078 |
- Peptide Label: | isoform X1 |
- Sequence: |
RefSeq Acc Id: | XP_006235141 ⟸ XM_006235079 |
- Peptide Label: | isoform X2 |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000028900 ⟸ ENSRNOT00000028900 |
RefSeq Acc Id: | XP_063140355 ⟸ XM_063284285 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | XP_063140356 ⟸ XM_063284286 |
- Peptide Label: | isoform X2 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q5U2V5-F1-model_v2 | AlphaFold | Q5U2V5 | 1-302 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13692460 | ||||||||
Promoter ID: | EPDNEW_R2983 | ||||||||
Type: | initiation region | ||||||||
Name: | Crls1_1 | ||||||||
Description: | cardiolipin synthase 1 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:1311037 | AgrOrtholog |
BioCyc Gene | G2FUF-47760 | BioCyc |
BioCyc Pathway | PWY-5269 [cardiolipin biosynthesis II] | BioCyc |
BioCyc Pathway Image | PWY-5269 | BioCyc |
Ensembl Genes | ENSRNOG00000021273 | Ensembl, UniProtKB/Swiss-Prot |
ENSRNOG00060002271 | UniProtKB/Swiss-Prot | |
ENSRNOG00065013892 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000028900.7 | UniProtKB/Swiss-Prot |
ENSRNOT00060003562 | UniProtKB/Swiss-Prot | |
ENSRNOT00065022900 | UniProtKB/Swiss-Prot | |
Gene3D-CATH | 1.20.120.1760 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IMAGE_CLONE | IMAGE:7189638 | IMAGE-MGC_LOAD |
InterPro | CDP-alcohol_PTase-I | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CDP-OH_P_trans | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
CDP-OH_PTrfase_TM_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:366196 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MGC_CLONE | MGC:94564 | IMAGE-MGC_LOAD |
NCBI Gene | 366196 | ENTREZGENE |
PANTHER | CARDIOLIPIN SYNTHASE (CMP-FORMING) | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | CDP-OH_P_transf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Crls1 | PhenoGen |
RatGTEx | ENSRNOG00000021273 | RatGTEx |
ENSRNOG00060002271 | RatGTEx | |
ENSRNOG00065013892 | RatGTEx | |
UniProt | A6HQH5 | ENTREZGENE, UniProtKB/TrEMBL |
CRLS1_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2008-02-27 | Crls1 | cardiolipin synthase 1 | RGD1311037 | similar to chromosome 20 open reading frame 155 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2005-12-06 | RGD1311037 | similar to chromosome 20 open reading frame 155 | RGD1311037_predicted | similar to chromosome 20 open reading frame 155 (predicted) | Symbol and Name updated | 1559027 | APPROVED |
2005-01-20 | RGD1311037_predicted | similar to chromosome 20 open reading frame 155 (predicted) | LOC366196_predicted | Symbol and Name status set to approved | 1331353 | APPROVED | |
2005-01-12 | LOC366196_predicted | similar to chromosome 20 open reading frame 155 (predicted) | Symbol and Name status set to provisional | 70820 | PROVISIONAL |