Gnrh1 (gonadotropin releasing hormone 1) - Rat Genome Database

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Gene: Gnrh1 (gonadotropin releasing hormone 1) Rattus norvegicus
Analyze
Symbol: Gnrh1
Name: gonadotropin releasing hormone 1
RGD ID: 2720
Description: Enables gonadotropin hormone-releasing hormone activity. Involved in several processes, including estrous cycle; negative regulation of immature T cell proliferation; and response to prolactin. Located in several cellular components, including cytoplasmic side of rough endoplasmic reticulum membrane; cytoplasmic vesicle; and perikaryon. Used to study prostatic hypertrophy. Human ortholog(s) of this gene implicated in breast cancer; hypogonadotropic hypogonadism 12 with or without anosmia; and periodontitis. Orthologous to human GNRH1 (gonadotropin releasing hormone 1); PARTICIPATES IN gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Gnrh; GNRHA; Gonadotropin releasing hormone; gonadotropin-releasing hormone 1; gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Lhrh; luteinizing hormone-releasing hormone; progonadoliberin I; progonadoliberin-1; Putative protein SH; RGNRHG1; SH-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   W-Tg(Gnrh1-EGFP)Nphy  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21541,972,482 - 41,976,690 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1544,441,856 - 44,446,064 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1544,442,555 - 44,442,875 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01544,441,856 - 44,446,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01547,151,131 - 47,155,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41547,303,309 - 47,307,517 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11547,319,088 - 47,323,286 (+)NCBI
Celera1541,636,731 - 41,640,939 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
acetamide  (EXP)
alfuzosin  (EXP)
ammonium chloride  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP)
beta-hexachlorocyclohexane  (ISO)
bicuculline  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calcium dichloride  (EXP)
carvone  (ISO)
chlormequat chloride  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clomiphene  (ISO)
cocaine  (ISO)
cypermethrin  (ISO)
DDE  (ISO)
DDT  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dopamine  (EXP)
Estradiol 17beta-cyclopentylpropionate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP)
glyphosate  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
KT 5823  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melittin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methoxychlor  (EXP,ISO)
methylene blue  (EXP)
methylmercury chloride  (EXP)
muscimol  (EXP)
ochratoxin A  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
Phenoxybenzamine  (EXP)
phenylephrine  (EXP)
potassium chloride  (EXP)
potassium chromate  (ISO)
procymidone  (EXP)
progesterone  (ISO)
raloxifene  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
tetrodotoxin  (ISO)
tributylstannane  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Adelman JP, etal., Science 1987 Mar 20;235(4795):1514-7.
2. Allen MP, etal., J Biol Chem 2002 Oct 11;277(41):38133-40.
3. Azad N, etal., J Endocrinol. 1998 Aug;158(2):229-35.
4. Bouligand J, etal., N Engl J Med. 2009 Jun 25;360(26):2742-8. doi: 10.1056/NEJMoa0900136. Epub 2009 Jun 17.
5. Chan YM, etal., Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11703-8. doi: 10.1073/pnas.0903449106. Epub 2009 Jun 30.
