Dck (deoxycytidine kinase) - Rat Genome Database

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Gene: Dck (deoxycytidine kinase) Rattus norvegicus
Analyze
Symbol: Dck
Name: deoxycytidine kinase
RGD ID: 620667
Description: Enables deoxycytidine kinase activity; heterocyclic compound binding activity; and magnesium ion binding activity. Involved in deoxycytidine metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human DCK (deoxycytidine kinase); PARTICIPATES IN gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; lamivudine pharmacokinetics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deoxyadenosine kinase; deoxyguanosine kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81419,589,298 - 19,610,326 (-)NCBIGRCr8
mRatBN7.21419,305,218 - 19,326,247 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,305,218 - 19,326,247 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1419,294,940 - 19,315,959 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01420,613,805 - 20,634,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01419,316,197 - 19,337,208 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01420,935,442 - 20,952,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,935,369 - 20,953,095 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,845,716 - 20,863,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,886,700 - 20,904,305 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,886,695 - 20,904,305 (-)NCBI
Celera1418,648,191 - 18,665,287 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2'-deoxycytidine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (EXP,ISO)
dCTP  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emtricitabine  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
zalcitabine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
mitochondrion  (IBA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Deoxycytidine kinase and thymidine kinase activities in rat brain. Singhal RL and Weber G, Oncol Res. 1993;5(4-5):191-5.
9. Transfection of wild-type deoxycytidine kinase (dck) cDNA into an AraC- and DAC-resistant rat leukemic cell line of clonal origin fully restores drug sensitivity. Stegmann AP, etal., Blood. 1995 Mar 1;85(5):1188-94.
10. Cloning of the Dck gene encoding rat deoxycytidine kinase. Stegmann AP, etal., Gene 1994 Dec 15;150(2):351-4.
11. Role of deoxycytidine kinase in an in vitro model for AraC- and DAC-resistance: substrate-enzyme interactions with deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-aza-2'-deoxycytidine. Stegmann AP, etal., Leukemia. 1993 Jul;7(7):1005-11.
Additional References at PubMed
PMID:2539852   PMID:2844225   PMID:11687801   PMID:12808445   PMID:20544526  


Genomics

Comparative Map Data
Dck
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81419,589,298 - 19,610,326 (-)NCBIGRCr8
mRatBN7.21419,305,218 - 19,326,247 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,305,218 - 19,326,247 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1419,294,940 - 19,315,959 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01420,613,805 - 20,634,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01419,316,197 - 19,337,208 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01420,935,442 - 20,952,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,935,369 - 20,953,095 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,845,716 - 20,863,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,886,700 - 20,904,305 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,886,695 - 20,904,305 (-)NCBI
Celera1418,648,191 - 18,665,287 (-)NCBICelera
Cytogenetic Map14p22NCBI
DCK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38470,993,649 - 71,030,914 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl470,992,538 - 71,030,914 (+)EnsemblGRCh38hg38GRCh38
GRCh37471,859,366 - 71,896,631 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36472,078,256 - 72,115,477 (+)NCBINCBI36Build 36hg18NCBI36
Build 34472,224,426 - 72,261,648NCBI
Celera469,216,290 - 69,253,648 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef467,664,417 - 67,701,817 (+)NCBIHuRef
CHM1_1471,895,140 - 71,932,501 (+)NCBICHM1_1
T2T-CHM13v2.0474,336,086 - 74,373,339 (+)NCBIT2T-CHM13v2.0
Dck
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39588,912,872 - 88,931,136 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl588,912,855 - 88,931,140 (+)EnsemblGRCm39 Ensembl
GRCm38588,765,013 - 88,783,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl588,764,996 - 88,783,281 (+)EnsemblGRCm38mm10GRCm38
MGSCv37589,194,038 - 89,212,302 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36589,839,588 - 89,857,838 (+)NCBIMGSCv36mm8
Celera586,914,328 - 86,932,500 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.96NCBI
Dck
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554472,031,258 - 2,067,210 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554472,031,851 - 2,067,005 (-)NCBIChiLan1.0ChiLan1.0
DCK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2359,054,071 - 59,094,834 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1459,249,120 - 59,286,370 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0453,193,475 - 53,230,708 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1459,537,350 - 59,574,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl459,536,997 - 59,574,537 (-)Ensemblpanpan1.1panPan2
DCK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11360,206,742 - 60,236,338 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1360,205,937 - 60,235,678 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1359,940,643 - 59,971,419 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01361,012,272 - 61,043,696 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1361,011,720 - 61,076,885 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11360,627,511 - 60,658,525 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01360,119,020 - 60,150,439 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01361,266,521 - 61,297,680 (+)NCBIUU_Cfam_GSD_1.0
Dck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528515,366,311 - 15,391,122 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365983,817,994 - 3,843,241 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365983,819,239 - 3,846,692 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1867,706,661 - 67,736,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2871,614,965 - 71,642,025 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DCK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1719,503,855 - 19,535,355 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl719,504,038 - 19,535,674 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660843,326,990 - 3,358,445 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dck
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248902,335,081 - 2,368,653 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248902,335,064 - 2,367,826 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dck
136 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:158
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000004440
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141757341219726296Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat

Markers in Region
RH141381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21419,306,660 - 19,306,840 (+)MAPPERmRatBN7.2
Rnor_6.01420,933,590 - 20,933,769NCBIRnor6.0
Rnor_5.01420,843,864 - 20,844,043UniSTSRnor5.0
RGSC_v3.41420,884,848 - 20,885,027UniSTSRGSC3.4
Celera1418,646,339 - 18,646,518UniSTS
RH 3.4 Map14305.39UniSTS
Cytogenetic Map14p22UniSTS
AI176044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21419,307,157 - 19,307,352 (+)MAPPERmRatBN7.2
Rnor_6.01420,934,087 - 20,934,281NCBIRnor6.0
Rnor_5.01420,844,361 - 20,844,555UniSTSRnor5.0
RGSC_v3.41420,885,345 - 20,885,539UniSTSRGSC3.4
Celera1418,646,836 - 18,647,030UniSTS
RH 3.4 Map14284.8UniSTS
Cytogenetic Map14p22UniSTS
AI231703  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21419,324,261 - 19,324,422 (+)MAPPERmRatBN7.2
Rnor_6.01420,951,257 - 20,951,417NCBIRnor6.0
Rnor_5.01420,861,326 - 20,861,486UniSTSRnor5.0
RGSC_v3.41420,902,623 - 20,902,783UniSTSRGSC3.4
Celera1418,663,605 - 18,663,765UniSTS
RH 3.4 Map14284.3UniSTS
Cytogenetic Map14p22UniSTS
GDB:437189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21497,517,490 - 97,517,920 (+)MAPPERmRatBN7.2
Rnor_6.014108,306,182 - 108,306,611NCBIRnor6.0
Rnor_5.014105,142,039 - 105,142,468UniSTSRnor5.0
RGSC_v3.414104,467,365 - 104,467,794UniSTSRGSC3.4
Celera1496,494,461 - 96,494,890UniSTS
Cytogenetic Map14p22UniSTS
Cytogenetic Map14q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 31 22 19 22 74 17 30 10
Low 17 26 19 19 8 11 18 11 1 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000004440   ⟹   ENSRNOP00000004440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1419,305,218 - 19,326,247 (-)Ensembl
Rnor_6.0 Ensembl1420,935,369 - 20,953,095 (-)Ensembl
RefSeq Acc Id: NM_024158   ⟹   NP_077072
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81419,589,298 - 19,610,326 (-)NCBI
mRatBN7.21419,305,218 - 19,326,247 (-)NCBI
Rnor_6.01420,935,442 - 20,952,939 (-)NCBI
Rnor_5.01420,845,716 - 20,863,008 (-)NCBI
RGSC_v3.41420,886,700 - 20,904,305 (-)RGD
Celera1418,648,191 - 18,665,287 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077072 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA65098 (Get FASTA)   NCBI Sequence Viewer  
  EDL88529 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004440
  ENSRNOP00000004440.5
GenBank Protein P48769 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077072   ⟸   NM_024158
- UniProtKB: P48769 (UniProtKB/Swiss-Prot),   G3V6E9 (UniProtKB/TrEMBL),   A6KKI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004440   ⟸   ENSRNOT00000004440
Protein Domains
Deoxynucleoside kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48769-F1-model_v2 AlphaFold P48769 1-260 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699238
Promoter ID:EPDNEW_R9763
Type:initiation region
Name:Dck_1
Description:deoxycytidine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01420,953,031 - 20,953,091EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620667 AgrOrtholog
BioCyc Gene G2FUF-16168 BioCyc
BioCyc Pathway PWY-7199 [pyrimidine deoxyribonucleosides salvage] BioCyc
  PWY-7224 [purine deoxyribonucleosides salvage] BioCyc
BioCyc Pathway Image PWY-7199 BioCyc
  PWY-7224 BioCyc
Ensembl Genes ENSRNOG00000003296 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004440 ENTREZGENE
  ENSRNOT00000004440.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DCK/DGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNK_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79127 UniProtKB/Swiss-Prot
NCBI Gene 79127 ENTREZGENE
PANTHER DEOXYCYTIDINE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEOXYNUCLEOSIDE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam dNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DCK RGD
PhenoGen Dck PhenoGen
PIRSF DNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003296 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KKI1 ENTREZGENE, UniProtKB/TrEMBL
  DCK_RAT UniProtKB/Swiss-Prot
  G3V6E9 ENTREZGENE, UniProtKB/TrEMBL
  P48769 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dck  deoxycytidine kinase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dck  deoxycytidine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression high expression in thymus and weak expression in liver and lung 727775
gene_homology shows 89.7 and 92.2% nucleotide identity with the human and mouse Dck 727775
gene_protein encodes 260 aa protein 727775