Bnip3l (BCL2 interacting protein 3 like) - Rat Genome Database

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Gene: Bnip3l (BCL2 interacting protein 3 like) Rattus norvegicus
Analyze
Symbol: Bnip3l
Name: BCL2 interacting protein 3 like
RGD ID: 621354
Description: Predicted to enable lamin binding activity and protein homodimerization activity. Involved in negative regulation of mitochondrial membrane potential; positive regulation of apoptotic process; and positive regulation of mitochondrial membrane permeability. Located in cytosol and mitochondrion. Biomarker of gestational diabetes; middle cerebral artery infarction; and pancreatitis. Orthologous to human BNIP3L (BCL2 interacting protein 3 like); PARTICIPATES IN intrinsic apoptotic pathway; mitochondrial autophagy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-nitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa-interacting protein 3-like; BCL2/adenovirus E1B interacting protein 3-like; Nix; UV93
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21541,174,594 - 41,197,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1541,174,594 - 41,197,803 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1543,040,103 - 43,063,202 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01544,190,315 - 44,213,414 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01542,634,876 - 42,658,005 (-)NCBIRnor_WKY
Rnor_6.01543,643,897 - 43,667,123 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1543,643,897 - 43,667,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01547,927,887 - 47,951,099 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41546,516,626 - 46,539,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11546,532,405 - 46,555,536 (-)NCBI
Celera1540,841,989 - 40,865,114 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(-)-demecolcine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
apigenin  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Brevetoxin B  (ISO)
bromochloroacetic acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
CCCP  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
enniatin  (EXP)
ethanol  (ISO)
finasteride  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP,ISO)
hydrogen peroxide  (ISO)
inositol  (EXP)
lamivudine  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP)
maneb  (ISO)
melatonin  (ISO)
mithramycin  (EXP,ISO)
motexafin gadolinium  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP,ISO)
nimesulide  (EXP)
Nonidet P-40  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
sanguinarine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
taurocholic acid  (EXP)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
Tributyltin oxide  (EXP)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vandetanib  (ISO)
vincristine  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro. Birse-Archbold JL, etal., J Cereb Blood Flow Metab. 2005 Oct;25(10):1356-65.
2. The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord. Duval N, etal., Front Cell Neurosci. 2018 Jan 30;12:15. doi: 10.3389/fncel.2018.00015. eCollection 2018.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
6. Role of hypoxia-inducible factor-1alpha in hypoxia-induced apoptosis of primary alveolar epithelial type II cells. Krick S, etal., Am J Respir Cell Mol Biol. 2005 May;32(5):395-403. Epub 2005 Feb 4.
7. Mitochondria and mitophagy: the yin and yang of cell death control. Kubli DA and Gustafsson AB, Circ Res. 2012 Oct 12;111(9):1208-21. doi: 10.1161/CIRCRESAHA.112.265819.
8. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells. Mughal W, etal., Cell Death Dis. 2015 Oct 29;6:e1944. doi: 10.1038/cddis.2015.306.
11. Increased expression of 19-kD interacting protein-3-like protein and the relationship to apoptosis in the lung of rats with severe acute pancreatitis. Nakamura H, etal., Crit Care Med. 2003 Oct;31(10):2527-34.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Up-regulated expression of Bnip3L after intracerebral hemorrhage in adult rats. Rui Y, etal., J Mol Histol. 2013 Oct;44(5):497-505. doi: 10.1007/s10735-013-9506-7. Epub 2013 Jun 15.
17. Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy. Schwarten M, etal., Autophagy. 2009 Jul;5(5):690-8. Epub 2009 Jul 20.
18. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
19. Changes in levels of hypoxia-induced mediators in rat hippocampus during chronic cerebral hypoperfusion. Yang Y, etal., Neurochem Res. 2013 Nov;38(11):2433-9. doi: 10.1007/s11064-013-1158-1. Epub 2013 Sep 26.
20. Selective inhibition of early--but not late--expressed HIF-1alpha is neuroprotective in rats after focal ischemic brain damage. Yeh SH, etal., Brain Pathol. 2011 May;21(3):249-62. doi: 10.1111/j.1750-3639.2010.00443.x. Epub 2010 Nov 3.
21. Induction of neuronal mitophagy in acute spinal cord injury in rats. Yu D, etal., Neurotox Res. 2013 Nov;24(4):512-22. doi: 10.1007/s12640-013-9397-0. Epub 2013 Apr 30.
Additional References at PubMed
PMID:9867803   PMID:9973195   PMID:10381623   PMID:12477932   PMID:14651853   PMID:16189514   PMID:19273585   PMID:20200478   PMID:21264228   PMID:21516116   PMID:22639046   PMID:23028046  
PMID:23603904   PMID:25416956   PMID:27107012   PMID:27726026   PMID:28006775   PMID:28507335   PMID:31629817   PMID:33125104   PMID:33779883  