6. Dalkin AC, etal., Endocrinology 2001 Jan;142(1):139-46.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. GOA data from the GO Consortium
9. Gore AC, etal., J Neuroendocrinol 2002 Apr;14(4):300-9.
10. Gore AC, etal., Mol Cell Endocrinol. 2006 Aug 15;256(1-2):40-8. Epub 2006 Jul 12.
11. Hiney JK, etal., Proc Natl Acad Sci U S A 2002 Feb 19;99(4):2386-91.
12. Kalcheim C, etal., J Comp Physiol Psychol. 1981 Feb;95(1):36-44.
13. Kelly MJ, etal., Exp Brain Res. 1982;48(1):97-106.
14. Kermath BA, etal., Endocrinology. 2014 Sep;155(9):3597-609. doi: 10.1210/en.2014-1017. Epub 2014 Jun 10.
15. Maione L, etal., PLoS One. 2013 Jul 25;8(7):e69616. doi: 10.1371/journal.pone.0069616. Print 2013.
16. Mason AJ, etal., Science. 1986 Dec 12;234(4782):1372-8.
17. Merchenthaler I, etal., Brain Res Bull. 1988 Jun;20(6):713-20.
18. MGD data from the GO Consortium
19. Nappi RE and Rivest S, Endocrinology. 1997 Apr;138(4):1374-84.
20. NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline
22. Online Mendelian Inheritance in Man, OMIM (TM).
23. Paruthiyil S, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):17191-6.
24. Piersma D, etal., Breast Cancer Res. 2007;9(4):R51.
25. Pipeline to import KEGG annotations from KEGG into RGD
26. RGD automated data pipeline
27. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. RGD automated import pipeline for gene-chemical interactions
29. RGD comprehensive gene curation
30. Rick FG, etal., J Urol. 2012 Apr;187(4):1498-504. doi: 10.1016/j.juro.2011.11.081. Epub 2012 Feb 17.
31. Schirman-Hildesheim TD, etal., Mol Cell Endocrinol. 2006 Jun 27;252(1-2):120-5. Epub 2006 May 2.
32. Sengupta A, etal., J Histochem Cytochem. 2007 Feb 5;.
33. Suzuki A, etal., Odontology. 2004 Sep;92(1):43-7.
34. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. Tsuruo Y, etal., Neurosci Lett. 1990 Mar 14;110(3):261-6.
36. Valenca MM, etal., Mol Cell Endocrinol. 1988 Jan;55(1):95-100.
37. Wilson TM, etal., Mol Endocrinol. 1995 Jan;9(1):44-53.
38. Yin P and Arita J, Neuroendocrinology 2002 Nov;76(5):272-82.
39. Yu WH, etal., Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9499-503.
40. Zakharova LA, etal., Biochemistry (Mosc). 2000 Oct;65(10):1135-9.
Additional References at PubMed
PMID:1468115   PMID:2476669   PMID:2867548   PMID:7771642   PMID:10803590   PMID:11738808   PMID:11897697   PMID:12198245   PMID:12403831   PMID:12433965   PMID:12598657   PMID:12639934  
PMID:12639939   PMID:12697272   PMID:12810529   PMID:12810551   PMID:12838577   PMID:12865345   PMID:14670985   PMID:14715715   PMID:15138251   PMID:15824321   PMID:15908340   PMID:15919747  
PMID:15964850   PMID:15994198   PMID:16337733   PMID:16405927   PMID:16469806   PMID:17241740   PMID:17280591   PMID:17332066   PMID:17557168   PMID:17935160   PMID:18032409   PMID:18063679  
PMID:18227283   PMID:18467526   PMID:18550775   PMID:18603625   PMID:18701637   PMID:18716286   PMID:18775461   PMID:19179437   PMID:19200975   PMID:19228890   PMID:19253008   PMID:19524128  
PMID:19757493   PMID:19819960   PMID:19856133   PMID:19889867   PMID:20016824   PMID:20380165   PMID:20680515   PMID:20814074   PMID:20937356   PMID:20970475   PMID:21074602   PMID:22039515  
PMID:22147011   PMID:22684563   PMID:23090753   PMID:23197165   PMID:23321696   PMID:23452939   PMID:23518222   PMID:23668015   PMID:23736294   PMID:24216131   PMID:24374911   PMID:24668712  
PMID:24708241   PMID:25048263   PMID:25177948   PMID:25794706   PMID:26248220   PMID:27349532   PMID:30130567   PMID:30218420   PMID:31272713   PMID:31430847  


