Dck (deoxycytidine kinase) - Rat Genome Database

Name: Dck
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Dck (deoxycytidine kinase) Rattus norvegicus

Analyze

Symbol:

Dck

Name:

deoxycytidine kinase

RGD ID:

620667

Description:

Enables several functions, including ATP binding activity; deoxycytidine kinase activity; and magnesium ion binding activity. Involved in deoxycytidine metabolic process and nucleotide phosphorylation. Located in cytosol. Orthologous to human DCK (deoxycytidine kinase); PARTICIPATES IN gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; lamivudine pharmacokinetics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 3-chloropropane-1,2-diol; 5-aza-2'-deoxycytidine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

deoxyadenosine kinase; deoxyguanosine kinase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DCK (deoxycytidine kinase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dck (deoxycytidine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dck (deoxycytidine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DCK (deoxycytidine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DCK (deoxycytidine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dck (deoxycytidine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DCK (deoxycytidine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DCK (deoxycytidine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dck (deoxycytidine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DCK (deoxycytidine kinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dck (deoxycytidine kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dck (deoxycytidine kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	19,305,218 - 19,326,247 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	19,305,218 - 19,326,247 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	19,294,940 - 19,315,959 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	20,613,805 - 20,634,822 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	19,316,197 - 19,337,208 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	20,935,442 - 20,952,939 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	20,935,369 - 20,953,095 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	20,845,716 - 20,863,008 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	20,886,700 - 20,904,305 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	20,886,695 - 20,904,305 (-)	NCBI
Celera	14	18,648,191 - 18,665,287 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Kabuki Syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

2'-deoxycytidine (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (EXP)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

arsenite(3-) (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP,ISO)

cadmium sulfate (ISO)

caffeine (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

clobetasol (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cytarabine (EXP,ISO)

dCTP (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

emtricitabine (ISO)

ethanol (ISO)

fenpyroximate (ISO)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

hydrogen peroxide (ISO)

ivermectin (ISO)

lamivudine (ISO)

methyl methanesulfonate (ISO)

miconazole (ISO)

N,N-diethyl-m-toluamide (EXP)

N-nitrosodiethylamine (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP)

PCB138 (ISO)

pentachlorophenol (ISO)

perfluorononanoic acid (ISO)

permethrin (EXP)

pirinixic acid (ISO)

poly(I:C) (EXP)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

tamoxifen (ISO)

Tanshinone I (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

zalcitabine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

CMP biosynthetic process (IEA)

dAMP salvage (IEA,ISO)

deoxycytidine metabolic process (IDA,IMP)

nucleoside phosphate biosynthetic process (ISO)

phosphorylation (IEA)

pyrimidine nucleotide metabolic process (ISO,ISS)

Cellular Component

cytoplasm (IBA)

cytosol (IDA)

mitochondrion (IBA)

nucleoplasm (IEA,ISO)

nucleus (IEA)

Molecular Function

ATP binding (IDA,IEA)

cytidine kinase activity (IEA,ISO)

deoxyadenosine kinase activity (IEA,ISO)

deoxycytidine kinase activity (IBA,IDA,IEA,IMP,ISO)

deoxyguanosine kinase activity (IEA,ISO)

deoxyribonucleoside binding (IPI)

magnesium ion binding (IDA)

protein homodimerization activity (IEA,ISO)

pyrimidine deoxyribonucleoside binding (IDA,IMP)