Genomics

Comparative Map Data
Bnip3l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21541,174,594 - 41,197,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1541,174,594 - 41,197,803 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1543,040,103 - 43,063,202 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01544,190,315 - 44,213,414 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01542,634,876 - 42,658,005 (-)NCBIRnor_WKY
Rnor_6.01543,643,897 - 43,667,123 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1543,643,897 - 43,667,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01547,927,887 - 47,951,099 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41546,516,626 - 46,539,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11546,532,405 - 46,555,536 (-)NCBI
Celera1540,841,989 - 40,865,114 (-)NCBICelera
Cytogenetic Map15p12NCBI
BNIP3L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38826,383,054 - 26,413,127 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl826,383,054 - 26,505,636 (+)EnsemblGRCh38hg38GRCh38
GRCh37826,240,570 - 26,270,643 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36826,296,440 - 26,326,561 (+)NCBINCBI36Build 36hg18NCBI36
Build 34826,296,439 - 26,326,561NCBI
Celera825,202,906 - 25,233,027 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef824,785,443 - 24,815,530 (+)NCBIHuRef
CHM1_1826,442,112 - 26,472,262 (+)NCBICHM1_1
T2T-CHM13v2.0826,659,614 - 26,689,692 (+)NCBIT2T-CHM13v2.0
Bnip3l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391467,222,688 - 67,246,580 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1467,222,688 - 67,246,326 (-)EnsemblGRCm39 Ensembl
GRCm381466,985,238 - 67,008,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,985,239 - 67,008,877 (-)EnsemblGRCm38mm10GRCm38
MGSCv371467,604,077 - 67,627,714 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361465,939,350 - 65,962,934 (-)NCBIMGSCv36mm8
Celera1464,740,567 - 64,764,166 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.6NCBI
Bnip3l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,122,408 - 49,144,998 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,122,408 - 49,144,162 (+)NCBIChiLan1.0ChiLan1.0
BNIP3L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1822,567,167 - 22,593,004 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl822,567,428 - 22,593,004 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0825,661,629 - 25,685,878 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BNIP3L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12531,133,512 - 31,149,750 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2531,136,168 - 31,148,905 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2531,721,380 - 31,744,197 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02531,333,654 - 31,356,477 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2531,309,183 - 31,357,312 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12531,290,601 - 31,313,410 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02531,138,672 - 31,161,471 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02531,305,758 - 31,328,586 (-)NCBIUU_Cfam_GSD_1.0
Bnip3l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049439,246,819 - 9,270,823 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936757499,147 - 523,541 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936757499,485 - 523,494 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BNIP3L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1410,318,732 - 10,345,679 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11410,318,688 - 10,345,689 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21411,483,806 - 11,510,808 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BNIP3L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1824,497,311 - 24,521,424 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl824,497,351 - 24,523,553 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605217,637,530 - 17,661,690 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bnip3l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475821,284,167 - 21,310,398 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475821,284,165 - 21,309,957 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bnip3l
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:980
Count of miRNA genes:316
Interacting mature miRNAs:417
Transcripts:ENSRNOT00000014798
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat

