Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | NPY2R (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors. | Adewale AS, etal., Neuropharmacology. 2007 May;52(6):1396-402. Epub 2007 Feb 20. |
| 2. | Neuropeptide-Y Y2-receptor agonist, PYY3-36 promotes non-rapid eye movement sleep in rat. | Akanmu MA, etal., Neurosci Res. 2006 Mar;54(3):165-70. Epub 2005 Dec 27. |
| 3. | Expression of neuropeptide Y and its receptors Y1 and Y2 in the rat heart and its supplying autonomic and spinal sensory ganglia in experimentally induced diabetes. | Chottova Dvorakova M, etal., Neuroscience. 2008 Feb 19;151(4):1016-28. doi: 10.1016/j.neuroscience.2007.07.069. Epub 2007 Dec 8. |
| 4. | BODIPY-conjugated neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypes. | Dumont Y, etal., Br J Pharmacol. 2005 Dec;146(8):1069-81. |
| 5. | Blockade of neuropeptide Y(2) receptors and suppression of NPY's anti-epileptic actions in the rat hippocampal slice by BIIE0246. | El Bahh B, etal., Br J Pharmacol. 2002 Jun;136(4):502-9. |
| 6. | The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors. | El Bahh B, etal., Eur J Neurosci. 2005 Sep;22(6):1417-30. |
| 7. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 8. | Neuropeptide Y modulates effects of bradykinin and prostaglandin E2 on trigeminal nociceptors via activation of the Y1 and Y2 receptors. | Gibbs JL, etal., Br J Pharmacol. 2007 Jan;150(1):72-9. Epub 2006 Dec 4. |
| 9. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 10. | The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning. | Goumain M, etal., Mol Pharmacol 2001 Jul;60(1):124-34. |
| 11. | Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells. | Igura K, etal., Rejuvenation Res. 2011 Aug;14(4):393-403. doi: 10.1089/rej.2010.1129. Epub 2011 May 19. |
| 12. | Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R. | Kloster E, etal., J Mol Med (Berl). 2014 Feb;92(2):177-84. |
| 13. | Involvement of NPY Y2 receptor subtype in the control of the spontaneous NO/GnRH release at the rat median eminence. | Knauf C, etal., Neuroreport. 2001 Oct 29;12(15):3365-9. |
| 14. | Of mice and men: neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability. | Li L, etal., J Cardiovasc Transl Res. 2011 Jun;4(3):351-62. doi: 10.1007/s12265-011-9271-5. Epub 2011 Apr 6. |
| 15. | Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. | Ma L, etal., Diabetes. 2005 May;54(5):1598-602. |
| 16. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 17. | Role of neuropeptide Y Y(1) and Y(2) receptors on behavioral despair in a rat model of depression with co-morbid anxiety. | Morales-Medina JC, etal., Neuropharmacology. 2012 Jan;62(1):200-8. doi: 10.1016/j.neuropharm.2011.06.030. Epub 2011 Jul 23. |
| 18. | Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation. | Moran TD, etal., J Neurophysiol. 2004 Dec;92(6):3266-75. Epub 2004 Aug 4. |
| 19. | Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors. | Morris MJ, etal., Eur J Neurosci. 2007 Feb;25(4):1136-43. |
| 20. | Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation. | Nave H, etal., J Neuroimmunol. 2004 Oct;155(1-2):1-12. |
| 21. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 22. | The neuropeptide Y receptors, Y1 and Y2, are transiently and differentially expressed in the developing cerebellum. | Neveu I, etal., Neuroscience 2002;113(4):767-77. |
| 23. | A Novel Long-Acting Selective Neuropeptide Y2 Receptor PEGylated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents. | Ortiz AA, etal., J Pharmacol Exp Ther. 2007 Aug 1;. |
| 24. | A pool of Y2 neuropeptide Y receptors activated by modifiers of membrane sulfhydryl or cholesterol balance. | Parker SL, etal., Eur J Biochem. 2002 May;269(9):2315-22. |
| 25. | Neuropeptide Y-induced contraction is mediated by neuropeptide Y Y2 and Y4 receptors in the rat colon. | Pheng LH, etal., Eur J Pharmacol. 1999 Jun 11;374(1):85-91. |
| 26. | GOA pipeline | RGD automated data pipeline |
| 27. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 28. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 29. | Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence. | Rimondini R, etal., Neurosci Lett. 2005 Feb 28;375(2):129-33. Epub 2004 Nov 30. |
| 30. | Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala. | Sajdyk TJ, etal., Pharmacol Biochem Behav 2002 Mar;71(3):419-23. |
| 31. | Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. | Torekov SS, etal., Diabetologia. 2006 Nov;49(11):2653-8. Epub 2006 Sep 22. |
| 32. | Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy? | Vezzani A and Sperk G, Neuropeptides. 2004 Aug;38(4):245-52. |
| 33. | Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet. | Wang C, etal., Horm Metab Res. 2007 Apr;39(4):262-7. |
Additional References at PubMed
| PMID:9636652 | PMID:10698177 | PMID:14615027 | PMID:15544855 | PMID:19119448 | PMID:19593212 | PMID:19953226 | PMID:20451563 | PMID:21658765 | PMID:22074679 | PMID:23074243 | PMID:23548582 |
| PMID:24316073 | PMID:25146309 | PMID:27847128 | PMID:28057538 | PMID:28154160 | PMID:28438668 | PMID:35313782 | PMID:37501148 |
Genomics
Comparative Map Data
| Npy2r (Rattus norvegicus - Norway rat) |
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| NPY2R (Homo sapiens - human) |
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| Npy2r (Mus musculus - house mouse) |
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| Npy2r (Chinchilla lanigera - long-tailed chinchilla) |
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| NPY2R (Pan paniscus - bonobo/pygmy chimpanzee) |
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| NPY2R (Canis lupus familiaris - dog) |
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| Npy2r (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| NPY2R (Sus scrofa - pig) |
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| NPY2R (Chlorocebus sabaeus - green monkey) |
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| Npy2r (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Npy2r
49 total Variants 
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