Genomics

Comparative Map Data
Gnrh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21541,972,482 - 41,976,690 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1544,441,856 - 44,446,064 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1544,442,555 - 44,442,875 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01544,441,856 - 44,446,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01547,151,131 - 47,155,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41547,303,309 - 47,307,517 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11547,319,088 - 47,323,286 (+)NCBI
Celera1541,636,731 - 41,640,939 (+)NCBICelera
Cytogenetic Map15p12NCBI
GNRH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl825,419,258 - 25,424,654 (-)EnsemblGRCh38hg38GRCh38
GRCh38825,419,258 - 25,425,040 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37825,276,774 - 25,282,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36825,332,691 - 25,338,473 (-)NCBINCBI36hg18NCBI36
Build 34825,332,692 - 25,337,836NCBI
Celera824,237,655 - 24,243,437 (-)NCBI
Cytogenetic Map8p21.2NCBI
HuRef823,821,751 - 23,827,534 (-)NCBIHuRef
CHM1_1825,478,220 - 25,484,032 (-)NCBICHM1_1
Gnrh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391467,982,630 - 67,986,885 (+)NCBIGRCm39mm39
GRCm39 Ensembl1467,982,630 - 67,986,888 (+)Ensembl
GRCm381467,745,181 - 67,749,440 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1467,745,181 - 67,749,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv371468,363,286 - 68,367,493 (+)NCBIGRCm37mm9NCBIm37
MGSCv361466,699,676 - 66,702,621 (+)NCBImm8
Celera1465,502,860 - 65,507,056 (+)NCBICelera
Cytogenetic Map14D1NCBI
Gnrh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540348,343,597 - 48,346,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540348,341,731 - 48,346,595 (-)NCBIChiLan1.0ChiLan1.0
GNRH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1821,609,407 - 21,616,521 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl821,609,407 - 21,615,936 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0824,700,268 - 24,707,332 (-)NCBIMhudiblu_PPA_v0panPan3
GNRH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12532,038,631 - 32,043,192 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2532,039,613 - 32,043,028 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2532,623,319 - 32,627,816 (+)NCBI
ROS_Cfam_1.02532,237,978 - 32,242,489 (+)NCBI
UMICH_Zoey_3.12532,193,651 - 32,198,162 (+)NCBI
UNSW_CanFamBas_1.02532,043,144 - 32,047,652 (+)NCBI
UU_Cfam_GSD_1.02532,208,954 - 32,213,456 (+)NCBI
Gnrh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,029,435 - 10,033,174 (+)NCBI
SpeTri2.0NW_0049367571,282,185 - 1,285,804 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNRH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl149,442,971 - 9,447,521 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1149,442,971 - 9,447,521 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21410,597,132 - 10,607,824 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNRH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1823,543,717 - 23,550,728 (-)NCBI
ChlSab1.1 Ensembl823,542,806 - 23,547,771 (-)Ensembl
Vero_WHO_p1.0NW_02366605218,616,776 - 18,623,795 (+)NCBI
Gnrh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475820,447,413 - 20,451,059 (-)NCBI

Position Markers
D15Mgh12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,971,604 - 41,971,702 (+)MAPPERmRatBN7.2
Rnor_6.01544,440,979 - 44,441,076NCBIRnor6.0
Rnor_5.01547,156,119 - 47,156,216UniSTSRnor5.0
RGSC_v3.41547,302,431 - 47,302,529RGDRGSC3.4
RGSC_v3.41547,302,432 - 47,302,529UniSTSRGSC3.4
RGSC_v3.11547,318,211 - 47,318,309RGD
Celera1541,635,854 - 41,635,951UniSTS
Cytogenetic Map15p12UniSTS
D15Arb6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,971,560 - 41,971,801 (+)MAPPERmRatBN7.2
Rnor_6.01544,440,935 - 44,441,175NCBIRnor6.0
Rnor_5.01547,156,020 - 47,156,260UniSTSRnor5.0
RGSC_v3.41547,302,387 - 47,302,628RGDRGSC3.4
RGSC_v3.41547,302,388 - 47,302,628UniSTSRGSC3.4
RGSC_v3.11547,318,167 - 47,318,408RGD
Celera1541,635,810 - 41,636,050UniSTS
FHH x ACI Map1546.36UniSTS
FHH x ACI Map1546.36RGD
Cytogenetic Map15p12UniSTS
RH94423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,973,792 - 41,973,984 (+)MAPPERmRatBN7.2
Rnor_6.01544,443,167 - 44,443,358NCBIRnor6.0
Rnor_5.01547,153,837 - 47,154,028UniSTSRnor5.0
RGSC_v3.41547,304,620 - 47,304,811UniSTSRGSC3.4
Celera1541,638,042 - 41,638,233UniSTS
Cytogenetic Map15p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151549236072568189Rat
9590272Scort14Serum corticosterone level QTL 142.780.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)151698090761980907Rat
8694427Bw163Body weight QTL 1634.820.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)151698090761980907Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151724964162249641Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151809320881255430Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151851391388036354Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152102134252831189Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152377896946825072Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1526381041106550657Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1526381041106550657Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1526381041106550657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152870974173709741Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)153321910189640841Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)153321910189640841Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)153321910189640841Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)153948079762596410Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153974955779033707Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153974955779033707Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154106809486068094Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154275724156027084Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154309747052831189Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1543097470106550657Rat