Molecular Pathway Annotations Click to see Annotation Detail View

gemcitabine pharmacodynamics pathway (ISO)

gemcitabine pharmacokinetics pathway (ISO)

lamivudine pharmacokinetics pathway (ISO)

purine metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Deoxycytidine kinase and thymidine kinase activities in rat brain.	Singhal RL and Weber G, Oncol Res. 1993;5(4-5):191-5.
9.	Transfection of wild-type deoxycytidine kinase (dck) cDNA into an AraC- and DAC-resistant rat leukemic cell line of clonal origin fully restores drug sensitivity.	Stegmann AP, etal., Blood. 1995 Mar 1;85(5):1188-94.
10.	Cloning of the Dck gene encoding rat deoxycytidine kinase.	Stegmann AP, etal., Gene 1994 Dec 15;150(2):351-4.
11.	Role of deoxycytidine kinase in an in vitro model for AraC- and DAC-resistance: substrate-enzyme interactions with deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-aza-2'-deoxycytidine.	Stegmann AP, etal., Leukemia. 1993 Jul;7(7):1005-11.

Additional References at PubMed

PMID:2539852	PMID:2844225	PMID:11687801	PMID:12808445	PMID:20544526

Genomics

Comparative Map Data

Dck
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	19,305,218 - 19,326,247 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	19,305,218 - 19,326,247 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	19,294,940 - 19,315,959 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	20,613,805 - 20,634,822 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	19,316,197 - 19,337,208 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	20,935,442 - 20,952,939 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	20,935,369 - 20,953,095 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	20,845,716 - 20,863,008 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	20,886,700 - 20,904,305 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	20,886,695 - 20,904,305 (-)	NCBI
Celera	14	18,648,191 - 18,665,287 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

DCK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	70,993,649 - 71,030,914 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	70,992,538 - 71,030,914 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	71,859,366 - 71,896,631 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	72,078,256 - 72,115,477 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	72,224,426 - 72,261,648	NCBI
Celera	4	69,216,290 - 69,253,648 (+)	NCBI		Celera
Cytogenetic Map	4	q13.3	NCBI
HuRef	4	67,664,417 - 67,701,817 (+)	NCBI		HuRef
CHM1_1	4	71,895,140 - 71,932,501 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	74,336,086 - 74,373,339 (+)	NCBI		T2T-CHM13v2.0

Dck
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	88,912,872 - 88,931,136 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	88,912,855 - 88,931,140 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	88,765,013 - 88,783,277 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	88,764,996 - 88,783,281 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	89,194,038 - 89,212,302 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	89,839,588 - 89,857,838 (+)	NCBI		MGSCv36	mm8
Celera	5	86,914,328 - 86,932,500 (+)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI

Dck
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955447	2,031,258 - 2,067,210 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955447	2,031,851 - 2,067,005 (-)	NCBI	ChiLan1.0	ChiLan1.0

DCK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	59,537,350 - 59,574,537 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	59,536,997 - 59,574,537 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	53,193,475 - 53,230,708 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

DCK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	60,206,742 - 60,236,338 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	60,205,937 - 60,235,678 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	59,940,643 - 59,971,419 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	61,012,272 - 61,043,696 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	61,011,720 - 61,076,885 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	60,627,511 - 60,658,525 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	60,119,020 - 60,150,439 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	61,266,521 - 61,297,680 (+)	NCBI		UU_Cfam_GSD_1.0

Dck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	15,366,311 - 15,391,122 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936598	3,817,994 - 3,843,241 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936598	3,819,239 - 3,846,692 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DCK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	8	67,706,661 - 67,736,743 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	71,614,965 - 71,642,025 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DCK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	19,503,855 - 19,535,355 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	19,504,038 - 19,535,674 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666084	3,326,990 - 3,358,445 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dck
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624890	2,335,081 - 2,368,653 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624890	2,335,064 - 2,367,826 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dck
112 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	221
Count of miRNA genes:	158
Interacting mature miRNAs:	187
Transcripts:	ENSRNOT00000004440
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat
2302277	Gluco38	Glucose level QTL 38	5.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	28035204	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
631212	Bw5	Body weight QTL5	5.43		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	11030812	30320092	Rat
1300140	Srn3	Serum renin concentration QTL 3	3.19		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	14875168	30883947	Rat
631528	Scl11	Serum cholesterol level QTL 11	4.9		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	14	17573412	19726296	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	17593761	42336881	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17622561	42337007	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18541332	63541332	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18631345	42337007	Rat

