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Gene: Gnrh1 (gonadotropin releasing hormone 1) Rattus norvegicus
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Symbol: Gnrh1
Name: gonadotropin releasing hormone 1
Description: Exhibits gonadotropin hormone-releasing hormone activity. Involved in several processes, including estrous cycle; negative regulation of immature T cell proliferation; and response to prostaglandin E. Localizes to several cellular components, including cytoplasmic side of rough endoplasmic reticulum membrane; cytoplasmic vesicle; and perikaryon. Used to study prostatic hypertrophy. Human ortholog(s) of this gene implicated in breast cancer; hypogonadotropic hypogonadism 12 with or without anosmia; and periodontitis. Orthologous to human GNRH1 (gonadotropin releasing hormone 1); PARTICIPATES IN gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Gnrh; GNRHA; Gonadotropin releasing hormone; gonadotropin-releasing hormone 1; gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Lhrh; luteinizing hormone-releasing hormone; progonadoliberin I; progonadoliberin-1; Putative protein SH; RGNRHG1; SH-4
Orthologs:
Homo sapiens (human) : GNRH1 (gonadotropin releasing hormone 1)  HGNC  Alliance
Mus musculus (house mouse) : Gnrh1 (gonadotropin releasing hormone 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnrh1 (gonadotropin releasing hormone 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GNRH1 (gonadotropin releasing hormone 1)
Canis lupus familiaris (dog) : GNRH1 (gonadotropin releasing hormone 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnrh1 (gonadotropin releasing hormone 1)
Sus scrofa (pig) : GNRH1 (gonadotropin releasing hormone 1)
Chlorocebus sabaeus (African green monkey) : GNRH1 (gonadotropin releasing hormone 1)
Heterocephalus glaber (naked mole-rat) : Gnrh1 (gonadotropin releasing hormone 1)
more info ...
Is Marker For: Strains:   W-Tg(Gnrh1-EGFP)Nphy  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01544,441,856 - 44,446,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1544,442,555 - 44,442,875 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1544,441,856 - 44,446,064 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01547,151,131 - 47,155,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41547,303,309 - 47,307,517 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11547,319,088 - 47,323,286 (+)NCBI
Celera1541,636,731 - 41,640,939 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gnrh1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2720
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.