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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:climbazole
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Accession:CHEBI:83499 term browser browse the term
Definition:A racemate composed of equimolar amounts of (R)- and (S)-climbazole. It is a topically applied antifungal agent used to treat human fungal skin infections.
Synonyms:exact_synonym: rac-1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one
 related_synonym: (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one;   1-(p-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl -2-butanone;   Climbazolum;   Formula=C15H17ClN2O2;   climbazol
 xref: CAS:38083-17-9
 xref_mesh: MESH:C108286
 xref: PMID:11552297;   PMID:11824557;   PMID:18950734;   PMID:21272039;   PMID:23542433;   PMID:23958691;   PMID:23982925;   PMID:24811958;   PMID:25794970;   PMID:27378240;   Patent:DE102012203240;   Pesticides:climbazole;   Reaxys:618020;   Wikipedia:Climbazole



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climbazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP climbazole results in increased expression of CYP2B1 mRNA; climbazole results in increased expression of CYP2B1 protein CTD PMID:11552297 PMID:11824557 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP climbazole results in increased expression of CYP3A2 protein CTD PMID:11552297 PMID:11824557 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP climbazole results in increased expression of CYP4A1 protein CTD PMID:11552297 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        xenobiotic 18664
          climbazole 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        hemiaminal 466
                                          hemiaminal ether 396
                                            1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one 3
                                              (R)-climbazole 3
                                                climbazole 3
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