Markers in Region
RH133328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,176,656 - 41,176,843 (+)MAPPERmRatBN7.2
Rnor_6.01543,645,959 - 43,646,145NCBIRnor6.0
Rnor_5.01547,948,851 - 47,949,037UniSTSRnor5.0
RGSC_v3.41546,518,688 - 46,518,874UniSTSRGSC3.4
Celera1540,844,049 - 40,844,235UniSTS
Cytogenetic Map15p12UniSTS
AW532315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,183,574 - 41,183,753 (+)MAPPERmRatBN7.2
Rnor_6.01543,652,877 - 43,653,055NCBIRnor6.0
Rnor_5.01547,941,941 - 47,942,119UniSTSRnor5.0
RGSC_v3.41546,525,606 - 46,525,784UniSTSRGSC3.4
Celera1540,850,967 - 40,851,145UniSTS
RH 3.4 Map15322.5UniSTS
Cytogenetic Map15p12UniSTS
RH140685  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,176,484 - 41,176,677 (+)MAPPERmRatBN7.2
Rnor_6.01543,645,788 - 43,645,979NCBIRnor6.0
Rnor_5.01547,949,017 - 47,949,208UniSTSRnor5.0
RGSC_v3.41546,518,517 - 46,518,708UniSTSRGSC3.4
Celera1540,843,880 - 40,844,069UniSTS
Cytogenetic Map15p12UniSTS
RH140982  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,174,674 - 41,174,868 (+)MAPPERmRatBN7.2
Rnor_6.01543,643,978 - 43,644,171NCBIRnor6.0
Rnor_5.01547,950,825 - 47,951,018UniSTSRnor5.0
RGSC_v3.41546,516,707 - 46,516,900UniSTSRGSC3.4
Celera1540,842,070 - 40,842,263UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB077364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF441118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000014798   ⟹   ENSRNOP00000014798
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1541,174,597 - 41,197,803 (-)Ensembl
Rnor_6.0 Ensembl1543,643,897 - 43,667,029 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095519   ⟹   ENSRNOP00000092276
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1541,174,594 - 41,191,623 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102793   ⟹   ENSRNOP00000093752
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1541,176,633 - 41,197,439 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112162   ⟹   ENSRNOP00000089819
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1541,176,527 - 41,197,803 (-)Ensembl
RefSeq Acc Id: NM_080888   ⟹   NP_543164
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21541,174,594 - 41,197,730 (-)NCBI
Rnor_6.01543,643,897 - 43,667,029 (-)NCBI
Rnor_5.01547,927,887 - 47,951,099 (+)NCBI
RGSC_v3.41546,516,626 - 46,539,756 (-)RGD
Celera1540,841,989 - 40,865,114 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252091   ⟹   XP_006252153
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21541,176,571 - 41,190,258 (-)NCBI
Rnor_6.01543,643,900 - 43,661,324 (-)NCBI
Rnor_5.01547,927,887 - 47,951,099 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599570   ⟹   XP_017455059
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21541,176,571 - 41,197,492 (-)NCBI
Rnor_6.01543,643,900 - 43,666,835 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092962   ⟹   XP_038948890
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21541,176,571 - 41,191,644 (-)NCBI
RefSeq Acc Id: XM_039092964   ⟹   XP_038948892
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21541,176,571 - 41,197,505 (-)NCBI
RefSeq Acc Id: XM_039092965   ⟹   XP_038948893
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21541,176,571 - 41,192,683 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_543164   ⟸   NM_080888
- UniProtKB: Q4G086 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252153   ⟸   XM_006252091
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017455059   ⟸   XM_017599570
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AKI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014798   ⟸   ENSRNOT00000014798
RefSeq Acc Id: XP_038948892   ⟸   XM_039092964
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948893   ⟸   XM_039092965
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948890   ⟸   XM_039092962
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000089819   ⟸   ENSRNOT00000112162
RefSeq Acc Id: ENSRNOP00000092276   ⟸   ENSRNOT00000095519
RefSeq Acc Id: ENSRNOP00000093752   ⟸   ENSRNOT00000102793

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4G086-F1-model_v2 AlphaFold Q4G086 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699761
Promoter ID:EPDNEW_R10284
Type:initiation region
Name:Bnip3l_1
Description:BCL2 interacting protein 3 like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01543,667,098 - 43,667,158EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621354 AgrOrtholog
BioCyc Gene G2FUF-13317 BioCyc
Ensembl Genes ENSRNOG00000009820 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014798 ENTREZGENE
  ENSRNOP00000014798.4 UniProtKB/TrEMBL
  ENSRNOP00000089819.1 UniProtKB/TrEMBL
  ENSRNOP00000092276 ENTREZGENE
  ENSRNOP00000092276.1 UniProtKB/TrEMBL
  ENSRNOP00000093752 ENTREZGENE
  ENSRNOP00000093752.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014798 ENTREZGENE
  ENSRNOT00000014798.6 UniProtKB/TrEMBL
  ENSRNOT00000095519 ENTREZGENE
  ENSRNOT00000095519.1 UniProtKB/TrEMBL
  ENSRNOT00000102793 ENTREZGENE
  ENSRNOT00000102793.1 UniProtKB/TrEMBL
  ENSRNOT00000112162.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191644 IMAGE-MGC_LOAD
  IMAGE:7324593 IMAGE-MGC_LOAD
InterPro BNIP3 UniProtKB/TrEMBL
KEGG Report rno:140923 UniProtKB/TrEMBL
MGC_CLONE MGC:112604 IMAGE-MGC_LOAD
  MGC:93241 IMAGE-MGC_LOAD
NCBI Gene 140923 ENTREZGENE
PANTHER PTHR15186 UniProtKB/TrEMBL
Pfam BNIP3 UniProtKB/TrEMBL
PhenoGen Bnip3l PhenoGen
UniProt A0A8I6ACG8_RAT UniProtKB/TrEMBL
  A0A8I6AG85_RAT UniProtKB/TrEMBL
  A0A8I6AKI3 ENTREZGENE, UniProtKB/TrEMBL
  Q4G086 ENTREZGENE, UniProtKB/TrEMBL
  Q66HQ4_RAT UniProtKB/TrEMBL
  Q8VBW4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-05 Bnip3l  BCL2 interacting protein 3 like  Bnip3l  BCL2/adenovirus E1B interacting protein 3-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Bnip3l  BCL2/adenovirus E1B interacting protein 3-like  Bnip3l  BCL2/adenovirus E1B 19 kDa-interacting protein 3-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Bnip3l  BCL2/adenovirus E1B 19 kDa-interacting protein 3-like      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Bnip3l  BCL2/adenovirus E1B 19 kDa-interacting protein 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a BH3 domain 631874