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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621354
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bnip3l
Name: BCL2 interacting protein 3 like
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bnip3laffects response to substanceISOBNIP3L (Homo sapiens)6480464CTDBNIP3L affects the susceptibility to FluorouracilPMID:15067352
Bnip3ldecreases expressionISOBNIP3L (Homo sapiens)6480464CTDFluorouracil results in decreased expression of BNIP3L mRNAPMID:15109396 PMID:16557594 PMID:16709241
Bnip3lincreases expressionISOBNIP3L (Homo sapiens)6480464CTDFluorouracil results in increased expression of BNIP3L mRNAPMID:17039268
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