Related Rat Strains
The following Strains have been annotated to Gnrh1

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:281
Count of miRNA genes:183
Interacting mature miRNAs:214
Transcripts:ENSRNOT00000017939, ENSRNOT00000018006
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 5 65 75 49 30 49 13 17 81 41 45 20 13
Below cutoff 6 1 2 12 2 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017939   ⟹   ENSRNOP00000017939
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1544,442,555 - 44,442,875 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000018006   ⟹   ENSRNOP00000018006
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1544,441,856 - 44,446,064 (+)Ensembl
RefSeq Acc Id: NM_012767   ⟹   NP_036899
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21541,972,482 - 41,976,690 (+)NCBI
Rnor_6.01544,441,856 - 44,446,064 (+)NCBI
Rnor_5.01547,151,131 - 47,155,339 (-)NCBI
RGSC_v3.41547,303,309 - 47,307,517 (+)RGD
Celera1541,636,731 - 41,640,939 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252096   ⟹   XP_006252158
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21541,973,270 - 41,976,683 (+)NCBI
Rnor_6.01544,442,651 - 44,446,057 (+)NCBI
Rnor_5.01547,151,131 - 47,155,339 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036899   ⟸   NM_012767
- Peptide Label: precursor
- UniProtKB: P07490 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006252158   ⟸   XM_006252096
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000018006   ⟸   ENSRNOT00000018006
RefSeq Acc Id: ENSRNOP00000017939   ⟸   ENSRNOT00000017939

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2720 AgrOrtholog
Ensembl Genes ENSRNOG00000013433 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000013441 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000017939 UniProtKB/Swiss-Prot
  ENSRNOP00000018006 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017939 UniProtKB/Swiss-Prot
  ENSRNOT00000018006 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GnRH UniProtKB/Swiss-Prot
  Gonadoliberin UniProtKB/Swiss-Prot
  Gonadoliberin_I_precursor UniProtKB/Swiss-Prot
KEGG Report rno:25194 UniProtKB/Swiss-Prot
NCBI Gene 25194 ENTREZGENE
PANTHER PTHR10522 UniProtKB/Swiss-Prot
Pfam GnRH UniProtKB/Swiss-Prot
PhenoGen Gnrh1 PhenoGen
PRINTS GONADOLIBRNI UniProtKB/Swiss-Prot
PROSITE GNRH UniProtKB/Swiss-Prot
TIGR TC231726
UniProt GON1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P55248 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Gnrh1  gonadotropin releasing hormone 1  Gnrh1  gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Gnrh1  gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)  Gnrh1  gonadotropin-releasing hormone 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gnrh1  gonadotropin-releasing hormone 1      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Gnrh1  gonadotropin-releasing hormone 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neurons and hypothalamus 628509
gene_process regulates synthesis and secretion of the pituitary gonadotropins LH and FSH 61523
gene_regulation secretion increases after gonadectomy in both sexes and during the proestrus LH surge in females 61523
gene_regulation hormone release in hypothalamus is mediated by the cAMP levels 628509