Markers in Region

RH141381

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	19,306,660 - 19,306,840 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	20,933,590 - 20,933,769	NCBI	Rnor6.0
Rnor_5.0	14	20,843,864 - 20,844,043	UniSTS	Rnor5.0
RGSC_v3.4	14	20,884,848 - 20,885,027	UniSTS	RGSC3.4
Celera	14	18,646,339 - 18,646,518	UniSTS
RH 3.4 Map	14	305.39	UniSTS
Cytogenetic Map	14	p22	UniSTS

AI176044

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	19,307,157 - 19,307,352 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	20,934,087 - 20,934,281	NCBI	Rnor6.0
Rnor_5.0	14	20,844,361 - 20,844,555	UniSTS	Rnor5.0
RGSC_v3.4	14	20,885,345 - 20,885,539	UniSTS	RGSC3.4
Celera	14	18,646,836 - 18,647,030	UniSTS
RH 3.4 Map	14	284.8	UniSTS
Cytogenetic Map	14	p22	UniSTS

AI231703

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	19,324,261 - 19,324,422 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	20,951,257 - 20,951,417	NCBI	Rnor6.0
Rnor_5.0	14	20,861,326 - 20,861,486	UniSTS	Rnor5.0
RGSC_v3.4	14	20,902,623 - 20,902,783	UniSTS	RGSC3.4
Celera	14	18,663,605 - 18,663,765	UniSTS
RH 3.4 Map	14	284.3	UniSTS
Cytogenetic Map	14	p22	UniSTS

GDB:437189

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	97,517,490 - 97,517,920 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	108,306,182 - 108,306,611	NCBI	Rnor6.0
Rnor_5.0	14	105,142,039 - 105,142,468	UniSTS	Rnor5.0
RGSC_v3.4	14	104,467,365 - 104,467,794	UniSTS	RGSC3.4
Celera	14	96,494,461 - 96,494,890	UniSTS
Cytogenetic Map	14	p22	UniSTS
Cytogenetic Map	14	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	26	31	22	19	22			74	17	30	10
Low		17	26	19		19	8	11		18	11	1	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_024158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212366	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L33894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000004440 ⟹ ENSRNOP00000004440

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	19,305,218 - 19,326,247 (-)	Ensembl
Rnor_6.0 Ensembl	14	20,935,369 - 20,953,095 (-)	Ensembl

RefSeq Acc Id:

NM_024158 ⟹ NP_077072

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	19,305,218 - 19,326,247 (-)	NCBI
Rnor_6.0	14	20,935,442 - 20,952,939 (-)	NCBI
Rnor_5.0	14	20,845,716 - 20,863,008 (-)	NCBI
RGSC_v3.4	14	20,886,700 - 20,904,305 (-)	RGD
Celera	14	18,648,191 - 18,665,287 (-)	RGD

Sequence:

show sequence

CCGCCTTCCTGAGGTCCCGCGTCCTTAGCATGGCCACCCCACCTAAGAGGTTCTGCTCTTCTCC
CTCAACCAGCTCTGAGGGGACCCGCATCAAGAAGATCTCCATCGAAGGGAACATCGCTGCCGGG
AAGTCAACGTTTGTGAATATCTTAAAGCAAGTCTGTGAGGATTGGGAAGTGGTTCCTGAGCCTG
TGGCCAGGTGGTGCAATGTGCAGAGTACCCAAGATGAGTTTGAGGAGTTGACAACATCTCAGAA
GAGTGGTGGGAATGTTCTTCAGATGATGTATGAGAAACCTGAGCGGTGGTCTTTTATCTTCCAA
TCATACGCCTGTCTCAGCCGGATCCGGGCCCAGCTTGCCTCTCTCAACGGCAGCCTCAGGGATG
CAGAGAAACCTGTATTATTTTTTGAACGATCTGTGTATAGTGACAGGTATATTTTCGCATCTAA
TTTGTATGAATCTGACTGCATGAATGAAACAGAATGGACAATATATCAAGACTGGCATGACTGG
ATGAATAGCCAGTTTGGCCAAAGCCTTGAATTGGATGGAATAATTTATCTTCGAGCTACTCCAG
AGAAGTGCTTAAATAGAATATATATACGGGGAAGGGATGAAGAGCAAGGCATTCCTCTTGAATA
TTTAGAGAAACTTCACTATAAACACGAAAGCTGGCTCCTTCATCGGACTCTGAAAACCAACTTT
GAATATCTCCAAGAGGTGCCTATCCTCACATTGGATGTTAATTTAGACTTTAAAGACAAAGAAG
AAAGTCTGGTTGAAAAGGTCAAAGAGTTTTTGAGTACTACTTGATTGCACAGGAGACAACAGGC
AACAAAATGTTTCTACATACTTCAGTTTTGTATATTGCCATAGCTTGATATTACTGCCAAAAAG
TCTTTAGAAGATTAAAGTTTTTAAACCATTTTTGTTTTAAGAAATAACCTTCCG

hide sequence

Protein Sequences


Protein RefSeqs	NP_077072	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA65098	(Get FASTA)	NCBI Sequence Viewer
	EDL88529	(Get FASTA)	NCBI Sequence Viewer
	P48769	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_077072 ⟸ NM_024158

- UniProtKB:

G3V6E9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATPPKRFCSSPSTSSEGTRIKKISIEGNIAAGKSTFVNILKQVCEDWEVVPEPVARWCNVQST
QDEFEELTTSQKSGGNVLQMMYEKPERWSFIFQSYACLSRIRAQLASLNGSLRDAEKPVLFFER
SVYSDRYIFASNLYESDCMNETEWTIYQDWHDWMNSQFGQSLELDGIIYLRATPEKCLNRIYIR
GRDEEQGIPLEYLEKLHYKHESWLLHRTLKTNFEYLQEVPILTLDVNLDFKDKEESLVEKVKEF
LSTT

hide sequence

RefSeq Acc Id:

ENSRNOP00000004440 ⟸ ENSRNOT00000004440

Protein Domains

Deoxynucleoside kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P48769-F1-model_v2	AlphaFold	P48769	1-260	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699238

Promoter ID:

EPDNEW_R9763

Type:

initiation region

Name:

Dck_1

Description:

deoxycytidine kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	20,953,031 - 20,953,091	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620667	AgrOrtholog
BioCyc Gene	G2FUF-16168	BioCyc
BioCyc Pathway	PWY-7199 [pyrimidine deoxyribonucleosides salvage]	BioCyc
	PWY-7224 [purine deoxyribonucleosides salvage]	BioCyc
Ensembl Genes	ENSRNOG00000003296	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000004440	ENTREZGENE
	ENSRNOP00000004440.5	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004440	ENTREZGENE
	ENSRNOT00000004440.8	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	DCK/DGK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DNK_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:79127	UniProtKB/Swiss-Prot
NCBI Gene	79127	ENTREZGENE
PANTHER	DEOXYCYTIDINE KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DEOXYNUCLEOSIDE KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	dNK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	DCK	RGD
PhenoGen	Dck	PhenoGen
PIRSF	DNK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	DCK_RAT	UniProtKB/Swiss-Prot
	G3V6E9	ENTREZGENE, UniProtKB/TrEMBL
	P48769	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Dck	deoxycytidine kinase			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Dck	deoxycytidine kinase			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	high expression in thymus and weak expression in liver and lung	727775
gene_homology	shows 89.7 and 92.2% nucleotide identity with the human and mouse Dck	727775
gene_protein	encodes 260 aa protein	727775

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)